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中国美容整形外科杂志 2012年第12期23卷 I0032-I0034页

作者： Roger K. Khouri thomas j. baker 魏峰(译) 高景恒(译) 张晨(译) 美国佛罗里达州迈阿密迈阿密大学医学院《中国美容整形外科杂志》编辑部大连大学附属新华医院

我们感谢Smith医师能将其应用Brava的初期经验进行周到地分享.应当为他取得的成果和发现 Brava是矫治乳房不对称畸形的有效方法的发现表示祝贺.同时,也为其对Brava的评论表示感谢.

关键词：乳房增大应用非手术乳房不对称畸形系统作者

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Surface Characterisation of Silicon Based MEMS

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Chemical Research in Chinese Universities 2004年第4期20卷 407-410页

作者： LI j. CUI Z M. A. baker The Surface Analysis Laboratory School of Engineering University of SurreyRutherford Appleton LaboratoryThe Surface Analysis Laboratory School of Engineering University of Surrey Guildford GU2 7XH UKChilton Didcot UKGuildford GU2 7XH UK

Polysilicon Microelectromechanical systems(MEMS) are the subj.ct of intensive researches. Surface chemistry and topography of a MEMS test structure fabricated at Sandia National Laboratory, USA, were studied by means of scanning electron microscopy(SEM), X-ray photoelectron spectroscopy(XPS) and atomic force microscopy(AFM). XPS C_ 1sand Si_ 2pspectra from the polysilicon components, silicon nitride substrate and a reference silicon wafer were compared. The results confirm the presence of a self-assembled monolayer(SAM) on the MEMS surface. An island-like morphology was found on both polysilicon and silicon nitride surfaces of the MEMS. The islands take the form of caps, being up to 0.5 μm in diameter and 20 nm in height. It is concluded that the co-existence of columnar growth and equiaxed growth during the low pressure chemical vapor deposition(LPCVD) of these layers leads to the observed morphology and the islands are caps to the columnar structures.

关键词： Microelectromechanical systems XPS Atomic force microscopy

Laser cut hole matrices in novel armour plate steel for appliqué battlefield vehicle protection

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Defence Technology（防务技术） 2016年第5期12卷 351-359页

作者： Daniel j. thomas Engineering Manufacturing Centre College of Engineering Swansea University Swansea UK

During this research, experimental rolled homogeneous armour steel was cast, annealed and laser cut to form an appliqué plate. This Martensitic–Bainitic microstructure steel grade was used to test a novel means of engineering lightweight armour. It was determined that a laser cutting speed of 1200 mm/min produced optimum hole formations with limited distortion. The array of holes acts as a double-edged solution, in that they provide weight saving of 45%, providing a protective advantage and increasing the surface area. Data collected were used to generate laser cut-edge hole proj.ctions in order to identify the optimum cutting speed, edge condition, cost and deformation performance. These parameters resulted in the generation of a surface, with less stress raising features. This can result in a distribution of stress across the wider surface. Provided that appropriate process parameters are used to generate laser cut edges, then the hardness properties of the surface can be controlled. This is due to compressive residual stresses produced in the near edge region as a result of metallurgical transformations. This way the traverse cutting speed parameter can be adj.sted to alter critical surface characteristics and microstructural properties in close proximity to the cut-edge. A relationship was identified between the width of the laser HAZ and the hardness of the cut edge. It is the thickness of the HAZ that is affected by the laser process parameters which can be manipulated with adj.sting the traverse cutting speed.

关键词： Armour steels Defence systems Steel processing Armour engineering

Expanding the phenotypic plasticity paradigm to broader views of trait space and ecological function

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Current Zoology 2016年第5期62卷 463-473页

作者： thomas j. DEWITT Department of Wildlife & Fisheries Sciences Texas A&M University College Station TX 77843-2258 USA

