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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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A Comprehensive Review of Exosomes with Therapeutic Potential in Cancer and Coeliac Disease

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Journal of Biosciences and Medicines 2024年第3期12卷 25-34页

作者： Fathima Assainar Joshua George thomas Zoya Saleem Shafa Thekkekara Fathima Mammoo navadir nidal Kallan RAK College of Medical Sciences RAK Medical and Health Sciences University Ras Al Khaimah UAE Department of Biotechnology American University of Ras Al Khaimah Ras Al Khaimah UAE School of International Education Zhengzhou University Zhengzhou China

The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provides an overview of exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic effect is that the phospholipid-binding protein AnXA1 improves its anti-inflammatory properties. The review also analyzes the intricate processes of exosome production and composition ability to transport biomolecules such as proteins, microRnAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of targeted drug administration due to their innate specificity. Through genetic engineering and chemical modifications, exosomes can be tailored for specific purposes, demonstrating their versatility in targeted therapy. with ongoing research uncovering their therapeutic potential, exosomes present a promising frontier in novel medical treatments across various health conditions.

关键词： Exosomes Cancer Coeliac Disease Therapeutic Potential Cell Communication Anti-inflammation

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Python Server Page Performance Analysis and Modeling

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Communications and network 2024年第1期16卷 1-30页

作者： Razafindraibe Marolahy Alix Randrianomenjanahary Lala Ferdinand Rafamantanantsoa Fontaine Mahatody thomas F. Angelo Raherinirina University of Fianarantsoa Fianarantsoa Madagascar

Today, in the field of computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself Apache. The number of solutions for this server is therefore growing continuously, these services are becoming more and more complex and expensive, without being able to fulfill the needs of the users. The absence of benchmarks for websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of access to information on the Internet. This is why the performance of the web server is critically important. Several factors influence performance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these factors, we propose a performance evaluation strategy for servers that allows us to determine the actual performance of different servers in terms of user satisfaction. Furthermore, we identified performance characteristics such as throughput, resource utilization, and response time of a system through measurement and modeling by simulation. Finally, we present a simple queue model of an Apache web server, which reasonably represents the behavior of a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traffic. we obtain server performance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightforward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Performance Analysis Queue Performance Model web Server Internet world wide web web Server Performance

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绿色转型先驱:施耐德电气

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现代制造 2024年第2期 34-35页

作者： thomas Tosse 不详

能源是一种稀有且极具争议的商品。因此,施耐德电气公司在其电力技术中采用了依托可再生能源和数字化技术相结合的方法,为能源密集型的行业提供了相应的产品和服务。施耐德电气公司想让用户了解“电气4.0”和“工业4.0”之间有着多么紧... 详细信息

能源是一种稀有且极具争议的商品。因此,施耐德电气公司在其电力技术中采用了依托可再生能源和数字化技术相结合的方法,为能源密集型的行业提供了相应的产品和服务。施耐德电气公司想让用户了解“电气4.0”和“工业4.0”之间有着多么紧密的联系。从这家国际化的电气工程集团公司的角度来看,这表示了两条平行的科学技术发展路线:工业化和电气化。

关键词：可再生能源绿色转型电气工程技术发展路线施耐德电气能源密集型国际化电气化

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工业自动化生产动力电池

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现代制造 2024年第S1期 46-46,48,49页

作者： thomas Eder 不详

尽管当前困难重重,但一些代工厂却生意兴隆。因为他们已经实现了数字化和自动化生产,并且是在没有增加企业员工数量的情况下提高了企业的生产能力。有些代工厂甚至实现了批量化大生产。一些小型企业也在推动生产数字化和自动化的进程,... 详细信息

尽管当前困难重重,但一些代工厂却生意兴隆。因为他们已经实现了数字化和自动化生产,并且是在没有增加企业员工数量的情况下提高了企业的生产能力。有些代工厂甚至实现了批量化大生产。一些小型企业也在推动生产数字化和自动化的进程,因为它们所承受的技术工人缺乏和竞争的压力尤为严重。田园诗般的土地为这些企业提供了犹如一家人般的亲情、和谐的工作环境和多种多样的工作岗位。

关键词：小型企业员工数量工作岗位自动化生产批量化动力电池代工厂数字化

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快速确定生产成本

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现代制造 2024年第2期 30-31页

作者： thomas Tosse 不详

产品还没有生产制造出来,订购这一产品的用户就想知道它的价格,这时怎么办呢?RK Rose+Krieger公司使用Simus Systems公司提供的Costing 24网络服务解决了这一难题。在网络服务的帮助下,RK Rose+Krieger公司节省了大量的精力,并能够快速... 详细信息

产品还没有生产制造出来,订购这一产品的用户就想知道它的价格,这时怎么办呢?RK Rose+Krieger公司使用Simus Systems公司提供的Costing 24网络服务解决了这一难题。在网络服务的帮助下,RK Rose+Krieger公司节省了大量的精力,并能够快速提供用户所需的报价,实现成本效益目标。

