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Hypertension and intracerebral hemorrhage in Brazzaville

World Journal of Cardiovascular Diseases 2013年第9期3卷 523-528页

作者： thierry Raoul Gombet paul Macaire Ossou-Nguiet Thibaut Naibe Gankama Bertrand Fikahem Ellenga-Mbolla Gilbert Fabrice Otiobanda Karen Obondzo-Aloba Benjamin Longo-Mbenza Department of Medicine Faculty of Health Sciences of Brazzaville Brazzaville Congo Service of Emergency University Hospital of Brazzaville Brazzaville Congo Department of Medicine Faculty of Health Sciences of Brazzaville Brazzaville CongoService of Cardiology University Hospital of Brazzaville Brazzaville Congo Department of Medicine Faculty of Health Sciences of Brazzaville Brazzaville CongoService of Neurology University Hospital of Brazzaville Brazzaville Congo Faculty of Health Sciences Walter Sisulu University Mthatha South Africa Service of Cardiology University Hospital of Brazzaville Brazzaville Congo Service of Neurology University Hospital of Brazzaville Brazzaville Congo Service of Reanimation University Hospital of Brazzaville Brazzaville Congo

Hypertension is not only an important risk factor, but also an important cause of spontaneous intracerebral hemorrhage. Its high prevalence in Africa reflects a high incidence of cerebral hemorrhage ranging from 30% to 60% against 10% to 20% in industrialized countries. The aim of our study was to determine the role of hypertension before the onset of intracerebral hemorrhage and its variations during the first three months. This was a longitudinal study conducted at the University Hospital of Brazzaville from 1st January to 31st August 2012 with all patients admitted for intracerebral hemorrhage. Patients with subarachnoid or pure intraventricular hemorrhage were excluded. The study variables were: history of hypertension, knowledge of its history, treatment, blood pressure on admission and during the first 3 months and the relationship between blood pressure and evolution. Statistical analysis was performed using the software SPSSS 16.1. The significance level was set at p < 0.05. During the study 261 patients were hospitalized for stroke, of which 82 (31.42%) were for intracerebral hemorrhage. The mean age was 55 ± 11 years and sex ratio of 2 men:1 woman. Hypertension was found in 80.5% of cases, of which 65.2% had known hypertension, but 82.6% had discontinued treatment. The mean systolic blood pressure was 194 ± 41 mm Hg and diastolic 104 ± 20 mm Hg. The location was deep in 85.71%. The normalization of blood pressure was obtained from the second week. After adjusting for confounders using logistic analysis, only uncontrolled hypertension was associated significantly and independently associated with a higher mortality rate (p = 0.042).

关键词： Hypertension Cerebral Hemorrhage Brazzaville

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Inverted Apical CD24 and Weak EZH2 Expressions Are Phenotypic Characteristics of Pure Invasive Micropapillary Carcinoma of the Breast

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Open Journal of Pathology 2013年第2期3卷 85-95页

作者： Nadège Gruel Aurélie Cédenot Marion Richardson paul Fréneaux Jaydutt Bhalshankar thierry Dubois Xavier Sastre-Garau Olivier Delattre Anne Vincent-Salomon INSERM Unit 830 Institut Curie Paris France

Invasive micropapillary carcinomas (IMPC) of the breast account for less than 2% of all breast cancers and have been recently described as luminal B carcinomas. CD24, CD44, ALDH1 and EZH2 are commonly used as stem-cell markers that display differential expression as a function of stage and molecular type, but their pattern of expression according to this rare histological type remains poorly defined and unknown for EZH2. We assessed expression of these markers in a series of 28 micropapillary breast carcinomas and compared the results with those obtained in a series of luminal A (27 cases) and B (34 cases) invasive carcinomas not otherwise specified (IC-NST). CD24 and CD44 were expressed in most cases. However, CD24 was expressed at the inverted apical membrane in 85% of invasive micropapillary carcinoma and at the apical pole of gland-forming cells in 45% of luminal A (p-val = 6.8 × 10-4) and 13% of luminal B cases (p-val = 1.1 × 10-7). ALDH1 was expressed in the stroma in most tumors, but in only 25%, 11% and 15% in epithelial cells of IMPC, luminal A and B IC-NST, respectively. Nuclear expression of EZH2 was not observed in luminal A tumors, and was detected in 35% (12/34) of luminal B carcinomas (p-val = 6.1 × 10-3) and only 4% (1/28) of invasive micropapillary carcinomas. This series shows that invasive micropapillary carcinomas harbor a CD24-positive inverted apical pole associated with weak EZH2 expression, phenotypical characteristics that distinguish this entity from other luminal carcinomas.

