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Ankle Arthroscopy: A Complimentary Adjunct in the Diagnosis and Management of Ankle Fractures

Open Journal of Orthopedics 2020年第12期10卷 403-411页

作者： Ciaran McDonald Conor O’Dwyer Peter McLoughlin Rebecca Jeanne Bermingham thomas Bayer Department of Orthopaedics and Trauma Midlands Regional Hospital Tullamore Tullamore Ireland

Ankle fractures are one of the most common injuries treated by orthopaedic surgeons. A minority of patients with ankle fractures go on to develop persistent pain following anatomical reduction. These sequelae may arise as a result of untreated ligamentous or chondral injuries. This study aims to correlate acute arthroscopic ankle findings with the Lauge-Hansen fracture pattern classification. We further aim to compare subjective functional outcomes at least one year following surgery between patients who have received Open Reduction and Internal Fixation (ORIF) alone, versus ORIF plus arthroscopy. This is a retrospective case series of patients who have undergone ankle fracture ORIF +/- arthroscopy from July 2014 to July 2017 inclusive. Each patient’s presenting radiograph was classified according to the Lauge-Hansen ankle fracture classification with subsequent correlation to intra-operative arthroscopic findings. Functional outcome at a minimum of one year was evaluated with the American Academy of Orthopaedic Surgeons (AAOS) metric. Twenty two patients underwent ankle ORIF plus arthroscopy (Group A) with a further 26 patients receiving ORIF alone (Group B). 1 in 3 supination-external-rotation type II (SER II) injuries possessed a concomitant syndesmosis injury or osteochondral lesion (OCL) on arthroscopy. 1 in 3 patients with an SER IV injury had an osteochondral lesion. The mean AAOS score achieved for Group A was 89.6 (±7.9) with the mean score for Group B being 82.0 (±13.7). In conclusion, ankle arthroscopy aids the diagnosis and treatment of ligamentous and osteochondral injuries not evident on plain film with subsequent superior short-term outcomes.

关键词： Ankle Fracture Arthroscopy Osteochondral Injury Syndesmosis Lauge-hansen ORIF Ligamentous Injury Syndesmosis Disruption Persistent Ankle Pain Post-Traumatic Arthritis

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针灸改善危重患者胃排空延迟的随机对照研究

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麻醉与镇痛 2012年第1期8卷 78-84页

作者： Florian Pfab, MD, PhD Martina Winhard, MD Martina Nowak-Machen, MD Vitaly Napadow, PhD Dominik Irnich, MD, PhD Michael Pawlik, MD, PhD thomas Bein, MD, PhD Ernil hansen, MD, PhD 姚凤珍（译） Department of Anesthesiology University Hospital Regensburg Regensburg Germany Marti-nos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Boston Massachusetts Department of Anesthesiology Brigham andWomen＇s Hospital Harvard Medical School Boston Massachusetts Department of Anesthe-siology University of Munich Campus Innenstadt Munich Germany

背景营养不良仍然是重症患者恢复过程中的一个严重问题，不仅增加住院死亡率，同时也延长住院时间。早期肠内营养已被证明可以全面改善重症监护室（intensivecareunit，ICU）患者的预后，然而，鼻饲可造成胃排空延迟和胃食管反流。针灸... 详细信息

