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Epidemiology of opportunistic invasive fungal infections in China： review of literature

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Chinese Medical Journal 2013年第2期126卷 361-368页

作者： LIAO Yong CHEN Min thomas hartmann YANG Rong-ya LIAO Wan-qing Department of Dermatology General Hospital of Beijing MilitaryCommand Beijing 100700 China Shanghai Key Laboratory of Molecular Medical Mycology Institute of Dermatology and Mycosis of Changzheng HospitalSecond Military Medical University Shanghai 200003 China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences Beijing I O0101 China

Objective To summarize the recent findings on the epidemiology of medically important, opportunistic invasive fungal infections （IFIs） in China and discuss the relevant social, economical reasons and medical factors. Data sources We performed a comprehensive search of both English and Chinese literatures of opportunistic IFIs from China up to April 2012. Study selection Relevant literatures involving researches and cases/case sedes were identified, retrieved and reviewed. Results The incidence of opportunistic IFIs in China was steadily increasing. The incidence and mortality of IFIs were different in patients with various underlying conditions/diseases, from 4.12% to 41.18% and 9.8% to 60.0%, respectively. Candida species, Aspergillus species and Cryptococcus neoformans species complex were the most frequent isolated pathogens. Other uncommon opportunistic IFIs were also been reported, including trichosporonosis, mucormycosis, hyalohyphomycosis （hyaline hyphomycetes） and phaeohyphomycosis （dematiaceous hyphomycetes）. Reports of Chinese patients differed from those of many other countries as there were a higher number of patients without identifiable underlying diseases/conditions. Conclusions Because of the rapid economic development, changing population structure and a growing number of immunocompromised hosts with risk factors, today opportunistic IFIs in China have a significant impact on public health, associated with high morbidity/mortality and higher care costs. Now information related to the epidemiology of opportunistic IFIs in China is still sparse, so we need more organized groups of clinical scientists performing related researches to help the clinicians to obtain more accurate epidemiological characteristics.

关键词： China, opportunistic fungal infection, Candida Aspergillus Cryptococcus

Fighting the Ignorance: Public Authorities’ and Land Users’ Responses to Land Subsidence in Indonesia

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American Journal of Climate Change 2017年第1期6卷 1-21页

作者： Erlis Saputra thomas hartmann Annelies Zoomers Tejo Spit Department of Human Geography and Spatial Planning Utrecht University Utrecht The Netherlands Department of Development Geography Universitas Gadjah Mada Yogyakarta Indonesia

Land subsidence can have a considerable impact on the socio-economic viability of areas. In urban areas, land subsidence tends to damage buildings and infrastructures gradually, while in rural peat land it slowly destroys vegetation. The damages will worsen since climate change has further implications for the areas affected by land subsidence. In Indonesia, the response to land subsidence varies in different areas in terms of awareness, urgency and action on the part of both public authorities and land users. This paper systematically investigates these varied responses in urban and rural peat land areas. Interviews with experts and surveys of 330 land users in selected sub-districts were conducted and further supplemented by focus group discussions. We found that both the public authorities as well as the land users’ responses were considered as of limited value to contest land subsidence. We suggest that the endorsement of land users’ response into governmental policies would make a significant difference in improving land subsidence management.

关键词： Indonesia Land Subsidence Land Users Public Authorities Response

For the Greater Good?—A Critical Reflection on Assessing Indirect Economic Effects Caused by Large Transport Projects

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Open Journal of Civil Engineering 2019年第2期9卷 135-156页

作者： Delphine Patrick Witte thomas hartmann Tejo Spit Annelies Zoomers Department of Human Geography and Planning Utrecht University Utrecht The Netherlands Faculty of Environmental Sciences Wageningen University and Research Wageningen The Netherlands

Investing in large transport projects affects the (potential) economic development of metropolitan areas. Yet, very little critical research has been performed to understand how to assess these effects. The relationship between infrastructure investments and regional economic development is complex and indirect, and many theoretical and methodological difficulties remain. On the one hand, the assumption that investing in infrastructure is important to sustain economic growth is sometimes doubted. On the other hand, it is argued that investments in infrastructure enhance the accessibility of urban regions and that in the slipstream of such investments, social problems in urban regions can be tackled as well. Despite these contrasting views, there is at least a consensus that transport infrastructure development depends on economic development and vice versa. Yet, in many cases, the method of assessing economic impacts highly affects the results. Therefore, this paper focuses on a critical reflection of methods for estimating economic effects of infrastructure investments. A critical evaluation is made based on Indonesian and Japanese cases. After conducting in-depth desk research on both cases, we found that the broader effects on affected group of people tend to be overlooked due to the problems of time and space dimensions, the chain reaction of effects, and inappropriate data practices. The assessment on the appraisal processes tends to overlook the broader economic implication due to narrow focus and the concept of efficiency of economic theory.

