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Teriflunomide provides protective properties after oxygen-glucose-deprivation in hippocampal and cerebellar slice cultures

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Neural Regeneration Research 2021年第11期16卷 2243-2249页

作者： Anna Wolters Judith Reuther Philipp Gude thomas weber Carsten Theiss Heike Vogelsang Veronika Matschke Institute of Anatomy Department of CytologyMedical FacultyRuhr University BochumBochumGermany Department of Anaesthesiology and Intensive Care Medicine Ruhr University BochumSt.Josef HospitalBochumGermany

One of the major challenges in emergency medicine is out-of-hospital cardiac arrest(OHCA).Every year,about 53–62/100000 people worldwide suffer an out-of-hospital cardiac arrest with serious consequences,whereas persistent brain injury is a major cause of morbidity and mortality of those surviving a cardiac ***,only few and insufficient strategies are known to limit neurological damage of ischemia and reperfusion *** aim of the present study was to investigate whether teriflunomide,an approved drug for treatment of relapsing-remitting-multiple-sclerosis,exerts a protective effect on brain cells in an in vitro model of ***,organotypic slice cultures from rat hippocampus and cerebellum were exposed to oxygen-glucose-deprivation and subsequently treated with *** administration of teriflunomide in the reperfusion time on both hippocampal and cerebellar slice cultures significantly decreased the amount of detectable propidium iodide signal compared with an untreated culture,indicating that more cells survive after ***,hippocampal slice cultures showed a higher vulnerability to ischemic conditions and a more sensitive response to teriflunomide compared with cerebellar slice *** study suggests that teriflunomide,applied as a post-treatment after an oxygenglucose-deprivation,has a protective effect on hippocampal and cerebellar cells in organotypic slice cultures of *** procedures were conducted under established standards of the German federal state of North Rhine Westphalia,in accordance with the European Communities Council Directive 2010/63/EU on the protection of animals used for scientific purposes.

关键词： brain damage cardiac arrest cell death hypoxic chamber ischemia organotypic slice cultures post-treatment resuscitation

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Shaping the Future through Innovation and Technology

Shaping the Future through Innovation and Technology

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2004年国际氢能大会

作者： Dr.thomas weber DaimlerChrysler AG 70546 Stuttgart Germany

As a global corporation, DaimlerChrysler is a motor of economic prosperity in many parts of the world. Manufacturing motor vehicles, DaimlerChrysler takes responsibility for sustainable mobility which is inseparably connected to the question of "Energy for the Future ". Regarding the fact that 5 7 million new vehicles are currently being produced each year worldwide, it will be necessary to optimize the entire system to meet the requirements concerning the advancement of conserving fossil fuel resources and the reduction of CO2 emissions: from the energy raw material for the fuel and fuel production through to the vehicle itself and its propulsion system. DaimlerChrysler is convinced that fuel cells clearly offer the best long-term potential. To attain the goal of sustainable mobility DaimlerChrysler has set up a long-term strategy.

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逐步完善的电机定子

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现代制造 2016年第34期 50-51页

作者： thomas Stuble thomas weber SWD股份公司

电动机的定了铁芯是由一片片硅钢片组成的：这些硅钢片逐层叠加起来，构成了一个定子铁芯。在硅钢片定子铁芯的绕组槽内嵌入的是产生磁场的铜线绕组。

关键词：电机定子定子铁芯硅钢片电动机绕组铜线

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Extracorporeal membrane oxygenation and inhaled sedation in coronavirus disease 2019-related acute respiratory distress syndrome

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World Journal of Critical Care Medicine 2021年第6期10卷 323-333页

作者： Martin Bellgardt Dennis Ozcelik Andreas Friedrich Christoph Breuer-Kaiser Claudia Steinfort thomas Georg Karl Breuer thomas Peter weber Jennifer Herzog-Niescery Anesthesia and Intensive Care Medicine St.Josef-HospitalUniversity Hospital of Ruhr-University of BochumBochum 44791Germany Chemistry|Biology|Pharmacy Information Center ETH ZürichZürich 8093Switzerland General and Visceral Surgery St.Josef-HospitalUniversity Hospital of Ruhr-University of BochumBochum 44791Germany Internal Medicine/Intensive Care St.Josef-HospitalUniversity Hospital of Ruhr-University of BochumBochum 44791Germany

