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Innovations with the scapula and subscapular system for head and neck microvascular reconstruction

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Plastic and Aesthetic Research 2023年第1期10卷 5-17页

作者： Farshad Chowdhury Eitan Prisman Carissa m.thomas Department of Otolaryngology-Head and Neck Surgery University of RochesterRochesterNY 14618USA Department of Otolaryngology-Head and Neck Surgery Vancouver General HospitalUniversity of British ColumbiaVancouverBC V5Z 1M9Canada Department of Otolaryngology-Head and Neck Surgery University of Alabama at BirminghamBirminghamAL 35294USA

microvascular free flap reconstruction based on the subscapular system is an established and versatile method of reconstructing complex head and neck *** the first published description in the mid-1980s,advances have been made to the harvest technique,positioning,use of virtual surgical planning,and endosseous ***,the most recent literature is reviewed for innovations related to the subscapular *** head and neck surgeon preferences related to the subscapular system are surveyed and *** concordance between virtual surgical plans using scapula cutting guides and pre-contoured plates with the postoperative result is assessed,and novel applications of the scapula free flap are *** system free flaps are an established and essential component of the reconstructive armamentarium for head and neck defects with minimal limitations and low donor site morbidity.

关键词： Scapula subscapular system microvascular reconstruction virtual surgical planning

The Chikungunya virus: An emerging US pathogen

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World Journal of Emergency medicine 2016年第1期7卷 65-67页

作者： thomas m.Nappe Craig m.Chuhran Steven A.Johnson Department of Emergency medicine Lehigh Valley Hospital USF Morsani College of Medicine Department of medicine Lehigh Valley Hospital USF Morsani College of Medicine

BACKGROUND:The Chikungunya(CHIK)virus was recently reported by the CDC to have spread to the United *** report an early documented case of CHIK from the state of Pennsylvania after a patient recently returned from Haiti in June of ***:A 39-year-old man presented to the emergency department complaining of fever,fatigue,polyarthralgias and a diffuse rash for two *** days before,he returned from a mission trip to Haiti and reported that four of his accompanying friends had also become ill.A CHIK antibody titer was obtained and it was found to be *** his hospital stay,he responded well to supportive care,including anti-inflammatories,intravenous hydration and ***:His condition improved within two days and he was ultimately discharged ***:manifestations of CHIK can be similar to Dengue fever,which is transmitted by the same species of mosquito,and occasionally as a *** should include Chikungunya virus in their differential diagnosis of patients who present with fever,polyarthralgia and rash with a recent history of travel to endemic areas,including those within the United States.

关键词： Chikungunya virus Arbovirus mosquito-borne disease Polyarthralgia

Bending reliability of screen-printed vias for a flexible energy module

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npj Flexible Electronics 2020年第1期4卷 210-217页

作者： manu Kujala Terho Kololuoma Jari Keskinen Donald Lupo matti mäntysalo thomas m.Kraft Faculty of Computing and Electrical Engineering Tampere University(formerly Tampere University of Technology)Korkeakoulunkatu 3FI-33720TampereFinland Faculty of Information Technology and Communication Sciences Tampere UniversityKorkeakoulunkatu 3TampereFI-33720Finland Sasken Finland Oy Vissavedentie 1FI-69600KaustinenFinland VTT Technical Research Centre of Finland Ltd. Kaitoväylä1OuluFI-90590Finland

