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Surface energy-mediated fibronectin adsorption and osteoblast responses on nanostructured diamond

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Journal of Materials Science & Technology 2019年第5期35卷 817-823页

作者： Yixing Tian Huiling Liu Brian W.Sheldon thomas J.webster Sichen Yang Huilin Yang Lei Yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated Hospital Soochow University Suzhou Jiangsu 215006 China School of Engineering Brown University Providence RI 02912 USA Department of Chemical Engineering Northeastern University Boston MA. 02115 USA International Research Center for Translational Orthopaedics (IRCTO) Soochow University Suzhou Jiangsu 215006 China UWC Changshu China Changshu Jiangsu 215500 China

Nanostructured diamond have potential applications in many biomedical related fields and demonstrated extraordinary capacity to influence cellular responses. Studying the surface property of nanodiamond and its influence to protein adsorption and subsequent cellular responses along with the mechanism behind such capacity becomes more important. Here the role of surface energy associated with nanostructured diamond in modulating fibronectin and osteoblast(OB, bone forming cells) responses was investigated. Nanocrystalline diamond(NCD) and submicron crystalline diamond(SMCD) films with controllable surface energy were prepared by microwave-enhanced plasma chemical vapor deposition(MPCVD) techniques. Fibronectin adsorption on the diamond films with varied surface energy values was measured via the enzyme-linked immunosorbent assay(ELISA) and the relationship between the surface energy and fibronectin adsorption was studied. The result indicated that fibronectin adsorption on nanostructured surfaces was closely related to both surface energy and material microstructures. The spreading and migration of OB aggregates(each containing 30–50 cells) on the NCD with varied surface energy values were also studied. The result indicates a correlation between the cell spreading and migration on nanodiamond and the surface energy of nanostructured surface.

关键词： Nanostructure Diamond films Surface characteristics Protein adsorption Cell responses

Decontamination of mobile phones and electronic devices for health care professionals using a chlorhexidine/carbomer 940■gel

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 192-198页

作者： Rafael Muniz de Oliveira Nereida Mello da Rosa Gioppo Jancineide Oliveirade Carvalho Francilio Carvalho Oliveira thomas Jay webster Fernanda Roberta Marciano Anderson Oliveira Lobo University Hospital of the West of Parana State University of West of Parana Cascavel PR Brazil University Center for Health. Humanities and Technology of Piaui (UNINOVAFAPI). Piaui Brazil Science and Technology Institute Brasil University Itaquera SP Brazil Nanomedicine Laboratory Department of Chemical Engineering Northeastern University MA 02115 USA Materials Science and Engineering graduation program Technology Center Federal University of Piaui. PI Brazil

Though they reduce microorganism growth, current hospital disinfectants also damage many of today’s modern electronic devices such as tablets and smartphones. Herein, the efficacy of a new chlorhexidine digluconate gel (CDG) was tested as a disinfectant for mobile and electronic devices in a clinical environment. Specifically, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin resistant Staphylococcus aureus were used to infect the screen of eight smartphones. The CDG was prepared at concentrations of 2%, 4% and 6%, and tested on paper disks infected with these bacteria before being tested on the smartphones. The devices were disinfected with the CDG gel (4%) at two times: immediately and after 5 min of the bacterial contamination. In all cases, the CDG gel eliminated 100% of gram-positive and gram-negative microorganisms compared to the control (without any agent). In addition, the gel did not damage the smartphones. Therefore, our study suggests that the CDG gel may be applied to disinfect a wide range of electronic devices for health care professionals in the hospital environment.

关键词： smartphones disinfection clinical environment chlorhexidine bacteria

CAR-T cells: Early successes in blood cancer and challenges in solid tumors

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1129-1147页

作者： Hassan Dana Ghanbar Mahmoodi Chalbatani Seyed Amir Jalali Hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina Raposo thomas J.webster Cancer Research Center Cancer Institute of IranTehran University of Medical SciencesTehran 13145-158Iran Department of Medical Immunology School of MedicineTehran University of Medical SciencesTehran ***Iron Department of Immunology School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Division of Oncology Department of Pediatricsthe Children's Hospital of PhiladelphiaPhiladelphiaPA 19104USA Center for Natural and Human Sciences Federal University of ABCSanto AndreSP 09210-580Brazil Faculty of Pharmaceutical Sciences State University of Campinas(UNICAMP)CampinasSP 13083-87JBrazil Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA

New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully.

