检索结果-南通市图书馆

Regular and p-Regular Orbits of Solvable Linear Groups,Ⅱ

在线全文

学校读者我要写书评

暂无评论

Algebra Colloquium 2023年第2期30卷 301-304页

作者： thomas Michael keller Yong Yang Department of Mathematics Texas State UniversitySan MarcosTX 78666USA College of Science China Three Gorges University Three Gorges Mathematical Research CenterYichangHubei 443002China Department of MathematicsTexas State UniversitySan MarcosTX 78666USA

Let V be a faithful G-module for a finite group G and let p be a prime dividing IG].An orbit yG for the action of G on V is regular if|v^(G)|=|G:C_(G)(v)]=|G|,and is p-regular if|v^(G)|_(p)=|G:C_(G)(v)|_(p)=|G|_(p).In this note,we study two questions,one by the authors and one by Isaacs,related to the p-regular orbits and regular orbits of the linear group actions.

关键词： regular orbits solvable linear groups group action

Novel synthetic opioids-toxicological aspects and analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forensic Sciences Research 2019年第2期4卷 111-140页

作者： Inês Tabarra Sofia Soares Tiago Rosado Joana Gonçalves Àngelo Luís Sara Malaca Mário Barroso thomas keller José Restolho Eugenia Gallardo Centro de Investigação em Ciências da Saude(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Laboratorio de Fármaco-Toxicologia-UBIMedical Universidade da Beira InteriorCovilhãPortugal Serviço de Química e Toxicologia Forenses Instituto Nacional de Medicina Legal e Ciências ForensesDelegac¸ão do SulLisboaPortugal Departament of Toxicology Institute of Forensic MedicineSalzburgAustria nal von minden GmbH RegensburgGermany

Over the past few years,there has been an emerging number of new psychoactive *** drugs are frequently mentioned as“legal highs”,“herbal highs”,“bath salts”and“research chemicals”.They are mostly sold and advertised on online forums and on the dark *** emerging new psychoactive substances are designed to mimic the effects of psychoactive groups,which are often abused *** synthetic opioids are a new trend in this context and represent an alarming threat to public *** the wide number of fatalities related to these compounds reported within the last few years,it is an important task to accurately identify these compounds in biologic matrices in order to administer an effective treatment and reverse the respiratory depression caused by opioid related *** dealing with fentanyl intoxication cases should consider that it could,in fact,be a fentanyl *** this reason,it is a helpful recommendation to include synthetic opioids in the routine toxicological screening procedures,including analysis in alternative matrices,if available,to investigate poly-drug use and possible tolerance to *** address this public health problem,better international collaboration,effective legislation,effective investigation,control of suspicious“research chemicals”online forums and continuous community alertness are *** article aims to review diverse reported fatalities associated with new synthetic opioids describing them in terms of pharmacology,metabolism,posology,available forms,as well as their toxic effects,highlighting the sample procedures and analytical techniques available for their detection and quantification in biological matrices.

关键词： Forensic sciences forensic toxicology new synthetic opioids biological specimens toxicity analysis

Liquid Phase Hydrogenation of Benzalacet0phen0ne:Effect of Solvent,Catalyst Support,Catalytic M etal and Reaction Conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

催化学报 2011年第8期32卷 1312-1322页

作者： Achim STOLLE[a] Christine SCHM?GER[a] Bernd ONDRUSCHKA[a] Werner BONRATH[b] thomas F.keller[c] Klaus D.JANDT[c] [a]Institute for Technical Chemistry and Environmental Chemistry(ITUC) Friedrich-Schiller University JenaLessingstrasse 12D-07743 JenaGermany [b]R&D Chemical Process Technology DSM Nutritional ProductsP.O.Box 2676CH-4002 BaselSwitzerland [c]Institute of Materials Science and Technology(IMT) Friedrich-Schiller University JenaLobdergraben 32D-07743 JenaGermany

Innovative catalysts based on a "porous glass" support material were developed and investigated for the reduction of benzalace-tophenone. The easy preparation conditions and possibility to use different metals (e.g. Pd, Pt, Rh) for impregnation gave a broad variety of these catalysts. Hydrogenation experiments with these supported catalysts were carried out under different hydrogen pressures and temperatures. Porous glass catalysts with Pd as the active component gave chemoselective hydrogenation of benzalacetophenone, while Pt- and Rh-catalysts tended to further reduce the carbonyl group, especially at elevated hydrogen pressures and temperatures. Kinetic analysis of the reactions revealed these had zero order kinetics, which was independent of the type of porous glass support and solvent used.

