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Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis

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World Journal of Gastroenterology 2016年第16期22卷 4160-4167页

作者： Mohamad Mokadem Lama Noureddine thomas howard Lee Mc Henry Stuart Sherman Evan L Fogel James L Watkins Glen A Lehman Division of Gastroenterology and Hepatology Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Division of Nephrology and Hypertension Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Community Health Network Indianapolis IN 46219 United States Division of Gastroenterology and Hepatology Indiana University Medical Center Indianapolis IN 46202 United States

AIM: To evaluate pain control in chronic pancreatitis patients who underwent total pancreatectomy with islet cell transplantation or intrathecal narcotic pump ***: We recognized 13 patients who underwent intrathecal narcotic pump(ITNP) infusion and 57 patients who underwent total pancreatectomy with autologous islet cell transplantation(TP + ICT) for chronic pancreatitis(CP) pain control between 1998 and 2008 at Indiana University Hospital. All patients had already failed multiple other modalities for pain control and the decision to proceed with either intervention was made at the discretion of the patients and their treating physicians. All patients were evaluated retrospectively using a questionnaire inquiring about their pain control(using a 0-10 pain scale), daily narcotic dose usage, and hospital admission days for pain control before each intervention and during their last follow-up. RESULTS: All 13 ITNP patients and 30 available TP + ICT patients were evaluated. The mean age was approximately 40 years in both groups. The median duration of pain before intervention was 6 years and 7 years in the ITNP and TP + ICT groups, respectively. The median pain score dropped from 8 to 2.5(on a scale of 0-10) in both groups on their last follow up. The median daily dose of narcotics also decreased from 393 mg equivalent of morphine sulfate to 8 mg in the ITNP group and from 300 mg to 40 mg in the TP + ICT group. No patient had diabetes mellitus(DM) before either procedure whereas 85% of those who underwent pancreatectomy were insulin dependent on their last evaluation despite ICT. CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients with CP however with high incidence of DM among those who underwent TP + ICT. Prospective comparative studies and longer follow up are needed to better define treatment outcomes.

关键词： Chronic pancreatitis Intractable pain Total pancreatectomy Islet cell transplantation Intrathecal narcotic pump infusion

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Natural history of intraductal papillary mucinous neoplasia:How much do we really know?

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World Journal of Gastrointestinal Surgery 2010年第10期2卷 368-372页

作者： Chad G Ball thomas J howard Department of Surgery Indiana University School of Medicine

Information on the natural history of intraductal papillary mucinous neoplasia(IPMN) is currently inadequate due to a lack of carefully orchestrated long-term followup on a large cohort of patients with asymptomatic *** on the available data,one can draw the conclusions that main duct IPMN is commonly associated with malignancy and an aggressive operative stance should be taken with resection being offered to most patients who are suitable operative *** contrast,the majority of branch type IPMN with a diameter of less than 3 cm can be safely followed with routine surveillance imaging provided they lack the high-risk covariates of age,symptomatology,nodularity or wall thickness.

关键词： Intraductal papillary mucinous neoplasia Cystic pancreatic neoplasm Pancreas

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Potential Use of Multipurpose <i>Paulownia elongata</i>Tree as an Animal Feed Resource

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American Journal of Plant Sciences 2018年第6期9卷 1212-1227页

作者： Whitley Marshay Stewart Brajesh Nanda Vaidya Ajit Kumar Mahapatra thomas howard Terrill Nirmal Joshee Agricultural Research Station Fort Valley State University Fort Valley GA 31030 USA

Paulownia is known as an economically important multipurpose tree genus due to its fast growth and short-rotation harvesting for timber. There is interest in growing Paulownia species as a woody biofuel crop. There are reports on its leaves being rich in nitrogen and double as good fodder, as well as fertilizer (green manure). Nutritional properties of Paulownia elongata leaves collected at monthly intervals from Paulownia Demonstration Plot, Fort Valley State University (FVSU), Fort Valley, Georgia, USA, from April to November, 2011, were studied. The leaves were dried and analyzed for crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF), acid detergent lignin (ADL), fat, gross energy, and ash content. The CP, NDF, ADF, ADL, fat and ash content ranged from 14% - 23%, 29% - 55%, 18% - 42%, 10% - 22%, 2% - 4%, and 6% - 9%, respectively, indicating that Paulownia leaves have potential as a feed resource for livestock. Forage potential research was followed up by developing protocols to manufacture feed pellets with 75% and 95% leaf component and assessing their physical properties. There is an economic market potential for the by-products of Paulownia, which is usually grown for timber.

