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美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：对阿尔茨海默病诊断指南的推荐和介绍

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中华神经科杂志 2012年第5期45卷 332-335页

作者： Jack CR Jr Albert MS Knopman DS McKhann GM Sperling RA Carrillo MC thies b Phelps CH 贾建平（译）李丹（译）閵芳菊（译）陆璐（译）张逸驰（译）黄丽（译）不详首都医科大学宣武医院神经科北京100053

背景：尽管早在1984年就制定了阿尔茨海默病（AD）的临床诊断标准，但是近年来的研究进展从未被补充到诊断标准中。因此，制定一个新的临床诊断标准已经成为大家的共识。方法：在2009年，美国国立老化研究所与AD协会组织了一系列圆桌会... 详细信息

背景：尽管早在1984年就制定了阿尔茨海默病（AD）的临床诊断标准，但是近年来的研究进展从未被补充到诊断标准中。因此，制定一个新的临床诊断标准已经成为大家的共识。方法：在2009年，美国国立老化研究所与AD协会组织了一系列圆桌会议，目的是讨论用于AD临床和科研的诊断标准的修订路线。经讨论后决定组建3个独立的工作组，分别制定AD在3个不同疾病发展阶段的诊断标准，即痴呆阶段、有症状的痴呆前期、无症状的临床前期。结果：修订版AD诊断标准与1984年版诊断标准有两处显著的差别：加入了能提示潜在疾病状态的生物标志物的内容；制定了不同认知障碍阶段的诊断标准。其中，3个工作组一致认为，生物标志物的诊断价值还需要更多研究来规范和验证。另外，修订版中还明确区分了仅存在AD病理生理改变（语义性）和仅存在AD临床表现（概念性）两种诊断的差别，该内容在1984年版中没有体现。结论：修订版AD诊断标准中共产生了3个文件，其中，核心的关于AD的痴呆阶段诊断标准和可归于AD的MCI阶段标准推荐用于临床诊断，而临床前期诊断标准仅推荐用于研究使用。

关键词：阿尔茨海默病诊断指南研究所临床诊断标准协会老化美国生物标志物

美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病源性轻度认知障碍诊断标准推荐

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中华神经科杂志 2012年第5期45卷 345-351页

作者： McKhann GM Knopman DS Chertkow H Hyman bT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC thies b Weintraub S Phelps CH 贾建平（译）陆璐（译）张逸驰（译）黄丽黄（译）礼媛（译）不详首都医科大学宣武医院神经内科北京100053

美国国立老化研究所（NIA）和阿尔茨海默病协会（ADA）组织了一个工作组，负责阿尔茨海默病（AD）痴呆前症状阶段——即本文所称的AD源性轻度认知障碍（MCI）的诊断标准的制订及完善。该工作组制订了以下两套标准：（1）在缺乏相应条件... 详细信息

美国国立老化研究所（NIA）和阿尔茨海默病协会（ADA）组织了一个工作组，负责阿尔茨海默病（AD）痴呆前症状阶段——即本文所称的AD源性轻度认知障碍（MCI）的诊断标准的制订及完善。该工作组制订了以下两套标准：（1）在缺乏相应条件进行先进影像技术及脑脊液检查时，医务人员适用的核心临床标准；（2）适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质，将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断，并在社区医疗服务中规范使用，尚需做大量的工作。

关键词：阿尔茨海默病轻度认知障碍诊断标准研究所诊断指南源性协会老化

美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病痴呆诊断标准的推荐

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中华神经科杂志 2012年第5期45卷 352-355页

作者： McKhann GM Knopman DS Chertkow H Hyman bT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC thies b Weintraub S Phelps CH 贾建平（译）陆璐（译）张逸驰（译）黄丽（译）韩阅（译）不详首都医科大学宣武医院神经科北京100053

由美国国立老化研究所（NIA）和阿尔茨海默病（AD）协会组织了一个工作组，负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性，既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用... 详细信息

由美国国立老化研究所（NIA）和阿尔茨海默病（AD）协会组织了一个工作组，负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性，既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用，也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准，保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上，工作组对临床诊断标准做了一些修改，保留了“可能的AD痴呆”的术语，但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础，但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断，还有许多工作摆在面前。

关键词：临床诊断标准阿尔茨海默病研究所痴呆诊断指南协会老化美国

美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病临床前阶段的定义

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中华神经科杂志 2012年第5期45卷 336-344页

作者： Sperling RA Aisen PS beckett LA bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC thies b Morrison-bogorad M Wagster MV Phelps CH 贾建平（译）郭起浩（译）黄丽（译）陆璐（译）张逸驰（译）邢怡（译）不详首都医科大学宣武医院神经科北京100053 复旦大学附属华山医院神经内科

阿尔茨海默病（AD）的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会，但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生... 详细信息

