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Signal-induced PARP1-Erk synergism mediates IEG expression

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Signal Transduction and Targeted Therapy 2019年第1期4卷 580-587页

作者： Malka Cohen-Armon Adva Yeheskel John M.pascal Department of Physiology and Pharmacology Sackler School of MedicineTel-Aviv UniversityTel-Aviv 69978Israel Sagol School of Neuroscience Tel-Aviv UniversityTel-Aviv 69978Israel Bioinformatics Unit George S.Wise Faculty of Life SciencesTel-Aviv UniversityTel-Aviv 69978Israel Department of Biochemistry and Molecular Medicine University of MontrealQuébecCanada

A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes(IEG)in response to a variety of extra-and intra-cellular signals implicated in memory acquisition,development and ***,we review this mechanism,which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the *** binding maintains their long-lasting activity in a synergism,which offers a new pattern for targeted therapy.

关键词： PARP1 Erk stimulation

A Nominally Second-Order Cell-Centered Finite Volume Scheme for Simulating Three-Dimensional Anisotropic Diffusion Equations on Unstructured Grids

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Communications in Computational Physics 2014年第9期16卷 841-891页

作者： pascal Jacq Pierre-Henri Maire Remi Abgrall CEA/CESTA 15 Avenue des Sablieres CS 6000133116 Le Barp cedexFrance. Institut fur Mathematik Universitat ZurichCH-8057 ZurichSwitzerland.

We present a finite volume based cell-centered method for solving diffusion equations on three-dimensional unstructured grids with general tensor *** main motivation concerns the numerical simulation of the coupling between fluid flows and heat *** corresponding numerical scheme is characterized by cell-centered unknowns and a local ***,the scheme results in a global sparse diffusion matrix,which couples only the cell-centered *** space discretization relies on the partition of polyhedral cells into sub-cells and on the partition of cell faces into *** is characterized by the introduction of sub-face normal fluxes and sub-face temperatures,which are auxiliary unknowns.A sub-cellbased variational formulation of the constitutive Fourier law allows to construct an explicit approximation of the sub-face normal heat fluxes in terms of the cell-centered temperature and the adjacent sub-face *** elimination of the sub-face temperatures with respect to the cell-centered temperatures is achieved locally at each node by solving a small and sparse linear *** system is obtained by enforcing the continuity condition of the normal heat flux across each sub-cell interface impinging at the node under *** parallel implementation of the numerical algorithm and its efficiency are described and *** accuracy and the robustness of the proposed finite volume method are assessed by means of various numerical test cases.

关键词： Finite volume methods unstructured grids anisotropic diffusion parallel computing

The USCACA hosted symposiums at the 7th CACA annual meeting and the 15th CSCO annual meeting in Beijing

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Chinese Journal of Cancer 2012年第11期31卷 505-506页

作者： Michael Shi Wancai Yang pascal Qian Li Yan Novartis Oncology One Health PlazaEast HanoverNJ 07936USA Department of Pathology Xinxiang Medical UniversityXinxiangHenan 453003P.R.China Department of Pathology University of Illinois at ChicagoIL 60612USA CDMA Pfizer OncologyShanghai 200041P.R.China USCACA 939 S Highland AveLos AngelesCA 90036USA.

In September 2012,the US Chinese Anti-Cancer Association(USCACA) hosted two symposiums in *** USCACA hosted the first joint session at the 7th annual meetings of the Chinese Anti-Cancer Association(CACA),themed on "Collaboration between the US and China in Cancer Research." Six experts from the United States and China presented their latest work on basic and translational cancer *** this symposium,5 young Chinese scholars,returnees after their training in the United States,were honored the"AFCR-USCACA Scholarships Award." The USCACA hosted a second symposium during the 15th annual meeting of the Chinese Society of Clinical Oncology(CSCO),focused on the "US-China Collaboration in Cancer Drug Clinical Development." An international delegation of oncology experts presented the innovative clinical trial strategies and discussed the biomarkers for cancer early detection and clinical trials,targeted therapy,and new drug *** Oncology Drug Clinical Development and Safety Evaluation Committee was also launched to promote an innovative environment and to provide a collaborative platform for anti-cancer drug development in China.

