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慢性肾脏病:新版NICE指南摘要

英国医学杂志中文版 2022年第7期25卷 413-416页

作者： Yolanda V Martinez Ivan Benett Andrew j P Lewington Anthony S Wierzbicki 无周津羽(译) 赵明辉(校) National Institute for Health and Care Excellence Manchester M14BDUK NHS ManchesterUK Renal Department St James's University HospitalLeedsUK Department of Metabolic Medicine/Chemical Pathology Guy's&St Thomas'HospitalsLondonUK on behalf of the Guideline Committee 北京大学第一医院肾内科

慢性肾脏病(CKD)很常见,在英国,约13%的成人(>16岁)患病1。从早期无症状到晚期肾衰竭,CKD患者临床表现多样[CKD分期和尿白蛋白/肌酐比值(ACR)分类见表1]。成人CKD患者中G3-G5期者占5%,在75岁及以上人群中这一比例升至34%。随着肾功能不... 详细信息

慢性肾脏病(CKD)很常见,在英国,约13%的成人(>16岁)患病1。从早期无症状到晚期肾衰竭,CKD患者临床表现多样[CKD分期和尿白蛋白/肌酐比值(ACR)分类见表1]。成人CKD患者中G3-G5期者占5%,在75岁及以上人群中这一比例升至34%。随着肾功能不全病情进展,死亡风险增加,心血管疾病风险也增加,部分共病(如糖尿病和高血压)更加严重。虽然大多数成人CKD的管理重点在一级保健,但随着疾病进展,他们需要更多二级保健管理。

关键词：慢性肾脏病死亡风险肾功能不全疾病进展晚期肾衰竭病情进展无症状二级保健

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卒中存活者中与长QT间期有关的心脏病变

世界核心医学期刊文摘(心脏病学分册) 2006年第2期 55-56页

作者： Wong K. Y. K. McSwiggan S. Kennedy N. S. j. 刘文秀 Cardiothoracic Centre-Liverpool NHS Trust Thomas Drive Liverpool L14 3PE United Kingdom Dr.

Objectives: To find out what spectrum of cardiac abnormalities are found in those stroke survivors who can be deemed to be at high cardiac risk by their having long QT. Methods: 202 patients with good recovery from a cerebrovascular event occurring at least one month previously were recruited into a prospective epidemiological study. These stroke survivors underwent a battery of cardiac investigations including 12 lead ECG, echocardiography, myocardial perfusion scanning, and heart rate variability assessment. The ECGs were digitised by a single observer blinded to the blood pressure and other investigations of the patients. The maximum heart rate corrected QT interval(QTc max) in the 12 lead ECG was derived by Bazett' s formula. Results: Prolonged QTc max significantly correlated with increasing blood pressure, left ventricular mass index, and depressed heart rate variability. As the number of cardiac abnormalities increased, QTc max became more prolonged. Conclusions: Long QT is significantly associated with left ventricular mass index even after adjustment for both systolic and diastolic blood pressures. Long QT was also associated with the total cardiac disease burden. These two observations may explain why stroke survivors with long QTc max were at greater risk of cardiac death.

关键词：存活者间期静止期(细胞学) QT 心脏病变

短暂性脑缺血发作的定义和评价:美国心脏协会/美国卒中协会卒中委员会、心血管外科和麻醉委员会、心血管放射学和介入委员会、心血管护理委员会和外周血管病跨学科委员会对医疗卫生专业人员发布的科学声明:美国神经病学学会确认该声明作为神经科医生继续教育工具的价值

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国际脑血管病杂志 2009年第9期17卷 643-660页

作者： j.Donald Easton jeffrey L.Saver Gregory W.Albers Mark j.Alberts Seemant Chaturvedi Edward Feldmann thomas S.Hatsukami Randall T.Higashida S.Claibome johnston Chelsea S.Kidwell Helmi L.Lutsep Elaine Miller Ralph L.Sacco 李海峰(译) 高翔(译) 不详青岛大学医学院附属医院神经内科 266003

本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料... 详细信息

本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料的合并分析,对数据进行综合处理。本文支持以下基于组织学的TIA定义:局灶性脑、脊髓或视网膜缺血引起的短暂性神经功能障碍发作,且无急性脑梗死。TIA患者的近期卒中风险较高,可根据临床量表、血管影像学和磁共振弥散加权成像进行风险分层。诊断推荐包括:TIA患者应在发病24h内接受神经影像学评价,最好是应用包括弥散序列在内的MRI;应进行无创性颈部血管成像检查,最好是无创性颅内血管成像;对于未能确定血管病因的患者,TIA发病后应尽快进行心电图检查,也应考虑持续心电监测和超声心动图检查;应进行常规血液化验;对于发病72h内就诊并且ABCD^(2)评分≥3分(提示近期复发风险较高)或在门诊不能迅速完成诊断评价的TIA患者,应收入院治疗。

关键词：美国心脏协会科学声明脑脑缺血缺血卒中短暂性脑缺血发作急性卒中综合征急性脑血管综合征

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织造加工中的即时维修理念

国际纺织导报 2016年第11期44卷 28-30页

作者： M.Saggiomo j.Heibeyn Y.S.Gloy T.Gries 郭文君(译) 李刚(校) 亚琛工业大学纺织研究所德国不详

任何机械生产系统都会因与磨损相关的故障等而导致必要的维修,从而降低其生产率。机器组件,如轴承出现故障,则必须停机至机器修复,因此必将影响生产进度。这些无法预料的停机可能造成不能如期完成生产,此外,停工也会给生产厂家带来损失... 详细信息