关键词： chalcone hydrogenation porous glass supported catalyst

大学生创业意向研究——创业教育作为向不同特征的大学生提供的支持性措施

在线全文

学校读者我要写书评

暂无评论

应用型高等教育研究 2017年第3期2卷 80-88页

作者： Walter Ruda Pierre G.keller thomas A.Martin 陈颖凯泽斯劳滕应用科学大学德国茨魏布吕肯66482 莱茵河畔路德维希港应用科学大学德国莱茵河畔路德维希港67059 奥斯纳布吕克应用科学大学

基于一个国际性的实证研究"学生创业意向"(GESt)研究项目为基础,研究结果显示,德国学生希望通过讲座和指导得到创业支持后,接下来需要研究有哪些措施可以提升学生的创业意向和企业管理专业知识的水平。如果这些措施能够达到预期效果,那... 详细信息

基于一个国际性的实证研究"学生创业意向"(GESt)研究项目为基础,研究结果显示,德国学生希望通过讲座和指导得到创业支持后,接下来需要研究有哪些措施可以提升学生的创业意向和企业管理专业知识的水平。如果这些措施能够达到预期效果,那么它们应当在国际上得到传播。中国是一个创业数量很高的国家,在此值得特别关注。企业管理方面的专业知识对初创企业能否成功会产生影响,这一点是已被证明的。这些专业知识的水平应当可以通过创业教育得以提高。因此,对这方面的研究也可能会对提高中国初创企业的质量有一定意义。

关键词：创业创业教育大学生创业意向研究意向与行为的关系企业管理专业知识

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

在线全文

学校读者我要写书评

暂无评论

FRP桥板和钢梁粘结节点的性能

钢结构(中英文) 2009年第6期 89-89页

作者： thomas keller Martin Schollmayer

对纤维增强复合材料桥板与钢梁之间粘结点的贯穿厚度性能进行试验与理论研究。由于桥板对桥轴的横向向上作用,产生贯穿厚度拉应力。随着板下部纤维增强织物较高的应力集中,粘结节点的拉应力呈非均匀分布状态。基于有限元方法计算的应力... 详细信息

对纤维增强复合材料桥板与钢梁之间粘结点的贯穿厚度性能进行试验与理论研究。由于桥板对桥轴的横向向上作用,产生贯穿厚度拉应力。随着板下部纤维增强织物较高的应力集中,粘结节点的拉应力呈非均匀分布状态。基于有限元方法计算的应力集中以及通过小比例试验所获得的贯穿板后抗拉强度能够准确预测节点的极限荷载。节点的总安全系数高于主梁间FRP板的安全系数。疲劳荷载达到1000万次循环时,刚度无退化。

关键词：粘合剂连接桥板疲劳玻璃纤维增强复合材料节点

Microglia:a promising therapeutic target in spinal cord injury

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Validation of the Danish version of the musculoskeletal tumour society score questionnaire

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2019年第1期10卷 23-32页

作者： Casper Kloster Pingel Saebye Johnny keller thomas Baad-Hansen Sarcoma Centre of Aarhus University Hospital Department of Orthopedic Surgery Aarhus University Hospital

BACKGROUND The musculoskeletal tumour society score(MSTS) is a well-known questionnaire for measuring functional outcome in patients with neoplasms in the *** guidelines for cross-cultural translation and validation ensure the equivalence of content between the original and translated versions. The translation and validation provide the possibility to compare different sarcoma populations on an international level. This study is based on the hypothesis that the Danish MSTS questionnaire is a valid tool for measuring the end result after surgery for neoplasms in the *** To validate the Danish version of the upper and lower extremity version of the *** The translation of the MSTS was conducted in accordance with international guidelines. Patients operated for sarcomas and aggressive benign tumors were invited to participate in the study. The psychometric properties of the Danish version of the MSTS were tested in terms of validity and reliability and for the risk of floor or ceiling effect. Spearman's rank coefficient was used to test the validity by comparing with the Toronto Extremity Salvage Score(TESS). The Intraclass Correlation Coefficient(ICC) was used to evaluate inter-rater reliability. Cronbach's alpha was used to test for internal consistency. Spearman's rank coefficient was used to compare the MSTS lower extremity version with the objective test, Timed Up and Go(TUG).RESULTS The upper extremity version demonstrated an ICC of 0.95 in the inter-rater reliability test. The lower extremity version had an ICC of 0.88 in the inter-rater reliability test, respectively. Both MSTS versions showed a ceiling effect. Thevalidity of the MSTS was measured by Spearman's rank correlation coefficient by comparing the MSTS with the TESS and found it to be of 0.80(P < 0.01) and 0.83(P < 0.01) for the upper extremity and lower extremity version, respectively. A Spearman's rank correlation coefficient of-0.26(P < 0.01) was found betwee

关键词： Sarcoma Patient outcome assessment Clinical oncology Surgical oncology Patient satisfaction