Foundational concepts of trait spaces, including phenotypic plasticity and function of traits, should be expanded and better integrated with ecological theory. This article addresses two areas where plasticity theory can become further integrated with ecological, evolutionary, and developmental thinking. First is the idea that not only trait means within environments and plasticity of trait means across environments is optimized by selection, but that the entire shape of phenotype distributions such as variance or skew should be optimized within and across environments. In order for trait distribution shape to evolve into adaptations, there must be a genetic basis for and selection upon variation in distribution shapes and their plasticities. I present published and new data demonstrating genetic control and selection for higher moments of phenotype distributions; though, plasticity in these values has not yet been tested. Genetic control of phenotype distribution moments is shown for Neurospora crassa ascospore size and shape. Selection on trait distribution moments is shown for Eurosta solidaginis gall size. Second, there is a tradition in modeling plasti- city as an adaptive strategy that pits it as an alternative to ecological specialization or generaliza- tion. However, these strategies need not be considered alternatives. Rather, with environmental fluctuation within generations plasticity may produce additive or non-additive intermediate （gener- alist） phenotypes, or something new altogether. I present published and new data on the snail Physa virgata and fish Gambusia affinis that show plasticity produces partly intermediate （general- ist） and partly unique phenotypic elements in mixed and fluctuating environments. Plasticity can thus be viewed in the context of a broader trait space and as having broader ecological roles than currently is conceived.

关键词： genetics of trait distributions multi-moment reaction norms non-additive plasticity off-plane phenotypes probabilisticoptimization selection on trait distributions specialists and generalists.

Fabrication of Polymeric Visual Decoys for the Male Emerald Ash Borer （Agrilus planipennis）

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j.urnal of Bionic Engineering 2013年第2期10卷 129-138页

作者： Drew P. Pulsifer Akhlesh Lakhtakia Mahesh S. Narkhede Michael j. Domingue Beverly G. Post j.yant Kumar Raul j. Martln-Palma thomas C. baker Department of Engineering Science & Mechanics Pennsylvania State University University Park Pennsylvania 16802 USA Center for Advanced Materials and Department of Plastics Engineering University of Massachusetts Lowell Lowell MA 01854 USA Department of Entomology Pennsylvania State University University Park PA 16802 USA Center for Advanced Materials and Department of Physics & Applied Physics University of Massachusetts Lowell Lowell MA 01854 USA Department of Materials Science & Engineering Pennsylvania State University University Park Pennsylvania 16802 USA

Through a bioreplication approach, we have fabricated artificial visual decoys for the invasive species Agrilus planipen- nis--commonly known as the Emerald Ash Borer （EAB）. The mating behavior of this species involves an overflying EAB male pouncing on an EAB female at rest on an ash leaflet before copulating. The male spots the female on the leaflet by visually detecting the iridescent green color of the female＇s elytra. As rearing EAB and then deploying dead females as decoys for trapping is both arduous and inconvenient, we decided to fabricate artificial decoys. We used a dead female to make a negative die of nickel and a positive die of epoxy. Decoys were then made by first depositing a quarter-wave-stack Bragg reflector on a polymer sheet and then stamping it with a pair of matched negative and positive dies to take the shape of the upper surface of an EAB female. As nearly 100 artificial decoys were fabricated from j.st one EAB female, this bioreplication process is industrially scalable. Preliminary results from a field trapping test are indicative of success.

关键词： bioreplication conformal-evaporated-film-by-rotation method electroforming negative die positive die stampingCopyright ~ 2013 j.lin University. Published by Science Press and Elsevier Limited. All rights reserved.

The impact of macroalgae on mean and turbulent flow fields

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j.urnal of Hydrodynamics 2015年第3期27卷 427-435页

作者： thomas Robert E. MCLELLAND Stuart j. Department of Geography Environment and Earth Sciences University of Hull

In this paper, we attempt to quantify the mean and turbulent flow fields around live macroalgae within a tidal inlet in Norway. Two Laminaria digitata specimens - 0.50 m apart were selected for detailed study and a profiling ADV was used to collect 45 velocity profiles, each composed of up to seven 0.035 m-high profiles collected for 240 s at 100 Hz, at a streamwise spacing of 0.25 m and cross-stream spacing of 0.20 m. To quantify the impact of the macroalgae, measurements were repeated over a sparser grid after the region had been completely cleared of algae and maj.r roughness elements.

