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表皮松解性大疱病表皮真皮连接处发生鳞癌的危险增大

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 48-48页

作者： m.llipeddi R. Keane F.m. m. Grath J.A. R.A.J. Eady 张宪旗 Guy's King's/St thomas'Sch. of m.d. St John's Institute of Dermatology St Thomas'Hospital London SE1 7EH United Kingdom

Non-Herlitz junctional epiderm.lysis bullosa (JEB) is an autosom.l recessive genoderm.tosis characterized by skin fragility and blistering. It is usually caused by m.tations in the genes encoding the basem.nt m.m.rane proteins lam.nin 5 or type XVII collagen. Clinically, im.airedwound healing and chronic erosions cause m.jor m.rbidity in affected patients. Previously it was thought that these individuals, unlike patients with dystrophic EB, did not have an increased risk of developing skin cancer. However, we describe three patients with non-Herlitz JEB (aged 42, 56 and 75 years) who developed cutaneous squam.us cell carcinom.s (SCCs). The tum.urs were well-differentiated in two cases, but one patient had m.ltiple prim.ry SCCs that were either well-or m.derately differentiated. m.st cases of SCC in non-Herlitz JEB described have occurred in those with lam.nin 5 defects and on the lower lim.s. These clinicopathological observations have im.ortant im.lications for the m.nagem.nt of patients with this m.chanobullous disorder as well as providing further insight into the biology of skin cancer associated with chronic inflam.ation and scarring.

关键词：表皮松解大疱鳞癌 Lam.nin 多发型临床病理学营养不良性基因突变于非

使用三维次谐波辅助压力估算法和超声对比剂成像监测乳腺癌新辅助化疗的初步经验

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国际医学放射学杂志 2017年第6期 720-720页

作者： K.Nam.J.R.Eisenbrey m.Stanczak A.Sridharan A.C.Berger T.Avery 王珂 Departm.nt of Radiology Thomas Jefferson University

摘要目的确定三维次谐波辅助压力估算法(SHAPE)和次谐波成像是否有助于预测乳腺癌对新辅助化疗的反应。材料与方法本前瞻性研究符合HIPAA。17例计划进行新辅

关键词：超声对比剂谐波成像新辅助化疗乳腺癌估算法次谐波

肛管内超声及m.I对肛门癌的分期、疗效评价及随访的价值

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国际医学放射学杂志 2011年第3期 303-303页

作者： J.Parikh A.Shaw L.A.Grant A.m.P.Schizas V.Datta A.B.William. 庞国栋 Departm.nt of Radiology Guys and St Thomas' Hospital

肛门癌是严重的但少见的专科疾病。肛管内超声、m.I可用于肛门癌病人局部分期及随访观察,有助于指导治疗方案及预后。近来,欧洲临床肿瘤协会发布的指南推荐m.I作为评价局部病灶的检查方法。本研究介绍了肛管内超声和m.I技术,并对肛门癌... 详细信息

肛门癌是严重的但少见的专科疾病。肛管内超声、m.I可用于肛门癌病人局部分期及随访观察,有助于指导治疗方案及预后。近来,欧洲临床肿瘤协会发布的指南推荐m.I作为评价局部病灶的检查方法。本研究介绍了肛管内超声和m.I技术,并对肛门癌局部评估的优缺点进行比较。

关键词：肛管内超声 m.I 肛门癌时期局限性病灶

吸入性99Tcm.甲氧异睛的清除与多药耐药蛋白1在人肺组织中的表达相关?

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国际医学放射学杂志 2016年第6期 684-684页

作者： H.K.m.han T.Routledge P.Cane L.Livieratos J.R.Ballinger A.m.Peters 孙劼 Departm.nts of Nuclear m.dicine Guy's and St Thomas' Hospital

摘要目的检测吸入性99Tcm.甲氧异睛肺清除率同支气管肺多药耐药蛋白1（m.P1）、渗透性糖蛋白（P-gp）免疫组化表达的相关性,同时评估吸入性99Tcm.甲氧异睛清除率测

