检索结果-南通市图书馆

Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis

International Journal of Oral Science 2015年第1期7卷 27-41页

作者： Laura E Zweifler Mudita K Patel Francisco h Nociti jr.helen F Wimer Jose L Milln Martha J Somerman Brian L Foster National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health (NIH) Department of Prosthodontics and Periodontics Division of Periodontics School of Dentistry Campinas State University Department of Vertebrate Zoology National Museum of Natural History Smithsonian Institution Sanford Children’s health Research Center Sanford-Burnham Medical Research Institute

Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone. Biomineralization is regulated by the ratio of inorganic phosphate （Pi） to mineral inhibitor pyrophosphate （PPi）, where local Pi and PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase （TNAP） and ectonucleotide pyrophosphatase/phosphodiesterase 1 （NPP1）. The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enppl null mouse increased acellular cementum, with little effect on cellular cementum. Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enppl gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPi environment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPi have little effect on cellular cementum formation, though matrix mineralization is affected.

关键词： cementum bone ectonucleotide pyrophosphatase phosphodiesterase 1 periodontal ligament progressive ankylosis protein tissue-nonspecific aJkalJne phosphatase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The world’s ten most feared fungi

引用

Fungal Diversity 2018年第6期93卷 161-194页

作者： Kevin D.hyde Abdullah M.S.Al-hatmi Birgitte Andersen Teun Boekhout Walter Buzina thomas L.Dawson jr. Dan C.Eastwood E.B.Gareth Jones Sybren de hoog Yingqian Kang Joyce E.Longcore Eric h.C.McKenzie Jacques F.Meis Laetitia Pinson-Gadais Achala R.Rathnayaka Florence Richard-Forget Marc Stadler Bart Theelen Benjarong Thongbai Clement K.M.Tsui Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Ministry of health Directorate General of Health ServicesIbriOman Department of Biotechnology and Biomedicine Technical University of Denmark2800 Kgs.LyngbyDenmark Institute for Biodiversity and Ecosystem Dynamics(IBED) University of AmsterdamAmsterdamThe Netherlands Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands R&D Institute for hygiene Microbiology and Environmental MedicineMedical University GrazNeue Stiftingtalstrasse 68010 GrazAustria Institute for Medical Biology(IMB) Agency for ScienceTechnologyand Research(A_(*)STAR)SingaporeSingapore Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology Center for Cell DeathInjury and RegenerationMedical University of South CarolinaCharlestonSCUSA Department of Bioscience Academic Office102First FloorWallace BuildingSwansea UniversitySingleton CampusSwanseaWalesUK Centre of Expertise in Mycology Radboudumc/Canisius Wilhelmina hospital(CWZ) NijmegenThe Netherlands Portsmouth Hampshire PO53DHUK Department of Microbiology and the Key Laboratory of Proteomics Guizhou Medical UniversityGuiyangChina School of Biology and Ecology University of MaineOronoME 04469USA Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Department of Medical Microbiology and Infectious Diseases Canisius Wilhelmina Hospital(CWZ)NijmegenThe Netherlands INRA UR1264 MycSA71 av Edouard Bourlaux2003233882 Villenave D’Ornon CedexFrance Department Microbial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigInhoffenstraße 738124 BraunschweingGermany Department of Pathology Sidra MedicineDohaQatar Department of Pathology and Laboratory Medicine Weill Corne

An account is provided of the world’s ten most feared *** areas of interest,we have organized the entries in the order of *** put four human pathogens first as this is of concern to most *** is followed by fungi producing mycotoxins that are highly harmful for humans;Aspergillus flavus,the main producer of aflatoxins,was used as an *** due to indoor air fungi may also directly affect our health and we use Stachybotrys chartarum as an *** everyone collects and eats edible ***,fatalities caused by mushroom intoxications often make news headlines and therefore we include one of the most poisonous of all mushrooms,Amanita phalloides,as an *** then move on to the fungi that damage our dwellings causing serious anxiety by rotting our timber structures and *** lacrymans,which causes dry rot is an excellent *** next example serves to represent all plant and forest *** we chose Austropuccinia psidii as it is causing devastating effects in Australia and will probably do likewise in New ***,we chose an important amphibian pathogen which is causing serious declines in the numbers of frogs and other amphibians *** we target the top ten most feared fungi,numerous others are causing serious concern to human health,plant production,forestry,other animals and our factories and *** highlighting ten feared fungi as an example,we aim to promote public awareness of the cost and importance of fungi.