Coronavirus disease 2019(COVID-19)related acute respiratory distress syndrome(ARDS)is a severe complication of infection with severe acute respiratory syndrome coronavirus 2,and the primary cause of death in the current *** ill patients often undergo extracorporeal membrane oxygenation(ECMO)therapy as the last resort over an extended *** therapy requires sedation of the patient,which is usually achieved by intravenous administration of *** shortage of intravenous sedative drugs due to the ongoing pandemic,and attempts to improve treatment outcome for COVID-19 patients,drove the application of inhaled sedation as a promising alternative for sedation during ECMO *** of volatile anesthetics requires an appropriate *** available ones are the anesthetic gas reflection systems AnaConDa®and MIRUSTM,and each should be combined with a gas scavenging *** this review,we describe respiratory management in COVID-19 patients and the procedures for inhaled sedation during ECMO therapy of COVID-19 related *** focus particularly on the technical details of administration of volatile ***,we describe the advantages of inhaled sedation and volatile anesthetics,and we discuss the limitations as well as the requirements for safe application in the clinical setting.

关键词： Extracorporeal membrane oxygenation COVID-19 Acute respiratory distress syndrome Critical care Volatile anesthetics Inhaled sedation

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新一代的蓝色光盘的测试仪

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光盘技术 2004年第1期 49-52页

作者： thomas weber 夏雨人

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基于现代控制理论的化学反应器最优化设计的一种考虑

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北京工业大学学报 1986年第3期 69-77页

作者：谭立扬 thomas W.weber 美国纽约州立大学布法罗分校化学工程系教授

本文讨论了一种新颖的化学反应器最优化设计技术。根据现代控制理论中的可控性概念及最优哈密尔顿函数计算的结果,应用系统的可控制判断,可以不必模拟反应器内部的温度分布及浓度分布,便能预言该设计要求是否同时可被满足。最优哈密尔... 详细信息

本文讨论了一种新颖的化学反应器最优化设计技术。根据现代控制理论中的可控性概念及最优哈密尔顿函数计算的结果,应用系统的可控制判断,可以不必模拟反应器内部的温度分布及浓度分布,便能预言该设计要求是否同时可被满足。最优哈密尔顿函数的计算,可把整个设计程序归结为两点边值问题,从而决定了最优控制向量。

关键词：反应器设计可控性化学反应器反应系统现代控制理论控制论最优化设计

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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

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测定血清S100蛋白用于诊断克-雅病:前瞻性病例对照研究

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英国医学杂志中文版 1998年第1期1卷 22-27页

作者： Markus Otto Jens Wiltfang Ekkehard Schtz Ingo Zerr Anke Otto Annette Pfahlberg Olaf Gefeller Manfred Uhr Armin Giese thomas weber Hans A Kretzschmar Sigrid Poser 张星虎 Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 Cttingen Germany group Leaderlaboratory diagnosis of CJD Psychiatrische Klinik und Poliklinik Georg-AugustUniversitt Gttingen senior research fellow Abteilung Klinische Chemie Georg-August-Universitt Gttingenresearch fellow Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 Cttingen Germany research fellow Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 GttingenGermany research fellow Abteilung Klinische Chemie Georg-August-Universitt Gttingen statistician Abteilung Medizinische Statistik Georg-August-Universitt Gttingen associate professor of medical statistics continued over Max-Planck lnstitut ftir Psychiatrie Kraepelinstrasse 10 D-80804 MunichGermany research fellow Institut fr Neuropathologie Georg-August-Universitt Gttingen research fellow Neurologische Abteilung Marienkrankenhaus Hamburg Alfredstrasse 9D-22087 Hamburg Germany headdepartment of neruology Institut fr Neuropathologie Georg-August-Universitt Gttingen headdepartment of neuropathology Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 Gttingen Germany headedidemiology and early diagnosis of CJD

目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患... 详细信息

目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患者、其他疾病引起的痴呆患者及对照组血清 S100浓度。结果:224例疑为 CJD 的患者中,65例经病理证实确诊;6例有基因突变而肯定诊断;43例很可能患 CJD;36例可能患 CJD;74例患有其他疾病。108例为肯定或很可能 CJD 患者,其血清 S100浓度中位数为395 pg/ml(SD 387 pg/ml)。这明显高于患其他疾病的74例患者(S100浓度中位数为109pg/ml,SDl77pg/ml;P=0.0001)。以213pg/ml为界值,S100测定用于 CJD 诊断的敏感性为77.8%(95%的可信区间为66.8%～85.2%),特异性为81.1%(70.3%～89.3%)。在 Kaplan-Meier 曲线上,不同浓度 S100患者的存活时间差异有显著性(P=0.023)。结论:S100血清浓度测定是一种有价值的工具,在 CJD 的鉴别诊断中,较测定脑脊液更有价值。尚需更多的研究以确定连续测定是否有助于提高此病的诊断准确性。

关键词：克-雅病 S100蛋白脑特异性存活时间差异有显著性鉴别诊断基因突变无痴截点病例对照研究

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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