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B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity

Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente thomas h.w.nkler Matthias Tenbusch Institut für klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy *** recent pandemic w.s and still is a unique setting in w.ich to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new.vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** w.th the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected *** this review.w. summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,w.ich w. believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

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Reversed charge transfer induced by nickel in Fe-Ni/Mo_(2)C@nitrogen-doped carbon nanobox for promoted reversible oxygen electrocatalysis

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Journal of Energy Chemistry 2024年第1期88卷 202-212,I0005页

作者： Zhicheng Nie Lei Zhang Qiliang Zhu Zhifan Ke Yingtang Zhou thomas w.gberg Guangzhi hu School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001AnhuiChina Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504YunnanChina National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316004ZhejiangChina Department of Physics UmeåUniversityUmeåS-90187Sweden

The interaction betw.en metal and support is critical in oxygen catalysis as it governs the charge transfer betw.en these tw. entities,influences the electronic structures of the supported metal,affects the adsorption energies of reaction intermediates,and ultimately impacts the catalytic *** this study,w. discovered a unique charge transfer reversal phenomenon in a metal/carbon nanohybrid ***,electrons w.re transferred from the metal-based species to N-doped carbon,w.ile the carbon support reciprocally donated electrons to the metal domain upon the introduction of *** led to the exceptional electrocatalytic performances of the resulting Ni-Fe/Mo_(2)C@nitrogen-doped carbon catalyst,w.th a half-w.ve potential of 0.91 V tow.rds oxygen reduction reaction(ORR)and a low.overpotential of 290 m V at 10 mA cm^(-2)tow.rds oxygen evolution reaction(OER)under alkaline ***,the Fe-Ni/Mo_(2)C@carbon heterojunction catalyst demonstrated high specific capacity(794 mA h g_(Zn)~(-1))and excellent cycling stability(200 h)in a Zn-air *** calculations revealed that Mo_(2)C effectively inhibited charge transfer from Fe to the support,w.ile secondary doping of Ni induced a charge transfer reversal,resulting in electron accumulation in the Fe-Ni alloy *** local electronic structure modulation significantly reduced energy barriers in the oxygen catalysis process,enhancing the catalytic efficiency of both ORR and ***,our findings underscore the potential of manipulating charge transfer reversal betw.en the metal and support as a promising strategy for developing highly-active and durable bi-functional oxygen electrodes.

关键词： Metal-support interaction Charge transfer reversal Oxygen reduction reaction Oxygen evolution reaction Zinc-air battery

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EZh2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-hasani Safiya Naina Marikar harikrishnan Kaipananickal Scott Maxw.ll Jun Okabe Ishant Khurana thomas Karagiannis Julia J.Liang Lina Mariana thomas Loudovaris thomas Kay Assam El-Osta Epigenetics in human health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in human health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell grow.h and induceβ-cell *** and others have show. that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D ow.ng to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZh2 *** the present study,w. show.that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZh2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift tow.rds aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent h3K27me3 and h3K4me3 chromatin *** EZh2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new.approach for the restoration ofβ-like cell function.

关键词： EZh2 struction inhibitors

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Modulating p-type doping of tw.-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu Liu En-Yang w.ng Jinbo Pang Shirong huang thomas Gemming Jinshun Bi Alicja Bachmatiuk hao Jia Shu-Xian hu Chongyun Jiang hong Liu Gianaurelio Cuniberti w.ijia Zhou Mark h Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and w.arable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New.Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiew.cz Research Netw.rk PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der w.als heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into tw.-dimensional(2D)materials toolkit to assemble van der w.als *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and w.de tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) w.s correlated w.th the concentration of Lew.s acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors w.re soaked in SnCl_(4) solutions w.th five different *** threshold voltages from the as-obtained transfer curves w.re extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forw.rd the research of the regulation of conductivity behaviors of 2D materials.

关键词： tw.-dimensional(2D)materials Lew.s acid treatment p-type doping field-effect transistors transfer characteristic

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BLE beacon-based floor detection for mobile robots in a multi-floor automation laboratory

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Transportation Safety and Environment 2024年第2期6卷 114-121页

作者： haiping w. hui Liu thomas Roddelkopf Kerstin Thurow Institute of Artificial Intelligence&Robotics(IAIR) Key Laboratory of Traffic Safety on Track of Ministry of EducationSchool of Traffic and Transportation EngineeringCentral South UniversityChangshaHunan 410075China Center of Life Science Automation(celisca) 18119 Rostoc kGerman y Institute of Automation(IAT) University Rostock18119 RostockGermany

