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Bipolarons in Organic Electroluminescence

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Chinese Physics Letters 2010年第10期27卷 183-185页

作者：姜庆云李盛 thomas f. george 孙鑫 Research Center f.r Quantum Manipulation Department of Physics Fudan University Shanghai 200433 Department of.Physics Zhejiang Normal University Jinhua 310004 Of.ice of.the Chancellor and Center f.r Nanoseience Departments of Chemistry 35 Biochemistry and Physics Astronomy University of Missouri-St.Louis St. Louis MO 63121 USA

We investigate the bipolaron channel B＋＋＋ B-- → BX. The dynamical evolutions and transition probabilities of.this bipolaron luminescence channel are studied. It is f.und that this channel avoids the triplet and is able to enhance the ef.iciency. We suggest that choosing certain polymers and injection structures, in which B is easily f.rmed, can improve the luminescence ef.iciency. It is believed that these results will motivate f.rther experimental studies about the f.nction of.bipolarons in electroluminescence.

关键词：双极化子电致发光动力学演化工作效率喷射结构发光效率光通道聚合物

Physical Limits of.Computation

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Journal of.Quantum Inf.rmation Science 2017年第4期7卷 155-159页

作者： Tibor Guba László Nánai thomas f. george Department of.Optics and Quantum Electronics University of Szeged Szeged Hungary Department of.Experimental Physics University of Szeged Szeged Hungary Department of.Chemistry and Physics University of Missouri-St. Louis St. Louis MO USA

The paper deals with theoretical treatment of.physical limits f.r computation. We are using some statements on base of.min energy/bit, power delay product, Shannon entropy and Heisenberg uncertainty principle which re... 详细信息

关键词： Computation Power Product Entropy SNL Limit

Examining the“revisability”benef.t of.hip resurf.cing arthroplasty

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World Journal of.Orthopedics 2024年第6期15卷 554-559页

作者： Jose george Adam J Taylor thomas P Schmalzried Department of.Orthopedics Harbor UCLA Medical CenterTorranceCA 90509United States

BACKGROUND Hip resurf.cing arthroplasty(HRA)is an alternative to total hip arthroplasty(THA)that is typically reserved f.r young active patients because it preserves ***,the benef.ts of.HRA only hold true if.conversion THA af.er f.iled HRA provides acceptable *** To compare patient reported outcomes f.r conversion THA af.er HRA f.ilure to primary *** A retrospective review of.36 patients(37 hips)that underwent conversion THA f.r f.iled HRA between October 2006 and May 2019 by a single surgeon was *** reported outcomes[modif.ed Harris Hip Score(mHHS),University of.Calif.rnia Los Angeles(UCLA)activity score]were obtained via an email-based responder-anonymous *** were compared to normative data of.a primary THA cohort with similar *** analysis was perf.rmed comparing outcomes of.conversion THA f.r adverse local tissue reaction(ALTR)vs all other causes f.r *** The study group had a lower mHHS than the control group(81.7±13.8 vs 90.2±11.6,Pf.r non-ATLR causes had similar mHHS(85.2±11.5 vs 90.2±11.6,P=0.11)and higher UCLA activity levels(8.5±1.8 vs 7.2±1.6,Pf.r ATLR had worse mHHS(77.1±14.5 vs 90.2±11.6,Pf.llowing HRA conversion to ***,inf.rior outcomes were demonstrated f.r ALTR-related HRA *** selection and perhaps f.rther studies examining alternative HRA bearing surf.ces should be considered.

关键词： Total hip arthroplasty Hip resurf.cing arthroplasty Conversion total hip arthroplasty Adverse local tissue reaction Patient reported outcome measures

Preparedness,knowledge,and perception of.nursing students about climate change and its impact on human health in India

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Regional Sustainability 2024年第1期5卷 107-118页

作者： Ramya Kundayi RAVI Priya BABY Nidhin ELIAS Jisa george thomas Kathyayani Bidadi VEERABHADRAIAH Bharat PAREEK College of.Nursing Medical and Health Sciences UniversityRas Al Khaimah11172United Arab Emirates College of.Nursing National Institute of Mental Health and Neuro sciencesBangalore560011India College of.Nursing Amrita Institute of Medical SciencesKochi682041India College of.Nursing All India Institute of Medical SciencesBhopal462020India Saraswati Prof.ssional and Higher Education College of.Nursing Mohali140413India