关键词： Feed Pellets Fodder Forage Analysis Nutritional Properties

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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje thomas Ty B Dunn Matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence Solid organ transplantation Bibliometric analysis

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X-波段电子顺磁共振的微观有序宏观无序谱分析

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光谱学与光谱分析 2007年第2期27卷 209-212页

作者：吴雪 Edmund howard Yuri Nesmelov David D thomas 南开大学物理学院南开大学生物活性材料教育部重点实验室天津300071 Department of Biochemistry Molecular Biology and BiophysicsUniversity of Minnesota

相关时间和序参量是表征自旋探针标记大分子运动与分布的两个重要参数。用合适的物理模型,通过线型分析同时确定这些参数在电子顺磁共振谱的解析中非常有意义。文章应用微观有序宏观无序(MO-MD)模型,在X-波段对具有轴对称磁参量自旋探针... 详细信息

相关时间和序参量是表征自旋探针标记大分子运动与分布的两个重要参数。用合适的物理模型,通过线型分析同时确定这些参数在电子顺磁共振谱的解析中非常有意义。文章应用微观有序宏观无序(MO-MD)模型,在X-波段对具有轴对称磁参量自旋探针的EPR谱进行了模拟计算,测量了波形的实验参数,比较了与经验公式分析的误差。对于MOMD谱,作者提出了分辨标准来筛选实验参数进行线型分析,以此确定了同时解析相关时间及内部序参量的有效区间。

关键词： EPR模拟 MOMD模型相关时间序参量

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Development of German-Ukrainian cooperations for education and research in photogrammetry and laser scanning

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Geo-Spatial Information Science 2021年第1期24卷 152-159,I0016页

作者： thomas Luhmann Institute for Applied Sciences and Geoinformatics Jade University of Applied Sciences OldenburgOldenburgGermany

Since 2011 an intensive international cooperation has been in place between the Institute for Applied Photogrammetry and Geoinformatics(IAPG)at the Jade University of Applied Sciences in Oldenburg,Germany,and various Ukrainian *** an initial contact by *** Konecny,the first visit was organized,and was followed by many *** subsequent years an intensive cooperation was established particularly with the National University for Construction and Architecture(KNUCA)in *** addition to architects and civil engineers,KNUCA also trains geodesists,geo-information scientists and landscape *** cooperation today includes the reciprocal exchange of scientists and students,research projects,courses and cooperation at many other *** addition,a commercial company has been established,SPM3D LLC,which now employs more than 14 engineers in the field of 3D acquisition,point cloud processing and *** article summarizes the history of the cooperation and presents the results of associated student *** addition,results of joint work on the development of a virtual laser scanner are presented,part of a German-Ukrainian initiative to digitize teaching.

关键词： Internationalization technology transfer curricula reform photogrammetry laser scanning e-learning

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Magnetohydrostatic modeling of the solar atmosphere

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Science China(Technological Sciences) 2022年第8期65卷 1710-1726页

作者： ZHU XiaoShuai NEUKIRCH thomas WIEGELMANN thomas State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Mathematics and Statistics University of St AndrewsSt Andrews KY169SSUK Max-Planck-Institut f¨ur Sonnensystemforschung G¨ottingen 37077Germany

Understanding structures and evolutions of the magnetic fields and plasma in multiple layers on the Sun is very important. A force-free magnetic field which is an accurate approximation of the solar corona due to the low plasma β has been widely studied and used to model the coronal magnetic structure. While the force-freeness assumption is well satisfied in the solar corona, the lower atmosphere is not force-free given the high plasma β. Therefore, a magnetohydrostatic(MHS) equilibrium which takes into account plasma forces, such as pressure gradient and gravitational force, is considered to be more appropriate to describe the lower atmosphere. This paper reviews both analytical and numerical extrapolation methods based on the MHS assumption for calculating the magnetic fields and plasma in the solar atmosphere from measured magnetograms.

关键词： magnetic field photosphere chromosphere corona

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