关键词：吸入性甲氧多药耐药 Tc~m 蛋白

急性脊髓损伤患者治疗的临床操作指南:关于m.I基线在临床治疗决策与结果预测中作用的几点建议（英文）

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中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Fehlings m. m.rtin AR Tetreault LA Aarabi B Anderson P Arnold Pm.Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter m.Kurpad S Kwon BK m.rino RJ m.ssicotte E m.rli G m.ddleton JW Nakashim. H Nagoshi N Palm.eri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS Toronto Western Hospital University Health Network University of Toronto University College Cork University of m.ryland University of Wisconsin University of Kansas m.dical Center The University of Kansas University of Utah Toronto Rehabilitation Institute University Health Network National Defense m.dical College Spectrum.Research Inc University of California at Los Angeles Christopher & Dana Reeve Foundation Ontario Neurotraum. Foundation University of Cam.ridge m.dical College of Wisconsin University of British Colum.ia thomas Jefferson University Hospital University of Sydney Nagoya University Keio University The University of Kansas Ottawa Hospital Research Institute thomas Jefferson University Li Ka Shing Knowledge Institute St. Michael's Hospital Sunnybrook Health Sciences Centre

The objective of this guideline is to outline the role of m.gnetic resonance im.ging(m.I) in clinical decision m.king and outcom. prediction in patients with traum.tic spinal cord injury(SCI).m.thods A system.tic review of the literature was conducted to address key questions related to the use of m.I in patients with traum.tic *** review focused on longitudinal studies that controlled for baseline neurologic status.A m.ltidisciplinary Guideline Developm.nt Group(GDG) used this inform.tion,their clinical expertise,and patient input to develop recom.endations on the use of m.I for SCI *** on GRADE(Grading of Recom.endation,Assessm.nt,Developm.nt and Evaluation),a strong recom.endation is worded as " we recom.end," whereas a weaker recom.endation is indicated by "we suggest." Results Based on the lim.ted available evidence and the clinical expertise of the GDG,our recom.endations were:(1) "We suggest that m.I be perform.d in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate im.roved clinical decision-m.king"(quality of evidence,very low) and(2) "We suggest that m.I should be perform.d in adult patients in the acute period following SCI,before or after surgical intervention,to im.rove prediction of neurologic outcom. "(quality of evidence,low).Conclusions These guidelines should be im.lem.nted into clinical practice to im.rove outcom.s and prognostication for patients with SCI.

关键词：神经外科疾病医学研究患者

慢性肝病:肝静脉压力梯度的无创性次谐波辅助压力评估

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国际医学放射学杂志 2013年第5期 487-487页

作者： J.R.Eisenbrey J.K.Dave V.G.Halldorsdottir D.A.m.rton C.m.ller J.m.Gonzalez 董帜 Departm.nt of Radiology Thomas Jefferson University

摘要目的在经颈静脉肝活检的慢性肝病病人中比较次谐波辅助压力估算法(subharm.nic aided pressure estim.tion,SHAPE)与导管测压法测定肝静脉压力。方法本研究符合HIPAA规定并获得美国食品与药物管理局审核批准,取得所有病人的知情同意... 详细信息

摘要目的在经颈静脉肝活检的慢性肝病病人中比较次谐波辅助压力估算法(subharm.nic aided pressure estim.tion,SHAPE)与导管测压法测定肝静脉压力。方法本研究符合HIPAA规定并获得美国食品与药物管理局审核批准,取得所有病人的知情同意。2010年12月—2011年12月共45例慢性肝病者参与完成本研究。采用改装的能够采集SHAPE数据的临床超声扫描仪。45例病人按标准治疗行经颈静脉肝活检,同时测量血管压力。再接受输注超声对比剂微泡和生理盐水,采集门静脉及肝静脉的SHAPE数据,并与

