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Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

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Nano-Micro Letters 2021年第6期13卷 284-294页

作者： yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Georges Humbert Libo Ma yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang yu Ho-Pui Ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Applied Physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Faculty of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting ***,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change *** precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift *** on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical *** this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of *** as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

关键词： 2D nanomaterials Cancer marker detection Phase singularity Surface plasmon

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2018 Continues Record Global Ocean Warming

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Advances in Atmospheric Sciences 2019年第3期36卷 249-252页

作者： Lijing CHENG Jiang ZHU John ABRAHAM Kevin E.TRENBERTH John T.FASULLO Bin ZHANG Fujiang yu Liying WAN Xingrong CHEN Xiangzhou SONG International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of Sciences University of St.thomas School of Engineering National Center for Atmospheric Research Institute of Oceanology Chinese Academy of Sciences Center for Ocean Mega-Science Chinese Academy of Sciences National Marine Environmental Forecasting Center Ministry of Natural Resources of China College of Oceanography Hohai University Bureau of Territorial and Spatial Planning Ministry of Natural Resources

The increasing heat-trapping gases emitted by human activities into the atmosphere produce an energy imbalance between incoming solar radiation and outgoing longwave radiation that leads to global heating(Rhein et al.,2013;Trenberth et al.,2014;von Schuckmann et al.,2016).The vast majority of global warming heat ends up deposited in the world’s oceans,and ocean heat content(OHC)change is one of the best—if not the best—metric for climate change(Cheng et al.,2019).In 2018,continued record heat was measured in the Earth’s climate *** fact,2018 has set a new record of ocean heating,surpassing 2017,which was the previous warmest year ever recorded(Cheng et al.,2018)(Fig.1).

关键词： increasing heat-trapping activities imbalance

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“爱迪生”珍珠及染色处理有核珍珠的谱学特征

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光谱学与光谱分析 2021年第8期41卷 2626-2632页

作者：于蕾王雅玫中国地质大学(武汉)珠宝学院湖北武汉430074

颗粒大、圆度高并具有浓郁颜色的淡水有核养殖珍珠(商贸名称为“爱迪生”珍珠)为珍珠市场提供了更高的品质与价值,然而受利益的驱使,染色的有核养殖珍珠也逐渐流入市场,扰乱了消费者的健康消费,在一定程度上阻碍了“爱迪生”珍珠产业的... 详细信息

颗粒大、圆度高并具有浓郁颜色的淡水有核养殖珍珠(商贸名称为“爱迪生”珍珠)为珍珠市场提供了更高的品质与价值,然而受利益的驱使,染色的有核养殖珍珠也逐渐流入市场,扰乱了消费者的健康消费,在一定程度上阻碍了“爱迪生”珍珠产业的良性发展。本文利用红外光谱仪、紫外—可见分光光度计和光致发光光谱仪对养殖和染色“爱迪生”珍珠进行了系统的谱学研究,并将其与海水珍珠、染色海水珍珠进行了比较。结果表明:(1)染色与养殖“爱迪生”珍珠在红外光谱上均显示1445,882和725 cm^(-1)处的文石振动峰,其中染色“爱迪生”珍珠在3800 cm^(-1)处均出现宽缓的弱吸收峰;(2)染色“爱迪生”珍珠的紫外可见光光谱中280 nm处的吸收峰明显弱于养殖“爱迪生”珍珠,染色后的“爱迪生”珍珠整体反射率降低,可能与染剂使珍珠中的蛋白质分子受损有关。染黄色“爱迪生”珍珠缺失养殖橙黄色“爱迪生”珍珠在360~380 nm处的吸收峰,而与染色海水金珠430 nm处的强吸收峰相似。染黑色“爱迪生”珍珠在425 nm处有吸收峰,染色海水黑珍珠在480和645 nm处有吸收峰,养殖海水黑珍珠在702 nm处有吸收峰,三者图谱的差异可能为各自的染料不同所致;(3)养殖“爱迪生”珍珠在光致发光光谱中450~550 nm范围内可见一组吸收峰,染色“爱迪生”珍珠的发光中心向红区偏移且在650 nm附近出现强度不等的与染色剂相关的吸收峰,染色海水金珠也在600 nm处有和染色剂有关的吸收峰。

