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Minor fibrillar collagens,variable regions alternative splicing,intrinsic disorder,and tyrosine sulfation

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Protein & Cell 2012年第6期3卷 419-433页

作者： Ming Fang reed Jacob Owen McDougal Julia thom Oxford Department of Biological sciences Boise State UniversityBoiseID 83725USA Department of Chemistry and Biochemistry Boise State UniversityBoiseID 83725USA Biomolecular research Center Boise State UniversityBoiseID 83725USA

Minor fibrillar collagen types V and XI,are those less abundant than the fibrillar collagen types I,II and *** alpha chains share a high degree of similarity with respect to protein sequence in all domains except the variable *** variation and,in some cases,extensive alternative splicing contribute to the unique sequence characteristics of the variable *** unique expression patterns in tissues exist,the functions and biological relevance of the variable regions have not been *** this review,we summarize the existing knowledge about expression patterns and biological functions of the collagen types V and XI alpha *** of biochemical similarities among the peptides encoded by each exon of the variable region suggests the potential for a shared *** alternative splicing,conservation of biochemical characteristics in light of low sequence conservation,and evidence for intrinsic disorder,suggest modulation of binding events between the surface of collagen fibrils and surrounding extracellular molecules as a shared function.

关键词： minor fibrillar collagens variable regions alternative splicing fibrillogenesis heparan sulfate binding sites intrinsic disorder tyrosine sulfation

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The Central Axis of Beijing and Chinese Wisdom

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China Today 2023年第1期72卷 42-45页

作者： LArs ULrIK thom Beijing Postcards

A foreigner’s probe into the cultural connotations and origins of the Central Axis of *** pioneering journalist Eliza scidmore,National Geographic’s first official female writer,photographer,and board member,visited... 详细信息

关键词： Axis Central journal

Improving cover and management factor (C-factor) estimation using remote sensing approaches for tropical regions

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International soil and Water Conservation research 2019年第4期7卷 325-334页

作者： André Almagro Thais Caregnatto thomé Carina Barbosa Colman rodrigo Bahia Pereira José Marcato Junior Dulce Buchala Bicca rodrigues Paulo Tarso sanches Oliveira Federal University of Mato Grosso do sul CxP 549 Campo Grande MS 79070-900 Brazil

The revised Universal soil Loss Equation (rUsLE)'s cover and management factor (C-factor) is one of the most difficult factors to obtain,mainly because long-term monitoring soil erosion plots under natural rainfall are ***,remote sensing approaches have been used as an alternative for obtaining this ***,there is a lack of studies comparing values of this factor computed from remote sensing approaches with measured *** this study,we compare two widely used remote sensing approaches (CrA and CVK) to estimate the C-factor based on the Normalized Difference Vegetation Index (NDVI) with the literature (CLIT) and field experimental data..We also investigated the influence of C-factor methods on the prediction of soil loss and sediment yield (sY) using measured data in the Guariroba basin,Central-West *** obtained mean C-factor values of 0.032,0.023 and 0.137 for CLIT,CrA and CVK,*** found an average annual soil loss of 2.20 tha-1 yr-1,2.02 t ha-1 yr-1 and 10.07 tha-1 yr-1 and sY values of 6875 tyr-1,6468 tyr-1 and 33,435 t yr1,for CLIT,CrA and CVK *** results indicated a significant improvement in soil loss and sY estimations by using the CrA approach developed for tropical regions,with a bias of 13% to the measured sY (5709tyr-1).We conclude that the CrA method present the most suitable alternative to compute soil loss and sY in tropical ***,this approach allows large-scale evaluation and temporal monitoring,therefore enhancing multi spatial and temporal assessment of soil erosion processes.

