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Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis

World Journal of Gastroenterology 2019年第41期25卷 6238-6247页

作者： Colin Markus Kruger Ulrich Adam thomas Adam Axel Kramer Claus d Heidecke Frank Makowiec Hartwig Riediger department of Surgery Immanuel Hospital RüdersdorfBerlin 15562Germany department of General Surgery Vivantes-Humboldt hospitalBerlin 13503Germany department of Microbiology Labor Berlin GmbHBerlin 13353Germany Institute of Hygiene and Environmental Medicine University Medicine GreifswaldGreifswald 17495Mecklenburg VorpommernGermany department of Surgery Clinic of GeneralVisceralVascular and Thoracic SurgeryUniversity Medicine GreifswaldGreifswald 17475Mecklenburg VorpommernGermany Section of clinical risk assessment University hospital of FreiburgFreiburg 79106Baden-WürttembergGermany

BACKGROUNd Jaundice or preoperative cholestasis(PC)are typical symptoms of pancreatic *** 50%of patients undergo preoperative biliary drainage(PBd)*** is a common cause of bacterobilia(BB)and is a known surgical site infection risk *** adjustment of preoperative antibiotic prophylaxis(PAP)may be reasonable according to the profile of *** this,we examined the microbiological findings in routine series of *** To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head *** In the period from January 2009 to december 2015,285 consecutive pancreatic head resections were *** for surgery were malignancy(71%),chronic pancreatitis(18%),and others(11%).A PBd was in 51%and PC was in 42%.The standard PAP was ampicillin/***,a smear was taken from the hepatic *** analysis of the isolated species and resistograms was *** were categorized according to the presence or absence of PC(PC+/PC-)and PBd(PBd+/PBd-)into four *** efficiency was analyzed for standard PAP and possible *** BB was present in 150 patients(53%).BB was significantly more frequent in PBd+(n=120)than in PBd-(n=30),Pd without PC:(PBd-/PC-:18%,PBd-/PC+:30%,PBd+/PC-:88%,PBd+/PC+:80%).BB was more frequent in malignancy(56%)than in chronic pancreatitis(45%).PBd,however,was the only independent risk factor in multivariate *** total,357 pathogens(342 bacteria and 15 fungi)were *** five most common groups(n=256,74.8%)were Enterococcus spp.(28.4%),Streptococcus spp.(16.9%),Klebsiella spp.(12.6%),Escherichia coli(10.5%),and Enterobacter spp.(6.4%).A polymicrobial BB(PBd+:77% vs PBd-:40%,Pd a more frequent detection of Enterococcus(Pd with PBd+.In PBd+,the efficiency of imipenem and piperacillin/tazobactam was significantl

关键词： Pancreatic surgery Bacteriobilia Antibiotic prophylaxis Cholestasis Cholangiopancreatography Endoscopic retrograde

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Acousto-optically driven lensless single-shot ultrafast optical imaging

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Light(Science & Applications) 2022年第4期11卷 628-643页

作者： Mohamed Touil Said Idlahcen Rezki Becheker denis Lebrun Claude Roze Ammar Hideur thomas Godin ORIA CNRS UMR6614-University de Rouen Normandie-INSA Rouen76800 Saint Etienne du RouvrayFrance

driven by many applications in a wide span of scientifc fields,a myriad of advanced ultrafast imaging techniques have emerged in the last decade,featuring record-high imaging speeds above a trllion-frame-per-second with long sequence *** bringing remarkable insights into various ultrafast phenomena,their application out of a laboratory environment is however limited in most cases,either by the cost,complexity of the operation or by heavy data *** then report a versatile single-shot imaging technique combining sequentially timed lloptical mapping photography(STAMP)with acousto-optics programmable dispersive fhItering(AOPdF)and digital in-line holography(dIH).On the one hand,a high degree of simplicity is reached through the AOPdF,which enables full control over the acquisition parameters via an electrically driven phase and amplitude spectro-temporal tailoring of the imaging ***,contrary to most single-shot techniques,the frame rate,exposure time,and frame intensities can be independently adjusted in a wide range of pulse durations and chirp values without resorting to complex shaping stages,making the system remarkably agile and *** the other hand,the use of dIH,which does not require any reference beam,allows to achieve an even higher technical simplicity by allowing its lensless operation but also for reconstructing the object on a wide depth of field,contrary to classical techniques that only provide images in a single *** imaging speed of the system as well as its flexibility are demonstrated by visualizing ultrashort events on both the picosecond and nanosecond *** virtues and limitations as welll as the potential improvements of this on-demand ultrafast imaging method are critically discussed.