背景营养不良仍然是重症患者恢复过程中的一个严重问题，不仅增加住院死亡率，同时也延长住院时间。早期肠内营养已被证明可以全面改善重症监护室（intensivecareunit，ICU）患者的预后，然而，鼻饲可造成胃排空延迟和胃食管反流。针灸已经成功用于治疗和预防围术期的恶心和呕吐。本研究中，我们评估在接受肠内营养的重症患者中，与常规胃动力剂相比针灸是否能改善胃排空状态。方法30例在ICU行机械通气并伴有胃排空延迟[定义为胃剩余容积（gastricresidualvolume，GRV）≥500ml，持续时间〉12天]的神经外科患者，前瞻性地随机分至穴位刺激组（acupointstimulationgroup，ASG，经皮电穴位刺激双侧内关穴，PC-6）或常规胃动力剂治疗组（drugtreatmentgroup，DTG），治疗时间超过6天（胃复安、西沙必利、红霉素）。ASG组患者不使用任何传统动力剂。治疗成功（鼻饲患者）的定义为GRV〈200ml／24h。结果两组人口统计学和血流动力学数据相似。治疗5天后，ASG组80％患者治疗成功，DTG组为60％。治疗第一天，ASG组GRV从970±87ml下降至346±71ml，而DTG组GRV从903±60ml显著增加至1040±211ml（P=0．015）。此外，ASG组（15例患者中有14例）比DTG组（15例患者中有7例）有更多患者出现GRV的下降和鼻饲平衡（定义为鼻饲容积减去GRV）的改善（P=0．014）。治疗第一天ASG组（121±128m1）鼻饲平衡显著高于DTG组（-727±259m1）（P=0．005）。总体来说，治疗的每一天，ASG组鼻饲平衡的改善显著超过DTG组。DTG组直至治疗第6天鼻饲平衡也没有得到改善。结论我们为重症监护提供了一项新的方案，即针灸治疗。本研究表明在重症患者胃排空延迟的治疗中，针灸比常规动力剂更加有效。针刺内关穴可能是预防和治疗重症患者营养不良的一个物美价廉的选择（几乎无副作用）。

关键词：胃排空延迟随机对照研究危重患者针灸治疗早期肠内营养鼻饲患者重症监护室重症患者

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蛇形画廊

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城市环境设计 2019年第2期118卷 44-53页

作者： Aaron Powers Alice Cladet Claire thomas Daniel Sundlin Jakob Lange Kai-Uwe Bergmann Kristian Hindsberg Kristoffer Negendahl Lorenz Krisai Maria Holst Maxwell Moriyama Rune hansen Tianze Li Tore Banke Wells Barber Iwan Baan Derek Shapton 陈子钰

对于2016年的蛇形画廊展厅,我们尝试设计一种包含多个通常意义上的对立面的结构:一种既形态自由又结构严谨、既模块化又具有雕塑感、既透明又不透明、既似盒子又难以名状的结构。我们决定使用建筑最基本的元素之一:砖墙。并非粘土砖或... 详细信息

对于2016年的蛇形画廊展厅,我们尝试设计一种包含多个通常意义上的对立面的结构:一种既形态自由又结构严谨、既模块化又具有雕塑感、既透明又不透明、既似盒子又难以名状的结构。我们决定使用建筑最基本的元素之一:砖墙。并非粘土砖或石块砖——这座墙是由

关键词：内部空间玻璃纤维

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心血管疾病死亡风险预测随着亚临床器官损害标记物的增加而提高

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中华高血压杂志 2010年第6期18卷 599-599页

作者：沈逸华谢良地 thomas Sehestedt Jorgen Jeppesen Tine W.hansen Kristian Wachtell Hans Ibsen Christian Torp-Petersen PER Hildebrandt Michael H.Olsen

该文明确了健康受试者的亚临床血管损伤是否会显著增加系统性冠脉风险评估（systematic coronary risk uation, SCORE）的危险分层。方法和结果：总共1968名受试者，年龄为41、51、61或71岁，排除心血管疾病，从未接受心血管药物、降糖... 详细信息

该文明确了健康受试者的亚临床血管损伤是否会显著增加系统性冠脉风险评估（systematic coronary risk uation, SCORE）的危险分层。方法和结果：总共1968名受试者，年龄为41、51、61或71岁，排除心血管疾病，从未接受心血管药物、降糖或降脂治疗的糖尿病患者。测量这些受试者的传统心血管危险因素，

关键词：亚临床器官损害心血管疾病死亡风险预测标记物健康受试者心血管危险因素心血管药物风险评估

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1981至1997年丹麦精神分裂症患者自杀率的变化:巢式病例对照研究