关键词： “爱迪生”珍珠有核养殖染色处理光谱学特征

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公司交通政策的最佳实践——以比利时为例

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城市交通 2012年第4期10卷 79-90页

作者： Laurent Van Malderen Bart Jourquin Isabelle thomas thomas Vanoutrive Ann Verhetsel Frank Witlox 张宇天主教鲁汶大学鲁汶管理学院天主教鲁汶大学运筹学与计量经济学中心及地理学院安特卫普大学交通与区域经济系根特大学地理系中国城市规划设计研究院北京100037

公司是通勤交通的主要创造者,在与交通相关的讨论中,公司扮演着重要角色。近几年,公司提出了多种政策措施,以改善员工的出行条件,但其愿景与行动通常被研究文献所忽视。为了讨论比利时公司在交通政策方面的最佳实践,分析了现有研究成果... 详细信息

公司是通勤交通的主要创造者,在与交通相关的讨论中,公司扮演着重要角色。近几年,公司提出了多种政策措施,以改善员工的出行条件,但其愿景与行动通常被研究文献所忽视。为了讨论比利时公司在交通政策方面的最佳实践,分析了现有研究成果和比利时的两次大规模通勤交通调查。首先,对公司进行分类,以便确定在推广替代交通方式方面受员工欢迎的公司。然后,通过量化分析确定交通政策的最佳实践。结果显示,最佳替代交通方式取决于公司特征;自行车交通最适合小型工作场所,大型工作场所和位于建筑密集区或市中心的公司则更适合推广公共交通;在公司交通管理中,财务激励、设施提供、信息传播和停车管理均起重要作用。

关键词：通勤交通雇主交通计划可持续交通

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托马斯·马丁的语言文论与可能世界理论

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文学评论 2020年第4期 65-72页

作者：张瑜浙江工商大学人文与传播学院

托马斯·马丁运用可能世界语义学对文学定义、文学意义等问题做出新的阐释和探索,为我们展现了21世纪语言文论发展的新的可能图景。他采用辛迪卡关于语言的两种观点——“语言作为普遍媒介”和“语言作为微积分”,分别对20世纪占据支配... 详细信息

托马斯·马丁运用可能世界语义学对文学定义、文学意义等问题做出新的阐释和探索,为我们展现了21世纪语言文论发展的新的可能图景。他采用辛迪卡关于语言的两种观点——“语言作为普遍媒介”和“语言作为微积分”,分别对20世纪占据支配地位的语言观做了总结并提出了替代方案,即建立以可能世界为前提和框架的新语言观。新语言观揭示了语言的可能性本质,由此初步构建起与20世纪语言文论存在鲜明差别的新语言文论雏形,为当前处于低潮的语言文论提供了一个富有启发意义的思考。

关键词：可能世界语义学语言文论模态逻辑语义

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Impact of immunosuppression on incidence of post-transplant diabetes mellitus in solid organ transplant recipients:Systematic review and meta-analysis

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World Journal of Transplantation 2021年第10期11卷 432-442页

作者： Sreelakshmi Kotha Bishoy Lawendy Saira Asim Charlene Gomes Jeffrey yu Ani Orchanian-Cheff George Tomlinson Mamatha Bhat Department of Gastroenterology Guy's and St Thomas'HospitalLondon SE17JDUnited Kingdom Department of Multi-Organ Transplantation Toronto General HospitalToronto M5G 2C4Canada Multi Organ Transplant Program Toronto General HospitalToronto M5G 2C4Canada Dalla Lana School of Public Health Department of MedicineUniversity Health Network-Toronto General HospitalUniversity of TorontoToronto M5G 2C4Canada Multi-organ Transplant Toronto General HospitalToronto M5G 2C4Canada

BACKGROUND Solid organ transplantation is a life-saving intervention for end-stage organ ***-transplant diabetes mellitus(PTDM)is a common complication in solid organ transplant recipients,and significantly compromises long-term survival beyond a *** To perform a systematic review and meta-analysis to estimate incidence of PTDM and compare the effects of the 3 major immunosuppressants on incidence of *** Two hundred and six eligible studies identified 75595 patients on Tacrolimus,51242 on Cyclosporine and 3020 on *** effects meta-analyses was used to calculate *** Network meta-analysis estimated the overall risk of developing PTDM was higher with tacrolimus(OR=1.495%CI:1.0–2.0)and sirolimus(OR=1.8;95%CI:1.5–2.2)than with *** overall incidence of PTDM at years 2-3 was 17%for kidney,19%for liver and 22%for *** risk factors for PTDM most frequently identified in the primary studies were age,body mass index,hepatitis C,and African American *** Tacrolimus tends to exhibit higher diabetogenicity in the short-term(2-3 years post-transplant),whereas sirolimus exhibits higher diabetogenicity in the longterm(5-10 years post-transplant).This study will aid clinicians in recognition of risk factors for PTDM and encourage careful evaluation of the risk/benefit of different immunosuppressant regimens in transplant recipients.