关键词： CD44 CD24 ALDH1 EZH2 Invasive Micropapillary Breast Carcinoma

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康熙年间两广总督石琳与法国船“安菲特利特号”的广州之行

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学术研究 2020年第4期 112-125,178页

作者： [法]梅谦立中山大学哲学系广东广州510275 中山大学广州与中外文化交流研究中心广东广州510275

据伯希和的研究,中法关系始于1698年“安菲特里特号”首航广州,由此开启了两国的贸易关系。然而,在“安菲特利特号”航行广州期间,法国耶稣会士对广州体制提出了挑战,目的是为法国公司争取优待政策。两广总督石琳给予了适度的支持,但最... 详细信息

据伯希和的研究,中法关系始于1698年“安菲特里特号”首航广州,由此开启了两国的贸易关系。然而,在“安菲特利特号”航行广州期间,法国耶稣会士对广州体制提出了挑战,目的是为法国公司争取优待政策。两广总督石琳给予了适度的支持,但最终还是要维护广州体制。本文基于大量法文相关文献,介绍并分析了在广州贸易体制形成初期总督石琳、粤海关及法国耶稣会士与商人各方势力的博弈。

关键词：安菲特里特号两广总督石琳粤海关中法关系

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Effect of Geogenic Lead on Fungal and Collembolan Communities in Garden Topsoil

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土壤圈：英文版 2018年第2期28卷 215-226页

作者： Sophie JOIMEL Hervé CAPIAUX Christophe SCHWARTZ Mickael HEDDE thierry LEBEAU Cécile LE GUERN Johanne NAHMANI Céline PERNIN Sandrine SALMON Lucia SANTORUFO Béatrice BECHET Jérome CORTET Université de Lorraine Laboratoire Sols et Environnement UMR 1120 Vandceuvre-lès-Nancy 54500 (France) INRA Laboratoire Sols et Environnement UMR 1120 Vandceuvre-lès-Naney 54500 (France) UMR ECOSYS INRA AgroParisTech Universitè Paris-Saclay Thiverval-Grignon 78850 (France) Plateforme d'Analyse Moléculaire Biodiversitg-Environnement IUT Ggnie Biologique La Roche sur Yon 85035 (France) Institut de Recherche sur les Sciences et Techniques de la Ville (IRSTV) CNRff 2488 Ecole Centrale de Nantes 1 rue de la Noē Nantes 44321 (France) Laboratoire Plandtologie & Gdodynamique Nantes Faculté des Sciences et des Techniques 2 rue de la Houssinière Nantes 44322 (Franee) Bureau de Reeherches Gdologiques et Minières (BRGM) Regional Geological Survey Direction Régionale des Pays de la Loire 1 rue des Saumonières Nantes 44000 (France) UMR CEFE 5175 Universitd de Montpellier EPHE Université Paul-Valdry Montpellier Montpellier 34199 (France) Université Lille 1 EA 4515 Laboratoire Gdnie Civil & Géo Environnement Villeneuve D'Ascq 59655 (France) Musdum National d'Histoire Naturelle CNRS UMR 7179 4 Avenue du Petit-Chateau Brunoy 91800 (France) Department of Biology University of Naples Federico Ⅱ Via Cinthia Naples 80126 (Italy) French Institut of Science and Technology for Transport Development and Networks Water and Environment Laboratory Route de Bouaye Bouguenais 44344 (France)

