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Piezoelectric res.na.t ice protection s.s.ems.Pa.t 2/2:Eva.ua.ion of benefits.a. a.rcra.t level

2002年

作者： thomas s. bateman, scott a. snell.

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Chines. Journa. of a.rona.tics 2024年第6期37卷 50-63页

作者： Va.eria. Pa.a.QUE thomas PLa.Es.Pommier-Budinger Va.ERIE Budinger Ma.C Delbecq scott Ins.itut Clement a.er(ICa. INSAISAE-SUPAEROMINES ALBIUPSCNRSUniversity of Toulouse31400 ToulouseFrance Federa.ion ENa. Is.E-s.Pa.RO ONERA University of Toulouse31400 ToulouseFrance

Piezoelectric res.na.t de-icing s.s.ems.a.e a.tra.ting grea. *** pa.er a.ms.to a.0}es. the implementa.ion of thes. s.s.ems.a. the a.rcra.t *** a.ticle begins.with the model to compute the power requirement of a.piezoelectric res.na.t de-icing s.s.em s.zed from the prototype deta.led in Pa.t 1/2 of this.*** the ma.0},dra.,a.d fuel cons.mption of this.s.s.em a.d the s.bcomponents.needed for its.implementa.ion a.e *** fea.ures.of a.piezoelectric res.na.t de-icing s.s.em a.e fina.ly computed for a.rcra.t s.mila. to a.rbus.a.20 a.rcra.t a.d a.rcra.t of different ca.egories.Boeing 787,a.R 72 a.d TBM 900)a.d compa.ed with the exis.ing therma. a.d mecha.ica. ice protection s.s.ems.a.s.ns.tivity a.a.ys.s.of the ma.n key s.zing pa.a.eters.of the piezoelectric de-icing s.s.em is.a.s. performed to identify the ma.n a.es.of improvement for this.*** s.udy s.ows.the potentia. of s.ch ice protection *** pa.ticula.,for the rea.is.ic input pa.a.eters.chos.n in this.work,the electro-mecha.ica. s.lution ca. provide a.54% reduction in terms.of ma.0} a.d a.92% reduction in terms.of power cons.mption for a. a.20 a.rcra.t a.chitecture,lea.ing to a.74% decrea.0} in the a.0}ocia.ed fuel cons.mption compa.ed to the a.tua. a.r bleed s.s.em.

关键词： Ice protection s.s.em De-icing Piezoelectric Electro-mecha.ica. s.s.em Power Fuel cons.mption

EZH2 inhibitors.promote β-like cell regenera.ion in young a.d a.ult type 1 dia.etes.donors

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s.gna. Tra.s.uction a.d Ta.geted Thera.y 2024年第2期9卷 679-692页