关键词： dealiasing laminaria digitata turbulence vectrino profiler velocity profile

p53:a tumor suppressor hiding in plain sight

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j.urnal of Molecular Cell Biology 2019年第7期11卷 536-538页

作者： Suzanne j.baker Bert Vogelstein St j.de Children's Research Hospital Department of Developmental Neurobiology262 Danny Thomas PlaceMemphisTN 38105USA Ludwig Center Howard Hughes Medical Institute Johns Hopkins Kimmel Cancer Center1650 Orleans Street StBaltimoreMD 21205USA

It is a pleasure to j.in the other authors in this issue to hon orDr Arnold Levi neand the remarkable impact of his *** paths crossed with Amie's when our genetic analyses of colorectal cancers led us to investigate the p53 gene and identify it as a tumor suppressor gene.p53 was initially identified by Arnie and others as an oncogene and tumor antigen,nearly a decade before its role as a tumor suppressor gene was *** fondly remember Arnie visiting our lab,and we visiting his,to discuss the implications of the genetic alterations our group identified in human cancers and how we could work together to investigate the voluminous new questions these mutations raised.

关键词： pleasure Arnold raised

Can inhibition of telomerase increase pancreatic cancer cell's susceptibility to chemotherapeutic reagents?

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 155-160页

作者： thomas j.Ⅲ Fahey Department of Surgery Cornell University Medical College New York NY USA

Obj.ctives: To clarify the inhibition of pancreatic can-cer cells by interference with the hTR component of thetelomerase reverse transcriptase enzymatic complexand evaluate susceptibility of antisense hTR pancreaticcancer cells to chemotherapeutic ***: A 593 bp of full length hTR cDNA was sub-cloned into a mammalian expression vector pcDNA3.1(-) in antisense orientation to construct an antisensehTR expression plasmid. The plasmids were introducedinto Pancl cells, a human pancreatic carcinoma cellline, by lipofectin, and G418-resistant stable trans-formants were expanded. Resulting stable clones werescreened for the presence of hTR insert by PCR withT7 and BGH reverse primers located on the flanks ofthe multiclonal site of pcDNA3.1 vector. Cell growth rate,hTR expression, telomerase activity, and anchorage-in-dependent growth property were analyzed. Finally, sus-ceptibility of antisense hTR cells to chemotherapeuticreagents was ***: Significant downregulation of endogenous hTRwas evident in the antisense-hTR transformed cells,and telomerase activity was markedly decreased com-pared to control cells in standard TRAP assays. Fur-thermore, the proliferation and the anchorage-inde-pendent growth ability in antisense-hTR expressingcells were significantly decreased compared with thecontrol parental cells. However, no crisis or senescencephenomena was observed. Antisense hTR appears toincrease Pancl cell's susceptibility to chemotherapeuticreagent cDDP, but not to differentiation reagent DM-SO, COX2 inhibitor sulinbac, NS-398, curcumin, andchemotherapeutic reagent adriamycin(ADM).Conclusions: These data indicate that hTR is probablya critical component of human telomerase activity andthat downregulation of the RNA component of humantelomerase is an effective target for anticancer strategyand antisense hTR can increase Pancl cell's susceptibilityto cDDP.

关键词： Telomerase hTR Antisense Pancreatic carcinoma cellline chemotherapeutic reagents

Particle flow simulations with homogenised lattice Boltzmann methods

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Particuology 2017年第5期15卷 1-13页

作者： Mathias j. Krause Fabian Klemens thomas Henn Robin Trunk Hermann Nirschl Institute for Applied and Numerical Mathematics Karlsruhe Institute of Technology 76021 Karlsruhe Germany Institute for Mechanical Process Engineering and Mechanics Karlsruhe Institute of Technology 76021 Karlsruhe Germany

An alternative approach to simulating arbitrarily shaped particles submersed in viscous fluid in two dimensions is proposed, obtained by adapting the velocity parameter of the equilibrium distribution function of a standard lattice Boltzmann method （LBM）. Comparisons of exemplifying simulations to results in the literature validate the approach as well as the convergence analysis. Pressure fluctuations occurring in Ladd＇s approach are greatly reduced. In comparison with the immersed boundary method, this approach does not require cost intensive interpolations. The parallel efficiency of LBM is retained. An intrinsic momentum transfer is observed during particle-particle collisions. To demonstrate the capa- bilities of the approach, sedimentation of particles of several shapes is simulated despite omitting an explicit particle collision model.

关键词： Particulate flow simulationsArbitrarily shaped particlesLattice Boltzmann methodsValidationSedimentation processes