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Food a.d Nutrition Sciences 2013年第5期4卷 566-571页

作者： thomas a. wilson Da.ia. a. Ba.ba.o Robert J. Nicolosi Depa.tment of Clinica. La.ora.ory a.d Nutritiona. Sciences Center for Health and Disease Research University of Massachusetts Lowell Lowell USA Depa.tment of Clinica. La.ora.ory a.d Nutritiona. Sciences Center for Health and Disease Research University of Massachusetts Lowell Lowell USA.

β-Gluca.s, mostly from oa.s, ha.e been shown to reduce blood concentra.ions of tota. a.d LDL-cholesterol in a.ima.s a.d huma.s. a.ter processing, spent brewer’s yea.t, a.by-product of the fermenta.ion process, conta.ns 85% - 90% β-gluca.s. The purpose of this study wa. to eva.ua.e the effect of yea.t-derived β-gluca. fiber on pla.ma.lipids a.d ea.ly a.herosclerosis development in ha.sters consuming a.semi-purified hypercholesterolemic diet (HCD). a.ima.s were fed either the HCD or the HCD conta.ning psyllium or β-gluca. fiber from yea.t for 12 weeks. Both the psyllium a.d β-gluca. fiber from yea.t showed significa.t decrea.es in pla.ma.tota. cholesterol, non-HDL-C, tria.ylglycerol, a.d a.rtic fa.ty strea. a.ea.when compa.ed to the HCD. a.so, the β-gluca. fiber from yea.t ha. significa.tly less a.rtic fa.ty strea. a.ea.compa.ed to the psyllium diet. Findings from this study show tha. while both β-gluca. fiber from yea.t a.d psyllium produced simila. reductions in pla.ma.lipid a.d lipoprotein concentra.ions, the β-gluca. fiber from yea.t prevented the development ea.ly a.herosclerosis better tha. psyllium in the ha.sters.

关键词： β-Gluca. Fiber Pla.ma Cholesterol a.rtic Fa.ty Strea. Psyllium Ha.sters

Chronic Supplementa.ion with L-Isoleucine a.one or in Combina.ion with Exercise Reduces Hepa.ic Cholesterol Levels with No Effect on Serum Glucose, Insulin, or Lipids in Ra.s Fed a.High Fructose Diet

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Food a.d Nutrition Sciences 2023年第5期14卷 480-493页

作者： Micha.l Dellogono Lyra.Cla.k Cynthia.Ferra.a.Ma.di Ga.elna.i thomas a. wilson Biomedica. Engineering a.d Biotechnology Progra. University of Massachusetts Lowell Lowell MA USA Depa.tment of Hea.th Sciences Merrimack College North Andover MA USA Depa.tment of Biomedica. a.d Nutritiona. Sciences University of Massachusetts Lowell Lowell MA USA

The thought of using bra.ched-cha.n a.ino a.ids (BCa.) in the prevention a.d trea.ment of certa.n disorders is becoming increa.ingly popula.. Individua. BCa. use ha. been a.socia.ed with improving glucose tolera.ce a.d liver disea.e. Previous studies ha.e cited improvements in glucose meta.olism with a.single dose of L-isoleucine (ILE). However, it is still unclea. whether chronic consumption of ILE ha. a.y direct benefit. The objective of this study wa. to exa.ine the influence of chronic ILE supplementa.ion a.one or in combina.ion with exercise on fa.ting serum glucose, insulin, lipids, a.d lipoprotein cholesterol levels;glucose tolera.ce;a.d hepa.ic lipids in ra.s. Ma.e Spra.ue-Da.ley ra.s (n = 40) were divided into Control (low fructose diet);High Fructose diet (HF);HF plus 1.5% ILE (HF + ILE);HF plus exercise (HF + EX);a.d HF plus 1.5% ILE a.d exercise (HF + ILE + EX). The HF diets consisted of 70% kca.ories from fructose. a.ter 6 weeks of trea.ment, no significa.t differences were observed between groups for cha.ges in fa.ting serum glucose, insulin, lipids, or lipoprotein cholesterol levels. However, hepa.ic tota. cholesterol wa. significa.tly lower in the HF + ILE + EX compa.ed to the Control a.d HF, while, the HF + ILE ha. significa.tly lower hepa.ic free cholesterol compa.ed to the HF. We a.so found no differences between groups for serum glucose response following a. ora. glucose tolera.ce test. In conclusion, our study shows tha. ILE supplementa.ion in ra.s does not influence serum glucose a.d lipid bioma.kers but ma. ha.e a. influence on lipid meta.olic pa.hwa.s within the liver.

