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Geomechanical response of overburden caused by CO_2 injection into a depleted oil reservoir

Journal of Rock Mechanics and Geotechnical Engineering 2016年第6期8卷 860-872页

作者： hema J.Siriwardane Raj K.Gondle Sai B.Varre Grant S.Bromhal thomas h.wilson Department of Civil and Environmental Engineering West Virginia University Department of Civil and Environmental Engineering University of Massachusetts Lowell National Energy Technology Laboratory U.S. Department of Energy Department of Geology and Geography West Virginia University

This study investigates the hydro-mechanical aspects of carbon dioxide(CO2) injection into a depleted oil reservoir through the use of coupled multiphase fluid flow and geomechanical *** singlephase and multiphase fluid flow analyses coupled with geomechanics were carried out at the West Pearl Queen depleted oil reservoir site,and modeling results were compared with available measured *** site geology and the material properties determined on the basis of available geophysical data were used in the *** results from the coupled multiphase fluid flow and geomechanical analyses show that computed fluid pressures match well with available measured *** hydromechanical properties of the reservoir have a significant influence on computed fluid pressures and surface ***,an accurate geologic characterization of the sequestration site and determination of engineering properties are important issues for the reliability of model *** computed fluid pressure response is also significantly influenced by the relative permeability curves used in multiphase fluid flow *** the multiphase fluid flow models provide more accurate fluid pressure response,single-phase fluid flow models can be used to obtain approximate *** ground surface deformations obtained from single-phase fluid flow models coupled with geomechanics are slightly lower than those predicted by multiphase fluid flow models coupled with ***,the advantage of a single-phase model is the *** field monitoring of subsurface fluid pressure and ground surface deformations during fluid injection can be used in calibrating coupled fluid flow and geomechanical *** calibrated models can be used for investigating the performance of large-scale CO2storage in depleted oil reservoirs.

关键词： Depleted oil reservoirs Multiphase flow Geomechanics Geologic sequestration Computational modeling

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Industrial and Small-Scale Biomass Dryers:An Overview

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Energy Engineering 2021年第3期118卷 435-446页

作者： P.Murugan S.Dhanushkodi K.Sudhakar Vincent h.wilson Department of Mechanical Engineering St.Anne’s College of Engineering and Technology(Affiliated to Anna University)Tamilnadu607106India School of Engineering and Technology PRIST UniversityPuducherry605007India Faculty of Mechanical and Automotive Engineering Technology University Malaysia PahangPahang26600Malaysia Automotive Engineering Centre University Malaysia PahangPahang26600Malaysia Department of Technology Management School of Mechanical EngineeringVellore Institute of TechnologyVellore632014India

The quality of the drying process depends mainly on the efficient use of thermal *** systems based on solar energy takes a leading role in the drying of agro-products because of low operating ***,they are limited in use during off–sun *** dryer is one of the simplest ways of drying because of its potential to dry products regardless of time and climate *** other benefit is that crop residues could be used as fuel in these ***,the major limitation of the dryer is unequal drying because of poor airflow distribution in the drying medium,which can be improved by integrating some design changes in the *** review analyses the two types of biomass dryers:industrial biomass dryers and small biomass dryers for food product,along with their ***,studies on technical,sustainability and economic aspects are expected to provide a greater understanding of biomass drying.

关键词： Biomass dryer sustainable energy biomass direct indirect drying time

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Applying reticular synthesis to the design of Cu-based MOFs with mechanically interlocked linkers

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Nano Research 2021年第2期14卷 417-422页

作者： Alexander J.Stirk Benjamin h.wilson Christopher A.O’Keefe hazem Amame Kelong Zhu Robert W.Schurko Stephen J.Loeb Department of Chemistry and Biochemistry University of WindsorWindsorOntarioN9B 3B4Canada Department of Chemistry The University of JordanAmman11942Jordan School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China Department of Chemistry and Biochemistry Florida State UniversityTallahasseeFlorida 32306-4390USA

