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Last line therapy with sorafenib in colorectal cancer: A retrospective analysis

World Journal of Gastroenterology 2016年第23期22卷 5400-5405页

作者： Ksenia Martchenko Irene Schmidtmann thomas thomaidis Verena Thole Peter R Galle Marc Becker Markus Mohler thomas C Wehler Carl C Schimanski Department of Internal Medicine Marienhospital 64285 Darmstadt Germany Institute of Medical Biostatistics Epidemiology and Informatics Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany First Department of Internal Medicine Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany Department of Internal Medicine Katholische Kliniken Mainz 55131 Mainz Germany Institute of Pathology Saarland University Medical Center 66421 Homburg Germany Third Department of Internal Medicine Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany

AIM: To analyze the efficacy of last line sorafenib treatment in colorectal cancer patients. METHODS: All patients receiving chemotherapy for colorectal cancer in the outpatient clinic of the University of Mainz since 2006 were retrospectively analyzed for last line sorafenib exposure. Charts of identified patients were analyzed for clinic-pathological parameters, like data on gender, age, date of initial diagnosis, UICC stage, number and kind of the pretherapies, therapy start and end of sorafenib, sorafenib mediated treatment cessation, side effects, response rates, time to progression and overall survival. RESULTS: Ten patients with a median of 3.0 prior chemotherapy lines had received a last line sorafenib therapy either alone(10%) or in combination with 5-fluorouracil derivates(90%). All patients suffered from colorectal cancer stage UICC 4 and were routinely seen in 2-wk intervals in the oncology outpatient clinic. Median duration of treatment was 142.0 d. At 8 wk 80% of patients showed stable disease but we did not observe any remissions. Median time to progression was 140.5 d(4.7 mo), while median overall survival reached 176.5 d. One patient ceased treatment due to side effects. Reason for treatment stop was bleeding complication in one case and non-specified sorafenib intolerance in another case. Due to the retrospective approach we did not further quantify side ***: This retrospective analysis encourages further investigation of sorafenib in colorectal cancer last line therapy.

关键词： Colorectal cancer Sorafenib Regorafenib Chemotherapy Last line

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Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility

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World Journal of Gastroenterology 2013年第38期19卷 6408-6415页

作者： thomas thomaidis Martin Goetz Sebastian Paul Gregor Arthur Hoffman Elias Kouroumalis Markus Moehler Peter Robert Galle Andreas Schwarting Ralf Kiesslich Medical Clinic Johannes-Gutenberg University55131 MainzRheinland-PfalzGermany Medical Clinic University of Tuebingen72076 TuebingenBaden-WürttembergGermany Medical Clinic SHG-Hospital55743 Idar-ObersteinRheinland-PfalzGermany Medical Clinic 60318 Frankfurt am MainHessenGermany Clinic of Gastroenterology Medical School of Crete71110 HeraklionCreteGreece Sana Rheumatology Centre 55543 Bad KreuznachRheinland-PfalzGermany

AIM:To assess the esophageal motility in patients with irritable bowel syndrome(IBS)and to compare those with patients with autoimmune ***:15 patients with IBS,22 with systemic lupus erythematosus(SLE)and 19 with systemic sclerosis(SSc)were prospectively selected from a total of 115patients at a single university centre and esophageal motility was analysed using standard manometry(Mui Scientific PIP-4-8SS).All patients underwent esophagogastro-duodenoscopy before entering the study so that only patients with normal endoscopic findings were included in the current *** patients underwent a complete physical,blood biochemistry and urinary *** grade of dysphagia was determined for each patient in accordance to the intensity and frequency of the presented esophageal ***,disease activity scores(SLEDAI and modified Rodnan score)were obtained for patients with autoimmune *** parameter:A correlation coefficient was calculated between amplitudes,velocity and duration of the peristaltic waves throughout esophagus and patients’dysphagia for all three ***:There was no statistical difference in the standard blood biochemistry and urinary analysis in all three *** with IBS showed similar pathologic dysphagia scores compared to patients with SLE and *** mean value of dysphagia score was in IBS group 7.3,in SLE group 6.73 and in SSc group7.56 with a P-value>***,the manometric patterns were *** patients showed during esophageal manometry peristaltic amplitudes at the proximal part of esophagus greater than 60 mmHg in46%of the patients,which was significant higher in comparison to the SLE(11.8%)and SSc-Group(0%,P=0.003).Furthermore,IBS patients showed lower mean resting pressure of the distal esophagus sphincter(Lower esophageal sphincter,22 mmHg)when compared with SLE(28 mmHg,P=0.037)and SSc(26 mmHg,P=0.052).23.5%of patients with SLE showed amplitudes greater as 160 mmHg in the

关键词： Irritable bowel syndrome Systemic lupus erythematosus Systemic sclerosis Esophageal manometry Dysphagia

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