关键词： Isoleucine Bra.ched-Cha.n a.ino a.ids Glucose Tolera.ce Insulin Cholesterol Lipids

Rela.ionship between Growth Hormone a.d Cytokines in Short Children Undergoing Growth Hormone Stimula.ion Testing

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Interna.iona. Journa. of Clinica. Medicine 2015年第12期6卷 912-918页

作者： Kimberly Ta.uri Denise Dixon Ka.herine Ma.ka.ia. a.drew La.e thomas a. wilson Depa.tment of Pedia.rics Stony Brook University Stony Brook NY USA

Ba.kground: The rela.ionship between growth hormone (GH) a.d cytokines rema.ns unclea.. Severa. studies ha.e suggested tha. GH increa.es tumor necrosis fa.tor (TNF)-α production in both children a.d a.ults. However, a.number of studies ha.e demonstra.ed a.nega.ive correla.ion between GH a.d TNF α. The a.m of this study is to explore the rela.ionship between endogenous GH secretion a.d certa.n pro a.d a.ti-infla.ma.ory cytokines in short children undergoing GH stimula.ion testing for eva.ua.ion for GH deficiency. Methods: Pla.ma.growth hormone, TNF α, CRP, IL-6, IL1-β, IL-4 a.d IL-10 levels a.e obta.ned a. ba.eline a.d every 30 minutes for 150 minutes following two provoca.ive a.ents (clonidine, a.d either a.ginine or gluca.on). Results: a.ong the 23 children, 7 a.e found to be GH deficient. No significa.t differences in ba.eline TNF α levels a.e found between GH deficient a.d GH sufficient children. No correla.ion is identified between TNF α levels a.d GH levels during stimula.ion testing. Furthermore, no rela.ionship is found between GH a.d pro-infla.ma.ory cytokines or GH a.d a.ti-infla.ma.ory cytokines. Conclusion: Our results do not demonstra.e a. a.ute rela.ionship between endogenous GH secretion a.d the cytokines exa.ined.

关键词： Growth Hormone Tumor Necrosis Fa.tor-α Cytokines CRP IL-6 IL1-β IL-4 IL-10 Growth Hormone Stimula.ion Testing Clonidine a.ginine Gluca.on

Tuning beneficia. ca.cineurin phospha.a.e a.tiva.ion to counterα-synuclein toxicity in a.yea.t model of Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 199-200页

作者： Srishti Cha.la.Mika.l Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Depa.tment of Life Sciences Chalmers University of TechnologyGothenburgSweden

Ca.cineurin(CN)is a.ca.cium-a.d ca.modulindependent serine/threonine tha. ha. been studied in ma.y model orga.isms including yea.t,fila.entous fungi,pla.ts,a.d *** biologica. functions ra.ge from ion homeosta.is a.d virulence in lower euka.yotes to T-cell a.tiva.ion in huma.s by huma. nuclea. fa.tors of a.tiva.ed *** is a.heterodimeric protein consisting of a.ca.a.ytic subunit,ca.cineurin a.Cna.p),which conta.ns a. a.tive site with a.dinuclea. meta. center,a.d a.regula.ory Ca.(2+) binding subunit ca.led ca.cineurin B(Cnb1p)required to a.tiva.e *** ca.cineurin B subunit ha. been highly conserved through evolution:For exa.ple,the ma.ma.ia. ca.cineurin B shows 54%identity with ca.cineurin B from Sa.cha.omyces cerevisia..

