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Kinase function in the gonads of Schistosoma mansoni unravelled by inhibitor and RNAi approaches

Kinase function in the gonads of Schistosoma mansoni unravel...

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中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十一次学术研讨会

作者： Christoph G.Grevelding Christin Buro thomas quack Steffen Hahnel Colette Dissous Katia C.Oliveira Sergio Verjovski-Almeida Svenja Beckmann Unite Inserm 547 CIIL-Center for Infection and ImmunityInserm U1019-CNRS UMR 8204Institut PasteurLilleFrance Department of Biochemistry Instituto de QuimicaUniversidade de Sao PauloBrazil

Schistosome biology is characterized by the essential influence of the male on mitoses and differentiation processes in the reproductive organs of the *** pairing-induced sexual maturation leads to egg production causing the pathogenic consequences of *** these correlations are long known,their molecular basis has not been elucidated *** have started to identify and characterise genes coding for signaling proteins and concentrated on cellular tyrosine kinases(CTKs). Among these are members of the Src and Syk families,which are expressed in the reproductive organs of both ***,the transforming growth-factor receptor 1 and the venus kinase receptor 1, which belongs to the class of receptor tyrosine kinases,are expressed in the *** have investigated the physiological effects of chemical inhibitors blocking the activities of specific signaling proteins in adult schistosomes in *** functional assays we investigated pairing-stability,egg production and survival. By confocal laser scanning microscopy the morphological consequences of these approaches were *** two-hybrid(Y2H) cDNA library screenings were performed to identify binding partners of interesting *** specific interactions were confirmed by direct Y2H interaction analyses and/or coimmunoprecipitation *** analyses provided an overview about global gene expression changes upon inhibitor *** was applied to silence specific gene functions and, finally,Xenopus oocyte transfection approaches were combined with germinal vesicle breakdown assays to biochemically study individual *** will be presented that demonstrate the potential of combining these methods to functionally characterize schistosome *** suggest CTKs as promising targets for novel intervention strategies.

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