关键词： Post-transplant diabetes mellitus solid organ transplantation Tacrolimus Cyclosporin Sirolimus

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Shear wave elastography results correlate with liver fibrosis histology and liver function reserve

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World Journal of Gastroenterology 2016年第17期22卷 4338-4344页

作者： Yan-Hong Feng Xiang-Dong Hu Lin Zhai Ji-Bin Liu Lan-Yan Qiu yuan Zu Si Liang yu Gui Lin-Xue Qian Department of Ultrasound Medicine Beijing Friendship Hospital Capital Medical University Division of Diagnostic Ultrasound Department of Radiology Thomas Jefferson University

AIM: To evaluate the correlation of shear wave elastography (SWE) results with liver fibrosis histology and quantitative function reserve. METHODS: Weekly subcutaneous injection of 60% carbon tetrachloride (1.5 mL/kg) was given to 12 canines for 24 wk to induce experimental liver fibrosis, with olive oil given to 2 control canines. At 24 wk, liver condition was evaluated using clinical biochemistry assays, SWE imaging, lidocaine metabolite monoethylglycine-xylidide (MEGX) test, and histologic fibrosis grading. Clinical biochemistry assays were performed at the institutional central laboratory for routine liver function evaluation. Liver stiffness was measured in triplicate from three different intercostal spaces and expressed as mean liver stiffness modulus (LSM). Plasma concentrations of lidocaine and its metabolite MEGX were determined using high-performance liquid chromatography repeated in duplicate. Liver biopsy samples were fixed in 10% formaldehyde, and liver fibrosis was graded using the modified histological activity index Knodell score (F0-F4). Correlations among histologic grading, LSM, and MEGX measures were analyzed with the Pearson linear correlation coefficient. RESULTS: At 24 wk liver fibrosis histologic grading was as follows: F0, n = 2 (control); F1, n = 0; F2, n = 3; F3, n = 7; and F4, n = 2. SWE LSM was positively correlated with histologic grading (r = 0.835, P < 0.001). Specifically, the F4 group had a significantly higher elastic modulus than the F3, F2, and F0 groups (P = 0.002, P = 0.003, and P = 0.006, respectively), and the F3 group also had a significantly higher modulus than the control F0 group (P = 0.039). LSM was negatively associated with plasma MEGX concentrations at 30 min (r = -0.642; P = 0.013) and 60 min (r = -0.651; P = 0.012), time to 1/2 of the maximum concentration (r = -0.538; P = 0.047), and the area under the curve (r = -0.636; P = 0.014). Multiple comparisons showed identical differences in these three measures: signific

关键词： Liver fibrosis Histologic grading Shear wave elastography Monoethylglycinexylidide test Experimental study

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An optimized protocol for stepwise optimization of real-time RT-PCR analysis

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Horticulture Research 2021年第1期8卷 2474-2494页

作者： Fangzhou Zhao Nathan A.Maren Pawel Z.Kosentka Ying-yu Liao Hongyan Lu James R.Duduit Debao Huang Hamid Ashrafi Tuanjie Zhao Alejandra I.Huerta thomas G.Ranney Wusheng Liu Soybean Research Institute Nanjing Agricultural University210095 NanjingChina Department of Horticultural Science North Carolina State UniversityRaleighNC 27607USA Mountain Crop Improvement Lab Department of Horticultural ScienceMountain Horticultural Crops Research and Extension CenterNorth Carolina State UniversityMills RiverNC 28759USA Department of Entomology and Plant Pathology North Carolina State UniversityRaleighNC 27607USA College of Biosystems Engineering and Food Science Zhejiang University310058 HangzhouChina

