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Journal of Sport and Health Science 2020年第6期9卷 620-627页

作者： Yassine Negra Helmi Chaabene thomas stöggl Mehréz Hammami Mohamed Souhaiel Chelly Younés Hachana Research Unit“Sport Performance Health&Society”Higher Institute of Sport and Physical Education of Ksar SaidTunis 2009Tunisia Tunisian Research Laboratory“Sports Performance Optimization” National Center of Medicine and Science in Sports(CNMSS)Tunis 1003Tunisia Department of Sport Science and Kinesiology University of SalzburgSalzburg 5400Austria Higher Institute of Sports and Physical Education Manouba UniversityTunis 2009Tunisia

Purpose:This study aimed to assess the effectiveness and time course for improvements in explosive actions through resistance training(RT)*** training(PT)in prepubertal soccer ***:Thirty-four male subjects were assigned to:a control group(n=11);an RT group(5 regular soccer training sessions per week,n=12);a PT group(3 soccer training sessions and 2 RT sessions per week,n=11).The outcome measures included tests for the assessment of muscle strength(e.g.,1 repetition maximum half-squat test),jump ability(e.g.,countermovement jump,squat jump,standing long jump,and multiple 5 bounds test),linear speed(e.g.,20m sprint test),and change of direction(e.g.,Illinois change of direction test).Results:The RTG showed an improvement in the half-squat(△=13.2%;d=1.3,pstanding long jump(△=7.2%;d=1.2,pstanding long jump(△=9.3%;d=1.1,psts(psted earlier in the RTG than in the *** outcomes may help coaches and fitness trainers set out clear and concise

关键词： Change of direction Jump performances Plyometric training Resistance training Soccer Time course

Methodological Guidelines Designed to Improve the Quality of Research on Cross-Country Skiing

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Journal of Science in Sport and Exercise 2021年第3期3卷 207-223页

作者： Barbara Pellegrini Øyvind Sandbakk thomas stoggl Matej Supej NielsØrtenblad Axel Schürer thomas steiner Angelica Lunina Chris Manhard Hui Liu Olli Ohtonen Chiara Zoppirolli Hans-Christer Holmberg CeRiSM University of VeronaRoveretoItaly Neuroscience Biomedicine and Movement Science DepartmentUniversity of VeronaVeronaItaly Centre for Elite Sports Research Department of Neuromedicine and Movement ScienceNorwegian University of Science and TechnologyTrondheimNorway Department of Sport Science and Kinesiology University of SalzburgSalzburgAustria Laboratory of Biomechanics Faculty of SportUniversity of LjubljanaLjubljanaSlovenia Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdenseDenmark Institute for Applied Training Science LeizpigGermany Swiss Federal Institute of Sport MagglingenSwitzerland Department of Theory and Methods in Ski Sports Russian State University of Physical EducationSportYouth and Tourism(SCOLIPE)MoscowRussia School of Kinesiology University of British ColumbiaVancouverB.CCanada Biomechanics Laboratory Beijing Sport UniversityBeijingChina Department of Biology of Physical Activity University of JyvaskylaJyväskylaFinland Swedish Winter Sports Research Centre Department of Health SciencesMid Sweden UniversityOstersundSweden

Cross-country(XC)ski races involve a variety of formats,two different techniques and tracks with highly variable topography and environmental *** addition,XC skiing is a major component of both Nordic combined and biathlon *** in this area,both in the laboratory and field,encounters certain difficulties that may reduce the reliability and validity of the data obtained,as well as complicate comparisons between ***,13 international experts propose specific guidelines designed to enhance the quality of research and publications on XC skiing,as well as on the biathlon and Nordic combined *** consider biomechanical(kinematic,kinetic and neuromuscular)and physiological methodology(at the systemic and/or muscle level),providing recommendations for standardization/control of the experimental *** describe the types of measuring equipment and technology that are most suitable in this ***,we also deal with certain aspects of nomenclature of the classical and skating *** addition to enhancing the quality of stud-ies on XC skiing,Nordic combined and biathlon,our guidelines should also be of value for sport scientists and coaches in other disciplines where physiological and/or biomechanical measurements are performed in the laboratory and/or outdoors.