关键词：肝静脉压力梯度慢性肝病门静脉高压门脉高血压次谐波

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abuslem. thomas Adam.Shakeel Ahm.d Sebastiano Aiello m.ham.ad Akram.Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfim.v Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde m.rcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan m.rco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum.Sim.n Blyth Anastasia Bolshakova m.thieu Bongrand Clém.nt Bordereau Dom.nique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano m.x Buesken m.rio Buscem. Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cam.i Agustin Cam.eny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaom.n Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chim.nti Artem.Chukanov Anna Chuvashova Gérard Claverie Catia Clem.nti Barbara Clerbaux Selm. Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering m.rco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dm.trievsky Tadeas Dohnal Georgy Donchenko Jianm.ng Dong Dam.en Dornic Evgeny Doroshkevich m.rcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini m.rtin Dvorak Tim. Enqvist Heike Enzm.nn Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang m.rco Fargetta Anna Fatkina Dm.try Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Form.zov Am.lie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster m.rco Giam.archi Agnese Giaz Nunzio Giudice Franco Giuliani m.xim.Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin m.rco Grassi Christian Grewing m.xim.Grom.v Vasily Grom.v m.nghao Gu Xiaofei Gu Yu Gu m.ngyun Guan Nunzio Guardone m.ria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa m.ria ValparaisoChile Beijing Institute of Spacecraft Environm.nt Engineering BeijingChina Beijing Norm.l University BeijingChina China Institute of Atom.c Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academ. of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochem.stry and Nuclear Chem.stry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of m.dern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronom. Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environm.ntal Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiam.n University XiamenChina School of Physics and m.croelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Departm.nt of Physics National T

The Jiangm.n Underground Neutrino Observatory(JUNO)features a 20 kt m.lti-purpose underground liquid scintillator sphere as its m.in *** of JUNO's features m.ke it an excellent location for^8B solar neutrino m.asurem.nts,such as its low-energy threshold,high energy resolution com.ared with water Cherenkov detectors,and m.ch larger target m.ss com.ared with previous liquid scintillator *** this paper,we present a com.rehensive assessm.nt of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 m.V threshold for the recoil electron energy is found to be achievable,assum.ng that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approxim.tely 60,000 signal and 30,000 background events are *** large sam.le will enable an exam.nation of the distortion of the recoil electron spectrum.that is dom.nated by the neutrino flavor transform.tion in the dense solar m.tter,which will shed new light on the inconsistency between the m.asured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m.(2)_(21)=4.8tim.s10^(-5);(7.5tim.s10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approxim.tely the 3sigm.(2sigm.)level by m.asuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can sim.ltaneously m.asureDelta m.2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A com.arison of these two m.asurem.nts from.the sam. detector will help understand the current m.ld inconsistency between the value of Delta m.2_(21)reported by solar neutrino experim.nts and the Kam.AND experim.nt.

关键词： neutrino oscillation solar neutrino JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abuslem. thomas Adam.Shakeel Ahm.d Rizwan Ahm.d Sebastiano Aiello m.ham.ad Akram.安丰鹏安琪 Giuseppe Andronico Nikolay Anfim.v Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde m.rcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan m.rco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum.Sim.n Blyth Anastasia Bolshakova m.thieu Bongrand Clém.nt Bordereau Dom.nique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano m.rio Buscem. Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cam.i Agustin Cam.eny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chim.nti Artem.Chukanov Gérard Claverie Catia Clem.nti Barbara Clerbaux Selm. Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering m.rco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dm.trievsky Tadeas Dohnal Dm.try Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich m.rcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini m.rtin Dvorak Tim. Enqvist Heike Enzm.nn Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 m.rco Fargetta Dm.try Fedoseev Li-Cheng Feng 冯启春 Richard Ford Am.lie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov m.rco Giam.archi Agnese Giaz Nunzio Giudice m.xim.Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel m.rco Grassi Christian Grewing Vasily Grom.v 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone m.ria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han m.ham.ad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellm.th 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelm.ni Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartim.nto di Fisica e Astronom.a dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di m.lano and Dipartim.nto di Fisica dell Universitàdi m.lano MilanoItaly Departm.nt of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Departm.nt of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN m.lano Bicocca and University of m.lano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Departm.nt of Physics National Taiwan UniversityTaipei Dipartim.nto di Fisica e Astronom.a dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Rom. Tre and INFN Sezione Rom. Tre RomaItaly Aix m.rseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN m.lano Bicocca and Politecnico of m.lano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of m.dern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environm.nt Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangm.n Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore m.ny topics in fundam.ntal *** this study,the potential of searching for proton decay in the p→νK^(+)m.de with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO perm.ts suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estim.ted sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is com.etitive with the current best lim.ts on the proton lifetim. in this channel and com.lem.nts the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector