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BIGH3: A Negative Regulator of Human Osteosarcoma Large Multicellular spheroids

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International Journal of Clinical Medicine 2016年第11期7卷 771-791页

作者： Brian s. thoma.Robert J. Moritz Fatemeh Rezapoor Chandler T. sargent Clyde F. Phelix Richard G. LeBaron Department of Biology The University of Texas at San Antonio One UTSA Circle San Antonio TX USA

Numerous studies have demonstrated a relationship between the extracellular matrix protein BIGH3 and variations in the malignant properties of different cancer cell types, including osteosarcoma cells. BIGH3 protein can suppress and promote tumor growth, even on the same cancer cell type, indicating that contextual cues regulate BIGH3-mediated divergent outcomes. We employed a multicellular tumor spheroid model to study the effects of BIGH3 with respect to physical and molecular features of three-dimensional tumor growth. The results demonstrated that exogenous recombinant BIGH3 blocked the development of multicellular large tumor spheroids so that only small spheroids formed. The effect was dependent on the BIGH3 concentration in the growth medium and the time of incubation of BIGH3 with the osteosarcoma cells in the spheroid model. TGF-β1 signaling induced multicellular tumor spheroids to synthesize a greater quantity of BIGH3 relative to non-treated spheroids. The TGF-β1-mediated increase in BIGH3 protein antagonized the development of multicellular large spheroids. Anti-BIGH3 antibody, and an inhibitor of TGF-β1 signaling, blocked the antagonistic effect induced through TGF-β1 stimulation and BIGH3 protein expression, resulting in the formation of multicellular large spheroids. Immunohistochemistry detected BIGH3 at cell bodies within the spheroid stroma, suggesting osteosarcoma cell-surface proteins bind BIGH3. Flow cytometry demonstrates that osteosarcoma cells interact with soluble BIGH3, and solid-phase cell adhesion assays show that osteosarcoma adhesion to BIGH3 substratum is mediated by integrin α4β1. However, anti-α4 antibody did not attenuate the BIGH3-mediated antagonism toward formation of multicellular large spheroids. We conclude that TGFβ1 and BIGH3 suppress the development of large osteosarcoma tumors.

关键词： Cancer 3-Dimensional TGFβ1 Extracellular Matrix TGFBI Beta-ig

Assessment of Uinta Basin Oil and Natural Gas Well Pad Pneumatic Controller Emissions

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Journal of Environmental Protection 2017年第4期8卷 394-415页

作者： Eben D. thoma.Parikshit Deshmukh Russell Logan Michael stovern Chris Dresser Halley L. Brantley Office of Research and Development National Risk Management Research Laboratory U.S. EPA Durham NC USA Jacobs Technology Inc. Durham NC USA Region 8 U.S. EPA Denver CO USA ORIsE Participant U.S. EPA Office of Research and Development National Risk Management Research Laboratory Durham NC USA

In the fall of 2016, a field study was conducted in the Uinta Basin Utah to improve information on oil and natural gas well pad pneumatic controllers (PCs) and emission measurement methods. A total of 80 PC systems at five oil sites (supporting six wells) and three gas sites (supporting 12 wells) were surveyed, and emissions data were produced using a combination of measurements and engineering emission estimates. Ninety-six percent of the PCs surveyed were low actuation frequency intermittent vent type. The overall whole gas emission rate for the study was estimated at 0.36 scf/h with the majority of emissions occurring from three continuous vent PCs (1.1 scf/h average) and eleven (14%) malfunctioning intermittent vent PC systems (1.6 scf/h average). Oil sites employed, on average 10.3 PC systems per well compared to 1.5 for gas sites. Oil and gas sites had group average PC emission rates of 0.28 scf/h and 0.67 scf/h, respectively. This difference was due in part to differing site selection procedures used for oil and gas sites. The PC system types encountered, the engineering emissions estimate approach, and comparisons to measurements are described. survey methods included identification of malfunctioning PC systems and emission measurements with augmented high volume sampling and installed mass flow meters, each providing a somewhat different representation of emissions that are elucidated through example cases.

关键词： Pneumatic Controller Emissions Oil and Natural Gas Production Uinta Basin Methane Volatile Organic Compounds

偏头痛与缺血性脑卒中有相关性,但风险低且可以控制

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英国医学杂志中文版 2005年第3期8卷 138-139页

作者： D J thoma.高晶 st Mary's Hospital LondonW21NY

偏头痛和缺血性脑卒中都是常见病,当病人同时出现这两种疾病时我们很少感到惊讶--但它们之间有没有因果关系呢?Etminan等在一篇汇总分析中为证明二者有因果关系提供了进一步的证据1(见本期第151页).而以前有资料证实偏头痛未增加出血性... 详细信息

偏头痛和缺血性脑卒中都是常见病,当病人同时出现这两种疾病时我们很少感到惊讶--但它们之间有没有因果关系呢?Etminan等在一篇汇总分析中为证明二者有因果关系提供了进一步的证据1(见本期第151页).而以前有资料证实偏头痛未增加出血性脑卒中的风险2.

