检索结果-南通市图书馆

Metastasis to Paranasal sinuses as the First Presenting sign of renal Cell Carcinoma

在线全文

学校读者我要写书评

暂无评论

评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究

Open Journal of Urology（泌尿学期刊） 2012年第1期

作者： Gustavo ruschi Bechara José Anacleto Dutra resende Júnior Hélio Assunção Gouveia thomás Accioly de souza

来源：评论

学校读者我要写书评

暂无评论

中华高血压杂志 2018年第10期26卷 999-999页

作者： Poulter Nr savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis s James rM Kanellos I szigeti M thom s sever P thompson D Hatzitolios AI 赵狄练桂丽

观察数据显示，临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而，动态血压监测显示，夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外，夜间与白天的血压比值和杓型状态也是心血管结局的重... 详细信息

观察数据显示，临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而，动态血压监测显示，夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外，夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响，一些研究表明，夜晚服用降压药可能较白天服药减少心血管事件。

关键词： 24h动态血压降压药服用不良心血管事件夜晚独立预测因素英国希腊

代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点（英文）

在线全文

学校读者我要写书评

暂无评论

中华神经外科疾病研究杂志 2017年第1期16卷 94-94页

作者： Pereira Ms Klamt F thomé CC Worm PV de Oliveira DL Department of Biochemistry Laboratory of Cellular NeurochemistryInstituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Department of Biochemistry Laboratory of Cellular BiochemistryInstituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Department of Neurosurgery Cristo Redentor Hospital-GHCPorto Alegre RS Department of Neurosurgery So José HospitalComplexo Hospitalar Santa Casa

Objective Metabotropic glutamate receptors(mG lur)are predominantly involved in maintenance of cellular homeostasis of central nervous ***,evidences have suggested other roles of mG lur in human *** mG lur signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain *** review intends to summarize recent findings regarding the involvement of mG lur-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG lur *** addition to the growing number of studies reporting mG lur gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG lur1 and mG lur3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K *** addition,mG lur3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG lur3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κ***,continuous pharmacological blockade of mG lur1 and mG lur3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft *** parallel,low levels of mG lur3 mrNA in GBM resections may be a predictor for long survival rate of *** several Phase I,II and III clinical trials are being performed using group I and II mG lur modulators,there is a strong scientifically-based rationale for testing mG lur antagonists as an adjuvant therapy for malignant brain tumors.

关键词：期刊编辑工作英文摘要

2004英国高血压学会高血压治疗指南(BHs-IV):概要

在线全文

学校读者我要写书评

暂无评论

英国医学杂志中文版 2004年第5期7卷 273-279页

作者： Bryan Williams Neil r Poulter Peter s sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 Department of Cardiovascular sciences University of Leicester Clinical Sciences Building Leicester Royal Infirmary Leicester professor of medicine International Centre for Circulatory Health Imperial College London and St Mary's Hospital London professor of preventive cardiovascular medicine International Centre for Circulatory Health Imperial College London and St Mary's Hospital London Peter S Sever professor of clinical pharmacology Simon McG Thom reader in medicine Clinical Pharmacology Unit Addenbrooke's Hospital University of Cambridge Cambridge professor of clinical pharmacology Moorfield House surgery Garforth Leeds general practitioner section of Clinical Pharmacology and stroke Medicine Division of Cardiovascular and Medical Sciences Gardiner Institute Western Infirmary University of Glasgow Glasgow professor of clinical pharmacology Ageing and stroke Medicine section Department of Cardiovascular Sciences Glenfield Hospital University of Leicester Leicester professor of ageing and stroke medicine the BHS guidelines working party for the British Hypertension Society

在高血压领域，不断出现的新证据已日益受到关注。例如：血压可作为心血管疾病的一个危险因素；改进生活方式对于预防和治疗高血压的重要意义；不同类型药物的有效性和安全性；高危高血压患者包括糖尿病患者的治疗；心血管疾病总体危险... 详细信息

在高血压领域，不断出现的新证据已日益受到关注。例如：血压可作为心血管疾病的一个危险因素；改进生活方式对于预防和治疗高血压的重要意义；不同类型药物的有效性和安全性；高危高血压患者包括糖尿病患者的治疗；心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。

关键词：高血压患者治疗指南心血管疾病高危预防和治疗他汀类药物糖尿病患者概要英国有效性

Assessment of Different WrF Configurations Performance for a rain Event over Panama

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Climate sciences 2020年第3期10卷 280-297页

作者： Maibys sierra-Lorenzo Arnoldo Bezanilla-Morlot Abel Dionisio Centella-Artola Anisbel León-Marcos Israel Borrajero-Montejo Adrián Luis Ferrer-Hernández Jesús Leonel salazar-Gaitán Alcely Lau-Melo Freddy Picado-Traña Joel Pérez-Fernández Center for Atmospheric Physics Meteorology Institute La Habana Cuba sección de recursos Hídricos Autoridad del Canal de Panama Panama City Panama Dirección de Hidrometeorología Empresa de Transmisión Eléctrica S.A. Panama City Panama Water Center for the Humid Tropics of Latin America and the Caribbean Panama City Panama

A set of 15 combinations of microphysics and cumulus parameterizations for the WrF numerical model were tested in the forecast of a rain event on January 16 2018 over Panama. GPM satellite, upper air soundings and ground weather stations were used to evaluate the performance of each configuration. Different metrics were used to obtain the configurations that produced the best forecasts. The analysis showed a strong fluctuation of the diurnal precipitation cycle from one region to another. From the set of tests carried, BMJ with Morrison performed slightly above the other combinations in representing well the diurnal cycle for some domain areas, followed by thom-Gr, WsM6-BMJ and WsM6-KF. While the experiments had a better performance forecasting over sea, they were not able to match the highest values of total precipitation. regarding spatial rain distribution, all BMJ cumulus combinations showed the best skills mainly over the area comprising the Panama Canal while the others tended to overestimate the rain. Finally, most BMJ experiments showed the highest correlation factor and performed quite well representing the vertical profiles of relative humidity, temperature and wind.

关键词： Parameterization Microphysics WrF rain