关键词： Immunotherapy T cell therapy Chimeric antigen receptor(CAR) Genetic engineering

A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation

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Nano Research 2019年第6期12卷 1381-1388页

作者： Haitao Cui Shida Miao Timothy Esworthy Se-jun Lee Xuan Zhou Sung Yun Hann thomas J.webster Brent T.Harris Lijie Grace Zhang Department of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDC 20052USA Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Neurology and Pathology Georgetown UniversityWashingtonDC 20007USA Departments of Electrical and Computer Engineering The George Washington UniversityWashingtonDC 20052USA Department of Biomedical Engineering The George Washington UniversityWashingtonDC 20052USA Department of Medicine The George Washington UniversityWashingtonDC 20052USA

Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over ***,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation ***,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell *** novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications.

关键词： near-infrared light responsive four-dimensional (4D) printing dynamically and remotely controllable graphene brain neural stem cell

Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles

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Bioactive Materials 2022年第1期7卷 74-84页

作者： Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza Ghaffarlou Navid Mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam thomas J.webster Behrooz Johari Hossein Danafar Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems DrohobychUkraineBakuAzerbaijan Department of Radiology School of Paramedical SciencesZanjan University of Medical SciencesZanjan45139-56184Iran Hacettepe University Department of ChemistryBeytepeAnkara06800Turkey Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjan45139-56184Iran Department of Pharmaceutical Nanotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Department of Surface Engineering The John Paul II Catholic University of Lublin20-950LublinPoland Drohobych Ivan Franko State Pedagogical University 82100DrohobychUkraine Department of Chemical Engineering Northeastern University360 Huntington AvenueBostonMA02115United States

Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer *** such treatment,nanoparticles can serve as improved carriers of chemotherapeutics into tumors and as better radiosensitizers for localized ***,we designed a Schottky-type theranostic heterostructure,Bi_(2)S_(3)-Au,with deep level defects(DLDs)in Bi_(2)S_(3) as a nano-radiosensitizer and CT imaging contrast agent which can generate reactive free radicals to initiate DNA damage within tumor cells under X-ray ***(MTX)was conjugated onto the Bi_(2)S_(3)-Au nanoparticles as a chemotherapeutic agent showing enzymatic stimuli-responsive release *** designed hybrid system also contained curcumin(CUR),which cannot only serve as a nutritional supplement for chemotherapy,but also can play an important role in the radioprotection of normal ***,this combined one-dose chemoradiation therapeutic injection of co-drug loaded bimetallic multifunctional theranostic nanoparticles with a one-time clinical X-ray irradiation,completely eradicated tumors in mice after approximately 20 days after irradiation showing extremely effective anticancer efficacy which should be further studied for numerous anti-cancer applications.

关键词： Combination therapy Radiosensitizer Semiconductor Heterojunction Radioprotector

Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy

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Stroke & Vascular Neurology 2022年第3期7卷 209-214页

作者： Matthew T Bender thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman webster H Pilcher Curtis G Benesch Adam G Kelly Tarun Bhalla Department of Neurosurgery University of Rochester Medical CenterRochesterNew YorkUSA Department of Emergency Medicine University of Rochester Medical CenterRochesterNew YorkUSA Department of Neurology University of Rochester Medical CenterRochesterNew YorkUSA

Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous *** questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical *** Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October *** reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical *** Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(p<0.001).Seven MSU patients(12%)received tPA from 3.5 hours to 4.5 hours since last known well and would likely have been outside the window with EMS *** thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal *** Mobile stroke care expedited both intravenous thrombolysis and endovascular *** is an ongoing need to show improved functional outcomes with MSU care.

