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Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment

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Natural Products and Bioprospecting 2017年第3期7卷 235-247页

作者： kennedy D.Nyongbela Fidele Ntie-Kang thomas R.Hoye Simon M.N.Efange Pharmacochemistry Research Group Department of ChemistryUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry University of Minnesota207 Pleasant StreetSEMinneapolisMNUSA Chemical and Bioactivity Information Centre Department of ChemistryUniversity of BueaP.O.Box 63BueaCameroon

We are grateful for financial support from the International Cooperative Biodiversity Groups(ICBG),a program of the Fogarty International Centre of the National Institutes of Health(NIH),USA through grant(no TW00327)awarded to Professor S.M.N.Efange and Medicines for Malaria Venture(MMV),Geneva,Switzerland.The US Fulbright Council for International Exchange of Scholars(CIES)is acknowledged for grant to kennedy D.Nyongbela to carry-out research at the University of Minnesota.We wish to thank M.Campbell and A.Powell from the Centre for Drug Candidate Optimisation(CDCO),Monash University for the DMPK data.Fidele Ntie-Kang is currently a Georg Forster fellow of the Alexander von Humboldt Foundation,Germany.We are equally grateful to Schro¨dinger Inc.for the academic license to use the QikProp software.

关键词： Sesquiterpenes Pharmacokinetics Drug metabolism Scleria striatinux

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金融服务业:如何简化信息技术

新金融 2006年第9期 12-14页

作者： thomas Reichert Andrew Dyer Simon kennedy Heinz Mollenkamp 波士顿咨询公司悉尼办公室波士顿咨询公司波士顿办公室波士顿咨询公司科隆办公室

目前大多数机构面临的主要信息技术问题是:如何应对日益增长的复杂性。IT复杂性造成的问题可以通过大幅简化IT系统来解决。简化IT系统,第一步是对当前的IT环境做出诊断,第二步是确定整体目标IT系统,第三步是制定一系列程序以简化IT。在... 详细信息

目前大多数机构面临的主要信息技术问题是:如何应对日益增长的复杂性。IT复杂性造成的问题可以通过大幅简化IT系统来解决。简化IT系统,第一步是对当前的IT环境做出诊断,第二步是确定整体目标IT系统,第三步是制定一系列程序以简化IT。在实施这些具体步骤时,还要注意一个重要方面:组织结构。IT简化不应是一次性事件,而应是一个不断进行的过程。

关键词：金融业信息技术

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向IT环境要成本

商学院 2005年第6期 65-66页

作者： thomas Reichert Andrew Dyer Simon kennedy Heinz Mollenkamp 波士顿咨询公司悉尼办公室公司波士顿办公室公司科隆办公室

简化AIT系统不但能将IT总成本降低30%之多，还能使将来改造IT环境的灵适性增大。但是，银行该如何实施全面的IT改善呢?

关键词： IT环境成本 IT系统银行

Drivers of early marriage and teenage pregnancy in Kenya and Uganda during COVID-19 lockdown period:A systematic review

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Journal of Integrative Nursing 2022年第4期4卷 202-210页

作者： Brian Barasa MASABA Rose MMUSI-PHETOE Jacklyne Atieno ODHIAMBO Bernard RONO Jane Wamuyu KABO Damaris MORAA Alex RUTTO John kennedy MOTURI thomas Ong’ondo NG’AMBWA Damaris OCHANDA Sammy Diana MAWIA Mary KIPMEREWO Samuel OYUGI Stephenie Lydia OJIAMBO Department of Health Studies School of Social SciencesCollege of Human SciencesUniversity of South AfricaPretoriaSouth Africa School of Nursing Great Lakes University of KisumuKisumuKenya Centre of Microbiology Research Kenya Medical Research InstituteKisumuKenya School of Nursing Kibabii UniversityBungomaKenya School of Nursing Kaimosi Friends UniversityKaimosiKenya School of Nursing Midwifery and Paramedical SciencesMasinde Muliro University of Science and TechnologyKakamegaKenya School of Nursing University of EmbuEmbuKenya School of Economics University of NairobiNairobiKenya

The present study aimed to explore the drivers of early marriage and teenage pregnancy in Kenya and Uganda during COVID-19 lockdown period.A systematic review design was adopted.The major online databases utilized were PubMed,Google Scholar,Uganda and Kenya Ministry of Health repositories,ScienceDirect,and Scopus.Studies that were originating from Kenya and Uganda that were publicly available in electronic format published from March 2020 to March 2022 were used.The thematic analysis identified major concepts that were drivers to the present research problem which were as follows:(1)school closure and(2)loss of income by parents.The COVID-19 containment measures introduced in the two countries were noted as major contributing factors.During the pandemic,lockdown led to school closures which meant the teenagers being idle at home with an increased opportunity to indulge in sexual risk behaviors.Schools have been noted to be a safe place protecting this vulnerable population.However,with their prolonged closure,the teenagers were exposed to sexual predators.Parents lost income,and this might have contributed to early marriages and teenagers’dependency on their sexual partners.Based on the reviewed evidence,the present study furthers the advocacy for the reduction of early marriages and teenage pregnancy,especially in the current COVID-19 pandemic era.The study calls upon the governments to intensify efforts toward the present research problem as the COVID-19 pandemic is eroding the earlier gains made within the region.