Geogenic lead (Pb) is considered to be less bioavailable than anthropogenic Pb and exerts less effect on the soil fauna. However,Pb contamination in vegetables has been reported in the case of geogenic anomalies, even at moderate concentrations (around 170 mgkg^(-1)). In this study, we investigated collembolan communities using both taxonomic- and trait-based approaches and observed fungal communities to assess the effects of a moderate geogenic Pb anomaly on collembolans and fungi in an urban vegetable garden *** indicated that geogenic Pb indeed modified fungi communities and altered the functional structure of collembolan communities in garden soils. Although geogenic Pb presented low bioavailability, it affected soil fauna and vegetables similar to anthropogenic Pb.

关键词： functional diversity functional trait soil fauna soil food web vegetable garden urban soil

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Floristic diversity and carbon stocks in the periphery of Deng–Deng National Park,Eastern Cameroon

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Journal of Forestry Research 2020年第3期31卷 989-1003页

作者： Louis paul Roger Kabelong Banoho Louis Zapfack Robert Bertrand Weladji Cedric Chimi Djomo Melanie Chichi Nyako Yannick Enock Bocko Damien Marie Essono Julliete Mancho Nasang Nade`ge Madountsap Tagnang Charles Innocent Memvi Abessolo Kenneth Roger Mvondo Sakouma Farikou Mamadou Souahibou Florence Jeanne Sarah Palla Tonga Ketchatang Peguy Remi Jiagho thierry Loic Kenmou Ulrich Arnaud Choumele Kana Jumo Boris Armel Anyam Yi Andjik Roger Bruno Tabue Mbobda Department of Plant Biology Faculty of ScienceUniversity of Yaounde IBP 812 YaoundeCameroon IUCN World Commission On Protected Areas Co-Vice Chair Commission Mondiale des Aires Protegees-Afrique Centrale(CMAP-UICN)GlandSwitzerland Organisation pour la Conservation et le Developpement(OCD) BP 33323 YaoundeCameroun Department of Biology Concordia University7141 Sherbrooke St.W.MontrealMontrealQC H4B 1R6Canada Institute of Agricultural Research for Development(IRAD) PO.BOX 2123YaoundeCameroon Laboratoire de Botanique et Ecologie Facultedes Sciences et TechniquesUniversiteMarien NgouabiBrazzavilleCongo Ministry of Forestry and Wildlife BP 34430 YaoundeCameroon Programme National de Developpement Participatif(PNDP) YaoundeCameroun Observatoire des Forets du Bassin du Congo(OFAC) BP 20818 YaoundeCameroun Fokabs International PO BOX 14097YaoundeCameroon International Union for Conservation of Nature Programme CamerounBP:5506 YaoundeCameroun Secretariat Technique REDD BP 320 YaoundeCameroun

Carbon is continuously being removed from the atmosphere by photosynthesis and stored in carbon pools(live,dead,and soil carbon)of forest ***,carbon stock in dead wood and of trees with diameters at breast height(dbh)between 5 and 10 cm is often not considered in many studies carried out in the Congo Basin *** relationship between tree diversity,life-forms and carbon stocks has received little *** study was carried out on the outskirts of Deng Deng National Park(DDNP)to determine tree diversity(dominant families,species richness and Shannon index),assess carbon stocks in the five carbon compartments(living tree,understory,fine roots,dead wood and litter)as well as to analyze the relationship between(1)carbon stocks and tree diversity;and,(2)between carbon stock and *** Shannon index of trees≥10 cm dbh ranged from 2.6 in riparian forest to 4.3 in secondary forest;and for the tree between 5 and 10 cm,it ranged to 1.56 in riparian forest to 3.68 in the secondary *** study site housed 16 species,7 genera and 3 families which are only found in trees of dbh between 5 and 10 *** average total carbon stock of the five compartments varied from 200.1 t ha-1 in forest residues to 439.1 t ha-1 in secondary *** wood carbon stock varied from 1.2 t ha-1 in riparian forests to 12.51t ha-1 in *** above ground carbon stocks for trees with diameter between 5 and 10 cm varied from 0.7 t ha-1 in young fallow fields to 5.02 t ha-1 in old secondary *** study reveals a low but positive correlation between species richness and total carbon stocks,as well as a significant positive relationship between life-forms and total carbon *** findings highlight the need for more data concerning carbon content of dead wood,carbon of trees≥5 cm<10 cm dbh and the relationship between carbon stocks and tree diversity from other areas of the Congo Basin for a good understanding of the contribution of tropical forests