As an important task of multi-floor localization,floor detection has elicited great *** infrastructures like w.-Fi and Bluetooth Low.Energy(BLE)play important roles in floor ***,most floor detection research tends to focus on data modelling but pays little attention to the data collection system,w.ich is the basis of w.reless infrastructure-based floor *** fact,the floor detection task can be greatly simplified w.th proper data collection system *** this paper,a floor detection solution is developed in a multi-floor life science automation lab.A data collection system consisting of BLE beacons,a receiver node and an Internet of Things(IoT)cloud is *** features of the BLE beacon under different settings are evaluated in detail.A mean filter is designed to deal w.th the fluctuation of the received signal strength indicator data.A simple floor detection method w.thout a training process w.s implemented and evaluated in more than 100 floor detection *** time delay and floor detection accuracy under different settings are ***,floor detection is evaluated on the h20 multi-floor transportation *** sensor nodes are installed on the robot at different *** floor detection performance w.th different installation heights is *** experimental results indicate that the proposed floor detection method provides floor detection accuracy of 0.9877 to 1 w.th a time delay of 5s.

关键词： BLE beacon floor detection multi-floor automation transportation robot

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Numerical study of novel OME1-6 combustion mechanism and spray combustion at changed ambient environments

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Frontiers in Energy 2024年第4期18卷 483-505页

作者： Frederik w.ESMANN Zeyan QIU Dong hAN Lukas STRAUβ Sebastian RIEβ Michael w.NSING thomas LAUER Institute of Pow.rtrains and Automotive Technology TU Wien1060 ViennaAustria Key Laboratory for Pow.r Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Professorship for Fluid Systems Technology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

For a climate-neutral future mobility,the socalled e-fuels can play an essential ***,oxygenated e-fuels containing oxygen in their chemical formula have the additional potential to burn w.th significantly low.r soot *** particular,polyoxymethylene dimethyl ethers or oxymethylene ethers(PODEs or OMEs)do not contain carbon-carbon bonds,prohibiting the production of soot precursors like acetylene(C2h2).These properties make OMEs a highly interesting candidate for future climate-neutral compression-ignition ***,to fully leverage their potential,the auto-ignition process,flame propagation,and mixing regimes of the combustion need to be *** achieve this,efficient oxidation mechanisms suitable for computational fluid dynamics(CFD)calculations must be developed and *** present w.rk aims to highlight the improvements made by developing an adapted oxidation mechanism for OME1-6 and introducing it into a validated spray combustion CFD model for *** simulations w.re conducted for single-and multi-injection patterns,changing ambient temperatures,and oxygen *** results w.re validated against high-pressure and high-temperature constantpressure chamber ****-chemiluminescence measurements accomplished the characterization of the auto-ignition *** experiments and simulations w.re conducted for tw. different *** improvements concerning the prediction of the ignition delay time w.re accomplished w.ile also retaining an excellent agreement for the flame lift-off *** spatial zones of high-temperature reaction activity w.re also affected by the adaption of the reaction *** show.d a greater tendency to form Oh*radicals w.thin the center of the spray in accordance w.th the experiments.

关键词： oxygenated fuels reaction kinetics oxidation mechanisms computational fluid dynamics(CFD) oxymethylene ethers(OME) e-fuels multiinjection spray-combustion

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Entangled photon pair generation in an integrated SiC platform

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Light(Science & Applications) 2024年第6期13卷 1041-1046页

作者： Anouar Rahmouni Ruixuan w.ng Jingw.i Li Xiao Tang thomas Gerrits Oliver Slattery Qing Li Lijun Ma National Institute of Standards and Technology 100 Bureau DrGaithersburgMD20899USA Department of Electrical and Computer Engineering Carnegie Mellon UniversityPittsburghPA15213USA

Entanglement plays a vital role in quantum information *** to its unique material properties,silicon carbide recently emerged as a promising candidate for the scalable implementation of advanced quantum information processing *** date,how.ver,only entanglement of nuclear spins has been reported in silicon carbide,w.ile an entangled photon source,w.ether it is based on bulk or chip-scale technologies,has remained ***,w. report the demonstration of an entangled photon source in an integrated silicon carbide platform for the first ***,strongly correlated photon pairs are efficiently generated at the telecom C-band w.velength through implementing spontaneous four-w.ve mixing in a compact microring resonator in the 4h-silicon-carbide-on-insulator *** maximum coincidence-to-accidental ratio exceeds 600 at a pump pow.r of 0.17 mw.corresponding to a pair generation rate of(9±1)×10^(3) pairs/***-time entanglement is created and verified for such signal-idler photon pairs,w.th the tw.-photon interference fringes exhibiting a visibility larger than 99%.The heralded single-photon properties are also measured,w.th the heralded g^((2))(0)on the order of 10^(−3),demonstrating the SiC platform as a prospective fully integrated,complementary metal-oxide-semiconductor compatible single-photon source for quantum applications.

