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High-Intensity Interval Training Prescribed Within the Secondary Severe-Intensity Domain Improves Critical Speed But Not Finite Distance Capacity

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Journal of Science in Sport and Exercise 2020年第2期2卷 154-166页

作者： Emma Jthomas Robert W.Pettitt Mark Kramer Biokinetics and Sport Science Unit Nelson Mandela UniversityPort Elizabeth 6070South Africa Rocky Mountain University of Health Professions ProvoUT 84606USA Physical Activity Sport and Recreation Research Focus AreaNorth West UniversityPotchefstroom 2520South Africa

Purpose Improvements in D'(the fatigability constant for running)subsequent to training interventions remain ***-intensity interval training(HIIT)within the severe intensity domain for short durations(vo2max(G140%:+7.60%;G90-s:+11.67%),speed evoking vo2max(svo2max;G140%:+4.33%;G90_s:+2.92%),gas exchange threshold(GET;G140%:+12.02%;G90-s:+20.52%),speed evoking GET(sGET;G140%:+4.17%;G90_s:+7.92%),CS(G140%:M=0.62 m/s;G90-s:M=0.46 m/s),D'(G140%:M=-56.34 m;G90-s:M=-18.36 m),FI%(G140%M=-6.75%;G90-s:M=-4.38%)and maximal distance(G140%:M=49.67 m;G90_s:M=58.38 m).Conclusions The prescribed intensities and durations were insufficient to elicit improvements in D'.Improvements in D'may be dependent on very short-duration intervals(i.e.<60 to 90-s)at speeds exceeding 140%CS but below maximal sprint speed.

关键词： Moderately active Severe intensity Threshold

Method to assess component contribution to toxicity of complex mixtures： Assessment of puberty acquisition in rats exposed to disinfection byproducts

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Journal of Environmental Sciences 2017年第8期29卷 311-321页

作者： Shahid Parvez Glenn E.Rice Linda K.Teuschler Jane Ellen Simmons thomas F.Speth Susan D.Richardson Richard J.Miltner E.Sidney Hunter Ⅲ Jonathan G.Pressman Lillian F.Strader Gary R.Klinefelter Jerome M.Goldman Michael G.Narotsky Indiana University Richard M. Fairbanks School of Public Health Department of Environmental Health Sciences IUPUI Campus Indianapolis IN 46202 USA National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Lincla Teuschler and Associates St. Petersburg FL 33707 USA National Health and Environmental Effects Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park NC 27711 USA National Risk Management Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Department of Chemistry and Biochemistry University of South Carolina Columbia SC 29208 USA

A method based on regression modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts（DBPs）. Chemical disinfection of drinking water forms DBP *** of concerns about possible reproductive and developmental toxicity, a whole mixture（WM） of DBPs produced by chlorination of a water concentrate was administered as drinking water to Sprague–Dawley（S–D） rats in a multigenerational study. Age of puberty acquisition,i.e., preputial separation（PPS） and vaginal opening（vo）, was examined in male and female offspring, respectively. When compared to controls, a slight, but statistically significant delay in puberty acquisition was observed in females but not in males. WM-induced differences in the age at puberty acquisition were compared to those reported in S–D rats administered either a defined mixture（DM） of nine regulated DBPs or individual DBPs. Regression models were developed using individual animal data on age at PPS or vo from the DM study. Puberty acquisition data reported in the WM and individual DBP studies were then compared with the DM models. The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed in the WM. This method is applicable to mixtures of other types of chemicals and other endpoints.