The concept of“robust dynamics”describes the incorporation of mechanically interlocked molecules(MIMs)into metal-organic framework(MOF)materials such that large amplitude motions(e.g.,rotation or translation of a macrocycle)can occur inside the free volume pore of the *** aid in the preparation of such materials,reticular synthesis was used herein to design rigid molecular building blocks with predetermined ordered structures starting from the well-known MOF *** linkers were synthesized that have a T-shape,based on a triphenylene tetra-carboxylate strut,and their incorporation into Cu(II)-based MOFs was *** single-crystal structures of three new MOFs,UWCM-12(fof),β-UWCM-13(loz),UWCM-14(lil),with naked T-shaped linkers were determined;β-UWCM-13 is the first reported example of the loz topology.A fourth MOF,UWDM-14(lil)is analogous to UWCM-14(lil)but contains a[2]rotaxane ***-temperature,^(2)h solid-state NMR was used to probe the dynamics of a 24-membered macrocycle threaded onto the MOF skeleton.

关键词： reticular chemistry metal-organic frameworks mechanically interlocked molecules rotaxane

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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

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Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat

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Journal of Integrative Agriculture 2022年第4期21卷 917-932页

作者： Marcus GRIFFIThS Jonathan A.ATKINSON Laura-Jayne GARDINER Ranjan SWARUP Michael P.POUND Michael h.wilson Malcolm J.BENNETT Darren M.WELLS School of Biosciences University of NottinghamSutton Bonington CampusLE125RDUK Future Food Beacon of Excellence University of NottinghamSutton Bonington CampusLE125RDUK Integrative Phenomics Group School of BiosciencesUniversity of NottinghamSutton Bonington CampusLE125RDUK IBM Research The Hartree CentreWarringtonWA44ADUK School of Computer Science University of NottinghamNottinghamNG81BBUK

The root system architecture(RSA) of a crop has a profound effect on the uptake of nutrients and consequently the potential yield. however, little is known about the genetic basis of RSA and resource adaptive responses in wheat(Triticum aestivum L.). here, a high-throughput germination paper-based plant phenotyping system was used to identify seedling traits in a wheat doubled haploid mapping population, Savannah×Rialto. Significant genotypic and nitrate-N treatment variation was found across the population for seedling traits with distinct trait grouping for root size-related traits and root distribution-related traits. Quantitative trait locus(QTL) analysis identified a total of 59 seedling trait QTLs. Across two nitrate treatments, 27 root QTLs were specific to the nitrate treatment. Transcriptomic analyses for one of the QTLs on chromosome 2 D, which was found under low nitrate conditions, revealed gene enrichment in N-related biological processes and 28 differentially expressed genes with possible involvement in a root angle response. Together, these findings provide genetic insight into root system architecture and plant adaptive responses to nitrate, as well as targets that could help improve N capture in wheat.

关键词： doubled-haploid population nitrate RNA-seq quantitative trait loci root system architecture Triticum aestivum L.(wheat)

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Magnetic resonance imaging of the dominant carpus and MCPs predicts radiographic joint damage and bone mass two years later in patients with rheumatoid arthritis

Magnetic resonance imaging of the dominant carpus and MCPs p...

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全国自身免疫性疾病专题研讨会暨第十一次全国风湿病学学术年会

作者： h.wilson RK．Will B Breidahl MetabolicBone and Musculoskeletal Diseases Research Unit Departmentof Imaging Services Nuclear Medicine Department 3 -5Royal Perth Hospital Perth Australia

To examine rheumatoid arthritis ( RA ) patients hand MRI, including wrist and MCP joints and assess its role as a predictor of X - ray damage and bone loss. Patients and methods: 54 patients fulfilled ACR criteria for RA and were followed up prospectively 2 years. All patients had baseline bone density(BMD) by dual X - ray absorptiometry (DXA) ,hand MRI and ra-diographic assessment. MRI was scored using the OMERACT RA MRI scoring system. which MRIs of the domi-

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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