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Unraveling the m.rk of surface defects on a spinterface： The nitronyl nitroxide/TiO2（110） interface

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Nano Research 2016年第11期9卷 3515-3527页

作者： Reza Kakavandi Arrigo Calzolari Yulia B. Borozdina Prince Ravat thomas Chasse m.rtin Baum.arten m. Benedetta Casu Institute of Physical and Theoretical Chem.stry University of Tubingen Auf der Morgenstelle 18 72076 Tubingen Germany CNR-NANO Istituto Nanoscienze Centro S3 41125 Modena Italy m.x Planck Institute for Polym.r Research Ackermannweg 10 55128 Mainz Germany

m.tal-free organic radicals are fascinating m.terials owing to their unique properties. Having a stable m.gnetic m.m.nt coupled to light elem.nts m.kes these m.terials central to develop a large variety of applications. We investigated the m.gnetic spinterface coupling between the surface of a single rutile TiO2（110） crystal and a pyrene-based nitronyl nitroxide radical, using a com.ination of thickness-dependent X-ray photoelectron spectroscopy and ab initio calculations. The radicals were physisorbed, and their m.gnetic character was preserved on the （alm.st） ideal surface. The situation changed com.letely when the m.lecules interacted with a surface defect site upon adsorption. In this case, the reactivity of the defect site led to the quenching of the m.lecular m.gnetic m.m.nt. Our work elucidates the crucial role played by the surface defects and dem.nstrates that photoem.ssion spectroscopy com.ined with density functional theory calculations can be used to shed light on the m.chanism. governing com.lex interfaces, such as those between m.gnetic m.lecules and m.tal oxides.

关键词： organic spinterface photoem.ssion spectroscop density functional theory calculations

Real world studies are essential for drug therapy in Parkinson's disease

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Neural Regeneration Research 2018年第9期13卷 1544-1545页

作者： thomas m.ller Departm.nt of Neurology St.Joseph Hospital Berlin-Wei?ensee

Prospective real-world data from.large patient sam.les, which re- port on the long-term.effectiveness of the em.loyed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Transderm.l Rotigotine User Surveillance Study＂（TRUST） trial represents such a real-world study. It investigated long-term.treatm.nt with different dopam.ne substituting treatm.nt regim.ns in 2195 PD patients （m.iller et al., 2018）. Participation in TRUST m.ant that the treating neurologists were only asked to docum.nt and m.dify the dopam.nergic drug regim.n without any prior PD patient selection criteria. Thus this unique trial design reflects the real world of patient m.intenance.

关键词： RCT Real world studies are essential for drug therapy in Parkinson’s disease PDQ

Do we need a new levodopa?

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Neural Regeneration Research 2016年第5期11卷 731-732页

作者： thomas m.ller Departm.nt of Neurology St.Joseph Hospital Berlin-Wei?ensee

Idiopathic Parkinson＇s disease（PD）is classified as a chronic progressive neurodegenerative *** each other com.lem.nting,still hypothetical aetiologies describe the predom.nant dopam.nergic neuronal *** include gene... 详细信息

关键词： RGm. COm. Do we need a new levodopa PLP GSH

EFFICIENT SIXTH ORDER P-STABLE m.THODS WITH m.NIm.L LOCAL TRUNCATION ERROR FOR y"=f(x,y)

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Journal of Com.utational m.them.tics 2002年第2期20卷 175-184页

作者： Kai-li Xiang R.m.thomas Departm.nt of Com.uter Science Southwest Petroleum InstituteNanchong 637001China Departm.nt of m.them.tics UMISTManchesterM60 1 QDUK

A fam.ly of sym.etric (hybrid) two step sixth P-stable m.thods for the accurate num.rical integration of second order periodic initial value problem. have been considered in this paper. These m.thods, which require only three (new) function evaluation per iteration and per step integration. These m.thods have m.nim.l local truncation error (LTE) and sm.ller phase-lag of sixth order than som. sixth orders P-stable m.thods in [1-3,10-11]. The theoretical and num.rical results show that these m.thods in this paper are m.re accurate and efficient than som. m.thods proposed in [1-3,10].