关键词： Deng Deng national park Carbon stocks Land cover types Species diversity Dead wood

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Stroke in type 2 diabetes mellitus patients admitted to emergency unit in Central African country (Congo): Preliminary findings

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Journal of Diabetes Mellitus 2013年第4期3卷 208-213页

作者： Bertrand Fikahem Ellenga-Mbolla Henri Germain Monabeka paul Macaire Ossou-Nguiet Gilbert Fabrice Otiobanda Kryste Chancel Mahoungou Guimbi thierry Raoul Gombet Suzy-Gisèle Kimbally-Kaky Benjamin Longo Mbenza Department of Cardiology University Hospital of Brazzaville Brazzaville Congo Department of Medicine Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Faculty of Health Sciences Walter Sisulu University Mthatha South Africa Intensive Care Unit University Hospital of Brazzaville Brazzaville Congo

Background: The cardiovascular risk factors including type 2 diabetes mellitus (T2DM) are a public health problem in sub-Saharan Africa. The aim of this study is to determine the prevalence and factors associated with stroke in T2DM patients admitted to the emergency Unit in Brazzaville. Patients and Methods: This is the preliminary findings of a cross-sectional study including patients with T2DM, admitted in Emergency Unit of University Hospital of Brazzaville from January to April 2011. One hundred and seven patients were included. Sex ratio was 1.5. Results: The mean age was 60.3 ± 10.2 years (range 40 - 80 years). Stroke story was noted in 5 cases (4.6%). The main pathologies were metabolic complications (n = 51;47.6%) and cardiovascular diseases (n = 36;33.6%), dominated by stroke (17 cases). Epidemiological factors associated with stroke were high standard living (OR = 3, 95% CI: 1.02 - 8.9, p = 0.03), polypharmacy (OR = 3.7, 95% CI: 1.27 - 10.8, p = 0.01), previous hospitalization (OR = 3.1, 95% CI: 1.07 - 8.9, p = 0.03), and the absence of antiplatelet therapy (OR = 4.2, 95% CI 1.2 to 15, p = 0.03). Clinical associated factors were coma (OR = 3.3, 95% CI 1.14 to 9.6, p = 0.02) and the presence of severe hypertension (OR = 4, 95% CI: 1.2 - 12, p = 0.02). Finally, prognostic factors were the transfer in intensive care unit (OR = 9.8, 95% CI: 2.7 - 34, p 0.001). Conclusion: The first cardiovascular complication in patients with T2DM admitted in emergency at University Hospital of Brazzaville is stroke. Primary prevention in high-risk patients is still inadequate.

关键词： Type 2 Diabetes Mellitus Stroke Emergency Brazzaville

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Relationship between Obesity, Serum Uric Acid, Serum Potassium and Glomerular Filtration Rate with Electric Left Ventricular Hypertrophy in Blacks Central Africans with High Blood Pressure

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World Journal of Cardiovascular Diseases 2018年第4期8卷 248-255页

作者： Bertrand Fikahem Ellenga Mbolla paul Macaire Ossou Nguiet Richard Loumingou Meo Stéphane Ikama Narcisse Ngangoue thierry Raoul Gombet Henri Germain Monabeka Benjamn Longo Mbenza Gisèle Kimbally Kaky Department of Doctoral Studies Faculty of Health Sciences Marien Ngouabi University of Brazzaville Brazzaville Congo Laboratoire de biochimie CHU de Brazzaville Brazzaville Congo Faculty of Health Sciences Walter Sisulu University Queenstown Eastern Cape South Africa