关键词： soil erosion rUsLE NDVI Landsat 8 Land use/land cover

燕麦草（Arrhenatherum　elatius）多倍体复合体的等位酶多样性研究

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热带亚热带植物学报 1996年第4期4卷 79-85页

作者：葛学军 thom.,JD 中国科学院华南植物研究所法国功能生态学和进化生态学研究中心

对欧洲及地中海地区燕麦草复合体２７个居群的等位酸电泳调查表明，燕麦草复合体维持比较高的等位酶多样性（Ｈｅ＝０．４４７，Ａ＝３．２９），亚种间遗传分化较小（Ｇ（ＳＴ）＝０．０５３）；在四个亚种内，也维持着比较高的多样性... 详细信息

对欧洲及地中海地区燕麦草复合体２７个居群的等位酸电泳调查表明，燕麦草复合体维持比较高的等位酶多样性（Ｈｅ＝０．４４７，Ａ＝３．２９），亚种间遗传分化较小（Ｇ（ＳＴ）＝０．０５３）；在四个亚种内，也维持着比较高的多样性（Ｈｅ：０．３２５—０．５３３），各亚种内的基因多样度主要存在于居群之内，居群间分化较小．四倍体的基因多样性高于二倍体的．燕麦草复合体内居群间基因流较高，表明燕麦草繁育方式主要为风媒远交．对Ｎｅｉ氏标准遗传距离的ＵＰＧＭＡ聚类结果表明，四倍体是从二倍体有鳞茎的ｓｓＰ．ｂａｅｔｉｃｕｍ中产生的．

关键词：燕麦草等位酸多样性多倍体

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The subgenual cingulate gyrus exhibits lower rates of bifurcation in schizophrenia than in controls, bipolar disorder and depression

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Open Journal of Psychiatry 2012年第4期2卷 253-257页

作者： Matthew r. Williams ronald K. B. Pearce steven r. Hirsch Olaf Ansorge Maria thom Michael Maier Department of Neuropathology The Radcliffe Infirmary Oxford UK Institute of Neurology UCL London UK King’s College London Institute of Psychiatry De Crespigny Park London UK Neuropathology Unit Department of Clinical Neuroscience Division of Neuroscience & Mental Health Imperial College London Charing Cross Hospital London UK Trust HQ West London Mental Health NHS Trust Middlesex UK

The subgenual cingulate cortex has been found to be different in structure and function in mood and affective disorders compared to healthy individuals. Imaging studies have shown a decrease in function of the subgenual region in bipolar disorder and depression, with overall glial number shown to be decreased in these disorders. Decreases in subgenual grey matter in sZ have been observed also. In this neuropathological study upon formalin-fixed coronal brain sections we describe the morphological finding of de- creased frequency of subgenual cingulate crown bifurcation (p = 0.02) as compared to control, bipolar and depression cases. This suggests that the cingulate cortex in schizophrenia may be morphologically distinct in utero formation, potentially enabling an early identification of high-risk individuals.

关键词： Neuropathology schizophrenia Cortical Flattening

Impacts of land use and land cover changes on hydrological processes and sediment yield determined using the sWAT model

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International Journal of sediment research 2022年第1期37卷 54-69页

作者： Edivaldo Afonso de Oliveira serr?o Madson Tavares silva thomás rocha Ferreira Lorena Concei??o Paiva de Ataide Cleber Assis dos santos Aline Maria Meiguins de Lima Vicente de Paulo rodrigues da silva Francisco de Assis salviano de sousa Denis José Cardoso Gomes Academic Unit of Atmospheric sciences Federal University of Campina Grande Department of Physics Center for Natural and Exact Sciences Federal University of Santa Maria Institute of Technology Civil Engineering Graduate Program Federal University of Pará Earth system science Center National Institute of Space Research Institute of Geosciences Federal University of Pará

Land use and land cover (LULC) changes strongly affect local hydrology and sediment *** current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1) to perform an effective diagnosis of flow and sediment yield,(2) to evaluate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and (3) to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield *** soil and Water Assessment Tool (sWAT) model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow ***,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric *** was also observed that the sub-basins in which pastureland is predominant are more susceptible to increased surface runoff and sediment *** to trend and homogeneity tests,these sub-basins had break points in the time series of these *** the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and *** current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water ***,it is concluded that the sWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources.