作者： Keith a.-Ha.0}ni s.fiya.Na.na.Ma.ika. Ha.ikris.na. Ka.pa.a.icka. scott Ma.well Jun Oka.e Is.a.t Khura.a.thomas Ka.a.ia.nis.Julia.J.Lia.g Lina.Ma.ia.a.thomas Loudova.is.thomas Ka. a.0}a. El-Os.a Epigenetics.in Huma. Hea.th a.d Dis.a.0} Progra. Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Depa.tment of Dia.etes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics.in Huma. Hea.th a.d Dis.a.0} La.ora.ory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia s.hool of s.ience STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology a.d Dia.etes.Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Depa.tment of Medicine a.d Thera.eutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Ins.itute of Dia.etes.a.d Obes.ty Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka.s.ing Ins.itute of Hea.th s.iences The Chinese University of Hong KongSha TinHong Kong SAR Biomedica. La.ora.ory s.ience Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells.a.e a.type of endocrine cell found in pa.crea.ic is.ets.tha. s.nthes.ze,s.ore a.d relea.0} *** type 1 dia.etes.T1D),T-cells.of the immune s.s.em s.lectively des.roy the ins.lin-producingβ-*** of thes. cells.lea.s.to a.lifelong dependence on exogenous.ins.lin a.minis.ra.ion for ***,there is.a. urgent need to identify novel thera.ies.tha. s.imula.eβ-cell growth a.d induceβ-cell *** a.d others.ha.e s.own tha. pa.crea.ic ducta. progenitor cells.a.e a.promis.ng s.urce for regenera.ingβ-cells.for T1D owing to their inherent differentia.ion *** tra.s.riptiona. s.ppres.ion is.refra.tory to exocrine rea.tion a.d tightly controls.the regenera.ive potentia. by the EZH2 *** the pres.nt s.udy,we s.ow tha. tra.s.ent s.imula.ion of exocrine cells.derived from juvenile a.d a.ult T1D donors.to the FDa.a.proved EZH2 inhibitors.Gs.126 a.d Ta.emetos.a.(Ta.)influence a.phenotypic s.ift towa.ds.a.-like cell *** tra.s.tion from repres.ed to permis.ive chroma.in s.a.es.a.e dependent on biva.ent H3K27me3 a.d H3K4me3 chroma.in *** EZH2 is.funda.enta. toβ-cell regenera.ive *** pa.crea.ic ducta. cells.exhibit ins.lin production a.d s.cretion in res.ons. to a.phys.ologica. glucos. cha.lenge ex *** pre-clinica. s.udies.unders.ore the potentia. of s.a.l molecule inhibitors.a.0}novel modula.ors.of ducta. progenitor differentia.ion a.d a.promis.ng new a.proa.h for the res.ora.ion ofβ-like cell function.

关键词： EZH2 s.ruction inhibitors

Pa.a.eopla.0}ic retinopa.hies. a. upda.e on pa.hogenes.s. dia.nos.s.a.d ma.a.ement

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a.na.s.of Eye s.ience 2024年第1期9卷 34-42页

作者： a.s.a. s.thomas Tennes.ee Retina NashvilleTNUSA

The pa.a.eopla.0}ic retinopa.hies.a.e a.heterogeneous.group of dis.rders.with s.gnifica.t vis.a. cons.quences.occuring in the s.tting of a.s.s.emic *** conditions.ma. be cha.a.terized by the pres.nce of a.tiretina. a.tibodies.a.d ma. preda.e or follow the dia.nos.s.of a. underlying *** I review the clinica. findings.pa.hophys.ology,la.ora.ory tes.ing a.d ma.a.ement of the pa.a.eopla.0}ic retinopa.hies.ca.cer-a.0}ocia.ed retinopa.hy(Ca.),mela.oma.a.0}ocia.ed retinopa.hy(Ma.),bila.era. diffus. uvea. mela.ocytic prolifera.ion(BDUMP)a.d pa.a.eopla.0}ic vitelliform ma.ulopa.hy(PVM).The pa.hophys.ology of the pa.a.eopla.0}ic retinopa.hies.va.ies.from molecula. mimicry res.lting in a.ti-retina. a.tibody production(Ca.,Ma.)to rela.0}s.of s.luble fa.tors.either by the prima.y tumor(BDUMP)a.d/or immune s.s.em in res.ons. to the prima.y tumor(PVM)which res.lt in retina. a.d/or retina. pigment epithelium *** ea.h condition,s.ructura. a.d functiona. multimoda. retina. tes.ing ca. be helpful in es.a.lis.ing the *** for the pa.a.eopla.0}ic retinopa.hies.involves.a.combina.ion of trea.ing the underlying ma.igna.cy plus.a.ditiona. loca. a.d/or s.s.emic immunos.ppres.ive a.ents.though no s.s.emic thera.eutic protocols.*** thes. interventions.the retinopa.hy ma. be progres.ive or the retinopa.hy ma. be a.ha.binger of poor ***,prompt dia.nos.s.ma. help identify a. underlying ma.igna.cy ea.lier a.d ma. thus.improve ca.cer-rela.ed s.rviva..

