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肝细胞癌患者辅助性131I-碘油治疗后的生存和预后因素:对20年间106例患者的回顾性分析

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中华核医学与分子影像杂志 2018年第1期38卷 71-72页

作者：唐军 Jonathan Olesinski Frangois Mithieux Olivier Guillaud Mane-Noёlle Hilleret Catherine Lombard-Bohas Luc Henry Olivier Boillot thomas Walter Christian Partensky Pierre Pahardt Pierre-Jean Valette Jean-Philippe Vuillez Frangoise Borson-Chazot Jean-Yves Scoazec Jérme dumortier 上海交通大学医学院附属苏州九龙医院核医学科 Hospices cwils de Lyon Hpital Edouard Herriot Fédération des Spécialités Digestivespavilion L Service de Médecine nucleaire CHU de Grenoble Hdpital A.Michallon

目的肝细胞癌根治性治疗后的复发率较高。该研究对长时间随访的较大样本量根治性治疗后接受了I-碘油辅助性治疗的肝细胞癌患者进行了回顾性分析,报道评估此类患者生存和预后因素的经验。方法将1991年至2009年间法国2个医疗中心中所有因... 详细信息

目的肝细胞癌根治性治疗后的复发率较高。该研究对长时间随访的较大样本量根治性治疗后接受了I-碘油辅助性治疗的肝细胞癌患者进行了回顾性分析,报道评估此类患者生存和预后因素的经验。方法将1991年至2009年间法国2个医疗中心中所有因肝细胞癌根治性治疗后接受I-碘油辅助性治疗的患者纳入该回顾性研究。结果共106例患者纳入研究,中位随访时间为6(0.3～22)年。43例患者(41%)有肝硬化。患者1、2、5、10和20年的无复发生存率分别为73%、57%、40%、30%和14%,肝硬化是复发的独立预测因素[相对危险度(RR)=1.18,95%CI:1.11～3.02,P=0.019];1、2、5、10和20年的总生存率分别为90%、83%、59%、37%和23%,预后因素分别为复发(RR=2.73,95%CI:1.35～5.54;P=0.005)、年龄大于60岁(RR=1.91,95%CI:1.02～3.61;P=0.044)和肿瘤病灶多于3个(RR=3.31,95%CI:1.25～8.77;P=0.016)。结论肝细胞癌患者根治性治疗后的I-碘油辅助性治疗可能会降低早期复发的风险,可使用放射性核素栓塞方法进行进一步的研究。

关键词：肝细胞癌辅助性治疗碘油生存

Cytotoxic Properties on Cervical and Liver Cancer Cells of Two Plant Recipes from Burkina Faso

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Journal of Biosciences and Medicines 2024年第6期12卷 216-229页

作者： Estelle Ouédraogo Bagora Bayala Théodora Mahoukèdè Zohoncon Samiratou Ouédraogo Olga Mélanie Lompo Essi Etonam dovo Jean-Marie Compaoré Albert Théophane Yonli Jacques Simpore Laboratory of Molecular Biology and Genetics (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso Center of Biomolecular Research Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Ecole Normale Suprieure Koudougou Burkina Faso Hspital Saint Camille of Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculty of Health University Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso Chair Research and Action against Cancer Department of Public Health Training and Research Unit in Health Sciences Joseph KI-ZERBO University Ouagadougou Burkina Faso National Population Health Observatory National Institute of Public Health Ouagadougou Burkina Faso The department of Epidemiology Biostatistics and Occupational Health School of Population and Global Health Montral Canada Laboratory of Pathological Anatomy and Cytology University Joseph KI-ZERBO Ouagadougou Burkina Faso TIIG LA TIIM Ouagadougou Burkina Faso

Cancer is one of the deadliest diseases in developing countries. In recent years, natural plant-based compounds have been used in the search for drugs to combat numerous diseases, including cancer. In this study, we evaluate the cytotoxic properties of paanfo tiben 1 and paanfo tiben 2, two traditional herbal formulations from Burkina Faso used in the treatment of cancer in Burkina Faso. To this end, the recipes were infused and freeze-dried. The dry extracts obtained were used to determine total phenolics and flavonoids content, assess antioxidant activity using the dPPH, ABTS and FRAP methods, evaluate anti-inflammatory properties by inhibiting 15-LOX, COX 1 and 2, and assess cytotoxic activity on HeLa cervical cancer and HePG2 liver cancer cell lines using the MTT test. The paanfo tiben 1 recipe showed the highest levels of total phenolics and flavonoids, as well as the best antioxidant activities, with IC50 values of 21.020 ± 0.6 µg/ml and 22.94 ± 0.57 µg/ml for dPPH and ABTS, and 165.15 mM EAA/mg dry extract for FRAP. It also exhibited the best cytotoxic activity with IC50 values of 112.02 ± 0.025 µg/ml on HeLa cells and 80.67 ± 6.08 µg/ml on HepG2 cells. On the other hand, paanfo tiben 2 exhibited the best anti-inflammatory activities through inhibition of 15-LOX and COX 1, with inhibition percentages at 100 µg/ml of 32.523% and 24.717 % respectively. These results could justify the traditional use of these two recipes by traditional health practitioners in the treatment of cancer sufferers in Burkina Faso.

