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Ope.-Labe., Pilot Study of the.Safe.y and Clinical e.fe.ts of Rituximab in Patie.ts with Rhe.matoid Arthritis-Associate. Inte.stitial Pne.monia

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Ope. Journal of Rhe.matology and Autoimmune.Dise.se. 2012年第3期2卷 53-58页

作者： e.ic L. Matte.on Tim Bongartz Jay H. Ryu Cynthia S. Crowson thomas e. hartman Paul F. De.laripa De.artme.t of He.lth Scie.ce. Re.e.rch De.artme.t of Radiology Mayo Clinic College of Medicine Rochester US Division of Pulmonary and Critical Care.Me.icine Division of Rhe.matology Brigham and Womens Hospital Boston US Division of Rhe.matology Milano Italy

Obje.tive. To inve.tigate.the.clinical e.fe.t of rituximab (RTX) in the.manage.e.t of progre.sive.rhe.matoid arthritis re.ate. inte.stitial lung dise.se.(RA-ILD). Me.hods: A total of 10 patie.ts with progre.sive.RA-ILD we.e.e.rolle. into this 48-we.k, ope.-labe. tre.tme.t study. Tre.tme.t was with RTX at 1000 mg at day 1, day 15, and again at we.ks 24 and 26, with concomitant me.hotre.ate.the.apy. Re.ults: The.study include. 4 me. and 6 wome.. Of 7 e.aluable.patie.ts at we.k 48, the.diffusing capacity to carbon monoxide.had worse.e. by at le.st 15% in 1 patie.t, was stable.in 4 patie.ts, and incre.se. by >15% of base.ine.value.in 2 patie.ts. The.force. vital capacity de.line. by at le.st 10% in 1 patie.t, was stable.in 4 patie.ts, and incre.se. by at le.st 10% in 2 patie.ts. High re.olution compute. tomo-graphy of the.che.t showe. improve.e.t in 1 patie.t, and was unchange. in 5. Thre. patie.ts we.e.withdrawn, one.who had an infusion re.ction at we.k 0, one.at we.k 5 who was hospitalize. for conge.tive.he.rt failure.at we.k 5 and who late. die. at we.k 32 of complications following a traumatic hip fracture. and one.die. at we.k 6 of possible.pne.monia. Conclusions: In this pilot study of 10 patie.ts with RA-ILD tre.te. with RTX, me.sure. of lung dise.se.re.aine. stable.in the.majority of study comple.e.s. Furthe. re.e.rch is ne.de. to clarify whe.he. this tre.tme.t has a role.in manage.e.t of RA-ILD.

关键词： Rhe.matoid Arthritis Inte.stitial Pne.monitis Rituximab

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CLASSIFICATIONS OF DUPIN HYPe.SURFACe. IN LIe.SPHe.e.Ge.Me.RY

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Acta Mathe.atica Scie.tia 2024年第1期44卷 1-36页

作者： thomas e.Ce.IL De.artme.t of Mathe.atics and Compute. Scie.ce College of the Holy CrossWorcesterMA01610USA

This is a surve. of local and global classification re.ults conce.ning Dupin hype.surface. in S^(n)(or R^(n))that have.be.n obtaine. in the.conte.t of Lie.sphe.e.*** e.phasis is on re.ults that re.ate.Dupin hype.surface. to isoparame.ric hype.surface. in *** with the.e.classification re.ults,many important conce.ts from Lie.sphe.e.ge.me.ry,such as curvature.sphe.e.,Lie.curvature.,and Le.e.dre.lifts of submanifolds of S^(n)(or R^(n)),are.de.cribe. in *** pape. also contains se.e.al important constructions of Dupin hype.surface. with ce.tain spe.ial prope.tie..

关键词： Dupin hype.surface. isoparame.ric hype.surface. Lie.sphe.e.ge.me.ry Lie.sphe.e.transformations Lie.curvature.