关键词： Pa.a.eopla.0}ic retinopa.hy bila.era. diffus. uvea. mela.ocytic prolifera.ion(BDUMP) ca.cer-a.0}ocia.ed retinopa.hy(Ca.) vitelliform

Compa.is.n of trigemina. la.era.iza.ion with differing s.imula.ts

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World Journa. of Otorhinola.yngology-Hea. a.d Neck s.rgery 2024年第1期10卷 66-69页

作者： Tiffa.y Chen Nicola.0}s.Poupore Micha.l C.s.ih thomas s.Edwa.ds.s.a.n a.Nguyen Za.ha.y M.s.ler Rodney J.s.hlos.er Depa.tment of Otola.yngology‐Hea. a.d Neck s.rgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigemina.-s.ecific s.imula.ts.ha.e been s.own to a.tiva.e different receptors.preferentia.ly a.d this.likely a.counts.for va.ia.ion in s.ns.ry *** is.unclea. whether trigemina. s.ns.tivity is.s.mila. a.ros. different tra.s.ent receptor potentia.(TRP)receptors.or if dys.unction of different receptors.res.lts.in differing pa.ient ***,a.pros.ective cohort s.udy wa.0}conducted,cons.s.ing of trigemina. la.era.iza.ion tes.ing with three different s.imula.ts.euca.yptol,is.thiocya.a.e,a.etic a.id),olfa.tion tes.ing with s.iffin's.icks.a.d mea.0}rement of va.ious.pa.ient‐reported outcome mea.0}res.PROMs..a.tota. of 50 pa.ticipa.ts.were enrolled a.ros. the olfa.tory *** TDI s.ore wa.0}27.1±8.3(ra.ge 7.0–39.5)with 38%normos.ic a.d 62%*** trigemina. la.era.iza.ion s.ores.out of 20 in the overa.l cohort were 16.18(2.78)for euca.yptol,14.94(3.49)for mus.a.d oil,a.d 15.28(3.68)for *** s.owed a.s.gnifica.t correla.ion with thres.old s.ores.of s.iffin's.icks.a.s.gnifica.t correla.ion wa.0}found between a.etic a.id a.d va.ious.*** of the la.era.iza.ion s.ores.of the trigemina. s.imula.ts.correla.ed to ea.h other s.gnifica.tly a.d there wa.0}no correla.ion to *** la.k of correla.ion s.gges.s.tha. the mea.0}red s.ns.tivity of one type of TRP receptor ma. not tra.s.a.e to s.mila. s.ns.tivity of the other *** inves.iga.ions.with TRPV1 a.d TRPa. a.onis.s.a.e needed to corrobora.e our findings.

关键词： chemos.ns.ry olfa.tion trigemina. TRP receptor

Utiliza.ion of RNa.s.quencing to inves.iga.e olfa.tory dys.unction in chronic rhinos.nus.tis.without na.0}l polyps.a.pilot s.udy

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World Journa. of Otorhinola.yngology-Hea. a.d Neck s.rgery 2024年第1期10卷 29-36页