关键词： Drinking water disinfection byproducts DBP Puberty delay Four Lab Study Mixtures risk assessment

MPTCP与CMT-SCTP拥塞控制机制研究

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计算机工程 2015年第4期41卷 117-124页

作者：刘镇谭毓银符发 thomas Dreibholz 周星白勇杨雄杜文才海南大学信息科学技术学院海口570228 Simula挪威国家实验室挪威奥斯陆0161

多路径传输控制协议(MPTCP)与并发多路径传输控制协议(CMT-SCTP)是下一代互联网多路径并发传输的2种热点技术,但传统拥塞控制算法只适合于单路径传输,应用于多路径传输时会面临公平性的问题。为此,研究传统TCP拥塞控制算法,针对多路径... 详细信息

多路径传输控制协议(MPTCP)与并发多路径传输控制协议(CMT-SCTP)是下一代互联网多路径并发传输的2种热点技术,但传统拥塞控制算法只适合于单路径传输,应用于多路径传输时会面临公平性的问题。为此,研究传统TCP拥塞控制算法,针对多路径并发传输的不公平性问题,基于资源池思想,引入慢启动阈值比因子、增长因子和抢占因子,给出3种新的拥塞控制算法,并通过仿真进行对比分析。

关键词：多路径传输拥塞控制公平性资源池增长因子抢占因子

心血管疾病死亡风险预测随着亚临床器官损害标记物的增加而提高

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中华高血压杂志 2010年第6期18卷 599-599页

作者：沈逸华谢良地 thomas Sehestedt Jorgen Jeppesen Tine W.hansen Kristian Wachtell Hans Ibsen Christian Torp-Petersen PER Hildebrandt Michael H.Olsen

该文明确了健康受试者的亚临床血管损伤是否会显著增加系统性冠脉风险评估(systematic coronary risk uation, SCORE)的危险分层。方法和结果:总共1968名受试者,年龄为41、51、61或71岁,排除心血管疾病,从未接受心血管药物、降糖或降脂... 详细信息

该文明确了健康受试者的亚临床血管损伤是否会显著增加系统性冠脉风险评估(systematic coronary risk uation, SCORE)的危险分层。方法和结果:总共1968名受试者,年龄为41、51、61或71岁,排除心血管疾病,从未接受心血管药物、降糖或降脂治疗的糖尿病患者。测量这些受试者的传统心血管危险因素,

关键词：亚临床器官损害心血管疾病死亡风险预测标记物健康受试者心血管危险因素心血管药物风险评估

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青春前儿童进行耐力训练的有氧反应

天津体育学院学报 1986年第3期 16-20页

作者： Rowland thomas W 宋桂茹

按每公斤体重计算,儿童和少年的最大吸氧量(vo)比年长者高。青春前儿童随着耐力训练能否增进有氧能力是有争论的.成人为了提高vo,每周进行3～5次训练,每次15～60分钟,训练时心率为最快心率的60～90%是必要的。在检查儿童的训练方案时发... 详细信息

按每公斤体重计算,儿童和少年的最大吸氧量(vo)比年长者高。青春前儿童随着耐力训练能否增进有氧能力是有争论的.成人为了提高vo,每周进行3～5次训练,每次15～60分钟,训练时心率为最快心率的60～90%是必要的。在检查儿童的训练方案时发现,如果不遵照成人的标准进行训练,就不能对有氧能力产生有益效果;遵照成人标准训练儿童时,则和成人一样显示出vo的提高,尽管这种方案有严重缺点.根据目前的资料看来,在安排儿童少年提高有氧耐力的训练计划时,应当参照成人相应的运动强度和运动时间。

关键词：有氧能力成人耐力训练运动处方儿童青春反应

1981至1997年丹麦精神分裂症患者自杀率的变化:巢式病例对照研究

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英国医学杂志中文版 2005年第3期8卷 194-194页

作者： Merete Nordentoft thomas Munk Laursen Esben Agerbo Ping Qin Eyd hansen Hyer Preben Bo Mortensen 朱丽琳

目的：研究精神分裂症及相关疾病患者自杀率的变化。设计：对相关资料进行巢式病例对照设计。资料来源：丹麦的4个纵向登记材料。研究对象：病例组包括1981至1997年的18 744名自杀者，其年龄均小于75岁，每名自杀者设置20名对照与之匹... 详细信息