关键词： Adolescent COVID-19 humans Kenya marriage sexual behavior teenage pregnancy Uganda

Safety and immunogenicity of a third dose of mRNA-1273 vaccine among cancer patients

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Cancer Communications 2023年第7期43卷 749-764页

作者： Anna Giuliano Barbara Kuter Shari Pilon-thomas Junmin Whiting Qianxing Mo Brett Leav Bradley Sirak Christopher Cubitt Christopher Dukes Kimberly Isaacs-Soriano Kayoko kennedy Somedeb Ball Ning Dong Akriti Jain Patrick Hwu Jeffrey Lancet Department of Cancer Epidemiology Moffitt Cancer CenterTampaFloridaUSA Moderna CambridgeMassachusettsUSA Department of Immunology Moffitt Cancer CenterTampaFloridaUSA Department of Biostatistics and Bioinformatics Moffitt Cancer CenterTampaFloridaUSA Immune Monitoring Core Moffitt Cancer CenterTampaFloridaUSA Non-Therapeutic Research Office(NTRO) Moffitt Cancer CenterTampaFloridaUSA Department of Malignant Hematology Moffitt Cancer CenterTampaFloridaUSA

Background:Compared to the general population,cancer patients are at higher risk of morbidity and mortality following SARS-CoV-2 infection.The immune response to a two-dose regimen ofmRNA vaccines in cancer patients is generally lower than in immunocompetent individuals.Booster doses may meaningfully augment immune response in this population.We conducted an observational study with the primary objective of determining the immunogenicity of vaccine dose three(100μg)of mRNA-1273 among cancer patients and a secondary objective of evaluating safety at 14 and 28 days.Methods:The mRNA-1273 vaccine was administered~7 to 9 months after administering two vaccine doses(i.e.,the primary series).Immune responses(enzyme-linked immunosorbent assay[ELISA])were assessed 28 days post-dose three.Adverse events were collected at days 14(±5)and 28(+5)post-dose three.Fisher exact or X^(2)tests were used to compare SARS-CoV-2 antibody positivity rates,and paired t-tests were used to compare SARS-CoV-2 antibody geometric mean titers(GMTs)across different time intervals.Results:Among 284 adults diagnosed with solid tumors or hematologic malignancies,dose three of mRNA-1273 increased the percentage of patients seropositive for SARS-CoV-2 antibody from 81.7%pre-dose three to 94.4%28 days post-dose three.GMTs increased 19.0-fold(15.8-22.8).Patients with lymphoid cancers or solid tumors had the lowest and highest antibody titers post-dose three,respectively.Antibody responses after dose three were reduced among those who received anti-CD20 antibody treatment,had lower total lymphocyte counts and received anticancer therapy within 3 months.Among patients seronegative for SARS-CoV-2 antibody pre-dose three,69.2%seroconverted after dose three.A majority(70.4%)experienced mostly mild,transient adverse reactions within 14 days of dose three,whereas severe treatment-emergent events within 28 days were very rare(<2%).Conclusion:Dose three of the mRNA-1273 vaccine was well-tolerated and augmented SARS-CoV-2 seropositivity in cancer patients,especi

关键词： Cancer Coronavirus disease 2019 Immunogenicity Observational study Vaccination

NERC system operators visit China

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Electricity 1991年第2期 35-38页

作者： Thomas Kennedy and Larry Kinard

Messrs Thomas Kennedy and Larry Kinard,representing NERC for the United Nations Sen-ior Technical Advisory Recruitment (STAR) Program,visited China from July 4 to 27,1990.The first two weeks ofthe visit were primarily devoted to the lectures on NERC operating reliability policies and procedures by the NERCoperators in Beijing.The members of the lecture class were much impressed with the experiences in bulk electricsystem operations of U.S.A.and extended heartfelt thanks to Messrs kennedy and Kinard for their lectures.Afterthey returned back to U.S.A.,they wrote the article“NERC system operators visit China”in the midst of pressingaffairs for us,in which,besides expressing their impressions in China’s electric power industry,they put forwardmany valuable suggestions in the improvements for Chinese electric system operations and hoped that the rela-tionship that has been established between NERC and MOE,China,will continue to grow and be mutually benefi-cial to both organizations.Although significant achievements have been witnessed in electric power industry sincethe founding of PRC,there exists still gap between the developed countries and our country in this field.Thereforeany observations,comments and suggestions from abroad for China’s electric power industry are sincerely wel-come.