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英国医学杂志中文版 2005年第3期8卷 194-194页

作者： Merete Nordentoft thomas Munk Laursen Esben Agerbo Ping Qin Eyd hansen Hyer Preben Bo Mortensen 朱丽琳

目的：研究精神分裂症及相关疾病患者自杀率的变化。设计：对相关资料进行巢式病例对照设计。资料来源：丹麦的4个纵向登记材料。研究对象：病例组包括1981至1997年的18 744名自杀者，其年龄均小于75岁，每名自杀者设置20名对照与之匹... 详细信息

目的：研究精神分裂症及相关疾病患者自杀率的变化。设计：对相关资料进行巢式病例对照设计。资料来源：丹麦的4个纵向登记材料。研究对象：病例组包括1981至1997年的18 744名自杀者，其年龄均小于75岁，每名自杀者设置20名对照与之匹配。结果：在此期间，研究发现这些精神分裂症及其他相关精神异常患者自杀率的下降幅度与普通人群相似(发生率比为1.00，95%可信区间为0.98～1.03)。其他相关精神疾病患者自杀率的下降比普通人群快。在住院的精神分裂症患者中，入院后第一年的自杀风险最高，年轻者的自杀风险更高，自杀风险随着年龄的增长逐年下降。结论：精神分裂症及相关疾病患者的自杀率已经下降。这可能是由于心理治疗水平的提高、自杀手段的限制或者患者试图自杀后治疗的改进。

关键词：巢式病例对照研究精神分裂症患者自杀率 1997年丹麦疾病患者

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Spatial distribution of leprosy in India:an ecological study

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Infectious Diseases of Poverty 2018年第1期7卷 206-214页

作者： Kyra H.Grantz Winnie Chabaari Ramolotja Kagiso Samuel Buri Gershom Laura Blum Lee Worden Sarah Ackley Fengchen Liu thomas M.Lietman Alison P.Galvani Lalitha Prajna Travis C.Porco Department of Biology University of FloridaGainesvilleFLUSA Emerging Pathogens Institute University of FloridaGainesvilleFLUSA DST/NRF Center for Excellence in Epidemiological Modeling and Analysis(SACEMA) StellenboschSouth Africa Stellenbosch University StellenboschSouth Africa African Institute of Mathematical Sciences MuizenbergSouth Africa University of California BerkeleyCAUSA Francis I.Proctor Foundation for Research in Ophthalmology University of CaliforniaSan FranciscoCAUSA Department of Ophthalmology University of CaliforniaSan FranciscoCAUSA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCAUSA Yale University New HavenCTUSA Aravind Eye Hospital MaduraiTamil NaduIndia

Background:As leprosy elimination becomes an increasingly realistic goal,it is essential to determine the factors that contribute to its *** evaluate social and economic factors as predictors of leprosy annual new case detection rates within India,where the majority of leprosy cases ***:We used correlation and linear mixed effect regressions to assess whether poverty,illiteracy,nighttime satellite radiance(an index of development),and other covariates can explain district-wise annual new case detection rate and Grade 2 disability ***:We find only weak evidence of an association between poverty and annual new case detection rates at the district level,though illiteracy and satellite radiance are statistically significant predictors of leprosy at the district *** find no evidence of rapid decline over the period 2008-2015 in either new case detection or new Grade 2 ***:Our findings suggest a somewhat higher rate of leprosy detection,on average,in poorer districts;the overall effect is *** divide between leprosy case detection and true incidence of clinical leprosy complicates these results,particularly given that the detection rate is likely disproportionately lower in impoverished *** information is needed to distinguish the determinants of leprosy case detection and transmission during the elimination epoch.