The authors conducted a retrospective study over a period of 6 months in a hypertensive population in order to determine the correlation between serum uric acid on glomerular filtration rate (GFR) and estimated serum potassium with left ventricular hypertrophy (LVH) and obesity. This study enrolled 122 patients including 63 women (51.6%). The mean age was 55.9 ± 10.6 years (range 30 to 74 years). Obesity weight was found in 38 cases (31.1%) of which 20?were men (33.9%) and 18 women (28.6%). Abdominal obesity was found in 104 cases (85.2%). The average serum uric acid in patients with obesity weight was 63.3 ± 18.9 mg/L vs 62.4 ± 14.2 mg/L for no-obese patients (p?= 0.63). The average serum potassium in obese patients was 4.06 ± 0.42 mEq/L vs 4.02 ± 0.46 mEq/L for no-obese (p?= 0.65). The average GFR was 73.4 ± 21.4 ml/L in obese patients vs 66.6 ± 22.6 ml/min in no-obese (p?= 0.03). The LVH was found in 81 cases (66.4%). The LVH was found in 65 (62.5%) obese patients vs?16 (88%) non-obese patients (OR = 4.8, 95% 1.04?-?22?p?= 0.02). Only abdominal?obesity has been correlated with left ventricular hypertrophy after multivariate analysis. Emphasis must be focused on public health actions for effective and appropriate measures against obesity and hypertension, whose prevalence is increasing in our region.

关键词： Obesity High Blood Pressure Glomerular Filtration Rate Uric Acid Serum Potassium Black African

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Short-Term Outcomes of Neonatal Resuscitation

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Open Journal of Pediatrics 2022年第3期12卷 507-513页

作者： Claude-Audrey Meguieze Eric Nseme Etouckey Isabelle Mekone Nkwele Félicité Nguefack Jocelyn Tony Nengom Dominique Enyama Cindy Brenda Ngassam Ivan Eboutou Rose Andréa Yaka Jules thierry Elong Evelyn Mah paul Koki Ndombo Paediatric Department Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Morphological Sciences and Anatomopathology Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Paediatric Department Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Introduction: Neonatal resuscitation is a means to restore life to a baby from the state of asphyxia. It can end in either survival or death. Survivors may develop short-term complications in the immediate postnatal period. Objective: Determine the short-term outcomes following neonatal resuscitation. Materials and Methods: A retrospective cross-sectional study was conducted for seven months running from November 2021 to June 2022 in two hospitals in Yaounde. Admission files of newborns who benefited from neonatal resuscitation at birth from the year 2019 to 2022 were included. We recorded the clinical characteristics of newborns (gestational age, gender, and birth weight), the frequency of transfers, the duration of admission, the rate and types of complications in an operating sheet The results were analysed using IBM SPSS 23.0 software and the data expressed as frequencies, percentages, and means. The threshold of significance was set at 5%. Results: A total of 245 files of newborns who benefited from neonatal resuscitation were included. The mean gestational age at delivery was 36.7 ± 3.6 weeks with a minimum and maximum of 25 weeks and 46 weeks respectively. 61.6% of newborns were born at term and were of the male sex (55.5%, sex ratio of 1.25). The average birth weight was 2748.4 ± 794.3 g (range: 800 - 5600 g) with 62.4% of newborns weighing between 2500 and 4000 g. 97.1% of the newborns were transferred to the neonatology unit with a median length of hospitalization of 5 days. The frequency of short-term complications during the study was 26.9% and hypoxic-ischemic encephalopathy was the most common (97%). Newborns resuscitated for more than 5 minutes were more likely to develop a short-term complication. Conclusion: Hypoxic-ischaemic encephalopathy was the most frequent complication post-resuscitation and a prolonged duration of resuscitation favoured the development of short-term complications.