关键词： NERC operators sincerely devoted primarily lecture representing operations hoped founding

Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study

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Asian Journal of Andrology 2021年第5期23卷 537-540页

作者： John K Amory Charles H Muller thomas J Walsh Department of Medicine University of WashingtonSeattleWA 98195USA Department of Urology University of WashingtonSeattleWA 98195USA

The treatment of men with infertility from azoospermia is challenging.As some men with severe oligozoospermia improve sperm output during treatment with isotretinoin,we treated nine men with azoospermia with isotretinoin to determine if azoospermic men would also respond to isotretinoin treatment.One of these men who had a previous negative testicular sperm extraction(TESE)was found to have an area of sperm production on a postisotretinoin testicular extraction.This man achieved a pregnancy and a live birth of a healthy,term daughter after in vitro fertilization coupled with intracytoplasmic sperm injection(IVF/ICSI).A second subject had a positive TESE after treatment as well.Additional study of isotretinoin therapy in men with azoospermia undergoing testicular sperm harvesting procedures is warranted.

关键词： treatment injection pregnancy

Development of time series stacks of Landsat images for reconstructing forest disturbance history

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International Journal of Digital Earth 2009年第3期2卷 195-218页

作者： Chengquan Huang Samuel N.Goward Jeffrey G.Masek Feng Gao Eric F.Vermote Nancy thomas Karen Schleeweis Robert E.kennedy Zhiliang Zhu Jeffery C.Eidenshink John R.G.Townshend Department of Geography University of Maryland2181 LeFrak HallCollege ParkMD 20742USA Code 614.4Biospheric Sciences NASA Goddard Space Flight CenterGreenbeltMD 20771USA Earth Resources Technology Inc. 10810 Guilford Rd.Annapolis JunctionMD 20701USA USDA Forest Service Pacific Northwest Research Station 3200 SW Jefferson WayCorvallisOR 97331USA U.S.Geological Survey 12201 Sunrise Valley DriveRestonVA 20192USA USGS Earth Resources Observation and Science(EROS) Sioux FallsSD 57198USA

Forest dynamics is highly relevant to a broad range of earth science studies,many of which have geographic coverage ranging from regional to global scales.While the temporally dense Landsat acquisitions available in many regions provide a unique opportunity for understanding forest disturbance history dating back to 1972,large quantities of Landsat images will need to be analysed for studies at regional to global scales.This will not only require effective change detection algorithms,but also highly automated,high level preprocessing capabilities to produce images with subpixel geolocation accuracies and best achievable radiometric consistency,a status called imagery-ready-to-use(IRU).This paper describes a streamlined approach for producing IRU quality Landsat time series stacks(LTSS).This approach consists of an image selection protocol,high level preprocessing algorithms and IRU quality verification procedures.The high level preprocessing algorithms include updated radiometric calibration and atmospheric correction for calculating surface reflectance and precision registration and orthorectification routines for improving geolocation accuracy.These automated routines have been implemented in the Landsat Ecosystem Disturbance Adaptive System(LEDAPS)designed for processing large quantities of Landsat images.Some characteristics of the LTSS developed using this approach are discussed.

关键词： Landsat time series stack imagery-ready-to-use LEDAPS forest change

Early developmental exposure to inorganic mercury does not alter affiliative behavior of adult prairie voles(Microtus ochrogaster)

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Integrative Zoology 2018年第6期13卷 761-768页

作者： Yue CHEN Robert LEWIS J.thomas CURTIS Department of Pharmacology and Physiology Oklahoma State University Center for Health SciencesTulsaOklahomaUK

Mercury chloride exposure through drinking water in adult male prairie voles(Microtus ochrogaster)has been shown to alter their social behavior.Here,we examined the potential disruption of adult social behavior in prairie voles that were exposed to 60 ppm mercury during early development.We used a cross-fostering approach to test the effects of mercury exposure:(1)from conception until birth;(ii)from birth until weaning;and(iii)from conception until weaning,on adult affiliative behavior.Untreated and mercury-treated voles were given the option of remaining in an empty cage or affiliating with a same-sex conspecific in a 3-h choice test.We found that early developmental mercury exposure had little if any effect on the reproductive success of breeder pairs or on affiliative behavior by either sex when subjects were tested as adults.These results suggest that,at least in the context of the behavior tested,the effects of early developmental exposure to mercury do not permanently alter adult prairie vole affiliative behavior,or do so in a way that is too subtle to be detected using the current testing paradigm.

关键词： behavioral testing metals toxicity social behavior prairie vole