关键词： Leprosy hansen’s disease India Poverty Spatial

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Development of a Functional Assessment of Chronic Illness Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune checkpoint modulators

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 74-87页

作者： Kimberly A.Webster Mary L.O’Connor Aaron R.hansen Sheetal Kircher Heather S.L.Jim Adam P.Dicker Monika Janda Kari Ala-leppilampi Clifton O.Bingham III Josephine Feliciano Norah Lynn Henry Laurie E.Steffen McLouth David Cella Department of Medical Social Sciences Northwestern University Feinberg School of MedicineChicagoIL 60611USA Princess Margaret Cancer Center University Health NetworkToronto M5G 1Z5Canada Robert H Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL 60611USA Department of Health Outcomes and Behavior Moffitt Cancer CenterTampaFL 33612USA Department of Radiation Oncology Sidney Kimmel Medical College and Cancer Center at Thomas Jefferson UniversityPhiladelphiaPA 19107USA Centre for Health Services Research The University of QueenslandQLD 4102Australia Applied Health Research Centre Li Ka Shing Knowledge InstituteSt Michael’s HospitalToronto M5B 1W8Canada Divisions of Rheumatology and Allergy and Clinical Immunology Johns Hopkins UniversityBaltimoreMD 21224USA Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center BaltimoreMD 21231USA University of Michigan Rogel Cancer Center Ann ArborMI 48109USA Department of Behavioral Science Center for Health Equity Transformation and Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY 40536USA

Aim:To develop a comprehensive item library of patient-reported,immunotherapy-related adverse events(irAEs)that draws from and expands on the Functional Assessment of Chronic Illness Therapy(FACIT)Measurement ***:Literature review and iterative expert *** on a literature review of irAEs,we developed a framework of immunotherapy classes and their associated *** experts then reviewed iterations of symptom summaries and item maps linked to the immunotherapy *** provided content review and feedback was shared across experts until consensus was *** iterative process facilitated creation of a Primary Symptom List associated with immune checkpoint modulators(ICMs),drawn from the larger set of *** FACIT items were mapped to the symptom list,and new items were written as needed to create the item ***:The full item library of irAEs is comprised of 239 items,covering 142 unique symptoms across 75 inflammatory reactions/immune conditions.A subset of 66 items comprises a Primary Symptom List considered most common/relevant to ICM *** includes gastrointestinal,skin,pulmonary,neurologic,musculoskeletal,and multiple miscellaneous and constitutional ***:The FACIT Immunotherapy Item Library is a compilation of 239 self-report items that capture the wide range of AEs experienced by people receiving immune treatments.A subset of 66 items comprises a Primary Symptom List meant for ICM *** of items selected from this library is encouraged in clinical research and clinical practice evaluation.

关键词： Immunotherapy immune checkpoint modulators quality of life immune-related adverse events patient reported outcomes cancer oncology

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A META-ANALYSIS OF SHAM-CONTROLLED ACUPUNCTURE – THE IMPORTANCE OF THE DERMATOMES

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Journal of Integrative Medicine 2014年第3期 223-223页

作者： thomas Ots Asal Kandirian Stefan Szilagyi Andreas Sandner Kiesling Medical University Graz

Background: The German model trials on acupuncture(Modellvorhaben; GERAC, ART) between 2000 and 2006 brought forth a cluster of results that puzzled the international community of *** acupuncture proved to be almost as effective as verum ***: Verum and sham acupuncture may share varying degrees of similar results according to the varying degrees of congruence of active *** defined these common active components as the segmental structure of the human *** our study we tested the following hypothesis: the more verum and sham acupuncture share the same dermatomes, the more identical clinical outcomes will be, and vice ***: Three major searches(2009, 2011, 2013) on RCTs comparing verum acupuncture against sham acupuncture were run to focus an all major data ***: Our literature search determined a total of 1613 ***-three studies met the inclusion *** and sham locations were mapped in the dermatome charts of hansen and *** clinical outcome was assessed in relation of congruency of identical dermatomes between verum and sham *** binar logistic regression showed a highly significant outcome: P<0.01 as well as a negative regression coefficient ***: The findings of this review confirm our hypothesis: The effects of verum and sham acupuncture vary according to the degree of congruency of stimulated *** holds true for any organs or affected structures of the segments between C1 and *** such correlation could be found in studies of ailments of the ***: Segmental anatomy offers a neurophysiological explanation of acupuncture's major *** findings of this study mark a paradigm change in the theoretical body of acupuncture and consequently for acupuncture *** meridian theory may no longer be the major guideline for acupuncture research and practice.