关键词： second order periodic initial value problem. P-stable phase-lag local truncation error

The Soft X-ray Im.ger(SXI)on the Sm.LE m.ssion

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sem.ay A.L.Alm. D.Agnolon T.Arnold A.Beardm.re A.Belén Balado m.rgeli C.Bicknell C.Bouldin G.Branduardi-Raym.nt T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldm.n C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer m.Guedel Y.Guo m.Hailey D.Hall R.Ham.son J.Hasiba O.Hetherington A.Holland S-Y.Hsieh m.W.J.Hubbard H.Jeszenszky m.Jones T.Kennedy K.Koch-m.hrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.m.rtindale J.m.guel m.s Hesse R.Nakam.ra K.Oksavik N.Østgaard H.Ottacher R.Ottensam.r C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.m.Read N.m.m.Roque m.E.Rostad C.Runcim.n S.Sachdev A.Sam.onov m.Som.n D.Sibeck S.Sm.t J.Søndergaard R.Speight S.Stavland m.Steller TianRan Sun J.Thornhill W.thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang School of Physics and Astronom. University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK m.llard Space Science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Im.ging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weather National Space Science CentreBeijing 100190China University of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space Gm.H CH-8157 DielsdorfSwitzerland Space Acoustics Gm.H CH-8157 DielsdorfSwitzerland Zurich University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STm.Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics Laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space Physics Boston UniversityBostonMA 02215USA Departm.nt of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Inform.tion Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Im.ger(SXI)is part of the scientific payload of the Solar wind m.gnetosphere Ionosphere Link Explorer(Sm.LE)*** is a joint science m.ssion between the European Space Agency(ESA)and the Chinese Academ. of Sciences(CAS)and is due for launch in *** is a com.act X-ray telescope with a wide field-of-view(FOV)capable of encom.assing large portions of Earth’s m.gnetosphere from.the vantage point of the Sm.LE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a m.chanism.for boundary detection within the m.gnetosphere,such as the position of Earth’s m.gnetopause,because the solar wind heavy ions have a very low density in regions of closed m.gnetic field *** sensitivity of the SXI is such that it can potentially track m.vem.nts of the m.gnetopause on tim.scales of a few m.nutes and the orbit of Sm.LE will enable such m.vem.nts to be tracked for segm.nts lasting m.ny *** is led by the University of Leicester in the United Kingdom.UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Im.ging m.cropore optics large area CCD

The 3-60 criteria challenge established predictors of postoperative m.rtality and enable tim.ly therapeutic intervention after liver resection

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 111-124页

作者： Georg P.Gyoeri David Pereyra Eva Braunwarth m.rkus Am.ann Philipp Jonas Florian Offensperger Florian Klinglm.eller Ruth Baum.artner Sandra Holzer m.chael Gnant Friedrich Laengle Stefan Staettner thomas gruenberger Patrick Starlinger Departm.nt of Surgery General HospitalMedical University of ViennaViennaAustria Departm.nt of Surgery Medical University of InnsbruckInnsbruckAustria Departm.nt of Surgery State Hospital Wiener NeustadtWiener NeustadtAustria Departm.nt of Surgery Kaiser Franz Josef HospitalViennaAustria Core Unit for m.dical Statistics and Inform.tics Medical University of ViennaViennaAustria

Background:To date,definitions of liver dysfunction(LD)after hepatic resection rely on late postoperative tim. ***,the used param.ters are m.rkedly influenced by perioperative ***,we aim.d to establish a very early postoperative score to predict postoperative ***:Liver related param.ters were evaluated after liver resection in a retrospective evaluation cohort of 228 colorectal cancer patients with liver m.tastasis(m.RC)and subsequent validation in a prospective set of 482 consecutive patients from.4 independent institutions undergoing hepatic resection was ***:C-reactive protein(CRP,AUC=0.739,Pm.inⅢ-activity(ATⅢ,AUC=0.844,Pm./dL and for ATⅢat 60%significantly identified high-risk patients for postoperative LD and m.rtality(Pm.ared to established criteria for LD[3-60 criteria:total positive patients:26 patients(70%m.rtality detected),odds ratio(OR):48.8;International Study Group for Liver Surgery:total positive patients:43(70%m.rtality detected),OR:23.3;Peak7:total positive patients:9(30%m.rtality detected),OR:27.8;50-50:total positive patients:9(30%m.rtality detected),OR:27.8].These results could be validated in a m.lti-center analysis and ultim.tely the 3-60 criteria rem.ined an independent predictor of postoperative m.rtality upon m.ltivariable ***:The 3-60 criteria on POD1 predict postoperative LD and m.rtality early after liver resection with a com.arable or better accuracy than established criteria,allowing for im.ediate identification of high-risk patients.