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Aulacaspis yasumatsui infe.tations acce.e.ate.Cycas le.f litte. de.omposition and nutrie.t re.e.se

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Pe.osphe.e 2024年第3期34卷 681-684页

作者： thomas e.MARLe. Bagong Kaalaman Botanikal Institute 15 Rizal StreetBarangay MalabañasAngeles City 2009(Philippines)

De.r e.itor,Nume.ous aspe.ts of e.osyste. e.ology are.influe.ce. by inse.ts(Prasad,2022).He.bivory of plant organs by inse.ts may influe.ce.the.bioge.che.istry of fore.ts by changing the.spe.d of litte. de.omposition(Schowalte.,2022).Cycas microne.ica *** is the.only native.gymnospe.m in the.Mariana *** once.abundant tre. e.pe.ie.ce. no known le.hal thre.ts prior to the.2003 invasion of Guam by the.scale.Aulacaspis yasumatsui Takagi(Marle.,2012).This insular case.study has be.n the.subje.t of abundant re.e.rch(Marle. e. al.,2021).Change. to le.f litte. che.istry improve. litte. quality following *** infe.tations(Marle. and Dongol,2016),but the.pre.iction of incre.se. de.omposition spe.d has not be.n confirme. with e.pe.ime.tal incubations.

关键词： litte. fir re.e.se

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Le.rning the.optimal powe. flow:e.vironme.t de.ign matte.s

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e.e.gy and AI 2024年第3期17卷 432-443页

作者： thomas Wolgast Astrid Nie.e Carl von Ossie.zky Unive.sität Olde.burg Department of Computing ScienceDigitalized Energy SystemsAmmerländer Heerstraße 114-118Oldenburg26129Germany

To solve.the.optimal powe. flow(OPF)proble.,re.nforce.e.t le.rning(RL)e.e.ge. as a promising ne. ***,the.RL-OPF lite.ature.is strongly divide. re.arding the.e.act formulation of the.OPF proble. as an RL *** this work,we.colle.t and imple.e.t dive.se.e.vironme.t de.ign de.isions from the.lite.ature.re.arding training data,obse.vation space.e.isode.de.inition,and re.ard function *** an e.pe.ime.tal analysis,we.show the.significant impact of the.e.e.vironme.t de.ign options on RL-OPF training ***,we.de.ive.some.first re.omme.dations re.arding the.choice.of the.e.de.ign *** cre.te. e.vironme.t frame.ork is fully ope.-source.and can se.ve.as a be.chmark for future.re.e.rch in the.RL-OPF fie.d.

关键词： Re.nforce.e.t le.rning Optimal powe. flow e.vironme.t de.ign e.onomic Dispatch Voltage.control Re.ctive.powe. marke.

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Dynamic conve.ge.t shock compre.sion initiate. by re.urn curre.t in high-inte.sity lase.-solid inte.actions

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Matte. and Radiation at e.tre.e. 2024年第4期9卷 40-53页

作者： Long Yang Martin Re.wald thomas Kluge.Ale.andro LasoGarcia Toma Toncian Karl Ze.l Ulrich Schramm thomas e.Cowan Linge. Huang He.mholtz-Ze.trum Dre.de.-Rosse.dorf 01328 DresdenGermany Te.hnische.Unive.sitat Dre.de. 01062 DresdenGermany

We.inve.tigate.the.dynamics of conve.ge.t shock compre.sion in solid cylindrical targe.s irradiate. by an ultrafast re.ativistic lase. *** particle.in-ce.l simulations and couple. hydrodynamic simulations re.e.l that the.compre.sion proce.s is initiate. by both magne.ic pre.sure.and surface.ablation associate. with a strong transie.t surface.re.urn curre.t with de.sity of the.orde. of 10^(17) A/m^(2) and life.ime.of 100 *** re.ults show that the.dominant compre.sion me.hanism is gove.ne. by the.plasma β,i.e.,the.ratio of the.mal pre.sure.to magne.ic *** targe.s with small radius and low atomic numbe. Z,the.magne.ic pre.sure.is the.dominant shock compre.sion *** to a scaling law,as the.targe. radius and Z incre.se.the.surface.ablation pre.sure.be.ome. the.main me.hanism ge.e.ating conve.ge.t ***,an indire.t e.pe.ime.tal indication of shocke. hydroge. compre.sion is provide. by optical shadowgraphy me.sure.e.ts of the.e.olution of the.plasma e.pansion *** re.ults pre.e.te. he.e.provide.a nove. basis for the.ge.e.ation of e.tre.e.y high pre.sure. e.ce.ding Gbar(100 TPa)to e.able.the.inve.tigation of high-pre.sure.physics using fe.tose.ond J-le.e. lase. pulse.,offe.ing an alte.native.to nanose.ond kJ-lase. pulse.drive. and pulse. powe. Z-pinch compre.sion me.hods.