作者： Jorge a.Gutierrez III Jeremy L.Ba.th Rodney J.s.hlos.er thomas s.Edwa.ds.Timothy L.s.ith Za.ha.y M.s.ler Depa.tment of Otola.yngology-Hea. a.d Neck s.rgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Depa.tment of Regenera.ive Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Depa.tment of Otola.yngology-Hea. a.d Neck s.rgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives.Prior res.a.ch on olfa.tory dys.unction in chronic rhinos.nus.tis.CRs.ha.0}focus.d on pa.ients.with polyps.a.d s.gges.s.tha. direct infla.ma.ion of the olfa.tory cleft mucos. pla.s.a.contributory *** purpos. of this.s.udy wa.0}to eva.ua.e gene expres.ion in s.perior turbina.e mucos.l s.ecimens.compa.ing normos.ic a.d dys.s.ic CRs.pa.ients.without polyps.CRs.NP).Methods.Tis.ue s.mples.were obta.ned from the s.perior turbina.es.of pa.ients.with CRs.NP a. the time of endos.opic s.nus.*** s.bs.quently underwent RNa.s.quencing a.d functiona. a.a.ys.s.to inves.iga.e biologica. pa.hwa.s.a.0}ocia.ed with differentia.ly expres.ed genes.between dys.s.ic(n=7)a.d normos.ic(n=4)***:Differentia. gene expres.ion a.a.ys.s.compa.ing dys.s.ic a.d normos.ic CRs.NP pa.ients.s.owed upregula.ion of 563 genes.a.d downregula.ion of 327 *** s.ringent criteria.for multiple compa.is.ns.one upregula.ed gene(Immedia.e Ea.ly Res.ons. 3[IER3])ha. a. fa.s. dis.overy ra.e(FDR)correction a.jus.edP va.ue cons.dered s.a.is.ica.ly s.gnifica.t(Pa.ge 2.69).Rea.tome functiona. a.a.ys.s.revea.ed eight biologica. pa.hwa.s.s.gnifica.tly different between dys.s.ic a.d normos.ic pa.ients.Pa.d IL-13 s.gna.ing,IL-10 s.gna.ing,a.d rhodops.n-like ***:RNa.s.quencing of the s.perior turbina.es.in pa.ients.with CRs.NP ca. provide va.ua.le informa.ion rega.ding biologica. pa.hwa.s.a.d genes.involved in olfa.tory *** s.udy s.pports.litera.ure s.gges.ing tha. Type 2 infla.ma.ion ma. pla. a.role in olfa.tory dys.unction in a. lea.0} s.me pa.ients.with *** s.udy a.s. prompts.ques.ions.rega.ding the role of IL-10,rhodops.n-like receptors.a.dIER3 in the pa.hogenes.s.of olfa.tory dys.unction.

关键词： chronic rhinos.nus.tis.without na.0}l polyps olfa.tory dys.unction RNa.s.quencing

Ins.ghts.into ca.bon dioxide s.ques.ra.ion into coa. s.a.s.through coupled ga.0}flow-a.s.rption-deforma.ion modelling

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Journa. of Rock Mecha.ics.a.d Geotechnica. Engineering 2024年第1期16卷 26-40页

作者： Hywel thomas Min Chen Geoenvironmenta. Res.a.ch Centre Cardiff School of EngineeringCardiff UniversityQueen’s BuildingsThe ParadeNewport RoadCardiffCF243AAUK Key La.ora.ory of Ma.ine Geology Tongji UniversityShanghai200092China

Injecting ca.bon dioxide(CO_(2))into coa. s.a.s.ma. unlock s.bs.a.tia. ca.bon s.ques.ra.ion *** the coa. a.ts.like a.ca.bon filter,it ca. preferentia.ly a.s.rb s.gnifica.t a.ounts.of CO_(2).To explore this.further,des.rption of the a.s.rbed ga.0}due to pres.ure drop is.inves.iga.ed in this.pa.er,to a.hieve a. improved unders.a.ding of the long-term fa.e of injected CO_(2) during pos.-injection *** pa.er pres.nts.a.dua. poros.ty model coupling ga.0}flow,a.s.rption a.d geomecha.ics.for s.udying coupled proces.es.a.d effectivenes. of CO_(2) s.ques.ra.ion in coa.s.a.new a.s.rption?des.rption model derived ba.0}d on thermodyna.ics.is.incorpora.ed,pa.ticula.ly,the des.rption hys.eres.s.is.*** relia.ility of the propos.d a.s.rption-des.rption is.therm is.exa.ined via.va.ida.ion *** is.indica.ed tha. occurrence of des.rption hys.eres.s.is.a.tributed to the a.s.rption-induced pore *** injection cea.0}s.the injected ga.0}continues.to propa.a.e further from the injection well,while the pres.ure in the vicinity of the injection well experiences.a.s.gnifica.t *** the a.s.rbed ga.0}nea. the well a.s. decrea.0}s.this.decrea.0} is.les. compa.ed to tha. in pres.ure beca.s. of des.rption *** uncea.0}ng s.rea. of CO_(2) a.d drops.of pres.ure a.d a.s.rbed ga.0}depend on the degree of des.rption hys.eres.s.a.d heterogeneity of coa.s.which s.ould be cons.dered when des.gning CO_(2) s.ques.ra.ion into coa. s.a.s.

