检索结果-南通市图书馆

Stagnant lids and mantle overturns:Implications for Archaean tectonics, magmagenesis,crustal growth, mantle evolution, and the start of plate tectonics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2018年第1期9卷 19-49页

作者： Jean h.bédard Geological Survey of Canada GSC-Québec

The lower plate is the dominant agent in modern convergent margins characterized by active subduction,as negatively buoyant oceanic lithosphere sinks into the asthenosphere under its own *** is a strong plate-driving force because the slab-pull force is transmitted through the stiff sub-oceanic lithospheric *** geological and geochemical data seem inconsistent with the existence of modernstyle ridges and arcs in the Archaean,a periodically-destabilized stagnant-lid crust system is proposed ***-lid intervals may correspond to periods of layered mantle convection where efficient cooling was restricted to the upper mantle,perturbing Earth's heat generation/loss balance,eventually triggering mantle *** basalts were derived from fertile mantle in overturn upwelling zones(OUZOs),which were larger and longer-lived than post-Archaean *** cratons/continents probably formed above OUZOs as large volumes of basalt and komatiite were delivered for protracted periods,allowing basal crustal cannibalism,garnetiferous crustal restite delamination,and coupled development of continental crust and sub-continental lithospheric *** mixing and rehomogenization during overturns retarded development of isotopically depleted MORb(mid-ocean ridge basalt)*** after the start of true subduction did sequestration of subducted slabs at the coremantle boundary lead to the development of the depleted MORb mantle *** Archaean mantle overturns,pre-existing continents located above OUZOs would be strongly reworked;whereas OUZOdistal continents would drift in response to mantle *** leading edge of drifting Archaean continents would be convergent margins characterized by terrane accretion,imbrication,subcretion and anatexis of unsubductable oceanic *** Earth cooled and the background oceanic lithosphere became denser and stiffer,there would be an increasing probability that oceanic crustal segments could

关键词： Archaean Mantle-overturn Stagnant-lid Continental crust Oceanic crust Subcretion

Exploring Variability in Sea Level at a Tide Gauge Station through Control Charts

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental & Earth Sciences 2024年第1期6卷 11-18页

作者： h.bâkiİz Independent Scholar Boca Raton Florida33496USA

Monitoring temporal changes in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random *** them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level *** study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control *** approach is demonstrated using Key West,Florida tide gauge *** mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the *** oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.

关键词： Climate change Sea level variance X-bar S control charts

Impact of heat shock on heat shock proteins expression, biological and commercial traits of bombyx mori

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2006年第4期13卷 243-250页

作者： VASUDhA b. ChAVADI APARNA h. SOSALEGOWDA MANJUNAThA h.b OREGOWDA Departments of Sericulture Dharwad 580003 Karnataka India Departments of biochemisrty Karnatak University Dharwad 580 003 Karnataka India

We report the thermotolerance of new bivoltine silkworm, bombyx mori strains Nb4D2, KSO1, NP2, CSR2 and CSR4 and differential expression of heat shock proteins at different instars. Different instars of silkworm larva were subjected to heat shock at 35℃, 40℃ and 45℃ for 2 hours followed by 2 hours recovery. heat shock proteins were analyzed by SDS-PAGE. The impact of heat shock on commercial traits of cocoons was analyzed by following different strategies in terms of acquired thermotolerance over control. Comparatively NP2 exh.bited better survivability than other strains. Resistance to heat shock was increased as larval development proceeds in the order of first instar 〉 second instar 〉 third instar 〉 fourth instar 〉 fifth instar in all silkworm strains. Expression of heat shock proteins varies in different instars. 90 kDa in the first, second and third instars, 84 kDa in the fourth instar and 84, 62, 60, 47 and 33 kDa heat shock proteins in fifth instar was observed in response to heat shock. Relative influence of heat shock on commercial traits that correspond to different stages was significant in all strains. In Nb4D2, cocoon and shell weight significantly increased to 17.52% and 19.44% over control respectively. heat shock proteins as molecular markers for evaluation and evolution of thermotolerant silkworm strains for tropics was discussed.