关键词： shock conve.ge.t re.urn

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Influe.ce.of wate. e.aporation on e.astohydrodynamic lubrication with wate.-containing polyalkyle.e.glycols

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Friction 2024年第10期12卷 2370-2388页

作者： Ste.an HOFMANN thomas LOHNe. Karste. STAHL Te.hnical Unive.sity of Munich School of Engineering and DesignDepartment of Mechanical EngineeringGear Research Center(FZG)Boltzmannstraße 1585748 Garching near MunichGermany

The.re.uction of frictional powe. losse. in powe. transmitting ge.rs take. a crucial role.in the.de.ign of e.e.gy-and re.ource.e.ficie.t ***-containing lubricants like.glyce.ol and polyalkyle.e.glycols have.shown gre.t pote.tial in achie.ing friction within the.supe.lubricity re.ime.with coe.ficie.ts of friction lowe. than 0.01 unde. e.astohydrodynamic ***,a bio-base. production of the.base.stocks can le.d to the.de.e.opme.t of gre.n ***,one.challe.ge.associate. with the.application of wate.-containing lubricants to ge.rboxe. is the.e.aporation of wate. and its impact on the.lubricant *** this study,the.influe.ce.of wate. e.aporation on e.astohydrodynamic friction and film thickne.s was inve.tigate. for thre. wate.-containing polyalkyle.e.*** nominal wate. conte.ts of 20 wt%and 40 wt%and two viscositie. we.e.*** re.ults show that the.friction incre.se. continuously with highe. e.aporate. wate. conte.t,while.the.ove.all friction le.e. re.ains low in ne.rly wate.-fre. state..A similar tre.d is obse.ve. for film thickne.s,whe.e.the.strong incre.se.in viscosity re.ults in a notable.incre.se.in film ***,the.se.sitivity of friction and film thickne.s to wate. e.aporation is low for small amounts of e.aporate. *** allows ge.e.ous thre.holds for pe.missible.variations in wate. conte.t.

关键词： friction supe.lubricity aque.us lubrication e.astohydrodynamic lubrication(e.L) e.aporation polyalkyle.e.glycol

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The.ry and classification of mass e.tinction causation

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National Scie.ce.Re.ie. 2024年第1期11卷 16-36页

作者： thomas J.Alge. Jun She. State.Ke. Laboratory of Bioge.logy and e.vironme.tal Ge.logy China University of Geosciences—Wuhan State.Ke. Laboratory of Ge.logical Proce.se. and Mine.al Re.ource. China University of Geosciences—Wuhan De.artme.t of Ge.scie.ce. University of Cincinnati

The.ry re.arding the.causation of mass e.tinctions is in ne.d of syste.atization, which is the.focus of this contribution. e.e.y mass e.tinction has both an ultimate.cause. i.e. the.trigge. that le.ds to various climato-e.vironme.tal change., and one.or more.proximate.cause.s), i.e. the.spe.ific climato-e.vironme.tal change. that re.ult in e.e.ate. biotic mortality. With re.ard to ultimate.cause., strong case. can be.made.that bolide.i.e. me.e.r) impacts, large.igne.us province.LIP) e.uptions and bioe.olutionary e.e.ts have.e.ch trigge.e. one.or more.of the.Phane.ozoic Big Five.mass e.tinctions, and that te.tono-oce.nic change. have.trigge.e. some.se.ond-orde. e.tinction e.e.ts. Apart from bolide.impacts, othe. astronomical trigge.s(*** flare., gamma bursts and supe.nova e.plosions) re.ain e.tire.y in the.re.lm of spe.ulation. With re.ard to proximate.me.hanisms, most e.tinctions are.re.ate. to e.the. carbon-re.e.se.or carbon-burial proce.se., the.forme. be.ng associate. with climatic warming, oce.n acidification, re.uce. marine.productivity and lowe. carbonate.δ13C value., and the.latte. with climatic cooling, incre.se. marine.productivity and highe. carbonate.δ13C value.. e.vironme.tal parame.e.s such as marine.re.ox conditions and te.re.trial we.the.ing inte.sity do not show consiste.t re.ationships with carbon-cycle.*** this conte.t, mass e.tinction causation can be.use.ully classifie. using a matrix of ultimate.and proximate.factors. Among the.Big Five.mass e.tinctions, the.e.d-Cre.ace.us biocrisis is an e.ample.of a bolide.trigge.e. carbon-re.e.se.e.e.t, the.e.d-Pe.mian and e.d-Triassic biocrise. are.e.ample. of LIP-trigge.e. carbon-re.e.se.e.e.ts, and the.Late.Ordovician and Late.De.onian biocrise. are.e.ample. of bioe.olution-trigge.e. carbon-burial e.e.ts. Whe.e.s the.bolide.impact and LIP-e.uption me.hanisms appe.r to invariably cause.carbon re.e.se. bioe.olutionary trigge.s can re.ult in variable.carbon-cycle.change., e.g. carbon burial durin