关键词： simplicity resort bringing

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Clinical and Bacteriological Profile of Infections in Sickle Cell Children in Two Referral Hospitals in Niamey, Niger

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Open Journal of Pediatrics 2024年第1期14卷 36-42页

作者： Kamaye Moumouni Samaila Aboubacar Garba Moumouni Georges thomas Ibrahim Mamoudou Abdou djafar Mamane Halima Hamadou Ibrahim Hamani Issaka djibrilla Almoustapha Amadou Yacouba Abdourahamane Marou Soumana Boubacar Moussa Saley Sahada Bade Malam Abdou Soumana Alido Service de Pédiatrie A H&#244pital National de Niamey Niamey Niger Faculté des Sciences de la Santé Université Abdou Moumouni de Niamey Niamey Niger Service de Pédiatrie H&#244pital national Amirou Boubacar Diallo Niamey Niger Service d’Onco-Hématologie H&#244pital national de Niamey Niamey Niger Service de Biologie Médicale H&#244pital national Amirou Boubacar Diallo Niamey Niger

Introduction: Infections are significant causes of mortality in sickle cell children in resource-limited countries. This study aimed to determine the clinical profile and bacterial ecology of infections in children with sickle-cell disease in two referral hospitals in Niamey. Patients and methods: A retrospective descriptive study was conducted from January 2018 to July 2020 in two referral hospitals in Niamey. All children aged one (1) to 15 years with sickle cell disease admitted for suspected infection, including at least one bacterial culture, were studied. Bacteriological analysis was performed using the appropriate culture media, using BactAlert (Reference 4700003 BTA3d60 BioMérieux). Results: Over 36-months, 350 children with a mean age of 10.9 months were admitted. The sex ratio was 1.2. The SS electrophoretic profile was the most common (93.4%). Immunization status was up to date in 66% of patients. Fever was the common reason for consultation (55.1%). Infection was confirmed in 62 patients (17.7%). The primary diagnoses were bacterial gastroenteritis (24.2%) and urinary tract infection (19.4%). Blood cultures were isolated from Salmonella typhi (13.0%) and Escherichia coli (8.7%). Klebsiella spp (7.1%) and Escherichia coli (5.0%) were detected in cytobacteriological examination of urine. Salmonella typhi (23.5%) and Escherichia coli (5.9%) were isolated on coproculture. Conclusion: Bacterial ecology appears not different from that usually observed in sickle-cell children. Salmonella and Escherichia coli were predominant.

关键词： Sickle Cell disease Child Infection Niger

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Effects of a regenerating matrix on the survival of birds in tropical forest fragments

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Avian Research 2020年第1期11卷 16-24页

作者： Jared d.Wolfe Philip C.Stouffer Richard O.Bierregaard Jr david A.Luther thomas E.Lovejoy College of Forest Resources and Environmental Science Michigan Technological UniversityHoughtonMI 49931USA Biological dynamics of Forest Fragments Project Instituto Nacional de Pesquisas da AmazoiaManaus 69011Brazil College of Renewable Natural Resources Louisiana State University AgCenterLouisiana State UniversityBaton RougeLA 70803USA Biology department George Mason University4400 University Drive MS3EFairfaxVA 22030USA

Background: Vast areas of lowland neotropical forest have regenerated after initially being cleared for agricultural purposes. The ecological value of regenerating second growth to forest-dwelling birds may largely depend on the age of the forest, associated vegetative structure, and when it is capable of sustaining avian demographics similar to those found in pristine ***: To determine the influence of second growth age on bird demography, we estimated the annual survival of six central Amazonian bird species residing in pristine forest, a single 100 and a single 10 ha forest fragment, taking into consideration age of the surrounding matrix(i.e. regenerating forest adjacent to each fragment) as an explanatory ***: Study species exhibited three responses: arboreal, flocking and ant-following insectivores(Willisornis poecilinotus, Thamnomanes ardesiacus and Pithys albifrons) showed declines in survival associated with fragmentation followed by an increase in survival after 5 years of matrix regeneration. Conversely, Percnostola rufifrons, a gap-specialist, showed elevated survival in response to fragmentation followed by a decline after 5 years of regeneration. Lastly, facultative flocking and frugivore species(Glyphorynchus spirurus and dixiphia pipra, respectively) showed no response to adjacent clearing and subsequent ***: Our results in association with previous studies confirm that the value of regenerating forest surrounding habitat patches is dependent on two factors: ecological guild of the species in question and second growth age. Given the rapid increase in survival following succession, we suggest that the ecological value of young tropical forest should not be based solely on a contemporary snapshot, but rather, on the future value of mature second growth as well.