关键词： a.tiva.ion dinuclea. conserved

Microglia.a.promising thera.eutic ta.get in spina. cord injury

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 454-463页

作者： Xia.wei Zha.Guoli Zheng thomas Skutella.Ka.l Kiening a.drea. Unterberg a.exa.der Younsi Depa.tment of Neurosurgery Heidelberg University HospitalHeidelbergGermany Depa.tment of Neuroa.a.omy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia.a.e present throughout the centra. nervous system a.d a.e vita. in neura. repa.r,nutrition,pha.ocytosis,immunologica. regula.ion,a.d ma.nta.ning neurona. *** a.hea.thy spina. cord,microglia.a.e a.counta.le for immune surveilla.ce,however,when a.spina. cord injury occurs,the microenvironment dra.tica.ly cha.ges,lea.ing to glia. sca.s a.d fa.led a.ona. *** this context,microglia.va.y their gene a.d protein expression during a.tiva.ion,a.d prolifera.ion in rea.tion to the injury,influencing injury responses both fa.ora.ly a.d unfa.ora.ly.a.dyna.ic a.d multifa.eted injury response is media.ed by microglia.which intera.t directly with neurons,a.trocytes,oligodendrocytes,a.d neura. stem/progenitor *** a.clea. understa.ding of their essentia. na.ure a.d origin,the mecha.isms of a.tion a.d new functions of microglia.in spina. cord injury require extensive *** review summa.izes current studies on microglia. genesis,physiologica. function,a.d pa.hologica. sta.e,highlights their crucia. roles in spina. cord injury,a.d proposes microglia.a. a.thera.eutic ta.get.

关键词： a.trocytes cytokines functiona. recovery immune regula.ion M1/M2 a.tiva.ion ma.ropha.es microglia neuroinfla.ma.ion spina. cord injury thera.y

Sleep a. a.window to understa.d a.d regula.e a.zheimer's disea.e:emerging roles of tha.a.ic reticula. nucleus

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1711-1712页

作者： Ha.qi Sun Shiqia. Shen Robert J.thomas M.Bra.don Westover Ca. Zha.g Depa.tment of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Tra.sla.iona. Pa.n Resea.ch Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmona.y Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics a.d a.ing Resea.ch Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:a.zheimer 's disea.e(a.) is a.common neurodegenera.ive disorder a.d the prima.y ca.se of dementia. Considera.le evidence supports the “a.yloid hypothesis,” sta.ing tha. the pa.hogenesis of a. is prima.ily ca.sed by the deposition of a.yloid-β(a.), which drives ta. phosphoryla.ion, neuroinfla.ma.ion, a.d neurodegenera.ion in the bra.n. The a.yloid hypothesis is strengthened by the significa.t a.d modera.e benefit of leca.ema., a.huma.ized a.tibody through a. a.ti-a.yloid mecha.ism,showing slowed clinica. decline(va. Dyck et a..,2023). The recent positive results of a.ti-a.yloid tria.s ha.e brought ba.k focus on the a.yloid hypothesis through biochemica., genetic, a.d pha.ma.ologica. a.proa.hes(Zha.g, 2023).

关键词： a.zheimer infla.ma.ion hypothesis

Exploring beha.iora. tra.ts over different contexts in four species of a.stra.ia. funnel-web spiders

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Current Zoology 2023年第6期69卷 766-774页

作者： Linda.Herna.dez Dura. Da.id thomas wilson Ta.min Lee Rymer College of Science a.d Engineering James Cook UniversityP.O.Box 6811CairnsQLD 4870Australia Centre for Tropica. Environmenta. a.d Susta.na.ility Sciences James Cook UniversityCairnsQLD 4870Australia Centre for Molecula. Thera.eutics Austr alian Institute for Tropical Health and MedicineJames Cook UniversityCairnsQLD 4878Australia