关键词： Aflatoxicosis Batrachochytrium Candida auris Frog decline Poisonous fungi human pathogens Indoor fungi Forest pathogens Wood decay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生油岩评价的热解-气相色谱研究

引用

地球与环境 1984年第11期 6-10页

作者： h.Dembicki,jr. 裴存民

引言近几年来,热解分析对生油岩潜力的评价做出了越来越重要的贡献。这种方法通过在惰性气体中,加热全岩或分离的干酪根样品使其降解程度发生变化。热解产物可直接提供给一个或多个检测器,以记录总产物的演化和产率。热解器还可以与气... 详细信息

引言近几年来,热解分析对生油岩潜力的评价做出了越来越重要的贡献。这种方法通过在惰性气体中,加热全岩或分离的干酪根样品使其降解程度发生变化。热解产物可直接提供给一个或多个检测器,以记录总产物的演化和产率。热解器还可以与气相色谱和质谱连接,以测定热解产物的详细组成。本文介绍了一种可用于快速测定潜在生油岩样品的有机质丰度、成熟度和生产类型的热解-气相色谱系统,同时,还讨论了一种检测和鉴别由运移的烃类和钻井添加剂而引起的污染的方法。

关键词：干酪根类型抽提物有机质全岩气相色谱分析生油岩评价热解产物岩样岩石样品粘土矿物粘粒矿物硅酸盐矿物

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model

引用

World Journal of Gastroenterology 1999年第6期5卷 544-546页

作者： Wang h Zheng Mh Zhang hB Zhu J he jr.Lu AG Ji YB Zhang MJ Jiang Y Yu BM Li hW Shanghai Second Med Univ Ruijin Hosp Dept Surg Shanghai 200025 Peoples R China Shanghai Inst Digest Surg Shanghai 200025 Peoples R China

INTRODUCTIONPort-site recurrence after laparoscopic tumor surgery is a frequent complication in cancer operations, such as gallbladder, stomach, ovary and colon[1-5]. The incidence of port-site recurrence after laparoscopic colectomy ranged from 1.1% to 6.3%, in contrast to a 0.68% tumor wound recurrence rate in patients undergoing curative open colectomy[6-8]. The possible mechanisms proposed were: ① contaminated laparoscopic instruments passing in and out of the port frequently; ② increased exfoliated cancer cells from laparoscopic manipulation; ③ adhered tumor cells by pneumoperitoneum[9-12]. Some experiments reported that desufflation related to seeding of port wounds via a stable suspension of tumor cells in CO2 gas was an unlikely cause of port tumors, some supported a direct intraperitoneal seeding of exfoliated tumor cells as its etiology and the instruments passing in and out of the port may play an important role in local recurrence[13-15]. The colon tumor cells were more common since laparoscopic colectomy was wildly performed.

关键词： stomach neoplasms colonic neoplasms cell movement carbon dioxide pneumoperitoneum murine model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opportunities for Remote Collaboration in a Social Web Search Model That Integrates Parents and Children

引用

Social Networking 2014年第2期3卷 127-133页

作者： Sandra Regina Rocha Silva Geraldo Bonorino Xexéo Moacir Florentino da Silva jr. Alberto Luiz Coimbra Institute for Graduate Studies and Research in Engineering Federal University of Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Instituto Federal de Ciência e Tecnologia do Maranhao (IFMA) Maranhao Brazil

Traditionally, search engines are designed to support a single user working alone. however, the construction of knowledge is enriched when one adds collaboration to search tasks. We identified opportunities for remote collaboration in a Social Web search model that integrates parents and children guided by 5W + 1h (who, what, where, when, why, how) dimensions. Our social search model aims at improving the search process for children. We found 7 opportunities for remote collaboration on the search process, based on implicit-explicit interactions.

关键词： Social Search Collaborative Information Retrieval Collaborative Information Seeking Opportunities for Collaboration Child

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境对四个棉花品种种子品质的影响

引用

棉花科学 1985年第4期 34-35页

作者： J.h.Turner ,h.h.Ramey jr. ,S.Worley jr. ,蔡以纯,周桃华安徽农学院安徽农学院

测定来自1973年国家棉花品种试验的136份棉子样本的油分含量,蛋白质含量、籽指和未成熟种子百分率。用在17个地点栽培的4个品种两个重复的样本来研究种子品质参数。环境对油分含量和种子成熟度的影响远大于品种。栽培于17种环境下各品... 详细信息

