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Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 470-475页

作者： ragunathan Irulappan PANNEERSELVAM Natarajan Research Centre and Postgraduate Studies in Botany the Madura College Madurai-625 011 Tamil Nadu India

Turmeric has long been used as a spice and food colouring agent in Asia. In the present investigation, the antimutagenic potential of curcumin was evaluated in Allium cepa root meristem cells. So far there is no report on the biological properties of curcumin in plant test systems. The root tip cells were treated with sodium azide at 200 and 300 μg/ml for 3 h and curcumin was given at 5, 10 and 20 μg/ml for 16 h, prior to sodium azide treatment. The tips were squashed after colchicine treatment and the cells were analyzed for chromosome aberration and mitotic index. Curcumin induces chromosomal aberration in Allium cepa root tip cells in an insignificant manner, when compared with untreated control. Sodium azide alone induces chromosomal aberrations significantly with increasing concentrations. The total number of aberrations was significantly reduced in root tip cells pretreated with curcumin. The study reveals that curcumin has antimutagenic potential against sodium azide induced chromosomal aberrations in Allium cepa root meristem cells. In addition, it showed mild cytotoxicity by reducing the percentage of mitotic index in all curcumin treated groups, but the mechanism of action remains unknown. The antimutagenic potential of curcumin is effective at 5 μg/ml in Allium cepa root meristem cells.

关键词： Chromosomal aberrations Sodium azide Genotoxicity Allium cepa

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Improving Performance of a Distributed File System Using a Speculative Semantics-Based Algorithm

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Tsinghua Science and Technology 2015年第6期20卷 583-593页

作者： Talluri Lakshmi Siva Rama Krishna thirum.laisam. ragunathan Sudheer Kumar Battula K L University Andhra PradeshIndia and Research ScholarJawaharlal Nehru Institute of Advanced Studies (JNIAS) ACE Engineering College

File-sharing semantics is used by the file systems for sharing data among concurrent client processes in a consistent manner. Session semantics is a widely used file-sharing semantics in Distributed File Systems(DFSs). The main disadvantage of session semantics is that writes to an open file are visible to the concurrent client processes only during their next session. Recently, "linearizability semantics" was introduced in Blob Seer DFS, in which a Read Client Process(RCP) can read only a previous version of a binary large object(blob), while update operations are carried out on that blob in a concurrent manner. In this paper, we propose a new type of file-sharing semantics, namely "speculative semantics", which permits writes to an open file to be visible to other concurrent processes provided that data consistency is not affected. In addition, we propose a new read algorithm for DFSs based on speculative semantics and a new performance measurement metric called Currency. The experimental results obtained using Blob Seer DFS indicate that the proposed read algorithm performs better than the existing read algorithm of Blob Seer DFS.

关键词： distributed system Hadoop Blobseer concurrency spe

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