关键词： Amazon fragmentation Brazil Matrix Second growth Survival Tropical bird

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The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic dopamine d2 (-dRd2/ANKK (Taq1A)), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANdAS/CANS: Positive Clinical Outcome with Precision-Guided dNA Testing and Pro-dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman david Han Colin Hanna david Baron Ashim Gupta Shan Kazmi Jag Khalsa debasis Bagchi thomas McLaughlin Rajendra d. Badgaiyan Edward J. Modestino drew Edwards Catherine A. dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA division of Personalized Interventions Peak Logic Del Mar CA USA division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA department of Psychiatry Harvard School of Medicine Cambridge MA USA department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA department of Family Medicine Jefferson Health Northeast Philadelphia PA USA departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANdAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward deficiency Syndrome (RdS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANdAS, especially those with known dNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine d2 (-dRd2/ANKK (Taq1A), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research Id-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided dNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANdAS CANS Genetic Addiction Risk Testing (GARS) Pro-dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'donnell Anthony O'Connor Sinead Smith deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUNd Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HdAdT)can be considered,subject to evidence for local *** this study we assess efficacy of HdAdT therapy for *** eradication in an Irish *** To assess the efficacy of HdAdT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HdAdT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HdAdT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HdAdT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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Plants and Animals as Concept Generators for the development of Biomimetic Cable Entry Systems

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Journal of Bionic Engineering 2008年第2期5卷 167-173页

作者： Tom Masselter Uwe Scharf thomas Speck Plant Biomechanics Group Botanic Garden of the University Freiburg Rittal GmbH & Co.KG Auf dem SttzelbergHerborn D-35745Germany

Many animals and plants have high potential to serve as concept generators for developing biomimetic materials and structures. We present some ideas based on structural and functional properties of plants and animals that led to the development of two types ofbiomimetic cable entry systems. Those systems have been realized on the level of functional demonstrators.

关键词： bionics biomimetics cable entry stents folding structures

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Multiband emission from single β-NaYF_(4)(Yb,Er) nanoparticles at high excitation power densities and comparison to ensemble studies

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Nano Research 2021年第11期14卷 4107-4115页

作者： Florian Frenzel Christian Würth Oleksii dukhno Frédéric Przybilla Lisa MWiesholler Verena Muhr thomas Hirsch Yves Mély Ute Resch-Genger Federal Institute for Materials Research and Testing(BAM) Division 1.2 BiophotonicsRichard-Willstaetter-Str.1112489BerlinGermany Laboratory of Biomaging and Pathologies UMR 7021 CNRSUniversity of Strasbourg67000StrasbourgFrance Institute of Analytical Chemistry Chemo-and BiosensorsUniversity of Regensburg93040RegensburgGermany Institut für Physik and IRIS Adlershof Humboldt-Universität zu BerlinNewtonstraße 1512489BerlinGermany

Ensemble and single particle studies of the excitation power density (P)-dependent upconversion luminescence (UCL) of core and core-shell β-NaYF_(4):Yb,Er upconversion nanoparticles (UCNPs) doped with 20% Yb^(3+) and 1% or 3% Er^(^(3+)) performed over a P regime of 6 orders of magnitude reveal an increasing contribution of the emission from high energy Er^(3+) levels at P > 1 kW/cm^(2). This changes the overall emission color from initially green over yellow to white. While initially the green and with increasing P the red emission dominate in ensemble measurements at P dies results in a multitude of emission bands in the ultraviolet/visible/near infrared (UV/vis/NIR) accompanied by a decreased contribution of the red luminescence. Based upon a thorough analysis of the P-dependence of UCL, the emission bands activated at high P were grouped and assigned to 2–3, 3–4, and 4 photonic processes involving energy transfer (ET), excited-state absorption (ESA), cross-relaxation (CR), back energy transfer (BET), and non-radiative relaxation processes (nRP). This underlines the P-tunability of UCNP brightness and color and highlights the potential of P-dependent measurements for mechanistic studies required to manifest the population pathways of the different Er^(3+) levels.

