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The subgenual cingulate gyrus exhibits lower rates of bifurcation in schizophrenia than in controls, bipolar disorder and depression

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Open Journal of Psychiatry 2012年第4期2卷 253-257页

作者： Matthew R. Williams Ronald K. b. Pearce steven R. Hirsch Olaf Ansorge Maria thom Michael Maier Department of Neuropathology The Radcliffe Infirmary Oxford UK Institute of Neurology UCL London UK King’s College London Institute of Psychiatry De Crespigny Park London UK Neuropathology Unit Department of Clinical Neuroscience Division of Neuroscience & Mental Health Imperial College London Charing Cross Hospital London UK Trust HQ West London Mental Health NHS Trust Middlesex UK

The subgenual cingulate cortex has been found to be different in structure and function in mood and affective disorders compared to healthy individuals. Imaging studies have shown a decrease in function of the subgenual region in bipolar disorder and depression, with overall glial number shown to be decreased in these disorders. Decreases in subgenual grey matter in sZ have been observed also. In this neuropathological study upon formalin-fixed coronal brain sections we describe the morphological finding of de- creased frequency of subgenual cingulate crown bifurcation (p = 0.02) as compared to control, bipolar and depression cases. This suggests that the cingulate cortex in schizophrenia may be morphologically distinct in utero formation, potentially enabling an early identification of high-risk individuals.

关键词： Neuropathology schizophrenia Cortical Flattening

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ID7 Isolated from bauhinia variegata stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative breast Cancer in Vivo

1989年

作者：托姆(thom R.)

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 368-384页

作者： Kamilla Monteiro dos santos Izabela Natalia Faria Gomes Renato Josésilva Oliveira Fernanda E.Pinto bruno Oliveira Fabrício P.batista Rafael Cesar Russo Chagas Hélio b.santos Ralph G.thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vilela Oliva Rosy Iara Maciel de Azambuja Ribeiro Laboratory of Experimental Pathology Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Josédo Rosário Vellano University UnifenasDivinópolisMGBrazil Molecular Oncology Research Center(CPOM) Barretos Cancer HospitalBarretosSPBrazil Petroleomic and Forensic Chemistry Laboratory Department of ChemistryFederal Institute of Espírito Santo(IFES)VitóriaESBrazil Chemistry Department Federal University of Sao PauloBrazil Tissue Processing Laboratory Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Life and Health sciences Research Institute(ICVs) Medical SchoolUniversity of MinhoBragaPortugal 3ICVs/3b’s-PT Government Associate Laboratory GuimaraesBragaPortugal

background:The breast cancer has been the most common form of cancer among women.The triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being aggressive.The main cause of death of patients with cancer is due to metastasis,which can reach the liver and lungs.Objective:The activities of ID7 fraction of the stems of bauhinia variegata L.on breast cancer,lung metastasis and liver inflammatory process were evaluated.Method:ID7 was characterized by mass-spectrometry.The viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of bT-20,MDA-Mb-231 and MCF-7 human breast cancer tumor lines by MTs.The cell migration,invasion using matrigel and adhesion were performed.The expression of cell death proteins was quanitified by western blot and the gelatinases by zimogram.The ID7 activity of the tumor(4T1)and metastatic progession in vivo was evaluated.Results:ID7 reduced the 4T1 and MDA-Mb-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active gelatinases.ID7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and TNF-R1.In vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the liver.The characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ID7.Conclusion:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the liver.It is suggested that fatty acids and flavonoids are correlated with such activities.

关键词： 4T1 cells MDA-Mb-231 medicinal plants kaempferol gelatinases apoptosis cell viabilty in vivo

局灶性皮层发育不良的临床病理分类新标准——ILAE诊断方法委员会协作组专家共识

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癫痫杂志 2020年第6期6卷 537-545页

作者： Ingmar blǖmcke Maria thom Eleonora Aronica 李劲梅(译) 慕洁(审) 不详

局灶性皮层发育不良(Focal cortical dysplasia,FCD)是常与癫痫相关的大脑局灶性皮层构层异常疾病,儿童和成人均可患病。最近,ILAE专项工作小组就FCD的分类新标准达成共识以更好地诠释其临床病理特征。32名专家重新评价现存癫痫数据库中... 详细信息

