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Multi-regional observations and validation of the M_(3)ocean tide

Science China Earth Sciences 2023年第10期66卷 2265-2277页

作者： adam thomas DEVLIN Jiayi PAN Déborah IDIER School of Geography and Environment Jiangxi Normal UniversityNanchang330022China Cooperative Institute for Marine and Atmospheric Research School of Ocean and Earth Science and TechnologyUniversity of Hawai’i at MānoaHonoluluHI96822USA Department of Oceanography University of Hawai’i at MānoaHonoluluHI96822USA The Chinese University of Hong Kong Hong Kong999077China Key Laboratory of Poyang Lake Wetland and Watershed Research of Ministry of Education Nanchang330022China BRGM Orléans45060France

Improved determinations of the oft-ignored third-degree ocean tides can yield better accuracy for tidal predictions,numerical model solutions,and *** only a small part of tidal range,these components can be larger at certain coastal locations due to shelf resonances and other ***,we discuss observations of the M3lunar terdiurnal tide using 9-year windowed tidal harmonic analyses at 157 tide gauges compares to a global assimilation model(TPXO9v5a),with a focus on the Western Pacific and the European ***9v5a does well in estimating the observed M_(3)amplitudes and phase lags in most regions,though determinations in coastal zones and in morphologically complex areas are coarse and often *** also employ a shallow-water model(MARS)on the European Shelf,which can yield localized improvement over *** five subregions of the European Shelf,regional root-mean-squared-errors(RMSEs)are lower(and thus a better fit)at three locations for TPXO for amplitudes,and three for phase lags,with MARS simulations being a better fit in the other *** also show that some locations have experienced significant long-term increases and/or decreases in the M_(3)amplitude over time,likely related to resonance changes under sea level rise(SLR)which can modulate the oceanic response to astronomical *** hypothesis is explored for Europe using the MARS model by applying various sea level rise scenarios,showing that the directionality(positive or negative)of the long-term changes in M_(3)amplitudes over time match the model results for more than half of our validation stations.

关键词： Third-degree tides M_(3)tide Altimetry Numerical simulation Sea level rise

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Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis

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World Journal of Gastroenterology 2019年第41期25卷 6238-6247页

作者： Colin Markus Kruger Ulrich adam thomas adam Axel Kramer Claus D Heidecke Frank Makowiec Hartwig Riediger Department of Surgery Immanuel Hospital RüdersdorfBerlin 15562Germany Department of General Surgery Vivantes-Humboldt hospitalBerlin 13503Germany Department of Microbiology Labor Berlin GmbHBerlin 13353Germany Institute of Hygiene and Environmental Medicine University Medicine GreifswaldGreifswald 17495Mecklenburg VorpommernGermany Department of Surgery Clinic of GeneralVisceralVascular and Thoracic SurgeryUniversity Medicine GreifswaldGreifswald 17475Mecklenburg VorpommernGermany Section of clinical risk assessment University hospital of FreiburgFreiburg 79106Baden-WürttembergGermany

BACKGROUND Jaundice or preoperative cholestasis(PC)are typical symptoms of pancreatic *** 50%of patients undergo preoperative biliary drainage(PBD)*** is a common cause of bacterobilia(BB)and is a known surgical site infection risk *** adjustment of preoperative antibiotic prophylaxis(PAP)may be reasonable according to the profile of *** this,we examined the microbiological findings in routine series of *** To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head *** In the period from January 2009 to December 2015,285 consecutive pancreatic head resections were *** for surgery were malignancy(71%),chronic pancreatitis(18%),and others(11%).A PBD was in 51%and PC was in 42%.The standard PAP was ampicillin/***,a smear was taken from the hepatic *** analysis of the isolated species and resistograms was *** were categorized according to the presence or absence of PC(PC+/PC-)and PBD(PBD+/PBD-)into four *** efficiency was analyzed for standard PAP and possible *** BB was present in 150 patients(53%).BB was significantly more frequent in PBD+(n=120)than in PBD-(n=30),P<*** was present both in patients with PC and without PC:(PBD-/PC-:18%,PBD-/PC+:30%,PBD+/PC-:88%,PBD+/PC+:80%).BB was more frequent in malignancy(56%)than in chronic pancreatitis(45%).PBD,however,was the only independent risk factor in multivariate *** total,357 pathogens(342 bacteria and 15 fungi)were *** five most common groups(n=256,74.8%)were Enterococcus spp.(28.4%),Streptococcus spp.(16.9%),Klebsiella spp.(12.6%),Escherichia coli(10.5%),and Enterobacter spp.(6.4%).A polymicrobial BB(PBD+:77% vs PBD-:40%,P<0.01)and a more frequent detection of Enterococcus(P<0.05)was significantly associated with PBD+.In PBD+,the efficiency of imipenem and piperacillin/tazobactam was significantl