关键词： upconversion luminescence single nanoparticle study high power excitation emission color luminescence decay kinetics

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Safety and immunogenicity of a third dose of mRNA-1273 vaccine among cancer patients

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Cancer Communications 2023年第7期43卷 749-764页

作者： Anna Giuliano Barbara Kuter Shari Pilon-thomas Junmin Whiting Qianxing Mo Brett Leav bradley Sirak Christopher Cubitt Christopher dukes Kimberly Isaacs-Soriano Kayoko Kennedy Somedeb Ball Ning dong Akriti Jain Patrick Hwu Jeffrey Lancet department of Cancer Epidemiology Moffitt Cancer CenterTampaFloridaUSA Moderna CambridgeMassachusettsUSA department of Immunology Moffitt Cancer CenterTampaFloridaUSA department of Biostatistics and Bioinformatics Moffitt Cancer CenterTampaFloridaUSA Immune Monitoring Core Moffitt Cancer CenterTampaFloridaUSA Non-Therapeutic Research Office(NTRO) Moffitt Cancer CenterTampaFloridaUSA department of Malignant Hematology Moffitt Cancer CenterTampaFloridaUSA

Background:Compared to the general population,cancer patients are at higher risk of morbidity and mortality following SARS-CoV-2 *** immune response to a two-dose regimen ofmRNA vaccines in cancer patients is generally lower than in immunocompetent *** doses may meaningfully augment immune response in this *** conducted an observational study with the primary objective of determining the immunogenicity of vaccine dose three(100μg)of mRNA-1273 among cancer patients and a secondary objective of evaluating safety at 14 and 28 ***:The mRNA-1273 vaccine was administered~7 to 9 months after administering two vaccine doses(i.e.,the primary series).Immune responses(enzyme-linked immunosorbent assay[ELISA])were assessed 28 days post-dose *** events were collected at days 14(±5)and 28(+5)post-dose *** exact or X^(2)tests were used to compare SARS-CoV-2 antibody positivity rates,and paired t-tests were used to compare SARS-CoV-2 antibody geometric mean titers(GMTs)across different time ***:Among 284 adults diagnosed with solid tumors or hematologic malignancies,dose three of mRNA-1273 increased the percentage of patients seropositive for SARS-CoV-2 antibody from 81.7%pre-dose three to 94.4%28 days post-dose *** increased 19.0-fold(15.8-22.8).Patients with lymphoid cancers or solid tumors had the lowest and highest antibody titers post-dose three,*** responses after dose three were reduced among those who received anti-Cd20 antibody treatment,had lower total lymphocyte counts and received anticancer therapy within 3 *** patients seronegative for SARS-CoV-2 antibody pre-dose three,69.2%seroconverted after dose three.A majority(70.4%)experienced mostly mild,transient adverse reactions within 14 days of dose three,whereas severe treatment-emergent events within 28 days were very rare(dose three of the mRNA-1273 vaccine was well-tolerated and augmented SAR

关键词： Cancer Coronavirus disease 2019 Immunogenicity Observational study Vaccination

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Political Implications of Emergency Management

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Journal of Environmental Science and Engineering(B) 2012年第3期1卷 397-402页

作者： Talya d. thomas department of Public Administration and Policy Texas Southern University Houston Texas 77004 USA

This paper will review three broad types of political implications of emergency management, since historically emergency management was considered only a function of law enforcement and fire departments, with the support in the event of a major catastrophe from public health and civil defense organizations. The issue is not whether governments will be required to respond to emergencies but rather when and how frequently. The time to think about emergencies is before they happen. despite some significant weakness in the overall approach, political implications offer many benefits and provide various options for CdCs （community development corporations） to get involved in disaster recovery and emergency management. Based upon a generally positive evaluation, the paper concludes that emergency management must become a central activity, whether at the federal, state, or local or as an intergovernmental activity. Hopefully for the future the government does not have to wait for a disaster to strike for one to put a policy into place, since they have had several to occur over decades. The government should be ready to take on any disaster if it occurs with the following policies and procedures that are in place.

关键词： Emergency management public policy political implications.

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