关键词： Antioxidant Anti-Inflammatory Cytotoxicity Paanfo Tiben Burkina

A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.danson Malcolm White John R.M.Barr thomas Bett Peter Blyth david Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker dangor Laurence devereux Peter E.dyer Anthony dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin denis R.Hall david C.Hanna Wayne Harris david I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull david Hunt dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.d.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin david Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng david Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK deBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBdA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

Evidence of a J/ψΛstructure and observation of excited■^(-)states in the■b^(-)→J/ψΛK^(-) decay

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Science Bulletin 2021年第13期66卷 1278-1287,M0003页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** d.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Bj┆rn M.P.Blago T.Blake F.Blanc S.Blusk d.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo d.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier d.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.da Silva E.dall’ Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-ringuet(llr) PalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Techno

First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)*** observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere *** mass and width are determined to be 4458:8±2:9t4:7-1:1 MeV and 17:3±6:5t8:0-5:7 MeV,respectively,where the quoted uncertainties are statistical and *** structure is also consistent with being due to two *** addition,the narrow excited■^(-)states,N■(1690)and■(1820),are seen for the first time in a■b^(-)decay,and their masses and widths are measured with improved *** analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb^(-1),collected with the LHCb experiment at centre-of-mass energies of 7,8 and 13 TeV.

关键词： QCd Exotics Pentaquark Spectroscopy Quarkonium Particle and resonance production

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固定导线的不同位点对漂浮传感器振动的影响

固定导线的不同位点对漂浮传感器振动的影响

腰椎间盘突出症的手术与非手术治疗比较——脊柱患者治疗结果研究试验（SPORT）：随机试验

中华医学会第十次全国耳鼻咽喉-头颈外科学术会议

作者：佘万东 d Jiang A Fitzgerald O Connor 南京大学医学院附属鼓楼医院耳鼻咽喉科 department of Otolaryngology-Head and Neck Surgery Guy’s and St.Thomas’ HospitalsLondonUK

目的固定漂浮传感器(floating mass transducer,FMT)导线的不同位点,探讨对 FMT 振动的影响。方法固定距 FMT 分别为10mm、5mm 和0mm 导线位点,应用激光多普勒(laser doppler vibra- tion,LdV),观测在声刺激强度为100dB SPL 和80dB SPL...

目的固定漂浮传感器(floating mass transducer,FMT)导线的不同位点,探讨对 FMT 振动的影响。方法固定距 FMT 分别为10mm、5mm 和0mm 导线位点,应用激光多普勒(laser doppler vibra- tion,LdV),观测在声刺激强度为100dB SPL 和80dB SPL 时的 FMT 振动强度。结果 FMT 在1k、1．5k 处振动强度较小,向两侧振动强度渐增大,0．25k 和8k 处最大。有利

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美国医学会杂志（中文版） 2007年第6期26卷 339-347页

作者： James N. Weinstein Tor d. Tosteson Jon d. Lurie Anna N. A. Tosteson Brett Hanscom Jonathan S. Skinner William A. Abdu Alan S. Hilibrand Scott d. Boden Richard A. deyo 李德强（译）戴尅戎（校）侯洪良（校） dartmouth Medical School Hanover NH Rothman Institute at thomas Jefferson University Philadelphia Pa Emory University Atlanta Ga Center for Cost and Outcomes Research University of Washington Seattle 不详

背景：在美国，腰椎间盘切除术是治疗腰背部及下肢症状患者最常用的手术。但是，这种手术方式的疗效较之非手术治疗仍存在争议。目的：评价手术治疗腰椎间盘突出症的疗效。设计、地点及参试者：“脊柱患者治疗结果研究试验（Spine Patie... 详细信息

背景：在美国，腰椎间盘切除术是治疗腰背部及下肢症状患者最常用的手术。但是，这种手术方式的疗效较之非手术治疗仍存在争议。目的：评价手术治疗腰椎间盘突出症的疗效。设计、地点及参试者：“脊柱患者治疗结果研究试验（Spine Patient Outcomes Research Trial，SPORT）”是一项随机临床试验。研究人员于2000年3月至2004年11月在美国11个州的13所多学科脊柱医院进行患者注册。参试者为501例将要实施手术治疗的患者（平均年龄为42岁，女性占42％），患者经影像学检查确定患有腰椎间盘突出症，有持续性神经根性症状和体征至少6周。干预：为不同患者实施标准的开放性椎间盘切除术或非手术治疗。主要观测指标：主要观测指标为36项健康调查表中的疼痛躯体功能评分以及改良的Oswestry残疾指数（美国骨科医师协会MOdEMS版）在6周、3个月、1年及2年时较基线值发生的变化。次要观测指标包括坐骨神经痛的严重程度（采用坐骨神经疼痛的焦虑指数进行评估）、症状缓解的满意程度、疾病改善的自我报告及就业状况。结果：坚持按计划接受治疗的患者比较有限。在计划接受手术治疗的患者中，50％的患者在注册后3个月内进行了手术治疗；而在计划接受非手术治疗的患者中，有30％的患者在注册后3个月内接受了手术治疗。意向治疗分析表明，两个治疗组主要指标和次要指标都有实质性改善。在整个试验期间，改善情况的组间差异表明手术治疗效果较好，但是主要指标的差异较小，而且无统计学显著性。结论：手术治疗组和非手术治疗组患者的病情在2年随访期内都有实质性地改善。由于两组均有许多患者改变了治疗计划，所以我们难以根据治疗意向分析比较、确定两种治疗方式的优越性或等效性。