The future of printed electronics involves advancements not only related to full system integration,but also lean process manufacturing.A critical aspect of this progress is developed in this study,which evaluates a highly flexible screen printed through-hole-via using silver microparticle inks,for applications in energy harvesting and storage *** printed vias’fabrication and durability are evaluated by means of a double sided screen-printing method and repetitive(cyclic)bending ***,through 125-µm-thick PET foil,were laser cut(nominally 50,100,150,and 200µm diameters)then filled,and simultaneously connected to adjacent vias by screen *** investigate the use of the printed via in a monolithic energy module,the vias were used for the fabrication of a flexible printed supercapacitor containing aqueous electrolyte and carbon *** results indicate that the lower viscosity silver ink(DuPont 5064H)fills the via less effectively than the higher viscosity ink(Asahi LS411AW),and as the via size increases(≥150µm diameter)via walls are coated rather than ***,the more viscous ink fills the via thoroughly and exhibited a 100%yield(1010 vias;100µm nominal via diameter)with the two-step direct screen-printing *** 10-mm radius bending test showed no signs of via specific breakdown after 30,000 *** results indicate that this via filling process is likely roll-to-roll compatible to enable multi-layered printed electronic devices.

关键词： silver printing nominal

Advanced surface coil layout with intrinsic noise cancellation properties for surface-NmR applications

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magnetic Resonance Letters 2023年第2期3卷 140-149,I0004页

作者： thomas Hiller Stephan Costabel Raphael Dlugosch Tobias Splith mike müller-Petke Federal Institute for Geosciences and Natural Resources Wilhelmstr.25-30Berlin13595Germany Federal Institute for Geosciences and Natural Resources Stilleweg 2Hannover3655Germany Leibniz Institute for Applied Geophysics Stilleweg 2Hannover30655Germany

A recent study demonstrated that in small-scale prepolarized surface nuclear magnetic resonance(SNmR-PP)measurements with a footprint of a few square meters,customized PP switch-off ramps can serve as an efficient excitation mechanism,eliminating the requirement for a conventional oscillating excitation *** approach enables the detection of short relaxation signals from the unsaturated soil zone and can,therefore,be used to directly provide soil moisture and pore geometry *** ultimately such small-scale SNmR-PP setups are intended for a mobile application,it is necessary to develop strategies that allow for speedy measurement progress and do not require noise cancellation protocols based on reference ***,we developed a new concentric figure-of-eight(cFOE)loop layout that combines the direction independence of a circular loop with the intrinsic noise cancellation properties of a classical *** approach significantly decreases the measurement time because suitable signal-to-noise ratios are reached much faster compared to a classical circular loop and will bring us one step further toward fast and non-invasive soil moisture mapping applications.

关键词： Surface-NmR Prepolarization Noise cancellation Loop layout

Is cardiac mRI an effective test for arrhythmogenic right ventricular cardiomyopathy diagnosis?

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World Journal of Cardiology 2014年第7期6卷 675-681页

作者： Santhi Chellamuthu Alyson m Smith Steven m thomas Catherine Hill Peter W G brown Abdallah Al-mohammad Department of Radiology Sheffield Teaching Hospitals NHS trustNorthern General HospitalSheffield S5 7AUUnited Kingdom Alyson m Smith Abdallah Al-MohammadDepartment of CardiologySheffield Teaching Hospitals NHS TrustNorthern General HospitalSheffield S5 7AUUnited Kingdom

AIm:To evaluate the referrals with suspected arrhythmogenic right ventricular cardiomyopathy(ARVC)and compare cardiac mR(cmR)findings against clinical ***:A retrospective analysis of 114(age range16 to 83,males 55%and females 45%)patients referred for cmR with a suspected diagnosis of ARVC between may 2006 and February 2010 was performed after obtaining institutional approval for service *** for referral including clinical symptoms and family history of sudden death,electrocardiogram and echo abnormalities,cmR findings,final clinical diagnosis and information about clinical management were *** results of cmR were classified as major,minor,non-specific or negative depending on both functional and tissue characterisation and the cmR results were compared against the final clinical ***:The most common reasons for referral included arrhythmias(30%)and a family history of sudden death(20%).Of the total cohort of 114 patients:4 patients(4%)had major cmR findings for ARVC,13patients(11%)had minor cmR findings,2 patients had non-specific cmR findings relating to the right ventricle and 95 patients had a negative *** the 4 patients who had major cmR findings,3(75%)had a positive clinical *** contrast,of the 13 patients who had minor cmR findings,only 2(15%)had a positive clinical *** of the 95 negative patients,clinical details were available for 81 patients and none of them had *** the 14 patients with no clinical data and final diagnosis,the sensitivity of the test was 100%,specificity 87%,positive predictive value29%and the negative predictive value 100%.CONCLUSION:CmR is a useful tool for ARVC evaluation because of the high negative predictive value as the outcome has a significant impact on the clinical decision-making.