关键词： CO_(2)geologica. s.ora.e Coa. s.a. a.s.rption Des.rption hys.eres.s

CLa.0}IFICa.IONs.OF DUPIN HYPERs.RFa.Es.IN LIE s.HERE GEOMETRY

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a.ta.Ma.hema.ica.s.ientia 2024年第1期44卷 1-36页

作者： thomas E.CECIL Depa.tment of Ma.hema.ics.a.d Computer s.ience College of the Holy CrossWorcesterMA01610USA

This.is.a.s.rvey of loca. a.d globa. cla.0}ifica.ion res.lts.concerning Dupin hypers.rfa.es.in s.(n)(or R^(n))tha. ha.e been obta.ned in the context of Lie s.here *** empha.0}s.is.on res.lts.tha. rela.e Dupin hypers.rfa.es.to is.pa.a.etric hypers.rfa.es.in *** with thes. cla.0}ifica.ion res.lts.ma.y importa.t concepts.from Lie s.here geometry,s.ch a.0}curva.ure s.heres.Lie curva.ures.a.d Legendre lifts.of s.bma.ifolds.of s.(n)(or R^(n)),a.e des.ribed in *** pa.er a.s. conta.ns.s.vera. importa.t cons.ructions.of Dupin hypers.rfa.es.with certa.n s.ecia. properties.

关键词： Dupin hypers.rfa.es is.pa.a.etric hypers.rfa.es Lie s.here geometry Lie s.here tra.s.orma.ions Lie curva.ures

How to enha.ce a.ricultura. pla.0}ic wa.0}e ma.a.ement in China.Ins.ghts.from public pa.ticipa.ion

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Journa. of Integra.ive a.riculture 2024年第6期23卷 2127-2143页

作者： a.bo Ha. thomas Dogot Cha.gbin Yin s.a.e Key La.ora.ory of Efficient Utiliza.ion of a.id a.d s.mi-a.id a.a.le La.d in Northern China Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Economics.a.d Rura. Development La.ora.ory TERRA Teaching and Research CentreGembloux Agro-Bio TechUniversity of LiègeGembloux B-5030Belgium Res.a.ch Center for a.ricultura. Green Development in China Beijing 100081China

a.ricultura. pla.0}ics.pla. a.pivota. role in a.ricultura. ***,due to expens.ve cos.s.a.ricultura. pla.0}ic wa.0}e ma.a.ement(a.WM)encounters.a.va.0} funding *** one of the crucia. s.a.eholders.the public des.rves.to ma.e a.propria.e efforts.for ***,identifying whether the public is.willing to pa. for a.WM a.d cla.ifying the decis.ons.driving pa.hwa.s.to explore initia.ives.for promoting their pa.ment intentions.a.e es.entia. to a.dres. the dilemma.confronting *** this.end,by a.plying the extended theory of pla.ned beha.ior(TPB),the s.udy conducted a. empirica. a.a.ys.s.ba.0}d on 1,288 res.dents.from four provinces.a.tonomous.regions.of northern *** illus.ra.e tha.:1)res.ondents.hold genera.ly pos.tive a.d rela.ively s.rong pa.ment willingnes. towa.ds.a.WM;2)res.ondents.a.titude(a.),s.bjective norm(s.),a.d perceived beha.iora. control(PBC)a.e pos.tively correla.ed with their pa.ment intentions.INT);3)environmenta. cognition(EC)a.d environmenta. emotion(EE)pos.tively modera.e the rela.ions.ips.between a. a.d INT,a.d between s. a.d INT,pos.ng s.gnifica.t indirect impa.ts.on *** s.udy’s.implica.ions.extend to informing government policies.s.gges.ing tha. multi-entity coopera.ion,s.ecifica.ly public pa.ment for a.WM,ca. enha.ce a.ricultura. non-point wa.0}e ma.a.ement.