Computational tool-assisted primer design for real-time reverse transcription(RT)PCR(qPCR)analysis largely ignores the sequence similarities between sequences of homologous genes in a plant *** can lead to false confidence in the quality of the designed primers,which sometimes results in skipping the optimization steps for ***,the optimization of qPCR parameters plays an essential role in the efficiency,specificity,and sensitivity of each gene’s ***,we proposed an optimized approach to sequentially optimizing primer sequences,annealing temperatures,primer concentrations,and cDNA concentration range for each reference(and target)*** approach started with a sequence-specific primer design that should be based on the single-nucleotide polymorphisms(SNPs)present in all the homologous sequences for each of the reference(and target)genes under *** combining the efficiency calibrated and standard curve methods with the 2−ΔΔCt method,the standard cDNA concentration curve with a logarithmic scale was obtained for each primer pair for each *** a result,an R 2≥0.9999 and the efficiency(E)=100±5% should be achieved for the best primer pair of each gene,which serve as the prerequisite for using the 2^(−ΔΔCt) method for data *** applied our newly developed approach to identify the best reference genes in different tissues and at various inflorescence developmental stages of Tripidium ravennae,an ornamental and biomass grass,and validated their utility under varying abiotic stress *** also applied this approach to test the expression stability of six reference genes in soybean under biotic stress treatment with Xanthomonas axonopodis ***(Xag).Thus,these case studies demonstrated the effectiveness of our optimized protocol for qPCR analysis.

关键词： optimization analysis stepwise

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特提斯域铝土矿物源及其构造背景转变：基于随机森林模型的分析

特提斯域铝土矿物源及其构造背景转变：基于随机森林模型的分析

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2022年中国地球科学联合学术年会

作者： Jintao Zhou Wenchao yu thomas J.Algeo Wei Wei yuansheng Du China University of Geosciences Innovation Center of Ore Resources Exploration Technology in the Region of Bedrock University of Cincinnati

近年来几乎所有经济领域对铝资源的需求都在快速增长,这促使我们需要进一步加强对铝土矿成矿作用的研究。虽然特提斯成矿域中喀斯特型铝土矿储量丰富,但多数研究仅局限于单一区域和时代,其整体性的成因和分布的控制因素仍不清楚。在这里...

近年来几乎所有经济领域对铝资源的需求都在快速增长,这促使我们需要进一步加强对铝土矿成矿作用的研究。虽然特提斯成矿域中喀斯特型铝土矿储量丰富,但多数研究仅局限于单一区域和时代,其整体性的成因和分布的控制因素仍不清楚。在这里,我们使用随机森林模型来分析特提斯成矿域内的三个铝土矿省(即地中海、中亚和中国省)的地球化学主量元素数据集,

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室内三种富营养模拟条件下水流调控对羊栖菜和石莼生长及生物质合成的影响

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浙江农业学报 2018年第8期30卷 1398-1407页

作者：于琰 WERNBERG thomas DE BETTIGNIES Thibaut 潘耀茹李超林芳周朝生黄志行吴嘉平肖溪浙江大学海洋学院浙江舟山316021 西澳大学植物生物学学院澳大利亚珀斯6009 国家自然历史博物馆法国巴黎75005 浙江大学环境与资源学院浙江杭州310058 浙江海洋水产养殖研究所浙江温州325005

大型海藻养殖是一种低成本、高效、环保的水体富营养化生物修复方法,而水流则是影响大型海藻生长的一个重要因素。研究结果表明,水流交换率为200 vol·d-1时,羊栖菜(Sargassum fusiforme)比生长率最高达(4.34±0.11)%·d-1,而水流交换率... 详细信息

大型海藻养殖是一种低成本、高效、环保的水体富营养化生物修复方法,而水流则是影响大型海藻生长的一个重要因素。研究结果表明,水流交换率为200 vol·d-1时,羊栖菜(Sargassum fusiforme)比生长率最高达(4.34±0.11)%·d-1,而水流交换率为100 vol·d-1、中高浓度营养盐条件下石莼(Ulva pertusa)比生长率最大值分别可达(6.31±1.42)%·d-1、(8.00±0.79)%·d-1,营养盐浓度决定了两种大型海藻的生长率,石莼更适宜在高营养盐环境中生长。石莼体内叶绿素a、可溶性蛋白和可溶性碳水化合物在不同应用情境间均存在明显差异,而羊栖菜体内仅可溶性蛋白表现出明显变化。水流交换的增强明显改变了石莼的生长和羊栖菜可溶性碳水化合物含量。陆基中试实验表明,与低水流速度相比,中、高流速条件下羊栖菜的比生长率分别增加80%、14%,石莼则分别增加41.3%、33.3%。

关键词：水流交换大型海藻色素生长率富氮化合物

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