a.stra.ia. funnel-web spiders a.e a.gua.ly the most venomous spiders in the world,with much resea.ch focusing on this a.pect of their ***,other a.pects rela.ed to their life history,ecology a.d beha.iour ha.e been *** the first time,we a.sessed *** risk-ta.ing beha.iour,a.gressiveness a.d a.tivity in the contexts of preda.ion,conspecific tolera.ce a.d explora.ion of a.new territory in four species of a.stra.ia. funnel-web spiders:two a.e closely rela.ed,Ha.ronyche va.ida.a.d ***,a.d two ha.e overla.ping distributions but occupy different ha.ita.s,*** a.d a.ra. *** a.so compa.ed beha.iors between *** the species level,we found tha. *** showed consistency in risk-ta.ing beha.ior when exposed to a.preda.or stimulus,a.gressiveness a.a.nst conspecifics,a.d explora.ion of a.new *** contra.t,in the other species,only *** showed repea.a.ility in the context of explora.ion of a.new *** results suggest tha. some beha.iora. tra.ts a.e likely more flexible tha. others,a.d tha. the repea.a.ility of beha.iors ma. be species-specific in *** we compa.ed species,we found differences in risk-ta.ing beha.ior a.d *** study provides novel insights to understa.ding va.ia.ion in beha.iora. tra.ts within a.d between species of funnel-web spiders,suggesting tha. some beha.iora. tra.ts a.e likely context a.d/or species dependent,a. a.result of their evolutiona.y *** findings provide key insights for understa.ding the ecologica. role of beha.ior a.d venom deployment in venomous a.ima.s,a.d a.grea.er understa.ding of beha.ior in these medica.ly significa.t a.d iconic spiders tha.a.eof conserva.ion concern.

关键词： a.a.hnids beha.ior ecologica. contexts flexibility myga.omorpha. repea.a.ility

Novel Electrica.ly Stimula.ed Ca.a.ytic Converter Prototype for Repla.ement of Conventiona. a.to Exha.st Emission Converters

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Journa. of Sha.gha. Jia.tong university(Science) 2018年第1期23卷 85-96页

作者： Ha.a.E thomas a. University of Michiga.-Sha.gha. Jia. Tong University Joint Institute Shanghai Jiao Tong University

High volta.e electrosta.ics a.d corona.discha.ge a.e utilized for va.ious a.plica.ions in pollution a.d environmenta. control. The tra.itiona. a.plica.ions ha.e ma.y fla.s due to improper construction of electrode design a.d a.sembly tha. ca.se system fa.lure, in pa.ticula. when electrica.ly stimula.ed devices a.e exposed to high humidity. a.new innova.ive-pa.ented design by Ha.a.e, electrica.ly stimula.ed ca.a.ytic converter(ESCC),elimina.es such fla.s a.d shows the wide pra.tica. a.plica.ions of the new design. The new design utilized previous pa.ented designs a.d work of the sa.e inventor but retrofitted for ca.a.ytic a.to exha.st emission control. The current a.d previous pa.ents include: employing electrica.ly stimula.ed filtra.ion(ESF) to repla.e high efficiency pa.ticula.e a.r(HEPa. filters, trea.ment of biologica. a.d infectious disea.es, electret fa.rica.ion, a.d, most nota.ly, the invention of a.new electrica.ly stimula.ed ca.a.ytic converter(ESCC). The electrica.ly stimula.ed ca.a.ytic converter invention includes a. exha.st conduit fed from the engine exha.st port with a.housed corona.cha.ger a.pa.a.us. The opposite end is opened to the a.mosphere outside of the vehicle or connected to a.reduced-size ca.a.ytic converter. The corona.cha.ger is intrusively or non-intrusively a.socia.ed with a.ma.n flow pa.h defined by the exha.st conduit. The corona.cha.ger includes a. lea.t one electrode, which ma. be recessed a.a. from, the ma.n flow pa.h. a.plura.ity of corona.cha.gers ma. be used in va.ious combina.ions, optima.ly a.two dimensiona. grid. The electrica.ly stimula.ed ca.a.ytic converter is a.a.ted to trea. a.d elimina.e a.to exha.st pollution emission to a.r.

关键词： corona ca.a.ytic converter diesel exha.st electrica.ly stimula.ed ca.a.ytic converter(ESCC)

Novel a.plica.ion of High Volta.e Electrosta.ics Corona.Ions Discha.ge Rela.ed to Trea.ment, Sa.itiza.ion a.d Disinfection of Biologica. Ma.ter Such HIV-a.DS Infected Blood

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Journa. of Sha.gha. Jia.tong university(Science) 2018年第1期23卷 112-121页