关键词： A META-ANALYSIS OF SHAM-CONTROLLED ACUPUNCTURE THE IMPORTANCE OF THE DERMATOMES

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老海勒鲁普高中体育馆

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城市环境设计 2019年第2期118卷 114-127页

作者： Ana Merino Anders Hjortn?s Christian Alvarez Dennis Rasmussen Gül Ertekin Henrick Poulsen Hjalti Gestsson Jan Magasanik Jakob Lange Jacob Thomsen Jeppe Ecklon Ji-young Yoon Michael Sch?nemann Narisara Schr?der Riccardo Mariano Rune hansen Snorre Nash thomas Juul-Jensen Vincent He Xu Li Agnete Jukneviciute Ambra Chiesa Brigitta Gulyás Dennis Rasmussen Enea Michelesio Greta Krenciute H?gni Laksáfoss Isabella Eriksson Jan Magasanik Mikkel Marcker Stubgaard Jeppe Ecklon Kamilla Heskje Michael Sch?nemann Narisara Schr?der thomas Juul-Jensen Brigitta Gulyás Enea Michelesio Jakob Lange Mikkel Marcker Stubgaard Narisara Schr?der Tobias Hjortdal Iwan Baan Peter Moldow Rasmus Hjortshoj Jens Lindhe 朱翰林

位于哥本哈根北部的老海勒鲁普高中,内部拥有1100m2的多功能大厅和最新的两层建筑,为现有学生提供了广阔的社交和创意展示空间,同时提升学校的容量,以应对持续增长的人口需求。原本校园旁边的一栋建筑里,体育设施匮乏而无法满足需求;老... 详细信息

位于哥本哈根北部的老海勒鲁普高中,内部拥有1100m2的多功能大厅和最新的两层建筑,为现有学生提供了广阔的社交和创意展示空间,同时提升学校的容量,以应对持续增长的人口需求。原本校园旁边的一栋建筑里,体育设施匮乏而无法满足需求;老海勒鲁普高中也缺少大型多功能空间,用以举办体育活动、毕业典礼和社交聚会。为此,BIG为学生

关键词：体育馆

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乐高之家

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城市环境设计 2019年第2期118卷 62-73页

作者： Snorre Nash Andreas Klok Pedersen Agne Tamasauskaite Annette Birthe Jensen Ariel Joy Norback Wallner Ask Hvas Birgitte Villadsen Chris Falla Christoffer Gotfredsen Daruisz Duong Vu Hong David Zahle Esben Christoffersen Franck Fdida Ioana Fartadi Scurtu Jakob Andreassen Jakob Ohm Laursen Jakob Sand Jakub Matheus Wlodarczyk Jesper Bo Jensen Jesper Boye Andersen Julia Boromissza Kasper Reimer hansen Katarzyna Krystyna Siedlecka Katarzyna Stachura Kekoa Charlot Leszek Czaja Lone Fenger Albrechtsen Louise B?geskov Hou Mads Enggaard Stidsen Magnus Algreen Suhr Manon Otto Marta Christensen Mathias Bank Stigsen Michael Kepke Ole Dau Mortensen Ryohei Koike Sergiu Calacean S?ren Askehave Stefan Plugaru Stefan Wolf thomas Jakobsen Randb?ll Tobias Hjortdal Tommy Bj?rnstrup Iwan Baan Kim Christensen 陈思瑾

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的... 详细信息

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的新世界,并为他们提供使之成为现实的技能。这就是孩子们每天用乐高积木来做的事情,这也是我们今天用真实的砖石在乐高之屋里完成的事情,使比伦德向真

关键词：乐高积木展览空间

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