局灶性皮层发育不良(Focal cortical dysplasia,FCD)是常与癫痫相关的大脑局灶性皮层构层异常疾病,儿童和成人均可患病。最近,ILAE专项工作小组就FCD的分类新标准达成共识以更好地诠释其临床病理特征。32名专家重新评价现存癫痫数据库中FCD患者的临床电生理表现、影像学数据、手术切除标本的神经病理表现及术后预后。专项工作小组就FCD分类提出3个亚型。FCDⅠ型指皮层神经元构层异常的单发病灶,可以是串珠样小神经元垂直分布异常(FCDⅠa型)或水平层次横贯性丢失(FCDⅠb型),累及单一或多个脑叶。FCDⅡ型除特征性皮层神经元构层异常之外,还出现异形神经元(FCDⅡa型)并发现气球样细胞(FCDⅡb型)。相对于旧分类标准,新分类标准最大的变动是引入FCDⅢ型:FCD合并海马硬化(FCDⅢa型),FCD合并与癫痫相关的肿瘤(FCDⅢb型),FCD合并血管畸形(FCDⅢc型),FCD合并其他早期发生的外伤、卒中或脑炎所遗留的病灶(FCDⅢd型)。新分类标准将为FCD患者临床、影像、电生理特征、术后癫痫控制及其分子病理机制研究提供重要依据。

关键词：癫痫局灶性皮层发育不良诊断分类新标准

Growth promoting effect of microbial inoculants on Acacia nilotica grown under nursery conditions

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studies in Fungi 2021年第1期6卷 400-407页

作者： Dash s Gupta N Plant Pathology and Microbiology Division Regional Plant Resource CentreBhubaneswar-751015 OdishaIndia

Present study was carried out on Acacia nilotica seedlings grown under different bioinoculation treatments by using laboratory grown liquid cultures of 10 fungal isolates,11 Rhizobium isolates and 5 other bacterial isolates.Microbial cultures were screened for their effects on growth of Acacia nilotica grown in greenhouse conditions.The selected microbial inoculants were assessed as considering their individual performance or in combination with the other inoculants in specific ratios.The higher performance was shown with the combination of Penicillum chrysogenum thom.1,b 5 bacterial isolate,R10 and/or R11 isolates of Rhizobium.Further,it was observed that the above microbial mixed culture inoculation was promoted plant growth specifically number of leaves and the leaf biomass.Therefore,nursery application of mixed microbial inoculants,specifically as above could be beneficial for the production of quality planting material(QPM)of Acacia nilotica and subsequent field applications.

关键词： Acacia nilotica Aspergillus Growth Penicillium Phosphate solubilization Rhizobium

产生白细胞介素23的经典树突状细胞控制脑卒中时有害的白细胞介素17反应

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中华高血压杂志 2018年第1期26卷 60-60页

作者：黄洁叶鹏 Gelderblom M Gallizioli M Ludewig P thom V Arunachalam P Rissiek b bernreuther C Glatzel M Korn T Arumugam TV sedlacik J Gerloff C Tolosa E Planas AM Magnus T

炎症可促进缺血性组织损伤并恶化脑卒中患者的临床结局。αβ和γδT细胞都是已经明确的脑卒中组织损伤介导因子,而树突状细胞（dendritic cells,DC）对脑卒中早期T细胞激活和脑卒中发生的作用仍不清楚。方法：在实验性脑卒中小鼠模型中... 详细信息

炎症可促进缺血性组织损伤并恶化脑卒中患者的临床结局。αβ和γδT细胞都是已经明确的脑卒中组织损伤介导因子,而树突状细胞（dendritic cells,DC）对脑卒中早期T细胞激活和脑卒中发生的作用仍不清楚。方法：在实验性脑卒中小鼠模型中,研究者通过流式细胞分析根据细胞表面标志物、发育标志物表达以及细胞因子水平确定浸润DC亚群的免疫表型。

关键词：脑卒中白细胞介素

代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点（英文）

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中华神经外科疾病研究杂志 2017年第1期16卷 94-94页

作者： Pereira Ms Klamt F thomé CC Worm PV de Oliveira DL Department of biochemistry Laboratory of Cellular NeurochemistryInstituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Department of biochemistry Laboratory of Cellular BiochemistryInstituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Department of Neurosurgery Cristo Redentor Hospital-GHCPorto Alegre RS Department of Neurosurgery So José HospitalComplexo Hospitalar Santa Casa

Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GbM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GbM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κb.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GbM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GbM resections may be a predictor for long survival rate of patients.since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors.

关键词：期刊编辑工作英文摘要