关键词：腰椎间盘突出症非手术治疗随机试验脊柱腰椎间盘切除术坐骨神经痛随机临床试验观测指标

熔融纺弹性纤维——弹性纤维技术与市场改变者

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国际纺织导报 2022年第12期50卷 4-5,24页

作者： J.Thiel P.K.Manvi I.Stappen T.B.M.Zhang T.Gries d.Cornils B.Minke 冯子卿(译) 孟粉叶(校) 亚琛工业大学技术研究所德国 FBW公司德国 Hohgardt公司德国不详

在过去几年,适用于服装和医用纺织品的弹性纱线市场需求增长迅速。目前,弹性纱线主要通过干法纺丝工艺生产,但弹性纱线的这种生产方式存在生产速度低、生产成本高、溶剂影响环境及纱线表面高黏性4个方面的局限性,从而使弹性纤维的进一... 详细信息

在过去几年,适用于服装和医用纺织品的弹性纱线市场需求增长迅速。目前,弹性纱线主要通过干法纺丝工艺生产,但弹性纱线的这种生产方式存在生产速度低、生产成本高、溶剂影响环境及纱线表面高黏性4个方面的局限性,从而使弹性纤维的进一步加工变得极为困难。ElasKosTex研究项目利用开发的熔融纺弹性双组分长丝作为这一问题的解决方案。

关键词：熔融纺弹性双组分纤维 ElasKosTex研究项目皮芯复合熔融纺丝

四价人乳头瘤病毒疫苗在中国境内9~26岁女性中的免疫原性和安全性研究:一项开放性、免疫桥接Ⅲ期临床试验

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中国妇产科临床杂志 2022年第1期23卷 4-8页

作者：黄竹航何剑锋苏家立欧志强刘桂秀付蓉寿琼郑明寰 thomas Group Alain Luxembourg 廖雪雁张吉凯广东省生物制品和药物研究所广州510440 广东省疾病预防控制中心默沙东(中国)投资有限公司默沙东总部(美国新泽西州)

目的四价人乳头瘤病毒疫苗(quadrivalent human papillomavirus,qHPV;HPV6/11/16/18型,临床试验注册号NCT03493542)于2017年在中国境内获批上市,适用于20~45岁女性。这项开放性Ⅲ期临床试验旨在评估并比较9~19岁和20~26岁中国境内女性四... 详细信息

目的四价人乳头瘤病毒疫苗(quadrivalent human papillomavirus,qHPV;HPV6/11/16/18型,临床试验注册号NCT03493542)于2017年在中国境内获批上市,适用于20~45岁女性。这项开放性Ⅲ期临床试验旨在评估并比较9~19岁和20~26岁中国境内女性四价HPV疫苗自第1剂接种至第7个月的免疫原性和安全性。方法9~26岁的受试者分别于第1天、第2个月和第6个月接种3剂次四价HPV疫苗。使用竞争性荧光免疫检测法(cLIA)分析首剂接种当天和第7个月时受试者血清样本中的抗-HPV6/11/16/18抗体几何平均滴度(GMT)和血清抗体阳转率。记录接种后30 d内的注射部位不良事件和全身性不良事件以及整个研究期间出现的严重不良事件。结果本研究共纳入766例接种至少1剂受试者(9~19岁组与20~26岁组各383例)。两个年龄组中所有符合免疫原性方案的受试者在第7个月时,疫苗所含四种HPV型别均产生血清学抗体阳转。9~19岁年龄组受试者在第7个月时产生的抗-HPV6/11/16/18 GMT值非劣效于20~26岁组受试者。9~19岁年龄组中,分别有36.6%和49.3%的受试者报告注射部位不良事件和全身性不良事件,20~26岁年龄组受试者中注射部位和全身性不良事件比例分别为40.7%和54.8%。没有发生疫苗相关严重不良事件。无受试者因不良事件终止研究,无死亡病例的报告。结论9~19岁中国境内女性中接种3剂次四价HPV疫苗后产生的抗体水平非劣效于20~26岁年龄组。该疫苗在研究人群中具有良好的耐受性。

关键词：中国境内预防性疫苗免疫桥接免疫原性四价人乳头瘤病毒疫苗安全性