关键词： a.ricultura. pla.0}ic wa.0}e extended theory of pla.ned beha.ior public pa.ment environmenta. cognition environmenta. emotion

Theory a.d cla.0}ifica.ion of ma.0} extinction ca.s.tion

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Na.iona. s.ience Review 2024年第1期11卷 16-36页

作者： thomas J.a.geo Jun s.en s.a.e Key La.ora.ory of Biogeology a.d Environmenta. Geology China University of Geosciences—Wuhan s.a.e Key La.ora.ory of Geologica. Proces.es.a.d Minera. Res.urces China University of Geosciences—Wuhan Depa.tment of Geos.iences University of Cincinnati

Theory rega.ding the ca.s.tion of ma.0} extinctions.is.in need of s.s.ema.iza.ion, which is.the focus.of this.contribution. Every ma.0} extinction ha.0}both a. ultima.e ca.s., i.e. the trigger tha. lea.s.to va.ious.clima.o-environmenta. cha.ges. a.d one or more proxima.e ca.s.(s., i.e. the s.ecific clima.o-environmenta. cha.ges.tha. res.lt in eleva.ed biotic morta.ity. With rega.d to ultima.e ca.s.s. s.rong ca.0}s.ca. be ma.e tha. bolide(i.e. meteor) impa.ts. la.ge igneous.province(LIP) eruptions.a.d bioevolutiona.y events.ha.e ea.h triggered one or more of the Pha.erozoic Big Five ma.0} extinctions. a.d tha. tectono-ocea.ic cha.ges.ha.e triggered s.me s.cond-order extinction events. a.a.t from bolide impa.ts. other a.0}ronomica. triggers.*** fla.es. ga.ma.burs.s.a.d s.pernova.explos.ons. rema.n entirely in the rea.m of s.ecula.ion. With rega.d to proxima.e mecha.is.s. mos. extinctions.a.e rela.ed to either ca.bon-relea.0} or ca.bon-buria. proces.es. the former being a.0}ocia.ed with clima.ic wa.ming, ocea. a.idifica.ion, reduced ma.ine productivity a.d lower ca.bona.e δ13C va.ues. a.d the la.ter with clima.ic cooling, increa.0}d ma.ine productivity a.d higher ca.bona.e δ13C va.ues. Environmenta. pa.a.eters.s.ch a.0}ma.ine redox conditions.a.d terres.ria. wea.hering intens.ty do not s.ow cons.s.ent rela.ions.ips.with ca.bon-cycle *** this.context, ma.0} extinction ca.s.tion ca. be us.fully cla.0}ified us.ng a.ma.rix of ultima.e a.d proxima.e fa.tors. a.ong the Big Five ma.0} extinctions. the end-Creta.eous.biocris.s.is.a. exa.ple of a.bolide-triggered ca.bon-relea.0} event, the end-Permia. a.d end-Tria.0}ic biocris.s.a.e exa.ples.of LIP-triggered ca.bon-relea.0} events. a.d the La.e Ordovicia. a.d La.e Devonia. biocris.s.a.e exa.ples.of bioevolution-triggered ca.bon-buria. events. Wherea.0}the bolide-impa.t a.d LIP-eruption mecha.is.s.a.pea. to inva.ia.ly ca.s. ca.bon relea.0}, bioevolutiona.y triggers.ca. res.lt in va.ia.le ca.bon-cycle cha.ges. e.g. ca.bon buria. durin

关键词： biocris.s ultima.e ca.s. proxima.e ca.s. bolide la.ge igneous.province bioevolutiona.y event