关键词：网络服务成本效益快速确定生产成本 Rose 用户

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持续25年的服务

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现代制造 2024年第S1期 55-56页

作者： thomas Eder 不详

在物流行业的广阔天地中,伍尔特工业服务公司独树一帜,以其无与伦比的能力著称——即在“精准时刻,将精确数量的理想产品送达指定位置”。历经25年的稳健前行与卓越发展,该公司已傲然屹立于欧洲小型工业零件供应领域的巅峰,成为行业内... 详细信息

在物流行业的广阔天地中,伍尔特工业服务公司独树一帜,以其无与伦比的能力著称——即在“精准时刻,将精确数量的理想产品送达指定位置”。历经25年的稳健前行与卓越发展,该公司已傲然屹立于欧洲小型工业零件供应领域的巅峰,成为行业内的领航标杆。总部地址位于巴登-符藤堡州Künzelsau市的伍尔特工业服务有限公司是一家从事紧固件和组装技术的家族企业。1999年1月13日,在千禧之交的前一年,伍尔特工业服务有限责任公司(würth Industrie Service Gmb H&***)分拆出来,成为伍尔特集团的子公司。

关键词：家族企业服务公司总部地址物流行业组装技术傲然屹立紧固件指定位置

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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PnO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEn You-qin HAn Yu-ying wEI Li-hui YAO Meng-ying FAnG Yi wU Mei-zhu CHEnG Ying thomas J.Sferra LIU Hui-xin LI Li PEnG Jun SHEn A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of nOB1 (PnO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRnA levels of PnO1, TP53, and CDKn1A. western blotting was performed to determine protein levels of PnO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PnO1. Colony formation assay was used to detect cell survival in PnO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PnO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PnO1 or sh-Ctrl lentivirus were evaluated. western blot assay was performed to detect PnO1, p53, p21 and PCnA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUnEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PnO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (PnO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (PnO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (PnO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PnO1 and up-regulation of p53 and p21 in vivo (PnclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PnO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of nOB1 proliferation p53/p21 pathway

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A trade-off between space exploration and mobilization of organic phosphorus through associated microbiomes enables niche differentiation of arbuscular mycorrhizal fungi on the same root

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Science China(Life Sciences) 2023年第6期66卷 1426-1439页

作者： Jiachao Zhou thomas w Kuyper Gu Feng College of Resources and Environmental Sciences China Agricultural UniversityBeijing100193China Soil Biology Group Wageningen University&ResearchWageningen6700 AAThe Netherlands

Ecology seeks to explain species coexistence,but experimental tests of mechanisms for coexistence are difficult to *** synthesized an arbuscular mycorrhizal(AM)fungal community with three fungal species that differed in their capacity of foraging for orthophosphate(P)due to differences in soil *** tested whether AM fungal species-specific hyphosphere bacterial assemblages recruited by hyphal exudates enabled differentiation among the fungi in the capacity of mobilizing soil organic P(P_(o)).we found that the less efficient space explorer,Gigaspora margarita,obtained less ^(13)C from the plant,whereas it had higher efficiencies in P_(o)mobilization and alkaline phosphatase(Al Pase)production per unit C than the two efficient space explorers,Rhizophagusintraradices and Funneliformis *** AM fungus was associated with a distinct alp gene harboring bacterial assemblage,and the alp gene abundance and P_(o)preference of the microbiome associated with the less efficient space explorer were higher than those of the two other *** conclude that the traits of AM fungal associated bacterial consortia cause niche *** trade-off between foraging ability and the ability to recruit effective P_(o)mobilizing microbiomes is a mechanism that allows co-existence of AM fungal species in a single plant root and surrounding soil habitat.

关键词： arbuscular mycorrhizal fungi carbon space exploration hyphosphere bacterial assemblages organic phosphorus mobilization

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Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients

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world Journal of Orthopedics 2024年第8期15卷 773-782页

作者： Peter C Brennan Stephanie M Peterson thomas J O'Byrne Mariana L Laporta Cody C wyles Paul J Jannetto Garvan C Kane Maria Vassilaki Hilal Maradit Kremers Department of Orthopedic Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States

BACKGROUnD There is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty(TJA)*** To determine the association of commonly used implant metals with echocardiographic measures in TJA *** The study comprised 110 TJA patients who had a recent history of high chromium,cobalt or titanium *** underwent two-dimensional,three-dimensional,Doppler and speckle-strain transthoracic echocardiography and a blood draw to measure metal *** and sex-adjusted linear and logistic regression models were used to examine the association of metal concentrations(exposure)with echocardiographic measures(outcome).RESULTS Higher cobalt concentrations were associated with increased left ventricular end-diastolic volume(estimate 5.09;95%CI:0.02-10.17)as well as left atrial and right ventricular dilation,particularly in men but no changes in cardiac *** titanium concentrations were associated with a reduction in left ventricle global longitudinal strain(estimate 0.38;95%CI:0.70 to 0.06)and cardiac index(estimate 0.08;95%CI,-0.15 to-0.01).COnCLUSIOn Elevated cobalt and titanium concentrations may be associated with structural and functional cardiac changes in some *** studies are warranted to better understand the systemic effects of metals in TJA patients.

关键词： Total joint arthroplasty Metal-on-metal Cardiotoxicity Heart failure Echocardiography Cobalt

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