目的：研究精神分裂症及相关疾病患者自杀率的变化。设计：对相关资料进行巢式病例对照设计。资料来源：丹麦的4个纵向登记材料。研究对象：病例组包括1981至1997年的18 744名自杀者，其年龄均小于75岁，每名自杀者设置20名对照与之匹配。结果：在此期间，研究发现这些精神分裂症及其他相关精神异常患者自杀率的下降幅度与普通人群相似(发生率比为1.00，95%可信区间为0.98～1.03)。其他相关精神疾病患者自杀率的下降比普通人群快。在住院的精神分裂症患者中，入院后第一年的自杀风险最高，年轻者的自杀风险更高，自杀风险随着年龄的增长逐年下降。结论：精神分裂症及相关疾病患者的自杀率已经下降。这可能是由于心理治疗水平的提高、自杀手段的限制或者患者试图自杀后治疗的改进。

关键词：巢式病例对照研究精神分裂症患者自杀率 1997年丹麦疾病患者

Spatial distribution of leprosy in India:an ecological study

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Infectious Diseases of Poverty 2018年第1期7卷 206-214页

作者： Kyra H.Grantz Winnie Chabaari Ramolotja Kagiso Samuel Buri Gershom Laura Blum Lee Worden Sarah Ackley Fengchen Liu thomas M.Lietman Alison P.Galvani Lalitha Prajna Travis C.Porco Department of Biology University of FloridaGainesvilleFLUSA Emerging Pathogens Institute University of FloridaGainesvilleFLUSA DST/NRF Center for Excellence in Epidemiological Modeling and Analysis(SACEMA) StellenboschSouth Africa Stellenbosch University StellenboschSouth Africa African Institute of Mathematical Sciences MuizenbergSouth Africa University of California BerkeleyCAUSA Francis I.Proctor Foundation for Research in Ophthalmology University of CaliforniaSan FranciscoCAUSA Department of Ophthalmology University of CaliforniaSan FranciscoCAUSA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCAUSA Yale University New HavenCTUSA Aravind Eye Hospital MaduraiTamil NaduIndia

Background:As leprosy elimination becomes an increasingly realistic goal,it is essential to determine the factors that contribute to its *** evaluate social and economic factors as predictors of leprosy annual new case detection rates within India,where the majority of leprosy cases ***:We used correlation and linear mixed effect regressions to assess whether poverty,illiteracy,nighttime satellite radiance(an index of development),and other covariates can explain district-wise annual new case detection rate and Grade 2 disability ***:We find only weak evidence of an association between poverty and annual new case detection rates at the district level,though illiteracy and satellite radiance are statistically significant predictors of leprosy at the district *** find no evidence of rapid decline over the period 2008-2015 in either new case detection or new Grade 2 ***:Our findings suggest a somewhat higher rate of leprosy detection,on average,in poorer districts;the overall effect is *** divide between leprosy case detection and true incidence of clinical leprosy complicates these results,particularly given that the detection rate is likely disproportionately lower in impoverished *** information is needed to distinguish the determinants of leprosy case detection and transmission during the elimination epoch.

关键词： Leprosy hansen’s disease India Poverty Spatial

GaAs-chip-based mid-infrared supercontinuum generation

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Light(Science & Applications) 2023年第11期12卷 2443-2450页

作者： Geoffroy Granger Myriam Bailly Hugo Delahaye Cristian Jimenez Idris Tiliouine Yann Leventoux Jean-Christophe Orlianges Vincent Couderc Bruno Gérard Rezki Becheker Said Idlahcen thomas Godin Ammar Hideur Arnaud Grisard Eric Lallier Sébastien Février Universitéde Limoges XLIM UMR CNRS 7252 123 Av.A.Thomas87060 LimogesFrance Thales Research&Technology 1 Av.Augustin Fresnel91767 Palaiseau CedexFrance III-V Lab 1 Av.Augustin Fresnel91767 Palaiseau CedexFrance CORIA(UMR 6614) CNRS-INSA Rouen-Universitéde Rouen NormandieNormandie UniversitéSaint-Etienne du RouvrayFrance