关键词： biocrisis ultimate.cause proximate.cause bolide large.igne.us province bioe.olutionary e.e.t

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e.fe.ts of the.urban landscape.on he.twave.mortality associations in Hong Kong: comparison of diffe.e.t he.twave.de.initions

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2024年第1期18卷 145-156页

作者： Jinglu Song Yi Lu thomas Fische. Ke.ia Hu De.artme.t of Urban Planning and De.ign Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China De.artme.t of Archite.ture.and Civil e.gine.ring City University of Hong KongKowloon TongHong Kong 999077China e.vironme.tal Asse.sme.t and Manage.e.t Re.e.rch Ce.tre School of Environmental SciencesUniversity of LiverpoolLiverpool L35TRUK Re.e.rch Unit for e.vironme.tal Scie.ce. and Manage.e.t Faculty of Natural and Agricultural SciencesNorth West UniversityPotchefstroom 31750South Africa Institute.of Big Data in He.lth Scie.ce School of Public HealthZhejiang UniversityZijingang CampusHangzhou 310058China

De.pite.incre.se. atte.tion give. to pote.tial modifie.s of te.pe.ature.mortality associations, e.ide.ce.for variations be.we.n diffe.e.t urban landscape.characte.istics re.ains limite.. It is in this conte.t that in this pape. e.fe.t modifications of multiple.urban landscape.characte.istics are.e.plore. unde. diffe.e.t he.twave.de.initions for diffe.e.t age.groups and ge.de. in Hong Kong, China. Daily me.e.rological data and he.twave.re.ate. mortality counts from 2008 to 2017 we.e.colle.te. from the.Hong Kong Ce.sus and Statistics De.artme.t, China. A case.only de.ign was adopte., combine. with logistic re.re.sion mode.s to e.amine.the.modification e.fe.ts of five.urban landscape.characte.istics unde. six he.twave.de.initions. Stratifie. analyse. we.e.conducte. to inve.tigate.age. and ge.de.-spe.ific e.fe.t modifications. It is found that individuals living in gre.ne. are.s e.pe.ie.ce. lowe. le.e.s of mortality during or imme.iate.y afte. he.twave.. In contrast, a highe. building de.sity and nighttime.land surface.te.pe.ature.(LST) we.e.associate. with a highe. he.twave.re.ate. mortality risk. Pronounce. e.fe.t modifications of the.e.urban landscape.characte.istics we.e.obse.ve. unde. hotte. and longe. he.twave., and in olde. adults (age.≥ 65 ye.rs) and male.. The.findings provide.a scie.tific basis for policymake.s and practitione.s whe. conside.ing me.sure. for coping with hotte., longe., and more.fre.ue.t he.twave. in the.conte.t of global climate.change.

关键词： Urban landscape He.twave Mortality e.fe.t modification Intra-urban diffe.e.ce. He.lth risk re.uction

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De.e.opme.t of gradie.t boosting-assiste. machine.le.rning data-drive. mode. for fre. chlorine.re.idual pre.iction

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2024年第2期18卷 35-46页

作者： Wile. He.m Shifa Zhong e.liot Re.d thomas Igou Yongshe.g Che. School of Civil and e.vironme.tal e.gine.ring Georgia Institute of TechnologyAtlantaGA 30332USA School of e.ological and e.vironme.tal Scie.ce. East China Normal UniversityShanghai 200241China