关键词： biological and commercial traits bombyx mori heat shock heat shockproteins molecular chaperones thermotolerance

The rigorous adjustment of the global mean sea level budget during 2005-2015

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2021年第3期12卷 175-180页

作者： h.bâki Iz T.Y.Yang C.K.Shum Division of Geodetic Science School of Earth SciencesThe Ohio State UniversityColumbusOHUSA

Global mean sea level budget is rigorously adjusted during the period *** emphasis is to provide the best estimates for the linear rates of changes(trends)of the global mean sea level budget components during this period subject to the constraint:Earth’s hydrosphere conserves *** newly simultaneously adjusted trends of the budget components suggest a larger correction for the global mean sea level trend implicated by the other budget components’trends under the budget *** simultaneous estimation of the linear trends of the budget components subject to the constraint for closure improves their uncertainties and enables a holistic assessment of the global mean sea budget,which has implications for future sea level science studies,including the future Intergovernmental Panel on Climate Change(IPCC)Assessment Reports,and the US Climate Assessment Reports.

关键词： Climate change Misclosure Global mean sea level Rigorous adjustment

Treatment of gastrointestinal neuroendocrine tumors with inh.bitors of growth factor receptors and their signaling pathways: Recent advances and future perspectives

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第16期14卷 2461-2473页

作者： Michael hpfner Detlef Schuppan hans scherübl Institute of Physiology Charité-Universitts-medizin Berlin Campus Benjamin Franklin beth Israel Deaconess Medical Center and harvard Medical School Klinik für Innere Medizin Gastroenterologie und Gastrointestinale Onkologie Klinikum am Urban Vivantes Netzwerk für Gesundheit

The limited efficacy of conventional cytotoxic treatment regimes for advanced gastrointestinal neuroendocrine cancers emphasizes the need for novel and more effective medical treatment options. Recent findings on the specific biological features of this family of neoplasms has led to the development of new targeted therapies, which take into account the high vascularization and abundant expression of specific growth factors and cognate tyrosine kinase receptors. This review will briefly summarize the status and future perspectives of antiangiogenic, mTOR- or growth factor receptor-based pharmacological approaches for the innovative treatment of gastrointestinal neuroendocrine tumors. In view of the multitude of novel targeted approaches, the rationale for innovative combination therapies, i.e. combining growth factor (receptor)-targeting agents with chemo- or biotherapeutics or with other novel anticancer drugs such as hDAC or proteasome inh.bitors will be taken into account.

关键词： Growth factor receptor Neuroendocrinegastrointestinal tumor Small molecule inh.bitor lonoclonal antibody Multi kinase inh.bition

Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第1期14卷 1-14页

作者： Michael hpfner Detlef Schuppan hans scherübl Institute of Physiology Charité-Universittsmedizin Berlin Campus Benjamin Franklin Berlin 12200 Germany beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 United States Klinik für Innere Medizin Gastroenterologie und Gastrointestinale Onkologie Klinikum am Urban Vivantes Netzwerk für Gesundheit Berlin 10967 Germany

Growth factors and their corresponding receptors are commonly overexpressed and/or dysregulated in many cancers including hepatocellular cancer （hCC）. Clinical trials indicate that growth factor receptors and their related signalling pathways play important roles in hCC cancer etiology and progression, thus providing rational targets for innovative cancer therapies. A number of strategies including monoclonal antibodies, tyrosine kinase inh.bitors （＂small molecule inh.bitors＂） and antisense oligonucleotides have already been evaluated for their potency to inh.bit the activity and downstream signalling cascades of these receptors in hCC. First clinical trials have also shown that multi-kinase inh.bition is an effective novel treatment strategy in hCC. In this respect sorafenib, an inh.bitor of Raf-, VEGF- and PDGF-signalling, is the first multi-kinase inh.bitor that has been approved by the FDA for the treatment of advanced hCC. Moreover, the serine-threonine kinase of mammalian target of rapamycin （mTOR） upon which the signalling of several growth factor receptors converge plays a central role in cancer cell proliferation, roTOR inh.bition of hCC is currently also being studied in preclinical trials. As hCCs represent hypervascularized neoplasms, inh.bition of tumour vessel formation via interfering with the VEGF/VEGFR system is another promising approach in hCC treatment. This review will summarize the current status of the various growth factor receptor-based treatment strategies and in view of the multitude of novel targeted approaches, the rationale for combination therapies for advanced hCC treatment will also be taken into account.