测定来自1973年国家棉花品种试验的136份棉子样本的油分含量,蛋白质含量、籽指和未成熟种子百分率。用在17个地点栽培的4个品种两个重复的样本来研究种子品质参数。环境对油分含量和种子成熟度的影响远大于品种。栽培于17种环境下各品种的油分含量和种子成熟度不同的反应可依据生长和结铃模式的因子型不同和它们对不同气候条件下的反应不同来解释。品种对蛋白质含量和环境条件对蛋白质含量的影响一样大,并已查出无互作。这些结果表明,育种学家筛选蛋白质含量比油分含量容易些,除非在棉花种质内找到油分含量差异很大。

关键词：油分含量种子地点繁殖器官品比试验田间试验品种试验结铃蛋白质含量籽指种子样本

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bone remodeling effect of a chitosan and calcium phosphate-based composite

引用

Regenerative Biomaterials 2019年第4期6卷 241-247页

作者： Lilja Kjalarsdottir Arna Dyrfjord Atli Dagbjartsson Elin h.Laxdal Gissur Orlygsson Johannes Gislason Jon M.Einarsson Chuen-how Ng halldor Jonsson jr Department of Orthopaedic Surgery Landspı´tali University HospitalReykjavik 108Iceland Faculty of Medicine University of IcelandReykjavik 101Iceland Genis hf. Siglufjordur 580Iceland Department of Materials Biotechnology and EnergyInnovation Center IcelandReykjavik 112Iceland Department of Vascular Surgery Landspitali University HospitalReykjavik 108Iceland

Chitosan is a biocompatible polymer that has been widely studied for tissue engineering *** aim of this research was to assess bone regenerative properties of an injectable chitosan and calcium phosphate-based composite and identify optimal degree of deacetylation(%DDA)of the chitosan *** holes were generated on the left side of a mandible in Sprague-Dawley rats,and the hole was either left empty or filled with the *** animals were sacrificed at several time points after surgery(7–22 days)and bone was investigated using micro-CT and *** significant new bone formation was observed in the implants themselves at any time ***,substantial new bone formation was observed in the rat mandible further away from the drill *** changes indicating bone formation were found in specimens explanted on Day 7 in animals that received *** bone formation pattern was seen in control animals with an empty drill hole at later time points but not to the same extent.A second experiment was performed to examine if the%DDA of the chitosan polymer influenced the bone remodeling *** results suggest that chitosan polymers with%DDA between 50 and 70%enhance the natural bone remodeling mechanism.

关键词： bone remodeling bone implant bone defects chitosan degree of deacetylation micro-CT rat mandible

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Organizational Behavior Don hellriegel, John W. Slocum, jr.

引用

2007年

作者： Don hellriegel John W. Slocum jr.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Ancient Muses: Archaeology and the Arts

引用

2003年

作者： John h. Jameson jr

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

沉积地质学回顾与展望

引用

地质科学译丛 1989年第1期6卷 64-71页

作者： R.h.Dott jr. 韩征辛文杰

沉积地质学1800年前后起源于地层学。尽管早期到处都有一些天才人物,但沉积学直到大约1920年才确立了自己的地位。20年代重矿物岩石学和粒度分析盛行起来,它们加上微体古生物在石油工业中大显身手,促进经济古生物和矿物学家协会(SEPM)于... 详细信息

沉积地质学1800年前后起源于地层学。尽管早期到处都有一些天才人物,但沉积学直到大约1920年才确立了自己的地位。20年代重矿物岩石学和粒度分析盛行起来,它们加上微体古生物在石油工业中大显身手,促进经济古生物和矿物学家协会(SEPM)于1926年成立。《沉积岩石学》杂志和几篇沉积岩石学论文出现于二次大战前。大战后,在标准化石占了150年统治地位后,出现了岩石地层学。对现代环境的研究直到二次大战后才发展较快,调查了三角洲、障壁岛、礁和碳酸盐滩。这些及以后类似的探索对海相和非海相体系都增加了极其大量的资料,但时常难于将这些结果与古代沉积物结合起来。在河流搬运和实验室浊流的工程实验促进下,50年代对沉积过程的精确研究亦告开始。不久开始进行垂向层序分析和系统阐述相模式。眼下我们正经历一股“模式热”,但关于什么才是真正的沉积模式,尚无一致意见。下一步往何处去?泥岩时代终将到来,精密仪器使对颗粒、化学沉积作用、成岩作用等的研究有可能不断取得进展。但更令人激动的是,由岩石地层学发展而来的层序地层学与由过程和相序研究发展而来的事件地层学相结合,保证了已被贻误的沉积地质学的形成。最终有可能建立真正定量和预言性的模式,它可以在任何规模上,从局部事件到全球海平面升降,评价随机性和确定性以及幕式和周期性现象。

关键词：沉积地质学沉积作用沉积岩

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：