关键词： Arrhythmogenic right ventricular cardiomyopathy Cardiomyopathy Right ventricular Arrhythmias magnetic resonance imaging Diagnosis Implantable cardiac defibrillator

A Biobank for Long-term and Sustainable Research in the Field of Congenital Heart Disease in Germany

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 181-190页

作者： thomas Pickardt Eva Niggemeyer Ulrike m.m.Bauer Hashim Abdul-Khaliq Competence Network for Congenital Heart Defects Investigators National Register for Congenital Heart Defects 13353 BerlinGermany Saarland University medical Center Department of Paediatrie Cardiology66421 HomburgGermany Competence Network for Congenital Heart Defects 13353 BerlinGermany

Congenital heart disease （CHD） is the most fi＇equent birth defect （0.8% 1% of all live births）. Due to the advance in prenatal and postnatal early diagnosis and treatment, more than 90% of these patients survive into adulthood today. However, several mid- and long-term morbidi- ties are dominating the follow-up of these patients. Due to the rarity and heterogeneity of the phenotypes of CHD, multicenter registry-based studies are required. The CHD-Biobank was established in 2009 with the aim to collect DNA from patients and their parents （trios） or fi＇om affected families, as well as cardiovascular tissues from patients undergoing corrective heart surgery for cardiovascular malformations. Clinical/phenotype data are matched to the International Paediatric and Congenital Cardiac Code （IPCCC） and the International Statistical Classification of Diseases and Related Health Problems 10th Revision （ICD-10）. The DNA collection currently comprises samples from approximately 4200 participants with a wide range of CHD phenotypes. The collection covers about 430 trios and 120 families with more than one affected member. The cardiac tissue collection comprises 1143 tissue samples [Yore 556 patients alter open heart surgery. The CHD-Biobank provides a comprehensive basis for research in the field of CHD with high standards of data privacy, IT management, and sample logistics.

关键词： Congenital heart defects multi-center research Biorepository Genetic research DNA

Low-k integration: Gas screening for cryogenic etching and plasma damage mitigation

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 511-516页

作者： Romain Chanson Remi Dussart thomas Tillocher P. Lefaucheux Christian Dussarrat Jean Francois de m arneffe ImEC v.z.w. 3001 LeuvenBelgium GREmI/University of Orleans OrleansFrance Air Liquide Laboratories TsukubaJapan

The integration of porous organo-silicate low-k materials has met a lot of technical *** of the main issues is plasma-induced damage,occurring for all plasma steps involved during interconnects *** the present paper,we focus on porous SiOCH low-k damage mitigation using cryogenic temperature so as to enable micro-capillary *** aim is to protect the porous low-k from plasma-induced damage and keep the k-value of the material unchanged,in order to limit the RC delay of interconnexion levels while shrinking the microchip *** cryogenic temperature is used to condense a gas inside the porous low-k ***,the etching process is performed at the temperature of condensation in order to keep the condensate trapped inside the material during the *** the first part of this work,the condensation properties of several gases are screened,leading to a down selection of five ***,their stability into the porous structure is evaluated at different *** of them are used for plasma damage mitigation *** mitigation is effective and shows negligible damage for one of the gases at-50℃.