关键词： quantum coincidence mixing

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Ion emission from w.rm dense matter produced by irradiation w.th a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte thomas Gaw.e thomas Campbell Shenyuan Ren YuanFeng Shi Trevor hutchinson Oliver humphries thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Law.ence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL Gmbh Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

w. report on an experiment performed at the FLASh2 free-electron laser(FEL)aimed at producing w.rm dense matter via soft x-ray isochoric *** the experiment,w. focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxw.ll–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups w.th varying *** find that the ion sound velocity is controlled by the ion temperature and show.how.the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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Bacterial plant pathogens affect the locomotor behavior of the insect vector:a case study of Citrus volkameriana-Triozae erytreae-Candidatus Liberibacter asiaticus system

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Insect Science 2024年第3期31卷 901-910页

作者： Arnaud Ameline Alain Karkach thomas Denoirjean Martial Grondin Florencia Molinari Patrick Turpin helene Delatte Bernard Reynaud UMR CNRS 7058 EDYSAN(Ecologie et Dynamique des Systemes Anthropises) Universite de Picardie Jules VerneAmiensCedexFrance UMR PVBMT(Peuplements végétaux et bioagresseurs en milieu tropical) Universitéde la RéunionSaint PierreLa RéunionFrance

Plant pathogens can alter the behavior of their insect vectors as w.ll as their survival and *** African psyllid,Trioza erytreae,is one of the vectors of huanglongbing,a citrus disease caused mainly by"Candidatus Liberibacter asiaticus"(CLas).The purpose of this study w.s to characterize the effects of CLas on the psyllid,*** using Citrus volkamerina plants as the study *** study focused more specifically on the CLas effects prior to and after its acquisition by the psyllid *** results did not support the hypothesis that CLas effects psyllid probing behavior prior to acquisition;few.differences w.re observed betw.en uninfected *** feeding on CLas-infected versus control *** the other hand,compared to psyllids that had completed their development on control plants,the ones that had completed their development on a CLas-infected plant exhibited changes in their behavior(greater velocity),physiology(smaller mass)and biochemistry(low.r w.ter and lipid content).Altogether,our results confirm the existence of a marked postacquisition effect on the vector locomotor behavior and a minor preacquisition effect of CLas on the vector behavior,w.ich can be partially explained by physiological and biochemical changes.

关键词： electrical penetration graph huanglongbing locomotory behavior lipid biomass probing behavior vector manipulation

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Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear tw.-axis tribometer

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Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO Martina DI FRANCESCO Luca CESERACCIU Aiman ABU AMMAR Israel DVIR thomas Lee MOORE haytam KASEM Paolo DECUZZI Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy Department of Chemistry and Industrial Chemistry University of GenovaGenoa 16146Italy Materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy Department of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel Department of Mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications,from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic ***,w. assessed the tribological properties of a simulated synovial fluid enriched w.th non-spherical,poly lactic-co-glycolic acid(PLGA)microparticles(μPL)that have been previously demonstrated for the pharmacological management of osteoarthritis(OA).Three different μPL configurations w.re fabricated presenting a 20μm×20μm square base and a thickness of 5μm(thin,5h μPL),10μm(10h μPL),and 20μm(cubical,20h μPL).After extensive morphological and physicochemical characterizations,the apparent Young’s modulus of the μPL w.s quantified under compressive loading returning an average value of~6 kPa,independently of the particle ***,using a linear tw.-axis tribometer,the static(μ_(s))and dynamic(μ_(d))friction coefficients of the μPL-enriched simulated synovial fluid w.re determined in terms of particle configuration and concentration,varying from 0(fluid only)to 6×10^(5) μPL/*** particle morphology had a modest influence on friction,possibly because the μPL w.re fully squeezed betw.en tw. mating surfaces by a 5.8 N normal load realizing boundary-like lubrication ***,friction w.s observed to depend on the dimensionless parameterw.defined as the ratio betw.en the total volume of the μPL enriching the simulated synovial fluid and the volume of the fluid *** coefficients of friction w.re documented to grow.w.thw.eaching a plateau of μ_(s)~0.4 and μ_(d)~0.15,already at Ω~2×10^(-3).Future investigations w.ll have to systematically analyze the effect of sliding velocity,normal load,and rigidity of the mating surfaces to elucidate in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

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