关键词： Hydrological modeling sediment yield Amazon basin sWAT model

Metastasis to Paranasal sinuses as the First Presenting sign of renal Cell Carcinoma

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Open Journal of Urology 2012年第1期2卷 28-31页

作者： Gustavo ruschi Bechara José Anacleto Dutra resende Júnior Hélio Assuncao Gouveia thomás Accioly de souza Department of Urology Hospital Federal da Lagoa Rio de Janeiro Brazil

The clear cell carcinoma is a relatively rare tumor, represented approximately 85% by renal cell carcinoma (rCC), but has a characteristic of early metastatic, which sometimes spread to unusual places. Metastatic tumors in the paranasal sinuses are very rare. This case report a 65 years-old patient who presented sinusitis and epitaxis as a first sign of renal cell carcinoma with metastasis to the right maxillary sinus, which was opereted at Lagoa Hospital—rJ and strengthen the inclusion of this disease in the differential diagnosis of sinus disease. The renal cell carcinoma is a relatively rare tumor, representing approximately 3% of malignant tumors. About a third of patients with renal cell carcinoma have metastasis at diagnosis. The sinuses are a rare location of metastasis. The maxillary sinuses and the paranasal sinuses are most commonly affected by metastatic tumors to the sinuses region. The most frequent primary tumor to metastasis to paranasal sinuses is the renal cell carcinoma. This report highlights the rarity of the case and the importance in the differential diagnosis of sinus disease.

关键词： renal Cell Carcinoma Metastasis sinuses Epistaxis

Artificial intelligence for characterization of diminutive colorectal polyps:A feasibility study comparing two computer-aided diagnosis systems

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第1期5卷 11-22页

作者： Quirine Eunice Wennie van der Zander ramon M schreuder Ayla Thijssen Carolus H J Kusters Nikoo Dehghani thom scheeve Bjorn Winkens Mirjam C M van der Ende-van Loon Peter H N de With Fons van der sommen Ad A M Masclee Erik J schoon Department of Gastroenterology and Hepatology Maastricht University Medical CenterMaastricht 6202 AZNetherlands GrOW School for Oncology and ReproductionMaastricht UniversityMaastricht 6200 MDNetherlands Division of Gastroenterology and Hepatology Catharina Hospital EindhovenEindhoven 5602 ZANetherlands Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBNetherlands Department of Methodology and statistics Maastricht UniversityPostbus 6166200 MD MaastrichtNetherlands school for Public Health and Primary Care Maastricht UniversityMaastricht 6200 MDNetherlands

BACKGrOUND Artificial intelligence(AI)has potential in the optical diagnosis of colorectal *** To evaluate the feasibility of the real-time use of the computer-aided diagnosis system(CADx)AI for Colorectal Polyps(AI4CrP)for the optical diagnosis of diminutive colorectal polyps and to compare the performance with CAD EYE^(TM)(Fujifilm,Tokyo,Japan).CADx influence on the optical diagnosis of an expert endoscopist was also *** AI4CrP was developed in-house and CAD EYE was proprietary software provided by *** CADxsystems exploit convolutional neural *** polyps were characterized as benign or premalignant and histopathology was used as gold ***4CrP provided an objective assessment of its characterization by presenting a calibrated confidence characterization value(range 0.0-1.0).A predefined cut-off value of 0.6 was set with valuess≥0.6 indicating premalignant colorectal *** confidence characterizations were defined as values 40%around the cut-off value of 0.6(0.76).self-critical AI4CrP’s diagnostic performances excluded low confidence *** AI4CrP use was feasible and performed on 30 patients with 51 colorectal ***-critical AI4CrP,excluding 14 low confidence characterizations[27.5%(14/51)],had a diagnostic accuracy of 89.2%,sensitivity of 89.7%,and specificity of 87.5%,which was higher compared to *** EYE had a 83.7%diagnostic accuracy,74.2%sensitivity,and 100.0%*** performances of the endoscopist alone(before AI)increased nonsignificantly after reviewing the CADx characterizations of both AI4CrP and CAD EYE(AI-assisted endoscopist).Diagnostic performances of the AI-assisted endoscopist were higher compared to both CADx-systems,except for specificity for which CAD EYE performed *** real-time use of AI4CrP was *** confidence values provided by a CADx is novel and self-critical AI4CrP sho

关键词： Artificial intelligence Colorectal polyp characterization Computer aided diagnosis Diminutive colorectal polyps Optical diagnosis self-critical artificial intelligence

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不安的摩托车骑士对死之冥想

大学英语 1986年第5期 35-35页

作者： thom Gun 罗逸清