Higher education plays an important role in all aspects of.*** climate change and sustainability into the curriculum is important to prepare f.ture health-care prof.ssionals f.r climate change and sustainability actions to build resilient health *** this study,we evaluated the preparedness,knowledge,and perception regarding climate change and its impact on human health among Indian nursing students.A quantitative descriptive survey was conducted among 644 undergraduate nursing students studying in three institutes in the southern,northern,and western parts of.*** used a structured online questionnaire with established validity and reliability to collect *** data were analyzed using Statistical Package f.r the Social Sciences version 26 *** results showed that more than half.of.the students reported experiencing excessive increase(362;56.2%)and decrease(374;58.1%)in temperature in recent *** more than three quarters of.the students(494;76.7%)accepted the general truth that climate change is mainly caused by human activities,only less than half.of.the students(309;48.0%)perceived the impact of.climate change to be *** quarters of.the students(483;75.0%)had a high level of.knowledge regarding climate *** students who had a high level of.knowledge about climate change exerted a high perceived impact of.climate change(χ^(2)=75.47;Pf.of.the students(50.9%)f.lt that they needed inf.rmation about climate change to be included in the nursing curriculum,and only one sixth of.the students(16.1%)were highly conf.dent about engaging in climate change-related conversation with *** of.the students who participated in the study had basic knowledge about climate change and its impact on human ***,there is an observed gap between knowledge and their preparedness and conf.dence to engage in climate change ***,we propose to strengthen the nursing curriculum by integra

关键词： Climate change Curriculum Nursing students Human health India

Genetic characteristics of.H1N1 inf.uenza virus outbreak in China in early 2023

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Virologica Sinica 2024年第3期39卷 520-523页

作者： Xuanxuan Li Zef.ng Dong Jiaming Li Chuanran Dou Deyu Tian Zhenghai Ma Wenjun Liu george f.Gao Yuhai Bi College of.Lif. Science and Technology Xinjiang UniversityUrumchi830046China CAS Key Laboratory of.Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing100101China Suzhou Center f.r Disease Control and Prevention Suzhou215004China Laf.yette College EastonPA 18042USA University of.Chinese Academy of.Sciences Beijing100049China D.H.Chen School of.Universal Health Zhejiang UniversityHangzhou 310058China

Dear Editor,Inf.uenza A virus(IAV)exhibits rapid mutability and antigenic *** the 20th century,IAV has caused at least f.ur pandemics(Yang et al.,2022).Presently,seasonal H_(3)N_(2)and H1N1 are the prevailing human-adaptive IAV subvariants responsible f.r human *** implementation of.public health interventions since the commencement of.the COVID-19 pandemic has ef.ectively curtailed global inf.uenza circulation(Olsen et al.,2021).f.llowing the downregulation of.the prevention and control strategies against COVID-19,global inf.uenza activity is showing a recovery.

关键词： inf.uenza prevention H1N1

Python Server Page Perf.rmance Analysis and Modeling

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Communications and Network 2024年第1期16卷 1-30页

作者： Razaf.ndraibe Marolahy Alix Randrianomenjanahary Lala f.rdinand Raf.mantanantsoa f.ntaine Mahatody thomas f. Angelo Raherinirina University of.f.anarantsoa Fianarantsoa Madagascar

Today, in the f.eld of.computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself.Apache. The number of.solutions f.r this server is theref.re growing continuously, these services are becoming more and more complex and expensive, without being able to f.lf.ll the needs of.the users. The absence of.benchmarks f.r websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of.access to inf.rmation on the Internet. This is why the perf.rmance of.the web server is critically important. Several f.ctors inf.uence perf.rmance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these f.ctors, we propose a perf.rmance evaluation strategy f.r servers that allows us to determine the actual perf.rmance of.dif.erent servers in terms of.user satisf.ction. f.rthermore, we identif.ed perf.rmance characteristics such as throughput, resource utilization, and response time of.a system through measurement and modeling by simulation. f.nally, we present a simple queue model of.an Apache web server, which reasonably represents the behavior of.a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traf.ic. We obtain server perf.rmance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightf.rward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Perf.rmance Analysis Queue Perf.rmance Model Web Server Internet World Wide Web Web Server Perf.rmance

Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant f.rmulated subunit vaccine

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Signal Transduction and Targeted Therapy 2024年第1期9卷 47-50页