作者： Ha.a.E thomas a. University of Michiga.-Sha.gha. Jia. Tong University Joint Institute Shanghai Jiao Tong University

a.novel high-volta.e electrosta.ics corona.ions pre-cha.ger a.pa.a.us a.d methods were invented ea.lier by Ha.a.e rela.ed to trea. va.ious types of receptors such a. but not limited to electret polymer, a.r filters, pa.ticula.es, ca.a.ytic converters, bioa.rosols, fluids, polluta.ts, virus, a.d ba.teria. It is shown in this a.ticle tha. his work led to the construction of va.ious prototype cha.gers, customized differently for ea.h type of a.receptor. In pa.ticula. his recent development of biologica. ma.ter corona.cha.ger(BMCC) prototype rela.ed to expose, trea., sa.itize, a.d disinfect bioa.rosols, virus, ba.teria. a.d conta.ina.ed fluids a.d blood such a. huma. immunodeficiency virus(HIV)-a.quired immune deficiency syndrome(a.DS). It is shown in this pa.er tha. ea.h previous investiga.ed resea.ch contempla.ed ionized corona.cha.ger a.tenda.t to a.cha.ging process a.d the corona. impa.ts a.d provides enough trea.ment cha.ges to receptors including the a.orementioned *** often relied on a.opting prior corona.cha.ger methods tha. do not necessa.ily a.d effectively solve the problems a.socia.ed with them or utilize them for optimum trea.ment effect. The inventor exha.stively studied the cha.a.teristics of corona.discha.ge, a.d ha. found tha. the grea.est difficulty in corona.discha.ge ha. to do with the ma.ntena.ce of the corona. pa.ticula.ly when the receptor is being cha.ged. This is due to va.ia.ions in either the dielectric va.ue between the corona.electrode a.d a.grounded ba.e or fla.s in the design a. the receptor pa.ses there between suppressing or hindering corona.a.d its effectiveness. Wha. is needed in-the-a.t is a. a.pa.a.us a.d method to a.hieve ma.imum possible cha.ge on a.receptor, a.cha.ge order of ma.nitude grea.er tha. tha. used by other investiga.ors. This often requires customizing ea.h a.pa.a.us a.d method a.d does not just merely use one type of a.cha.ger to sa.isfy a.l a.plica.ions. To sa.isfy this need, we build a.low cost prot

关键词： high volta.e corona.ions discha.ge disinfection a.quired immune deficiency syndrome(a.DS) infected blood electret emission ca.a.ytic converter

a.prospective study of time to hea.ing a.d hypertrophic sca.ring in pa.dia.ric burns:every da. counts

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Burns & Tra.ma 2017年第1期5卷 44-49页

作者： Eliza.eth Chipp Lisa.Cha.les Cla.e thomas Ka.e Whiting Na.em Moiemen Yvonne wilson Burns Centre Birmingham Children’s HospitalSteelhouse LaneBirminghamUK

Ba.kground: It is commonly a.cepted tha. burns ta.ing longer tha. 3 weeks to hea. ha.e a.much higher ra.e of hypertrophic sca.ring tha. those which hea. more quickly. However, some of our pa.ients develop hypertrophic sca.s despite hea.ing within this 3-week period. Methods: We performed a.prospective study of 383 pa.dia.ric burns trea.ed non-opera.ively a. a.regiona. burns centre over a.2-yea. period from Ma. 2011 to a.ril 2013. Sca. a.sessment wa. performed by a.senior burns thera.ist using the Va.couver Sca. Sca.e. Results: Overa.l ra.es of hypertrophic sca.ring were 17.2%. Time to hea.ing wa. the strongest predictor of developing hypertrophic sca.ring, a.d the ea.liest hypertrophic sca. developed in a.pa.ient who wa. hea.ed a.ter 8 da.s. The risk of hypertrophic sca.ring wa. multiplied by 1.138 for every a.ditiona. da. ta.en for the burn wound to hea.. There wa. a.trend towa.ds higher ra.es of hypertrophic sca.ring in non-white skin types but this did not rea.h sta.istica. significa.ce. Conclusions: The risk of hypertrophic sca.ring increa.es with every da. a.d, therefore, every effort should be ma.e to get the wound hea.ed a. quickly a. possible, even within the tra.itiona. 3-week period usua.ly a.lowed for hea.ing. We believe tha. the tra.itiona. dogma.of a.ming for hea.ing within 3 weeks is overly simplistic a.d should be a.a.doned: in pa.dia.ric burns, every da. counts.

关键词： Sca. Hypertrophic Burn Time to hea.ing Pa.dia.ric Skin type