关键词： Large Infrastructure Projects High-Speed Railways Economic Effects Transport Investment Economic Assessment

Breakthrough trichosporonosis in patients receiving echinocandins： case report and literature review

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Chinese Medical Journal 2012年第14期125卷 2632-2635页

作者： LIAO Yong thomas hartmann ZHENG Tao YANG Rong-ya AO Jun-hong WANG Wen-ling Department of Dermatology GeneralHospital of Beijing Military Command Beijing 100_700~ China Department of Intensive Care Unit GeneralHospital of Beijing Military Command Beijing 100700 China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences Beijing 100101 China

Trichosporon species now ranks as the second most common cause of disseminated yeast infections with a high mortality rate. Breakthrough trichosporonosis in patients receiving echinocandins therapy is being recognized recently. We present a case of breakthrough trichosporonosis with acute viral myocarditis while receiving caspofungin therapy. Trichosporon infection should be considered in patients, who have risk factors for invasive fungal infection and develop unexplained clinical manifestations of infection despite treatment with echinocandins.

关键词： trichosporonosis caspofungin echinocandins

Risk factors for invasive fungal infections in liver transplant recipients

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Chinese Medical Journal 2012年第2期125卷 400-400页

作者： Liao Yong hartmann, thomas Ao Jun-hong Yang Rong-ya Beijing Mil Command Gen Hosp Dept Dermatol Beijing 100700 Peoples R China Chinese Acad Sci Inst Microbiol State Key Lab Mycol Beijing 100101 Peoples R China

To the editor： Invasive fungal infections （IFIs） are significant complications in liver transplant recipients, which are associated with high morbidity/mortality and higher healthcare costs. The incidence of IFIs is mainly influenced by the patients＇ clinical condition, the level of immune suppression, surgical factors and the technical complexity of the surgery. We read with great interest the research article by Shi et alJ Although they have reached a high curative ratio with their ＂experiential＂ therapy based on their previous clinical experience, they did not provide us with detailed, definite criteria for identifying suspected patients and allowing for their early ＂experiential＂ treatment. Updated, standardized guidelines from the Invasive Fungal Infections

关键词： Risk factors invasive fungal infections liver transplant

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA

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Molecular Plant 2022年第5期15卷 840-856页

作者： thomas Roulé Aurelie Christ Nosheen Hussain Ying Huang Caroline hartmann Moussa Benhamed Jose Gutierrez-Marcos Federico Ariel Martin Crespi thomas Blein UniversitéParis-Saclay CNRSINRAEUniversitéEvryInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Universitéde Paris Institute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Instituto de Agrobiotecnología del Litoral CONICETFBCBUniversidad Nacional del LitoralColectora Ruta Nacional 168 km 03000 Santa FeArgentina School of Life Sciences University of WarwickCoventry CV47ALUK

Clustered organization of biosynthetic non-homologous genes is emerging as a characteristic feature of plant *** co-regulation of clustered genes seems to largely depend on epigenetic reprogram-ming and three-dimensional chromatin *** this study,we identified the long non-coding RNA(lncRNA)MARneral Silencing(MARS),localized inside the Arabidopsis marneral cluster,which con-trols the local epigenetic activation of its surrounding region in response to abscisic acid(ABA).MARS modulates the POLYCOMB REPRESSIVE COMPLEX 1(PRC1)component LIKE HETEROCHROMATIN PROTEIN 1(LHP1)binding throughout the cluster in a dose-dependent manner,determining H3K27me3 deposition and chromatin *** response to ABA,MARS decoys LHP1 away from the cluster and promotes the formation of a chromatin loop bringing together the MARNERAL SYNTHASE 1(MRN1)locus and a distal ABA-responsive *** enrichment of co-regulated lncRNAs in clustered meta-bolic genes in Arabidopsis suggests that the acquisition of novel non-coding transcriptional units may constitute an additional regulatory layer driving the evolution of biosynthetic pathways.

关键词： lncRNA enhancer cluster chromatin conformation LHP1 ABA seed germination epigenetics marneral