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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from saccharomyces cerevisiae.

关键词： activation dinuclear conserved

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje thomas Ty B Dunn Matthew Cooper Division of Transplant surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of science *** and transplantation-related keywords were *** the aid of the VOs viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United states emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence solid organ transplantation Bibliometric analysis

Analogy between adsorption and sorption： An elementary mechanistic approach. I. Monolayer adsorption and sorption without solvent cluster formation

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Chinese Journal of Chemical Engineering 2017年第12期25卷 1740-1749页

作者： Pierre schaetzel sébastien thomas Hasna Louahlia Gualous Laboratoire Universitaire des sciences Appliquées de Cherbourg Université de Caen IUT de Caen Boulevard Marechal Juin 14032 Caen cedex France Institut de chimie et procédés pour l'énergie l'environnement et la santé Université de Strasbourg 25 rue Becquerel 67087 Strasbourg cedex 2 France

The elementary mechanistic model of adsorption and sorption is based on a simple hypothesis： the adsorption sites are uniformly distnbuted on the surface of the pore walls in the adsorbent, the sorption sites are uniformly distributed in the volume of the polymer. In this first paper we will analyze the simple case where one solute molecule is only allowed to occupy a single adsorption or sorption site. A common elementary occupation law of the free sites is assumed： the differential increase of the number of the adsorbed/sorbed molecules is proportional to the differential increase of the activity of the solute and the concentration of the free （non-occupied） sites in the solid. The proportionality coefficient is called affinity coefficient depending on the solid/solute couple and on the temperature and independent of the concentration of the solute. In adsorption the concentration of the free sites is a surface concentration on the pore walls and in sorption it is expressed by the molarity. The simple monolayer adsorption law of Jovanovic is obtained： n = no（1 - e KP） where n is the number of moles adsorbed when the pressure is P. no is the total number of adsorption sites and K the affinity coefficient for adsorption. The sorption law writes： a = 1/k [Ф/1-Ф] ＋ 1-r/k In [1 ＋ 1/r Ф/1-Ф] where Ф, r and k hold respectively for the volume fraction of the solvent in the polymer, for the ratio of the molar volumes of the solvent to the elementary polymer chain containing one single adsorption site and for the sorption affinity coefficient. The confrontation of these equations to experimental isotherms is satisfactory in comparison with the classical Langmuir and Flory-Huggins equations： the best results are obtained for adsorption of vapors on a 5A zeolite and for all analyzed sorption results.

关键词： Adsorption isotherms sorption isotherms Flory-Huggins theory Langmuir equation

Ageing behaviour of a polyethylene blend:influence of chemical defects and morphology on charge transport

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High Voltage 2020年第3期5卷 270-279页

作者： somyot Tantipattarakul Alun s.Vaughan thomas Andritsch Tony Davies High Voltage Laboratory University of SouthamptonSouthamptonSO171BJUK Maintenance Division Electricity Generating Authority of ThailandNonthaburiThailand

Abstract:The properties of novel cable insulation systems will rely critically upon the morphology of the ***,a blend of high and low-density polyethylene(PE)was processed in order to generate three sets of samples with different *** influence of thermo-oxidative ageing at 120℃ was then *** resulting chemical changes included the introduction of unsaturation and oxygen-containing groups and were determined by antioxidant consumption and oxygen *** chemical defects were found to be concentrated in the fraction of each system that was molten at 120°C and,consequently,served to inhibit recrystallisation following *** resulting spatial distribution of charge trapping sites was therefore strongly dependent on *** electrical conductivity of each system varied non-monotonically with ageing:short times reduced the conductivity;a rapid increase in conductivity over five orders of magnitude occurred beyond a critical ageing *** the pronounced structural differences between the morphologically distinct sets of samples,all exhibited comparable conductivity values beyond this threshold,implying that while charge transport is strongly influenced by chemical factors,crystallinity is relatively *** experimental finding appears at odds with theoretical studies of the electronic states in crystalline and amorphous PE.

关键词： charge chemical conductivity

Does intra-ruminal nitrogen recycling waste valuable resources? A review of major players and their manipulation

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Journal of Animal science and Biotechnology 2018年第3期9卷 497-517页

作者： thomas Hartinger Nina Gresner Karl-Heinz südekum Institute of Animal science University of Bonn

Nitrogenous emissions from ruminant livestock production are of increasing public concern and, together with methane, contribute to environmental pollution. The main cause of nitrogen-(N)-containing emissions is the inadequate provision of N to ruminants, leading to an excess of ammonia in the rumen, which is subsequently excreted. Depending on the size and molecular structure, various bacterial, protozoal and fungal species are involved in the ruminal breakdown of nitrogenous compounds(NC). Decelerating ruminal NC degradation by controlling the abundance and activity of proteolytic and deaminating microorganisms, but without reducing cellulolytic processes, is a promising strategy to decrease N emissions along with increasing N utilization by ruminants. Different dietary options, including among others the treatment of feedstuffs with heat or the application of diverse feed additives, as well as vaccination against rumen microorganisms or their enzymes have been evaluated. Thereby, reduced productions of microbial metabolites, e.g. ammonia, and increased microbial N flows give evidence for an improved N retention. However, linkage between these findings and alterations in the rumen microbiota composition, particularly NC-degrading microbes, remains sparse and contradictory findings confound the exact evaluation of these manipulating strategies, thus emphasizing the need for comprehensive research. The demand for increased sustainability in ruminant livestock production requests to apply attention to microbial N utilization efficiency and this will require a better understanding of underlying metabolic processes as well as composition and interactions of ruminal NC-degrading microorganisms.

关键词： Ammonia Bacteria Deamination Hyper-ammonia producing Nitrogen efficiency Protein Proteolysis Protozoa Ruminant

Breaking the scattering limits of water waves

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National science Review 2024年第6期11卷 85-86页

作者： Adrià Canós Valero thomas Weiss Yuri Kivshar Institute of Physics University of Graz 4th Physics Institute University of Stuttgart Research school of Physics Australian National University

When water, light or sound waves impinge on objects smaller than the wavelength, a scattering process takes place[1]. The scattering of waves plays an essential role in a myriad of natural phenomena. In ocean engineering, enhancing the scattering of water waves allows capturing energy from larger areas, with clear implications for energy harvesting and coastal protection.

关键词： water breaking limits scattering waves

Management : competing in the new era / thomas s. Bateman, scott A. snell. 5th ed.

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MULTIsCALE IssUEs IN DNs OF MULTIPHAsE FLOWs

2002年

作者： thomas s. Bateman, scott A. snell.

来源：畅想之星图书光盘版（南... 评论

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Acta Mathematica scientia 2010年第2期30卷 551-562页

作者： G.Tryggvason s.thomas B.Aboulhasanzadeh Worcester Polytechnic Institute

Direct numerical simulations （DNs） have now become a well established tool to examine complex multiphase flows. such flows typically exhibit a large range of scales and it is generally necessary to use different descriptions of the flow depending on the scale that we are examining. Here we discuss multiphase flows from a multiscale perspective. Those include both how DNs are providing insight and understanding for modeling of scales much larger than the ＂dominant scale＂（defined where surface tension, viscous forces or inertia are important）, as well as how DNs are often limited by the need to resolve processes taking place on much smaller scales. Both problems can be cast into a language introduced for general classes of multiscale problems and reveal that while the classification may be new, the issues are not.

关键词： direct numerical simulations multiphase flow multiscale problems