关键词： Pancreatic surgery Bacteriobilia Antibiotic prophylaxis Cholestasis Cholangiopancreatography Endoscopic retrograde

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Diverse plant mixtures sustain a greater arbuscular mycorrhizal fungi spore viability than monocultures after 12 years

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Journal of Plant Ecology 2020年第4期13卷 478-488页

作者： Peter Dietrich Christiane Roscher adam thomas Clark Nico Eisenhauer Bernhard Schmid Cameron Wagg Institute of Ecology and Evolution Friedrich-Schiller-University JenaDornburger Strasse 15907743 JenaGermany Department of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Department of Physiological Diversity UFZHelmholtz Centre for Environmental ResearchPermoserstrasse 1504318 LeipzigGermany German Centre of Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany Institute of Biology Leipzig UniversityDeutscher Platz 5e04103 LeipzigGermany Department of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Fredericton Research and Development Center Agriculture and Agri-Food Canada850 Lincoln RoadFrederictonNew Brunswick E3B 1P9Canada

Aims Intensive land management practices can compromise soil biodiversity,thus jeopardizing long-term soil *** mycorrhizal fungi(AMF)play a pivotal role in promoting soil productivity through obligate symbiotic associations with ***,it is not clear how properties of plant communities,especially species richness and composition influence the viability of AMF populations in *** Here we test whether monocultures of eight plant species from different plant functional groups,or a diverse mixture of plant species,maintain more viable AMF *** address this question,we extracted AMF spores from 12-year old plant monocultures and mixtures and paired single AMF spores with single plants in a factorial design crossing AMF spore origin with plant species *** Findings AMF spores from diverse plant mixtures were more successful at colonizing multiple plant species and plant individuals than AMF spores from plant ***,we found evidence that AMF spores originating from diverse mixtures more strongly increased biomass than AMF from monocultures in the legume Trifolium repens *** viability and ability to interact with many plant species were greater when AMF spores originated from 12-year old mixtures than *** results show for the first time that diverse plant communities can sustain AMF viability in soils and demonstrate the potential of diverse plant communities to maintain viable AMF propagules that are a key component to soil health and productivity.

关键词： aboveground–belowground interactions biodiversity biomass production mutualism plant–AMF interaction root colonization

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Versioned geoscientific workflow for the collaborative geosimulation of human-nature interactions-a case study of global change and human activities

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International Journal of Digital Earth 2021年第4期14卷 510-539页

作者： Yuting Chen Hui Lin Ling Xiao Qi Jing Lan You Yulin Ding Mingyuan Hu adam thomas Devlin Institute of Space and Earth Information Science The Chinese University of Hong KongHong KongPeople’s Republic of China Key Lab of Poyang Lake Wetland and Watershed Research of Ministry of Education/School of Geography and Environment Jiangxi Normal UniversityNanchangPeople’s Republic of China School of Computer Science and Information Engineering Hubei UniversityWuhanPeople’s Republic of China School of Earth Science and Environmental Engineering Southwest Jiaotong UniversityChengduPeople’s Republic of China

Global change refers to changes in the relationship between humans and *** is desirable to actively integrate human social activities into the unified framework of global change so that their mutual relations and functional mechanisms can be *** complicated issue necessitates an appropriate method allowing domain experts to collaboratively contribute their knowledge to geoscientific ***,an efficient approach to optimize experimentation is of great *** reproducibility of research methods and results needs to be improved to boost the sharing of geographic knowledge and *** paper proposes a versioned geoscientific workflow and characterizes its full lifecycle using Virtual Geographic Environments,intending to facilitate and improve research related to the interactions between global change and human *** geoscientific workflow management is realized using the concept of version management,making geographic simulation methods and computational results easily reproducible and *** sharing and reuse of geographic knowledge in various forms are archived through version management of geoscientific workflows.A versatile prototype system is implemented which enables the visual modeling of geoscientific workflows,the interactive optimization and collaborative evaluation of geoscientific workflows at runtime,the multi-dimensional dynamic visualization of geo-workflow outputs,and role-based access control for data security.