阿尔茨海默病（AD）的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会，但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议，以确定能够预测由“正常”认知到轻度认知功能障碍（MCI）及AD痴呆的最佳预测指标。根据目前已有的主要科学证据，我们提出了一个概念性的框架和用于操作的研究标准，以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的，目前不涉及临床应用。我们希望这些建议能提供一个共识，以推进临床前AD的研究，最终推动更早期治疗干预的进展，使得一些疾病减缓药物的疗效发挥最大。

关键词：阿尔茨海默病诊断指南临床前研究所协会老化美国轻度认知功能障碍

The potential of vertebrate microfossils for marine to non-marine correlation in the Late Jurassic

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Progress in Natural Science:Materials International 2007年第6期17卷 655-663页

作者： Detlev thies Alexander Mudroch Susan Turner Institute of Geology und Paleontology University of HannoverD-30167 HannoverGermany Independent Palaeobiologist Bcklinplatz 4D-30177 HannoverGermany School of Geosciences Monash UniversityVictoria 3800AustraliaQueensland MuseumGeology/Palaeontology122 Gerler RoadHendraQueensland 4011Australia

Fish (cartilaginous: elasmobranch and bony: osteichthyan actinopterygian) and reptile (crocodile) microfossils comprising scales and teeth have been examined from a series of limestone samples in the Upper Jurassic of France and Germany to gauge the possibilities of using them for correlation between fully marine and hypo-or hyper-saline (non-marine) deposits.

关键词： Upper Jurassic Kimmeridgian chondrichthyans actinopterygians crocodilians microfossils biostratigraphy

Production and achievements of Sesamum indicum industry in the world:Past and current state

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Oil Crop Science 2024年第3期9卷 187-197页

作者： Gazali b.T.A.Sanni Vincent Ezin Ifagbémi bienvenue Chabi Antoine Abel Missihoun Quenum Florent Zangui Hamissou Mareme Niang Adam Ahanchede Department of Crop Production Faculty of Agricultural SciencesUniversity of Abomey-Calavi01BP 526CotonouBenin Laboratory of Valorization and Quality Management of Food bio-Ingredients Faculty of Agricultural SciencesUniversity of Abomey-Calavi01BP 526CotonouBenin Laboratory of Genetic and biotechnology Faculty of Sciences and TechnologyUniversity of Abomey-CalaviBP 526CotonouBenin Department of Vegetal Production Abdou Moumouni UniversityFaculty of AgronomyBP:10960Niamey-Niger ISRA-CERAAS Thies-EscaleThiesBP 3320Senegal

Sesame production is important in agriculture,food industry,and the crop diversity due to its rich nutritional profile and health *** its significant value,sesame is still an orphan crop that has received little scientific attention,resulting in low yield compared to other major oilseed *** review offers a comprehensive overview of the present state of production,knowledge,and research advancements concerning Sesamum indicum on a global *** FAOSTAT database was extensively used to examine the global trends from 1961 to *** the past 60 years,global sesame production has substantially increased,with Asia and Africa being the primary *** integration of omics technologies and biotechnological interventions has revolutionized our understanding of the genetic basis of sesame,enhanced productivity,invigorated stress resilience,and improved seed ***-throughput sequencing methods such as RNA-seq,RAD-seq,SLAF-seq,and GbS technology are used in various studies,linkage mapping,and identification of trait-associated *** linkage maps,and multi-omics studies such as genomics,proteomics,transcriptomics,and metabolomics have been employed in sesame research for gene and QTL *** and metabolic pathways related to oil content,yield,and stress tolerance were *** and QTLs related to yield and its components,drought,salt,and osmotic stress tolerance were *** genes associated with capsule shattering and seed shattering were recently *** more achievement in sesame,it is important to enhance sesame production efficiency through mechanization,advanced agricultural practices,and knowledge dissemination to *** and multi-omics integration should be particularly *** advancements in sesame production present a significant and promising opportunity for farmers,governments,and stakeholders in the agricultural sector.

关键词： Sesamum indicum Oil yield Genetic markers Sesame industry Omics improvement

Study of the Drinkability of Groundwater on the Island of MAR in Senegal

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Journal of Water Resource and Protection 2022年第6期14卷 419-432页

作者： Saidou Ndao Papa b. Diop Thioune Diadioly Gassama Faculty of Science and Technology University of Thies Thies Senegal

For a long time, the supply of drinking water to the island of Mar was ensured by drilling and wells. The advance of the salt wedge led the populations to stop the exploitation of the drilling due to the accentuation of the salinity of the water characterized by high fluorine content. The marine environment and the rainfall deficit of recent decades as well as population growth have highlighted the sensitivity of this resource. The objective of this article is to study the drinkability of the water supplied by the drilling and the wells of the island of Mar. for this, water samples were taken in the Continental Terminal and their analysis made in situ or in the laboratory. Data processing was done by using Surfer 11 and ArcGIS software. It was emerged from this study that the drop in the piezometric level caused an entry of salt water. The mineralization of the water follows a decreasing trend from areas with marine influence inland. Groundwater in certain areas is generally of good quality with some sources of pollution linked to salinity but also to high levels of nitrate, chloride and fluorine. The island of Mar being confronted with a problem of drinkability of groundwater, the alternative would be to proceed to a transfer of better quality water from nearby areas after a hydrogeological and physico-chemical study of these waters in relation to their fitness for consumption.

