检索结果-南通市图书馆

Optimizing beam transport in rapidly compressing beams on the neutralized drift compression experiment-II

Matter and Radiation at Extremes 2018年第2期3卷 78-84页

作者： Anton D.Stepanov John J.Barnard Alex Friedman Erik P.Gilson David P.Grote Qing Ji Igor D.Kaganovich Arun Persaud Peter A.Seidl thomas schenkel University of Washington SeattleWAUSA Lawrence Livermore National Laboratory LivermoreCAUSA Princeton Plasma Physics Laboratory PrincetonNJUSA Lawrence Berkeley National Laboratory BerkeleyCAUSA

The Neutralized Drift Compression Experiment-II(NDCX-II)is an induction linac that generates intense pulses of 1.2 MeV helium ions for heating matter to extreme ***,we present recent results on optimizing beam *** NDCX-II beamline includes a 1-m-long drift section downstream of the last transport solenoid,which is filled with charge-neutralizing plasma that enables rapid longitudinal compression of an intense ion beam against space-charge *** transport section on NDCX-II consists of 28 *** optimal field settings for a group of solenoids requires knowledge of the envelope parameters of the *** the beam on the scintillator gives the radius of the beam,but the envelope angle is not measured *** demonstrate how the parameters of the beam envelope(radius,envelop angle,and emittance)can be reconstructed from a series of images taken by varying the B-field strengths of a solenoid upstream of the *** use this technique to evaluate emittance at several points in the NDCX-II beamline and for optimizing the trajectory of the beam at the entry of the plasma-filled drift section.

关键词： Charged-particle beams Induction accelerators Beam dynamics Beam emittance Ion beam diagnostics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line

引用

中华医学杂志(英文版) 2002年第5期000卷 28-36页

作者： WEI Zhang, Dierk thomas, Christoph A Karle, Sven Kathfer, Johannes schenkel, Volker A W Kreye, Eckhard Ficker Barbara A Wible and Johann Kiehn Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany (Zhang W, T Department of Cardiology Medical University Hospital Heidelberg Heidelberg Germany Department of Physiology and Pathophysiology University of HeidelbergHeidelberg Germany Rammelkamp Center for Education and Research Case Western Reserve University School of Medicine MetroHealth Medical Center Cleveland USA

Objective To investigate the molecular mechanism of human ether a go go related gene (HERG) potassium channels regulated by protein kinase A (PKA) in a human cell line Methods HERG channels were stably expressed in human embryonic kidney (HEK) 293 cells, and currents were measured with the patch clamp technique The direct phosphorylation of HERG channel proteins expressed heterologously in Xenopus laevis oocytes was examined by 32 P labeling and immunoprecipitation with an anti HERG antibody Results Elevation of the intracellular cAMP concentration by incubation with the adenylate cyclase activator, forskolin (10?μmol/L), and the broad range phosphodiesterase inhibitor, IBMX (100?μmol/L), caused a HERG tail current reduction of 83 2% In addition, direct application of the membrane permeable cAMP analog, 8 Br cAMP (500?μmol/L), reduced the tail current amplitude by 29 3% Intracellular application of the catalytic subunit of protein kinase A (200 U/ml) led to a tail current decrease by 56 9% and shifted the activation curve by 15 4 mV towards more positive potentials HERG WT proteins showed two phosphorylated bands, an upper band with a molecular mass of ≈155 kDa and a lower band with a molecular mass of ≈135 kDa, indicating that both the core and the fully glycosylated forms of the protein were phosphorylated Conclusions PKA mediated phosphorylation of HERG channels causes current reduction in a human cell line The coupling between the repolarizing cardiac HERG potassium current and the protein kinase A system could contribute to arrhythmogenesis under pathophysiological conditions

关键词： adrenergic stimulation · arrhythmia · cyclic AMP · HERG potassium channel · protein kinase A

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：