Chlorine.base. disinfe.tion is ubiquitous in conve.tional drinking wate. tre.tme.t (DWT) and se.ve. to mitigate.thre.ts of acute.microbial dise.se.cause. by pathoge.s that may be.pre.e.t in source.wate.. An important inde. of disinfe.tion e.ficie.cy is the.fre. chlorine.re.idual (FCR), a re.ulate. disinfe.tion parame.e. in the.US that indire.tly me.sure. disinfe.tant powe. for pre.e.tion of microbial re.ontamination during DWT and distribution. This work de.onstrate. how machine.le.rning (ML) can be.imple.e.te. to improve.FCR fore.asting whe. supplie. with wate. quality data from a re.l, full-scale.chlorine.disinfe.tion syste. in Ge.rgia, USA. More.pre.ise.y, a gradie.t-boosting ML me.hod (CatBoost) was de.e.ope. from a full ye.r of DWT plant-ge.e.ate. chlorine.disinfe.tion data, including wate. quality parame.e.s (e.g., te.pe.ature. turbidity, pH) and ope.ational proce.s data (e.g., flowrate.), to pre.ict FCR. Four gradie.t-boosting mode.s we.e.imple.e.te., with the.highe.t pe.formance.achie.ing a coe.ficie.t of de.e.mination, R2, of 0.937. Value. that provide.e.planations using Shaple.’s additive.me.hod we.e.use. to inte.pre. the.mode.’s re.ults, uncove.ing that standard DWT ope.ating parame.e.s, although non-intuitive.and the.re.ically non-causal, vastly improve. pre.iction pe.formance. The.e.re.ults provide.a base.case.for data-drive. DWT disinfe.tion supe.vision and sugge.t proce.s monitoring me.hods to provide.be.te. information to plant ope.ators for imple.e.tation of safe.chlorine.dosing to maintain optimum FCR.

关键词： Machine.le.rning Data-drive. mode.ing Drinking wate. tre.tme.t Disinfe.tion Chlorination

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e.H2 inhibitors promote.β-like.ce.l re.e.e.ation in young and adult type.1 diabe.e. donors

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Signal Transduction and Targe.e. The.apy 2024年第2期9卷 679-692页

作者： Ke.th Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwe.l Jun Okabe.Ishant Khurana thomas Karagiannis Julia J.Liang Lina Mariana thomas Loudovaris thomas Kay Assam e.-Osta e.ige.e.ics in Human He.lth and Dise.se.Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia De.artme.t of Diabe.e. Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia e.ige.e.ics in Human He.lth and Dise.se.Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Scie.ce STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabe.e. Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia De.artme.t of Me.icine.and The.ape.tics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute.of Diabe.e. and Obe.ity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute.of He.lth Scie.ce. The Chinese University of Hong KongSha TinHong Kong SAR Biome.ical Laboratory Scie.ce Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-ce.ls are.a type.of e.docrine.ce.l found in pancre.tic isle.s that synthe.ize.store.and re.e.se.*** type.1 diabe.e.(T1D),T-ce.ls of the.immune.syste. se.e.tive.y de.troy the.insulin-producingβ-*** of the.e.ce.ls le.ds to a life.ong de.e.de.ce.on e.oge.ous insulin administration for ***,the.e.is an urge.t ne.d to ide.tify nove. the.apie. that stimulate.-ce.l growth and induce.-ce.l *** and othe.s have.shown that pancre.tic ductal proge.itor ce.ls are.a promising source.for re.e.e.atingβ-ce.ls for T1D owing to the.r inhe.e.t diffe.e.tiation *** transcriptional suppre.sion is re.ractory to e.ocrine.re.ction and tightly controls the.re.e.e.ative.pote.tial by the.e.H2 *** the.pre.e.t study,we.show that transie.t stimulation of e.ocrine.ce.ls,de.ive. from juve.ile.and adult T1D donors to the.FDAapprove. e.H2 inhibitors GSK126 and Taze.e.ostat(Taz)influe.ce.a phe.otypic shift towards aβ-like.ce.l *** transition from re.re.se. to pe.missive.chromatin state. are.de.e.de.t on bivale.t H3K27me. and H3K4me. chromatin *** e.H2 is fundame.tal toβ-ce.l re.e.e.ative.*** pancre.tic ductal ce.ls e.hibit insulin production and se.re.ion in re.ponse.to a physiological glucose.challe.ge.e. *** pre.clinical studie. unde.score.the.pote.tial of small mole.ule.inhibitors as nove. modulators of ductal proge.itor diffe.e.tiation and a promising ne. approach for the.re.toration ofβ-like.ce.l function.

关键词： e.H2 struction inhibitors

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