关键词： Growth factor receptor hepatocellular cancer Small molecule inh.bitor Monoclonal antibody Innovative cancer treatment Sorafenib bevacizumab Erlotinib

Targeted medical therapy of biliary tract cancer:Recent advances and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第46期14卷 7021-7032页

作者： Michael hpfner Detlef Schuppan hans scherübl Institute of Physiology Charité-Universittsmedizin BerlinCampus Benjamin Franklin beth Israel Deaconess Medical Center and harvard Medical School Klinik für Innere Medizin Gastroenterologieund Gastrointestinale OnkologieKlinikum am Urban Vivantes Netzwerk für Gesundheit10967 BerlinGermany

The limited efficacy of cytotoxic therapy for advanced biliary tract and gallbladder cancers emphasizes the need for novel and more effective medical treatment options. A better understanding of the specific biological features of these neoplasms led to the development of new targeted therapies, which take the abundant expression of several growth factors and cognate tyrosine kinase receptors into account. This review will briefly summarize the status and future perspectives of antiangiogenic and growth factor receptor-based pharmacological approaches for the treatment of biliary tract and gallbladder cancers. In view of multiple novel targeted approaches, the rationale for innovative therapies, such as combinations of growth factor (receptor)-targeting agents with cytotoxic drugs or with other novel anticancer drugs will be highlighted.

关键词： Growth factor receptor biliary tract cancer Small molecule inh.bitor lonoclonal antibody Innovative cancer treatment Sorafenib bevacizumab Erlotinib

Luminosity determination for the pd reaction at 2.14 GeV with WASA-at-COSY

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2012年第7期36卷 605-609页

作者：郑川 M.büscher P.Fedorets V.hejny h.Stroher 徐瑚珊袁小华 Institut für Kernphysik Forschungszentrum Jülich Jülich Center for hadron Physics Forschungszentrum Jülich Institute of Modern Physics Chinese Academy of Sciences Institute of Modern Physics Fudan University Institute for Theoretical and Experimental Physics State Scientific Center of the Russian Federation

The luminosity for a WASA-at-COSY experiment involving the pd reaction at 2.14 GeV proton- beam energy is determined by the forward pd elastic scattering, which yields an average beam-on-target value of [5.2±0.3（stat）±0.3（syst）] × 10^30 s^-1 cm^-2. In addition, the forward pd elastic-scattering angular distribution is obtained with four-momentum transfer squared -t between 0.16 （GeV/c）2 and 0.78 （GeV/c）2 at this beam energy, which is compared with other experimental data and the pd double scattering model.

关键词： luminosity pd elastic scattering angular distribution double scattering

histone deacetylase inh.bitor MS-275 alone or combined with.bortezomib or sorafenib exh.bits strong antiproliferative action in human cholangiocarcinoma cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第33期13卷 4458-4466页

作者： Viola baradari Michael hpfner Alexander huether Detlef Schuppan hans scherübl Institute of Physiology Charité-Universit?tsmedizin Berlin CampusBenjamin Franklin Berlin Germany Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School Boston United States Klinik für Gastroenterologie und Gastrointestinale Onkologie Klinikum Am Urban Vivantes Netzwerk fürGesundheit Berlin Germany

AIM: To investigate the antiproliferative effect of the histone deacetylase (hDAC) inh.bitor MS-275 on cholangiocarcinoma cells alone and in combination with conventional cytostatic drugs (gemcitabine or doxorubicin) or the novel anticancer agents sorafenib or bortezomib. METhODS: Two human bile duct adenocarcinoma cell lines (EGI-1 and TFK-1) were studied. Crystal violet staining was used for detection of cell number changes. Cytotoxicity was determined by measuring the release of the cytoplasmic enzyme lactate dehydrogenase (LDh). Apoptosis was determined by measuring the enzyme activity of caspase-3. Cell cycle status reflected by the DNA content was detected by flow ***: MS-275 treatment potently inh.bited the proliferation of EGI-1 and TFK-1 cholangiocarcinoma cells by inducing apoptosis and cell cycle arrest. MS-275-induced apoptosis was characterized by activation of caspase-3, up-regulation of bax and down-regulation of bcl-2. Cell cycle was predominantly arrested at the G1/S checkpoint, which was associated with induction of the cyclin-dependent kinase inh.bitor p21Waf/CIP1. Furthermore, additive anti-neoplastic effects were observed when MS-275 treatment was combined with gemcitabine or doxorubicin, while combination with the multi-kinase inh.bitor sorafenib or the proteasome inh.bitor bortezomib resulted in overadditive anti-neoplastic ***: The growth of human cholangiocarcinoma cells can be potently inh.bited by MS-275 alone or in combination with conventional cytostatic drugs or new, targeted anticancer agents.

关键词： Apoptosis Cholangiocarcinoma bortezomib Combination treatment histone deacetylase inh.bitor MS-275 Proteasome inh.bitor Sorafenib