The mid-infrared spectral region opens up new possibilities for applications such as molecular spectroscopy with high spatial and frequency *** example,the mid-infrared light provided by synchrotron sources has helped for early diagnosis of several ***,alternative light sources at the table-top scale would enable better access to these state-of-the-art characterizations,eventually speeding up research in biology and *** supercontinuum generation in highly nonlinear waveguides pumped by compact fiber lasers represents an appealing alternative to ***,we introduce orientation-patterned gallium arsenide waveguides as a new versatile platform for mid-infrared supercontinuum *** and fiber-based pump lasers are optimized in tandem to allow for the group velocities of the signal and the idler waves to match near the degeneracy *** configuration exacerbates supercontinuum generation from 4 to 9μm when waveguides are pumped at 2750 nm with few-nanojoule energy *** brightness of the novel mid-infrared source exceeds that of the thirdgeneration synchrotron source by a factor of *** also show that the nonlinear dynamics is strongly influenced by the choice of waveguide and laser parameters,thus offering an additional degree of freedom in tailoring the spectral profile of the generated *** an approach then opens new paths for high-brightness mid-infrared laser sources development for high-resolution spectroscopy and ***,thanks to the excellent mechanical and thermal properties of the waveguide material,further power scaling seems feasible,allowing for the generation of watt-level ultra-broad frequency combs in the mid-infrared.

关键词： waveguide pumped pump

Development of a Functional Assessment of Chronic Illness Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune checkpoint modulators

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 74-87页

作者： Kimberly A.Webster Mary L.O’Connor Aaron R.hansen Sheetal Kircher Heather S.L.Jim Adam P.Dicker Monika Janda Kari Ala-leppilampi Clifton O.Bingham III Josephine Feliciano Norah Lynn Henry Laurie E.Steffen McLouth David Cella Department of Medical Social Sciences Northwestern University Feinberg School of MedicineChicagoIL 60611USA Princess Margaret Cancer Center University Health NetworkToronto M5G 1Z5Canada Robert H Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL 60611USA Department of Health Outcomes and Behavior Moffitt Cancer CenterTampaFL 33612USA Department of Radiation Oncology Sidney Kimmel Medical College and Cancer Center at Thomas Jefferson UniversityPhiladelphiaPA 19107USA Centre for Health Services Research The University of QueenslandQLD 4102Australia Applied Health Research Centre Li Ka Shing Knowledge InstituteSt Michael’s HospitalToronto M5B 1W8Canada Divisions of Rheumatology and Allergy and Clinical Immunology Johns Hopkins UniversityBaltimoreMD 21224USA Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center BaltimoreMD 21231USA University of Michigan Rogel Cancer Center Ann ArborMI 48109USA Department of Behavioral Science Center for Health Equity Transformation and Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY 40536USA

Aim:To develop a comprehensive item library of patient-reported,immunotherapy-related adverse events(irAEs)that draws from and expands on the Functional Assessment of Chronic Illness Therapy(FACIT)Measurement ***:Literature review and iterative expert *** on a literature review of irAEs,we developed a framework of immunotherapy classes and their associated *** experts then reviewed iterations of symptom summaries and item maps linked to the immunotherapy *** provided content review and feedback was shared across experts until consensus was *** iterative process facilitated creation of a Primary Symptom List associated with immune checkpoint modulators(ICMs),drawn from the larger set of *** FACIT items were mapped to the symptom list,and new items were written as needed to create the item ***:The full item library of irAEs is comprised of 239 items,covering 142 unique symptoms across 75 inflammatory reactions/immune conditions.A subset of 66 items comprises a Primary Symptom List considered most common/relevant to ICM *** includes gastrointestinal,skin,pulmonary,neurologic,musculoskeletal,and multiple miscellaneous and constitutional ***:The FACIT Immunotherapy Item Library is a compilation of 239 self-report items that capture the wide range of AEs experienced by people receiving immune treatments.A subset of 66 items comprises a Primary Symptom List meant for ICM *** of items selected from this library is encouraged in clinical research and clinical practice evaluation.

关键词： Immunotherapy immune checkpoint modulators quality of life immune-related adverse events patient reported outcomes cancer oncology