关键词：缺血性脑卒中偏头痛风险相关性控制出血性脑卒中因果关系汇总分析常见病

Erratum to “Assessment of Uinta Basin Oil and Natural Gas Well Pad Pneumatic Controller Emissions” [Journal of Environmental Protection, 2017, 8, 394-415]

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Journal of Environmental Protection 2017年第12期8卷 1445-1445页

作者： Eben D. thoma Office of Research and Development National Risk Management Research Laboratory U.S. EPA Durham NC USA

关键词： Pneumatic Controller Emissions Oil and Natural Gas Production Uinta Basin Methane Volatile Organic Compounds

Precision health: A nursing perspective

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International Journal of Nursing sciences 2020年第1期7卷 5-12页

作者： Mei R.Fu Emma Kurnat-thoma.Angela starkweather Wendy A.Henderson Ann K.Cashion Janet K.Williams Maria C.Katapodi Karin Reuter-Rice Kathleen T.Hickey Veronica Barcelona de Mendoza Kathleen Calzone Yvette P.Conley Cindy M.Anderson Debra E.Lyon Michael T.Weaver Pamela K.shiao Rose E.Constantino shu-Fen Wung Marilyn J.Hammer Joachim G.Voss Bernice Coleman William F.Connell school of Nursing Boston CollegeChestnut HillMAUSA National Institute of Nursing Research National Institutes of HealthBethesdaMDUSA school of Nursing and Health studies Georgetown UniversityWashingtonDCUSA school of Nursing University of ConnecticutStorrsCTUSA school of Nursing The University of IowaIowa CityIAUSA Nursing science University of BaselBaselSwitzerland school of Nursing Duke UniversityDurhamNCUSA school of Nursing Columbia UniversityNew YorkNYUSA school of Nursing Yale UniversityOrangeCTUSA National Cancer Institute Center for Cancer ResearchGenetic BranchBethesdaMDUSA school of Nursing University of PittsburghPittsburghPAUSA College of Nursing The Ohio State UniversityOHUSA University of Florida Gainesville FLUSA Center for Biotechnology and Genomic Medicine Medical College of GeorgiaAugusta UniversityAugustaGAUSA College of Nursing The University of Arizona TucsonAZUSA Dana-Farber Cancer Institute 450 Brookline AvenueLW523BostonMAUSA Frances Payne Bolton school of Nursing Case Western Reserve UniversityClevelandOHUSA Nursing Research and Development Cedars-Sinai Medical CenterLos AngelesUSA

Precision health refers to personalized healthcare based on a person's unique genetic,genomic,or omic composition within the context of lifestyle,social,economic,cultural and environmental influences to help individuals achieve well-being and optimal *** health utilizes big data sets that combine omics(*** sequence,protein,metabolite,and microbiome information)with clinical information and health outcomes to optimize disease diagnosis,treatment and prevention specific to each *** implementation of precision health requires interprofessional collaboration,community outreach efforts,and coordination of care,a mission that nurses are well-positioned to *** the surge of interest and attention to precision health,most nurses are not well-versed in precision health or its implications for the nursing *** on a critical analysis of literature and expert opinions,this paper provides an overview of precision health and the importance of engaging the nursing profession for its *** topics reviewed in this paper include big data and omics,information science,integration of family health history in precision health,and nursing omics research in symptom *** paper concludes with recommendations for nurse leaders in research,education,clinical practice,nursing administration and policy settings for which to develop strategic plans to implement precision health.

关键词： Nurses Genomics Omics Precision medicine Precision health

New and noteworthy records of lichens from Pathanamthitta district,Kerala,India

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studies in Fungi 2018年第1期3卷 349-356页

作者： Zachariah sA Nayaka s Joseph s Gupta P thoma. s Varghese sK Department of Botany Mar Thoma CollegeKuttapuzhaTiruvallaKerala-689103India Lichenology Laboratory National Botanical Research InstituteRana Pratap MargLucknow-226001India Department of Botany SB CollegeChanganacherryKottayamKerala-686101India

Lichen biota of Pathanamthitta district of Kerala state was thoroughly studied which resulted in 24 lichen species as new to Kerala and one species,Phaeographis nylanderi(Vain.)*** new to *** the species identified are either crustose or foliose forms belonging to families Graphidaceae and Caliciaceae indicating the dominance of these groups in the study *** of all the 25 species are provided along with their distribution.

关键词： Biodiversity Caliciaceae Endemic Graphidaceae Lichenized fungi Western Ghats

Amazonia atlantiicola ***.(Ascomycetes,Meliolales)from Malabar Wildlife sanctuary in Kerala state,India

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studies in Fungi 2017年第1期2卷 14-16页

作者： Lini KM Neeta NN swapna s Post Graduate&Research Dept.of Botany Mar Thoma CollegeThiruvalla-689103PathanamthittaKeralaIndia

A new species,Amazonia atlantiicola,infecting leaves of Atlantia sp.(Rutaceae),was collected from Malabar Wildlife sanctuary of Kozhikode *** is introduced,described and illustrated in this paper.

关键词： Atlantia black mildew new species