关键词： low-A nanotechnology micro-electronics cryo-etching plasma processing

Endoscopic Coregistered Ultrasound Imaging and Precision Histotripsy:Initial In Vivo Evaluation

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Biomedical Engineering Frontiers 2022年第1期3卷 323-336页

作者： thomas G.Landry Jessica Gannon Eli Vlaisavljevich matthew G.mallay Jeffrey K.Woodacre Sidney Croul James P.Fawcett Jeremy A.brown School of Biomedical Engineering Dalhousie UniversityCanada Division of Surgery Nova Scotia Health AuthorityCanada Department of Biomedical Engineering and mechanics Virginia Polytechnic Institute and State UniversityVirginiaUSA Department of Pathology&Laboratory medicine Dalhousie UniversityCanada Department of Pharmacology Dalhousie UniversityCanada Department of Surgery Dalhousie UniversityCanada

*** performance evaluation of a system for simultaneous high-resolution ultrasound imaging and focused mechanical submillimeter histotripsy ablation in rat *** *** study used a novel combination of high-resolution imaging and histotripsy in an endoscopic *** would provide neurosurgeons with unprecedented accuracy in targeting and executing nonthermal ablations in minimally invasive *** is a safe and effective nonthermal focused ablation ***,neurosurgical applications,such as brain tumor ablation,are difficult due to the presence of the *** devices are too large to use in the minimally invasive approaches surgeons *** have developed a combined imaging and histotripsy endoscope to provide neurosurgeons with a new tool for this *** histotripsy component had a 10 mm diameter,operating at 6.3 *** within a cutout hole in its center was a 30 mHz ultrasound imaging *** coregistered pair was used to ablate brain tissue of anesthetized rats while *** sections were examined,and qualitative descriptions of ablations and basic shape descriptive statistics were *** ablations with submillimeter area were produced in seconds,including with a moving *** progress could be monitored in real time using power Doppler imaging,and B-mode was effective for monitoring post-ablation *** damage was minimal,with a 100μm maximum distance of cellular damage from the ablation *** results demonstrate a promising hardware suite to enable precision ablations in endoscopic procedures or fundamental preclinical research in histotripsy,neuroscience,and cancer.

关键词： trips millimeter qualitative

Using physiological conditions to assess current and future habitat use of a Subarctic frog

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Integrative Zoology 2023年第1期18卷 2-14页

作者： thomas P.HASTINGS Blake R.HOSSACK LeeAnn FISHBACK Jon m.DAVENPORT Department of Biology Appalachian State UniversityBooneNorth CarolinaUSA U.S.Geological Survey Northern Rocky Mountain Science Centerand Wildlife Biology ProgramW.A.Franke College of Forestry&ConservationUniversity of MontanaMissoulaMontanaUSA Churchill Northern Studies Centre ChurchillManitobaCanada

Species with especially close dependence on the environment to meet physiological requirements,such as ectotherms,are highly susceptible to the impacts of climate *** change is occurring rapidly in the Subarctic and Arctic,but there is limited knowledge on ectotherm physiology in these *** investigated how environmental conditions and habitat characteristics inﬂuence the physiological conditions and habitat use of wood frogs(Rana sylvatica)in a Subarctic landscape near Churchill,manitoba(Canada).We used plaster models to estimate water loss rates and surface body temperatures among different habitat types and at speciﬁc locations used by radio-tracked *** loss(R2=0.67)and surface temperature(R2=0.80)of plaster models was similar to that of live ***-based water loss rates were greater in tundra habitat than in boreal forest and ecotone *** use of wood frogs was strongly tied with available surface moisture and decreased water loss rates that were observed with plaster *** conditions,such as wind speed and ground tem-perature,explained 58%and 91%of the variation in water balance and temperature of plaster *** physiological conditions may be challenging for semi-aquatic ectotherms in environments vulnerable to future cli-mate *** ability to predict physiological conditions based on environmental conditions,as demonstrated in our study,can help understand how wildlife will respond to climatic changes.

关键词： Arctic climate change landscape physiology water balance wood frog