关键词： Biomechanics Measurement Physiology Reliability Technology Validity

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Continuous germinal center invasion contributes to the diversity of the immune response

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四川生理科学杂志 2022年第12期44卷 2166-2166页

作者： thomas Hägglöf Laboratory of Molecular Immunology The Rockefeller University New York NY 10065 USA Laboratory of Lymphocyte Dynamics The Rockefeller University New York NY 10065 USA Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA

Antibody responses are characterized by increasing affinity and diversity over *** maturation occurs in germinal centers by a mechanism that involves repeated cycles of somatic mutation and *** antibody responses dive... 详细信息

关键词： invasion Antibody centers

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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亚洲谷精草属植物研究(III)

北京林业大学学报 2001年第5期23卷 27-30页

作者：张志翔 thomas stützel 北京林业大学生物科学与技术学院北京100083 德国波鸿鲁尔大学生物系波鸿44780

该文对亚洲分布的E .barbeyanum ,E .dipsacoides,E .cristatum ,E .echinulatum ,E .hamiltonianum ,E .henryanum ,E .hookerianum ,E .kradungense,E .nautiliforme ,E .nigrum和E .thwaitesii等谷精草属 (EriocaulonL .) 11个种的分类问题进行了详细的研究 .补充并纠正了E .nigrumLec .和E .halmitoniamumMartius的形态描写 .公开发表新种E .pseudotruncatum和新变种E .truncatumHam .***.E .seticuspeOhwi,E .***,E .*** ,E .robinsoniiMoldenke和E .poilaneiMoldenke 5个种 (变种 )

关键词：谷精草属新种同物异名亚洲

Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje thomas Ty B Dunn Matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United states emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence Solid organ transplantation Bibliometric analysis

T-lymphoblastic lymphoma with cutaneous involvement

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World Journal of Clinical Cases 2015年第8期3卷 727-731页

作者： Emmanuelle Ginoux Fanny Julia Brigitte Balme Luc thomas stéphane Dalle Department of Dermatology Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Université Claude Bernard Lyon 1 Unit of Pathology Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Cancer Research Center of Lyon

To study dermatological manifestation of T-lymphoblastic lymphoma and to help clinicians in the diagnosis, we report here the case of a 75-year-old patient who presented with violaceous nodules acquired during the last 4 wk and affecting the scalp and right arm. The diagnosis of systemic lymphoma was suggested upon the appearance of cutaneous tumors, palpable lymph nodes and general symptoms including asthenia and weight-loss. The pathology features: positive immunostaining for CD3 and terminal deoxynucleotidyl transferase(Td T) and staging, led us to the final diagnosis of T-lymphoblastic lymphoma(T-LBL) with cutaneous involvement. He received a CHOP regimen as first-line treatment. Unfortunately, the patient relapsed and died 8 mo after the treatment initiation. T-LBL may be diagnosed by skin lesions. Additional immunostaining including Td T and experienced histopathologists are needed to correctly classify this aggressive disease and discuss the correct management including bone-marrow transplantation where appropriate.

关键词： Cutaneous lymphoma Lymphoblastic lymphoma Skin

Comparison of estimators of variance for forest inventories with systematic sampling-results from artificial populations

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Forest Ecosystems 2020年第2期7卷 215-233页

作者： steen Magnussen Ronald EMcRoberts Johannes Breidenbach thomas Nord-Larsen Göran ståhl Lutz Fehrmann Sebastian Schnell 506 West Burnside Road VictoriaBC V8Z 1M5Canada Raspberry Ridge Analytics 15111 Elmcrest Avenue NorthHugoMN 55038USA Norwegian Institute of Bioeconomy Research Høgskolevegen 81431ÅsNorway Department of Geosciences and Natural Resource Management University of CopenhagenRolighedsvej 23DK-1958 Frederiksberg CDenmark Department of Forest Resource Management Swedish University of Agricultural SciencesUmeåSweden Forest Inventory and Remote Sensing Faculty of Forest SciencesUniversity of GöttingenBüsgenweg 5D37077GöttingenGermany Alfred-Möller-straße 1 Haus 41-4216225 EberswaldeGermany.

Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this ***,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important *** better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi *** this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear *** compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance ***:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for *** latter always produced the greatest *** populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design ***:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow *** a strong or moderate linear trend,Matern’s estimator is *** large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar.

关键词： Spatial autocorrelation Linear trend Model based Design biased Matern variance Successive difference replication variance Geary contiguity coefficient Random site effects