任何机械生产系统都会因与磨损相关的故障等而导致必要的维修,从而降低其生产率。机器组件,如轴承出现故障,则必须停机至机器修复,因此必将影响生产进度。这些无法预料的停机可能造成不能如期完成生产,此外,停工也会给生产厂家带来损失。如果未持续监控机器组件,则其失效通常都不可预知。维修机器所需的时间通常比更换坏组件花费的时间更多。这也是安装状态监测系统的价值所在,状态监则系统能够自动监测组件的状态并预估可能发生的故障。该系统在纺织生产上非常有用,因为纺织品是在高速条件下生产的,即时维修的理念旨在尽可能多地减少因机器维修造成的耽搁,生产过程中很小的耽搁都会对利润产生巨大的影响。

关键词：织造加工即时维修状态监测故障

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle järv Hugo Madrid jenni Nordén jian-Kui Liu julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu jane Oja john Y.Kupagme józsef Geml julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu jie Chen jinhua Bao Liang Hu Qinmei Wang Zibing jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan jeremy A. Guggenheim Rupal L. Shah Cathy Williams jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei jia jun jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael j Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica jong Brien A. Holden thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy j. Gawne john T. Siegwart, jr. Alexander H. Ward thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma

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World journal of Radiology 2013年第12期5卷 484-490页

作者： juliano j Cerci Camila C G Linardi Luís F Pracchia josé Soares junior Evelinda Trindade Dominique Delbeke Rodrigo j Cerci Robert Carr josé C Meneghetti Valeria Buccheri Department of Nuclear Medicine Heart Institute (InCor) University of Sāo Paulo Medical School Division of PET/CT Quanta-Diagnóstico Nuclear Division of Hematology Clinical Hospital of the University of Sāo Paulo Medical School Health Technology Assessment/Executive Direction Heart Institute (InCor) University of Sāo Paulo Medical School Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Department of Haematology St Thomas’ Hospital

AIM:To assess the prognostic value and risk classification improvement of metabolic staging(MS)with Initial2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography(FDG-PET)in initial staging of Hodgkin’s Lymphoma(HL)patients to predict 5 years overall survival(5y-OS)and event free survival(EFS).METHODS:A total of 275 patients were included in this retrospective study,155 patients were staged with conventional anatomical staging(AS),and 120 also submitted to MS(FDG-PET).Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and ***-adjusted models incorporated clinical risk factors,computed tomography and FDG-PET ***:During the follow up of 267 evaluated patients,220(122 AS and 98 MS)achieved complete remission after first-line therapy(median follow-up:70±29 mo),treatment failure occurred in 79 patients and 34 *** 5y-EFS for early vs advanced disease in AS patients was 79.3%and 66.7%,and 85.6%and53.6%in MS patients,respectively(P<0.01).The5y-OS for early and advanced disease with AS was91.3%and 81.5%,and 97.5%and 80.7%for patients staged with MS,*** proportional hazards analysis demonstrated that FDG-PET added signifcant prognostic information and improved risk prediction(P=0.02).CONCLUSION:Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL,with impact in 5y-EFS and OS.

关键词： Hodgkin disease Positron-emission tomography 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography Neoplasm staging Prognosis

基于GPS测站垂向速度的南极地区冰川均衡调整(GIA)模型分析

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中国科学：地球科学 2020年第3期50卷 353-368页

作者：李斐马超张胜凯雷锦韬郝卫峰张卿川李文浩武汉大学中国南极测绘研究中心武汉430079

由于数据稀缺,南极冰川均衡调整(glacial isostatic adjustment, GIA)建模相比北美和北欧古冰盖区域更为困难,现有GIA模型在南极地区还存在较大的不确定性.空间大地测量技术不断发展和进步,为GIA建模提供了外部检核和新的约束.利用GAMIT... 详细信息

由于数据稀缺,南极冰川均衡调整(glacial isostatic adjustment, GIA)建模相比北美和北欧古冰盖区域更为困难,现有GIA模型在南极地区还存在较大的不确定性.空间大地测量技术不断发展和进步,为GIA建模提供了外部检核和新的约束.利用GAMIT/GLOBK10.5软件对南极及周边区域73个测站1996~2014年的GPS数据进行解算和平差,并考虑有色噪声估计其地壳垂向运动速度.为了研究不同因素对地壳垂向运动的影响,将GPS测站垂向速度与Argus等(2014)、thomas等(2011)的GPS结果以及各GIA模型预测结果划分区域进行比较,主要包括南极半岛北部、龙尼-菲尔希纳冰架、阿蒙森海沿岸、罗斯冰架、埃里伯斯火山、西南极内陆、东南极沿海等七个区域,结果表明在南极半岛北部和阿蒙森海沿岸派恩艾兰湾地区存在现今冰雪负荷变化引起的显著地壳弹性抬升,在埃尔伯斯火山区域存在的显著下沉可能与其地下岩浆活动有关,东南极沿海测站垂向运动速度都不显著,其他区域的测站垂向运动主要受到GIA的影响.对文章GPS结果与各GIA模型的相关性和GIA模型的不确定性进行分析,结果表明ICE-6G(VM5a)模型与文章GPS结果的一致性最好,其次是Geruo13模型,而W12a和Ij05_R2系列模型与本文GPS结果一致性相对较差.虽然目前南极GIA模型相比以前版本的模型有了很大改进,但是南极地区GIA建模的状况仍然不容乐观:GIA模型相比北美地区不确定性偏大,在BENN等部分测站上存在较大不符值,在现今冰雪负荷变化显著地区由于弹性改正模型不确定性偏大而缺乏精确GPS约束.

关键词：南极 GPS 冰川均衡调整垂向速度不确定性

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变异组分析揭示番茄的育种历史

变异组分析揭示番茄的育种历史