关键词： intravenous throm endovascular

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

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Cancer Drug Resistance 2021年第2期4卷 264-297页

作者： Aleksandra Benko David Medina-Cruz Ada Vernet-Crua Catherine P.O'Connell MałgorzataŚwiętek Hamed Barabadi Muthupandian Saravanan thomas J.webster AGH University of Science and Technology Faculty of Materials Science and CeramicsKrakow 30059Poland Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Institute of Macromolecular Chemistry Czech Academy of SciencesPrague 16206Czech Republic Department of Pharmaceutical Biotechnology School of PharmacyShahid Beheshti University of Medical SciencesTehran 19919-53381Iran Department of Medical Microbiology and Immunology Division of Biomedical SciencesSchool of MedicineCollege of Health SciencesMekelle UniversityMekelle 231Ethiopia.

Cancer is one of the biggest healthcare concerns in our century,a disease whose treatment has become even more difficult following reports of drug-resistant *** this happens,chemotherapy treatments fail or decrease in efficiency,leading to catastrophic consequences to the *** discovery,along with the fact that drug resistance limits the efficacy of current treatments,has led to a new wave of discovery for new methods of *** use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in *** in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive ***,these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better *** review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers,including polymeric,viral,lipid-based,metal-based,carbon-based,and magnetic nanocarriers,opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

关键词： Drug-resistance cancer nanotechnology nanocarriers drug delivery

The enhanced element enrichment in the supercritical states of granite–pegmatite systems

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Acta Geochimica 2019年第3期38卷 335-349页

作者： Rainer thomas Paul Davidson Karen Appel Section 3.6.Chemistry and Physics of Earth Materials Helmholtz-Centre Potsdam German Research Centre for Geoscience – GFZ CODES Centre for Ore Deposit and Earth Sciences School of Natural Sciences University of Tasmania High Energy Density scientific instrument European X-Ray Free-Electron Laser Facility GmbH

In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical melt or fluid is a silicate phase in which volatiles; principally H_2O are completely miscible in all proportions at magmatic temperatures and pressures. This phase evolves from felsic melts and changes into hydrothermal fluids, and its unique properties are particularly important in sequestering and concentrating low abundance elements, such as metals. In our past research, we have focused on processes observed at upper crustal levels, however extensive work by us and other researchers have demonstrated that supercritical melt/fluids should be abundant in melting zones at deep-crustal levels too. We propose that these fluids may provide a connecting link between lower and upper crustal magmas,and a highly efficient transport mechanism for usually melt incompatible elements. In this paper, we explore the unique features of this fluid which allow the partitioning of variouselements and compounds, potentially up to extreme levels,and may explain various features both of mineralization and the magmas that produced them.

关键词： Granites Pegmatites Supercritical state Extreme element enrichment

A quantitative RT-PCR assay for rapid detection of Eurasianlineage H10 subtype influenza A virus

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Virologica Sinica 2016年第5期31卷 444-447页

作者： Hailiang Sun Jian-Li Xue Elizabeth Bailey Yifei Xu Guoliang Hu John Baroch Yi Zhang Lanny Pace thomas J DeLiberto Xiu-Feng Wan Department of Basic Sciences College of Veterinary MedicineMississippi State UniversityMississippi 39762USA College of Animal Science and Technology Jiangxi Agricul-tural UniversityNanchang 330045China Animal and Plant Health Inspection Service of the US Depart-ment of Agriculture Fort Collins 80526USA Mississippi Veterinary Research and Diagnostic Laboratory College of Veterinary MedicineMississippi State UniversityMississippi 39762USA

Dear Editor,Influenza A viruses(IAVs)are single-stranded,negative sense RNA *** subtype is determined on the basis of the viral surface glycoproteins,hemagglutinin(HA),and neuraminidase(NA).To date,18 HA and 11NA subt... 详细信息

关键词： PCR A quantitative RT-PCR assay for rapid detection of Eurasianlineage H10 subtype influenza A virus RT