关键词： Salinity Terminal Continental Salt Wedge Pollution Solutions

Soil Subgrade’s Characterization and Classification of thies (Senegal, West Africa) on a Radius of 2.5 Kilometers along Five Roads

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Geomaterials 2016年第1期6卷 1-17页

作者： E.H.b.M. Niakhate Séni Tamba Makhaly ba Adama Dione Issa Ndoye Laboratoire de Mécanique et Modélisation-UFR Sciences de l’Ingénieur Université de Thies Thies Sénégal Ecole Polytechnique de thies (EPT/thies) Thies Sénégal

This article explains the results of a study conducted on the characterizations of subgrade soils in the region of thies. The road platforms are mainly composed of a background soil, which is generally overlapped by a surface layer that plays two roles. Firstly, it protects the soil structure, ensures the leveling, and facilitates the movement of vehicles. Secondly, it brings harmony in the mechanistic characteristics of the materials that compose the soil while improving the long-term life force. The methodology consisted in taking samples of subgrade soil along the roads all over the region of thies in a 5 km diameter span. The identification tests allowed the thies-Tivaoune, thies-Khombole and thies-Noto axes are characterized by tight sands, poorly graded size. While thies Pout-axis is characteristic of severe solid particle size and spread well graded and serious to spread and well graded particle size. Finally the thies-Montrolland axis is characterized by severe to very tight particle size and graduated to spread and serious and well graded particle size. The specific gravity values found Proctor test shows the presence of sand, sandy laterite and laterite. In the target area, polished soils of the A-3 type according to the AASHTO classification system are the most represented with 60%, followed by the A-2-6 type 25%, and the A-2-4 type with 9%, which are typical of gravel, clay, and silty sands. Soils of the A-1-b type (2%) typical of roc fragments, sands and clay are also represented. Polished sands of the A-3 type have a better efficiency on road infrastructures than other types of soil listed above. Finally, we’ve also noted the presence of soils of the A-2-7 and A-4 types with the low percentage of 2%. Subgrade soils of class S4 are the most represented with 58%, followed by those of class S5 with 42%. Samples of the thies-Montrolland road have a claylike plasticity (CL or CH group), while those of the thies-Pout road belong to the ML or OL and CL or OL

关键词： Subgrade Soil Mechanistic Pavement Design Arc GIS AASHTO CbR Resilient Modulus

Acute Coronary Syndromes: Epidemiological, Clinical and Management Aspects in thies (Senegal)

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World Journal of Cardiovascular Diseases 2023年第3期13卷 114-123页

作者： Désiré Alain Affangla Jean-Paul Degue Wally Niang Mboup Stéphanie Claudia Akanni Sheikh Mouhamadou b. M. Diop Malick Ndiaye Jean-Michel Amath Dione Hugues Elie Elame Ngwa Adamson Phiri Djibril Marie ba Mohamed M. C. b. O. Leye Cardiac Unit Saint Jean de Dieu Hospital Thies Senegal Health Sciences Training and Research Unit University of Thies Thies Senegal

Purpose: To describe the epidemiological, clinical and management characteristics of acute coronary syndromes (ACS) in thies, Senegal. Methods: This was a prospective study that included consecutively from October 1st, 2018 to March 03rd, 2019, patients aged 18 years or older admitted for an ACS at the DIAbCARMET department of the Saint Jean de Dieu Hospital in thies. Results: Of the 516 patients admitted, 29 had ACS, the prevalence was 5.62%. The average age of the patients was 64.2 ± 11.6 years. Nineteen patients (65.5%) were male and 10 (34.5%) were female, the sex ratio was 1.91. The number of direct admissions was 18 (62%) versus 11 patients (38%) referred. The mode of transport was a private vehicle in 19 patients (65.5%), an ambulance in 7 patients (24.1%) and public transport in 3 patients (10.3%). STEMI (ST segment elevation myocardial infarction) was the most common presentation observed in 19 patients (65.5%). Fifteen patients (51.7%) were admitted before the 12th hour. Of the 19 patients with STEMI, 11 (57.9%) had arrived in hospital before the 12th hour and 10 patients had streptokinase thrombolysis. No patients received primary PCI. Ten patients (34.5%) had heart failure and five patients (17.2%) died during hospitalization. Conclusion: Delayed consultation and high mortality characterize ACS in thies. Prevention must be the rule.

关键词： ACS Myocardial Infarction Thrombolysis thies Senegal