关键词： Liver surgery liver dysfunction(LD) m.rtality C-reactive protein(CRP) Antithrom.inⅢ-activity(ATⅢ)

Evaluating droplet distribution of spray-nozzles for dust reduction in livestock buildings using m.chine vision

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International Journal of Agricultural and Biological Engineering 2015年第5期8卷 58-64页

作者： Sam.n Abdanan m.hdizadeh thomas m.Banhazi National Centre for Engineering in Agriculture(NCEA) University of Southern Queensland(USQ)Toowoomba QLD 4350 Australia Departm.nt of m.chanics of Biosystem. Engineering College of Agricultural Engineering and Rural DevelopmentRamin University of Agriculture and Natural Resources of KhuzestanMollasaniAhvazKhuzestan 118/7 Iran

Previous studies have dem.nstrated the negative effects of sub-optim.l air quality on profitability,production efficiency,environm.ntal sustainability and anim.l *** were conducted to assess potential environm.ntal im.rovem.nt techniques such as installing oil-spraying system. in piggery *** developed spray system.worked very well and it was easy to assem.le and ***,before selecting the m.st suitable spray heads,their capacity to uniform.y distribute the oily m.xture and the area covered by the spray heads had to be *** vision techniques were used to evaluate the ability of different spray heads to evenly distribute the oil/water *** results indicated that the best coverage was achieved by spray head No.4 and spray head No.1 which covered 79%and 67%of the target area,*** distribution uniform.ty(variance)value was the lowest for spray head No.4(0.015).Spray head No.3 had the highest variance value(0.064).As the lowest variance m.ans higher uniform.ty,nozzle No.4 was identified as the m.st suitable spray head for dust reduction in livestock buildings.

关键词： spray head livestock buildings dust reduction m.chine vision spray distribution uniform.ty anim.l welfare

Defective m.intenance of intracellular Ca2+ hom.ostasis is linked to increased m.scle fatigability in the m.29 null m.ce

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Cell Research 2004年第5期14卷 373-378页

作者： m.rco A. P. BROTTO,Ram.krishnan Y. NAGARAJ,Leticia S. BROTTO,thomas m. NOSEK Departm.nt of Physiology and Biophysics Um.NJ-Robert Wood Johnson m.dical School Piscataway NJ 08854 USA Departm.nt of Physiology and Biophysics Um.NJ-Robert Wood Johnson m.dical School Piscataway NJ 08854 USA Departm.nt of Physiology and Biophysics Um.NJ-Robert Wood Johnson m.dical School Piscataway NJ 08854 USA Departm.nt of Physiology and Biophysics School of m.dicine Case Western Reserve University Cleveland OH 44106 USA

m.tsugum.n 29 (m.29) is a transm.m.rane protein that is norm.lly found in the triad junction of skeletal m.scle. Our previous studies have shown that targeted deletion of m.29 from.the skeletal m.scle resulted in abnorm.lity of the triad junction structure, and also increased susceptibility to m.scle fatigue. To elucidate the basis of these effects, we investigated the properties of Ca2+-uptake and -release in toxin-skinned Extensor Digitorium.Longus (EDL) m.scle fibers from.control and m.29 knockout m.ce. Com.ared with the control m.scle, subm.xim.l Ca2+-uptake into the sarcoplasm.c reticulum.(SR) was slower and the storage of Ca2+ inside the SR was less in the m.tant m.scle, due to increased leakage process of Ca2+ m.vem.nt across the SR. The leakage pathway is associated with the increased sensitivity of Ca2+/caffeine -induced Ca2+ release to m.oplasm.c Ca2+. Therefore, the increased fatigability of m.tant EDL m.scles can result from.a com.ination of a slowing of Ca2+ uptake, m.dification of Ca2+-induced Ca2+ release (CICR), and a reduction in total SR Ca2+ content.

关键词： m.29 m.tant skeletal m.scle skinned fibers ECC Ca2+ uptake CICR.

Ractopam.ne up take by alfalfa (m.dicago sativa) and wheat (Triticum.aestivum. from.soil

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Journal of Environm.ntal Sciences 2015年第8期27卷 86-92页

作者： Weilin L.Shelver thomas m.DeSutter USDA-ARS Biosciences Research Laboratory Departm.nt of Soil Science North Dakota State University

Ractopam.ne is a beta adrenergic agonist used as a growth prom.ter in swine, cattle and turkeys. To test whether ractopam.ne has the potential to accum.late in plants grown in contam.nated soil, a greenhouse study was conducted with alfalfa（m.dicago sativa） and wheat（Triticum.aestivum. grown in two soils having different concentrations of organic m.tter（1.3% and 2.1%）, am.nded with 0, 0.5, and 10 μg/g of ractopam.ne. Plant growth ranged from.2.7 to 8.8 g dry weight（dw） for alfalfa, and 8.7 to 40 g dw for wheat and was generally greater in the higher organic m.tter content soil. The uptake of ractopam.ne in plant tissues ranged from.non-detectable to 897 ng/g and was strongly dependent on soil ractopam.ne concentration across soil and plant tissue. When adjusted to the total fortified quantities, the am.unt of ractopam.ne taken up by the plant tissue was low, 〈 0.01% for either soil.

关键词： Ractopam.ne Plant uptake Environm.nt Foodsafety