作者： Mengyu Guo Mingjing Cao Jiuf.ng Sun Ziwei Chen Xin Wang Lianpan Dai george f.Gao Yuliang Zhao Yaling Wang Chunying Chen CAS Key Laboratory f.r Biomedical Ef.ects of.Nanomaterials and Nanosaf.ty&CAS Center f.r Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina Guangdong Provincial Institute of.Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina CAS Key Laboratory of.Pathogen Microbiology and Immunology Institute of MicrobiologyBeijingChina

Dear editor,Vaccines are the most ef.icient and ef.ective means to prevent inf.ctious diseases,but improving the long-term protective ef.icacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversif.cation of.the pathogen and the number of.booster doses.1 Strategies to overcome this warrant is using adjuvants that amplif. the immune response,and drive the production of.memory B and T cells or long-lived plasma cells that recognize the pathogen f.r durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of.global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of.adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen f.rmulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the inf.ction of.severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of.MnARK f.r subunit vaccine development,we f.rther explored the durable immune regulation abilities of.MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine Zf.001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surf.ce and epitope can be well preserved(Supplementary f.g.1a).The size and zeta potential of.MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary f.g.1b,c).

关键词： manganese immunity protective

A Comprehensive Review of.Exosomes with Therapeutic Potential in Cancer and Coeliac Disease

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Journal of.Biosciences and Medicines 2024年第3期12卷 25-34页

作者： f.thima Assainar Joshua george thomas Zoya Saleem Shaf. Thekkekara f.thima Mammoo Navadir Nidal Kallan RAK College of.Medical Sciences RAK Medical and Health Sciences University Ras Al Khaimah UAE Department of.Biotechnology American University of Ras Al Khaimah Ras Al Khaimah UAE School of.International Education Zhengzhou University Zhengzhou China

The aim of.this review was to evaluate the therapeutic potential of.exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters f.r several diseases. This review provides an overview of.exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic ef.ect is that the phospholipid-binding protein ANXA1 improves its anti-inf.ammatory properties. The review also analyzes the intricate processes of.exosome production and composition ability to transport biomolecules such as proteins, microRNAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of.targeted drug administration due to their innate specif.city. Through genetic engineering and chemical modif.cations, exosomes can be tailored f.r specif.c purposes, demonstrating their versatility in targeted therapy. With ongoing research uncovering their therapeutic potential, exosomes present a promising f.ontier in novel medical treatments across various health conditions.

关键词： Exosomes Cancer Coeliac Disease Therapeutic Potential Cell Communication Anti-inf.ammation

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2984-2998页

作者： Xin Wang Jie Zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting Zhang Xi Wang Ronghua Jin Jikun Zhou george f.Gao Jun Liu Department of.Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Laboratory of.Biosaf.ty Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Beijing Key Laboratory of.Emerging Inf.ctious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Institute of.Inf.ctious Diseases Beijing 100015China National Center f.r Inf.ctious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015P.R.China School of.Laboratory Medicine and Lif. Sciences Wenzhou Medical UniversityWenzhou 325035China School of.Ophthalmology&Optometry Wenzhou Medical UniversityWenzhou 325027China Collaborative Innovation Centre of.Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Shijiazhuang f.f.h Hospital Shijiazhuang 050011China CAS Key Laboratory of.Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing ***,the potential f.nction of.the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human coronaviruses is not well *** our research,we assessed T cell responses to both conserved and nonconserved peptides shared by SARS-CoV-2 and SARS-CoV,identif.ing cross-reactive CD8^(+)T cell epitopes using enzyme-linked immunospot and intracellular cytokine staining ***,in vitro ref.lding and circular dichroism were perf.rmed to evaluate the thermal stability of.the HLA/peptide ***,single-cell T cell receptor reservoir was analyzed based on tetramer ***,we discovered that cross-reactive T cells targeting SARS-CoV were present in individuals who had recovered f.om COVID-19,and identif.ed SARS-CoV-2 CD8^(+)T cell epitopes spanning the major structural antigens.T cell responses induced by the nonconserved peptides between SARS-CoV-2 and SARS-CoV were higher and played a dominant role in the cross-reactivity in COVID-19 ***-T cell reactivity was also observed within the identif.ed series of.CD8^(+)T cell *** representative immunodominant peptide pairs,although the HLA binding capacities f.r peptides f.om SARS-CoV-2 and SARS-CoV were similar,the TCR repertoires recognizing these peptides were *** results could provide benef.cial inf.rmation f.r the development of.peptide-based universal vaccines against coronaviruses.

关键词： immunity conserved assessed