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Using physiological conditions to assess current and future habitat use of a Subarctic frog

Integrative Zoology 2023年第1期18卷 2-14页

作者： thomas p.hastings Blake R.HOSSACK LeeAnn FISHBACK Jon M.DAVENpORT Department of Biology Appalachian State UniversityBooneNorth CarolinaUSA U.S.Geological Survey Northern Rocky Mountain Science Centerand Wildlife Biology ProgramW.A.Franke College of Forestry&ConservationUniversity of MontanaMissoulaMontanaUSA Churchill Northern Studies Centre ChurchillManitobaCanada

Species with especially close dependence on the environment to meet physiological requirements,such as ectotherms,are highly susceptible to the impacts of climate *** change is occurring rapidly in the Subarctic and Arctic,but there is limited knowledge on ectotherm physiology in these *** investigated how environmental conditions and habitat characteristics inﬂuence the physiological conditions and habitat use of wood frogs(Rana sylvatica)in a Subarctic landscape near Churchill,Manitoba(Canada).We used plaster models to estimate water loss rates and surface body temperatures among different habitat types and at speciﬁc locations used by radio-tracked *** loss(R2=0.67)and surface temperature(R2=0.80)of plaster models was similar to that of live ***-based water loss rates were greater in tundra habitat than in boreal forest and ecotone *** use of wood frogs was strongly tied with available surface moisture and decreased water loss rates that were observed with plaster *** conditions,such as wind speed and ground tem-perature,explained 58%and 91%of the variation in water balance and temperature of plaster *** physiological conditions may be challenging for semi-aquatic ectotherms in environments vulnerable to future cli-mate *** ability to predict physiological conditions based on environmental conditions,as demonstrated in our study,can help understand how wildlife will respond to climatic changes.

关键词： Arctic climate change landscape physiology water balance wood frog

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Safety,immunogenicity,and cross-species protection of a plasmid DNA encoding plasmodium falciparum SERA5 polypeptide,microbial epitopes and chemokine genes in mice and olive baboons

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The Journal of Biomedical Research 2017年第4期31卷 321-332页

作者： Nyamongo Onkoba Ruth M.Mumo Horace Ochanda Charles Omwandho hastings S.Ozwara thomas G.Egwang Department of Tropical & Infectious Diseases Institute of Primate Research Nairobi P O. Box 24481-00502 Kenya School of Biological Sciences University of Nairobi Nairobi P. O. Box 30197-00100 Kenya Department of Biochemistry School of Medicine University of Nairobi Nairobi P. O. Box 30197-00100 Kenya Kirinyaga University College Kerugoya P O. Box 143-10300 Kenya Med-Biotech Laboratories Kampala P O. Box 9364 Uganda

Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of straintranscending malarial *** present study sought to determine safety,immunogenicity and cross-species efficacy of plasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of BacilleCalmette Guerin（BCG）,tetanus toxoid（TT） and a chemokine *** baboons and BALB/c mice were randomly assigned into vaccine and control *** vaccine group animals were primed and boosted twice with pIRES plasmids encoding the SERA5 ＋ BCG ＋ TT alone,or with either CCL5 or CCL20 and the control group with pIRES plasmid vector *** and baboons were challenged with *** ANKA and *** H strain parasites,*** was determined by observing for injection sites reactogenicities,hematology and clinical *** and survivorship profiles were used to determine cross-species efficacy,and T cell phenotypes,Th1-,Th2-type,T-regulatory immune responses and antibody responses were assessed to determine vaccine *** pSeBCGTT plasmid DNA vaccines were safe and induced Thl-,Th2-type,and Tregulatory responses vaccinated animals showed enhanced CD4~＋（p〈0.01）,CD 8~＋ T cells（p〈 0.001） activation and IgG anti-SE36 antibodies responses（p〈 0.001） at week 4 and 8 post vaccination compared to the control *** mice had a 31.45-68.69%cumulative parasite load reduction and 60%suppression in baboons（p〈0.05）and enhanced survivorship（p〈 0.001） with no clinical signs of malaria compared to the control *** results showed that the vaccines were safe,immunogenic and conferred partial cross-species protection.

关键词： malaria DNA vaccines serine repeat antigen chemokines cross-species protection immunogenicity safety

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