关键词： Complications Neonatal Resuscitation Hypoxic Ischaemic Encephalopathy Cameroon

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Hypertension, diabetes mellitus, overweight and obesity in employees under health transition at the railways company in Congo-Brazzaville

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World Journal of Cardiovascular Diseases 2014年第2期4卷 45-49页

作者： Bertrand Fikahem Ellenga Mbolla thierry Raoul Alexis Gombet Henri Germain Monabeka paul Macaire Ossou-Nguiet Solange Flore Mongo-Ngamami Christian Michel Kouala Landa Suzy-Gisèle Kimbally-Kaky Benjamin Longo-Mbenza Department of Cardiology University Hospital of Brazzaville Brazzaville Congo Department of Cardiology University Hospital of Brazzaville Brazzaville Congo Department of Medicine Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Medicine Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Faculty of Health Sciences Walter Sisulu University Mthatha South Africa

Background and Aim: Cardiovascular risk (CVR) factors, namely hypertension (HT), diabetes mellitus and obesity, are a public health problem in sub-Saharan Africa because of health transition. The additional effect of the social gradient within the railway companies in Congo-Brazzaville on high CVR is not yet established. The aim of this study was to determine the extent of hypertension, diabetes mellitus, overweight, and obesity and to identify the contributing factors of fatness and hypertension. Methods: This was a cross-sectional study conducted in April 2013. A simple random sample of 255 out of all 2550 workers from the railway companies of Congo was examined for epidemiological, clinical and biological variables. Results: Out of the study sample, 231 (90.6%), 79 (31%), and 52 (20.4%) were men, rural dwellers, and senior executives, respectively. The mean age was 45 ± 13 years (range 19 to 63 years). The rates of overweight, hypertension, obesity, and diabetes mellitus were 40.3% (n = 103), 29.4% (n = 75), 7.5% (n = 19), and 3.5% (n = 9), respectively. In univariate analysis, female sex (OR 2.7, 95% CI 1.13 - 6.45, p = 0.01), senior executive (OR 2.4;95% CI: 1.3 - 4.5;p = 0.003) and physical inactivity (OR 2.5;95% CI: 1.5 - 4.2;p < 0.001) were significantly associated with overweight. Female sex (OR 7.5, 95% CI: 2.6 - 21;p < 0.001) and senior executive (OR 3.17;95% CI: 1.2 - 8.3) were also significantly associated with obesity. In logistic regression, overweight (OR = 4.8, 95% CI 2.8 - 11, p < 0.0001), and obesity (OR = 6.8, 95%CI 2.1 - 22, p = 0.01) were identified as the most important and independent determinants of hypertension. Conclusions: Fatness is emerging and it is the most contributing factor of hypertension among workers at the Congolese railway companies. There is also a significant interaction between non-modifiable factors (genetic: females and family history) and modifiable factors (inactivity, fatness) for higher risk of hypertension. Health pr

关键词： Hypertension Diabetes Mellitus Overweight Obesity Workplace Congo Sub-Saharan Africa

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First seismic evidence for continental subduction beneath the Western Alps

First seismic evidence for continental subduction beneath th...

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中国科学院地质与地球物理研究所2015年度（第15届）学术年会

作者： Liang Zhao Anne paul Stéphane Guillot Stefano Solarino Marco G. Malusà Tianyu Zheng Coralie Aubert Simone Salimbeni thierry Dumont Stéphane Schwartz Rixiang Zhu Qingchen Wang State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Université Grenoble Alpes Institut des Sciences de la Terre (ISTerre) CNRS Institut des Sciences de la Terre (ISTerre)

The first discovery of ultrahigh-pressure coesite in the European Alps 30 years ago led to the inference that a positively buoyant continental crust can be subducted to mantle depth;this had been considered impossible since the advent of the plate tectonics concepts. Although continental subduction is now widely accepted, there remains debate because there is little direct(geophysical) evidence of a link between exhumed coesite at the surface and subducted continental crust at depth. Here we provide the first seismic evidence for continental crust at 75 km depth that is clearly connected with the European crust exactly along the transect where coesite was found at the surface. Our data also provide evidence for a thick suture zone with downward-decreasing seismic velocities, demonstrating that the European lower crust underthrusts the Adriatic mantle. These findings, from one of the best-preserved and long-studied ultrahigh-pressure orogens worldwide, shed decisive new light on geodynamic processes along convergent continental margins.

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