作者:
Tolia VWuerth Athomas R.郝筱倩Children
s Hospital of Michigan Wayne State University 3901 Beaubien Boulevard Detroit MI 48201 United States.Dr
Our aims were to compare the specificity and sensitivity of the reflux index ( RI), Euler and Byrne score (EBS), and area under the curve (AUC) at pH < 4.0 in infants 1 year old for identifying pathologic gastroesopha...
详细信息
Our aims were to compare the specificity and sensitivity of the reflux index ( RI), Euler and Byrne score (EBS), and area under the curve (AUC) at pH ertook a prospective investigation of extended pH monitoring (EPM) in 117 infants with symptoms of G er. Infants were categorized as having pathologic reflux by three measures: RI ≥5%, EBS ≥50, or AUC pHermined by receiver operating c haracteristic (ROC) curve analysis. Using the RI as a criterion, 27 infants (23 %) had pathologic reflux. When EBS and AUC were used, 65 (56%), and 67 (57%) respectively, were classified as having pathologic reflux. The specificities of RI,EBS, and AUC w ere 97.8, 100.0, and 100.0%, respectively, and the sensitivities were 93.0, 91. 5, and 94.4, respectively. A new cutoff value for RI of 2.1%was determined usin g ROC curve analysis to improve the specificity and sensitivity of RI to the abo ve values. The number of infants with pathologic Ger is likely to be significant ly less using the traditional RI alone on formula feedings, however, the revised RI cutoff value and AUC analysis by computerized pH tracings can enhance the acc uracy on formula feedings.
<正> Since 1977, numerous studies have indicated the existence of a putative membrane-based estrogen receptor. However, the identity of this membrane-based estrogen receptor has not been established. Through an exte...
<正> Since 1977, numerous studies have indicated the existence of a putative membrane-based estrogen receptor. However, the identity of this membrane-based estrogen receptor has not been established. Through an extensive homology search in Gene Bank, we recently identified and cloned a novel variant of er-αwith a predicted molecular weight of 35.7 kDa. The transcript of this er-a variant is initiated from a previously unidentified promoter in the first intron of the original er-a gene. This er-a variant differs from the original er-a by lacking both transcriptional activation domains (AF-1 and AF-2) but retaining the
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