关键词： Geoscientific workflow geographic simulation version management global change virtual geographic environment

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多区域海洋M_(3)分潮的观测与验证

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中国科学：地球科学 2023年第10期53卷 2300-2313页

作者： adam thomas DEVLIN 潘家祎 Déborah IDIER 江西师范大学地理与环境学院南昌330022 Cooperative Institute for Marine and Atmospheric Research School of Ocean and Earth Science and TechnologyUniversity of Hawaiʻi at MānoaHonolulu HI 96822USA Department of Oceanography University of Hawaiʻi at MānoaHonolulu HI 96822USA 香港中文大学太空与地球信息科学研究所中国香港999077 教育部鄱阳湖湿地与流域研究重点实验室南昌330022 French Geological Survey(BRGM) Orléans 45060France

M_(3)海洋分潮(三阶潮或一日三次周期潮汐)经常受到忽视,因而对M_(3)分潮进行更精确的分析研究,可以提高潮汐预测、海洋数值模拟、大地测量的准确度.尽管M_(3)分潮在整体潮汐所占比例较小,但由于陆架共振及其他影响,某些沿海地区M_(3)... 详细信息

M_(3)海洋分潮(三阶潮或一日三次周期潮汐)经常受到忽视,因而对M_(3)分潮进行更精确的分析研究,可以提高潮汐预测、海洋数值模拟、大地测量的准确度.尽管M_(3)分潮在整体潮汐所占比例较小,但由于陆架共振及其他影响,某些沿海地区M_(3)潮可大大增强.本文使用157个验潮站的数据,以及9年时间窗口,对水位变化进行了潮汐谐波分析.本文还分析了太阴M_(3)潮,将这些结果与全球同化的模型数据(TPXO9v5a)进行了比较,重点研究了西太平洋和欧洲陆架地区.与验潮站数据相比,大部分区域TPXO9v5a导出的M_(3)潮振幅和相位滞后表现良好,但在沿海和地形复杂的区域,其结果误差较大.在欧洲陆架海域使用了一个浅水数值模型(MARS),该模型在某些地区优于TPXO的结果.在欧洲陆架海域的五个子区域中,TPXO在三个地点的M_(3)振幅及相位滞后预测的均方根误差(RMSE)更小.而在其他子区域,MARS模拟结果更为准确.本文发现一些地点的M_(3)振幅有着显著长周期变化,这与海平面上升(SLR)导致的共振效应有关,这种共振效应可以调制海洋对天文引潮力的响应.本文使用MARS模型,应用各种海平面上升的预设情境,对M_(3)振幅的长周期变化进行了模拟研究.结果表明随着时间的推移,超过一半验潮站M_(3)振幅长期变化方向(增加或减少)与MARS模型结果一致.

关键词：三阶海洋潮汐 M3分潮卫星高度计数值模拟海平面上升

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Principles of Arrhythmia Management During Pregnancy

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Cardiovascular Innovations and Applications 2016年第B02期1卷 143-155页

作者： thomas adam Burkart,MD,FACC,FHRS William M.Miles,MD,FACC,FHRS Jamie Beth Conti,MD,FACC,FHRS Electrophysiology Section Division of CardiologyUniversity of Florida College of MedicineGainesvilleFLUSA Division of Cardiology University of Florida College of MedicineGainesvilleFLUSA

This paper reviews current recommendations on the appropriate evaluation and management of cardiac arrhythmias in the pregnant *** arrhythmias during pregnancy are benign and require no *** required,the decision to treat should be based on symptom severity and the associated risk to mother and fetus posed by potentially recurring arrhythmia episodes throughout the *** treatment strategy in this patient population has inherent risk to both mother and unborn *** the initiation of any intervention,documentation of a clinical arrhythmia and correlation with clinical symptoms should be *** is no role for empiric therapy.

关键词： arrhythmias pregnancy pregnancy and heart disease Correspondence:thomas

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足球运动的跨文化迁移:以德国和阿根廷为背景

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北京体育大学学报 2019年第9期42卷 60-72页

作者：托马斯·亚当李娟(译) 美国德克萨斯大学阿灵顿分校历史系阿灵顿76019 北京体育大学国际体育组织学院北京100084

体育历史学家很少关注现代体育比如足球运动如何从其发源地迁移至世界的其他文化。尽管现在公认足球起源于19世纪的英国公学,但这项运动如何转变为现代德国足球和现代阿根廷足球却鲜为人知。运用跨文化迁移的模型,研究足球运动从英国公... 详细信息

体育历史学家很少关注现代体育比如足球运动如何从其发源地迁移至世界的其他文化。尽管现在公认足球起源于19世纪的英国公学,但这项运动如何转变为现代德国足球和现代阿根廷足球却鲜为人知。运用跨文化迁移的模型,研究足球运动从英国公学到德国和阿根廷中学的迁移过程。足球运动的兴起和向世界各地的迁移和传播得益于教师和学生,因为足球作为教育改革的一种新兴手段,可以取代强调纪律的传统教学方法。在足球运动中,纪律的训练并非来自教师等外部力量,而是来自于对比赛规则的遵守。而且,足球运动鼓励队员通过团队合作取得胜利,让中产阶级家庭的孩子可以了解资本主义市场的运作机制。将足球引入都市文化也是社会卫生保健的一大议题,许多足球运动的倡导者也参与了关于提升现代城市生活质量的社会改革讨论中。

关键词：足球运动跨文化迁移德国阿根廷

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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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