关键词：协会北京年会中国学者临床试验抗癌药物邪教开发过程

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Modelling of Electrical Conductivity of a Silver Plasma at Low Temperature

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Plasma Science and Technology 2016年第8期18卷 812-820页

作者： pascal ANDRE William BUSSIERE Alain COULBOIS Jean-Louis GELET David ROCHETTE Université Clermont Auvergne LAEPT MERSEN 15 rue Jacques de Vaucanson

During the working of electrical fuses, inside the fuse element the silver ribbon first begins to melt, to vaporize and then a fuse arc appears between the two separated parts of the element. Second, the electrodes are struck and the burn-back phenomenon takes place. Usually, the silver ribbon is enclosed inside a cavity filled with silica sand. During the vaporization of the fuse element, one can consider that the volume is fixed so that the pressure increase appears to reach pressures higher than atmospheric pressure. Thus, in this paper two pressures, 1 atm and 10 atm, are considered. The electrical field inside the plasma can reach high values since the distance between the cathode surface and the anode surface varies with time. That is to say from zero cm to one cm order. So we consider various electrical fields： 102 V/m, 103 V/m, 5×103 V/m, 104 V/m at atmospheric pressure and 105 V/m at a pressure of 10 atm. This study is made in heavy species temperature range from 2,400 K to 10,000 K. To study the plasma created inside the electric fuse, we first need to determine some characteristics in order to justify some hypotheses. That is to say： are the classical approximations of the thermal plasmas physics justified？ In other words： plasma frequency, the ideality of the plasma, the Debye-Hückel approximation and the drift velocity versus thermal velocity. These characteristics and assumptions are discussed and commented on in this paper. Then, an evaluation of non-thermal equilibrium versus considered electrical fields is given. Finally, considering the high mobility of electrons, we evaluate the electrical conductivities.

关键词： electrical conductivity silver fuses non-ideal plasma Debye-Hiickelapproximation drift velocity thermal velocity thermal non-equilibrium electrical fields

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ARISTOTLE SAID ＂HAPPINESS IS A STATE OF ACTIVITY＂ - PREDICTING MOOD THROUGH BODY SENSING WITH SMARTWATCHES

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Journal of Systems Science and Systems Engineering 2018年第5期27卷 586-612页

作者： Peter A Gloor Andrea Fronzetti Colladon Francesca Grippa pascal Budner Joscha Eirich MIT Center for Collective Intelligence 245 First Street 02142 Cambridge MA USA Department of Enterprise Engineering University of Rome Tor Vergata Via del Politecnico n°1 00133 Rome Italy Northeastern University 360 Huntington Avenue 02115 Boston MA USA University of Cologne Albertus-Magnus-PIatz 50923 Koln Germany University of Bamberg Kapuzinerstraβe1696047 Bamberg Germany

We measure and predict states of Activation and Happiness using a body sensing applicationconnected to smartwatches. Through the sensors of commercially available smartwatches we collectindividual mood states and correlate them with body sensing data such as acceleration, heart rate, lightlevel data, and location, through the GPS sensor built into the smartphone connected to the smartwatchWe polled users on the smartwatch for seven weeks four times per day asking for their mood state. Wefound that both Happiness and Activation are negatively correlated with heart beats and with the levelsof light. People tend to be happier when they are moving more intensely and are feeling less activatedduring weekends. We also found that people with a lower Conscientiousness and Neuroticism andhigher Agreeableness tend to be happy more frequently. In addition, more Activation can be predictedby lower Openness to experience and higher Agreeableness and Conscientiousness. Lastly, we find thattracking people＇s geographical coordinates might play an important role in predicting Happiness andActivation. The methodology we propose is a first step towards building an automated mood trackingsystem, to be used for better teamwork and in combination with social network analysis studies.

关键词： Body sensing systems mood tracking smartwatch experience sampling happiness activation

GeoLink Data Set:A Complex Alignment Benchmark from Real-world Ontology

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Data Intelligence 2020年第3期2卷 353-378页

作者： Lu Zhou Michelle Cheatham Adila Krisnadhi pascal Hitzler DaSe Lab Kansas State UniversityManhattanKS 66506USA Wright State University DaytonOH 45435USA Faculty of Computer Science Universitas IndonesiaDepokJawa Barat 16424Indonesia

Ontology alignment has been studied for over a decade,and over that time many alignment systems and methods have been developed by researchers in order to find simple 1-to-1 equivalence matches between two ***,very few alignment systems focus on finding complex *** reason for this limitation may be that there are no widely accepted alignment benchmarks that contain such complex *** this paper,we propose a real-world data set from the GeoLink project as a potential complex ontology alignment *** data set consists of two ontologies,the GeoLink Base Ontology(GBO)and the GeoLink Modular Ontology(GMO),as well as a manually created reference alignment that was developed in consultation with domain experts from different *** alignment includes 1:1,1:n,and m:n equivalence and subsumption correspondences,and is available in both Expressive and Declarative Ontology Alignment Language(EDOAL)and rule *** benchmark has been expanded from its original version to contain real-world instance data from seven geoscience data providers that has been published according to both *** allows it to be used by extensional alignment systems or those that require training *** benchmark has been incorporated into the Ontology Alignment Evaluation Initiative(OAEI)complex track to help researchers test their automated alignment systems and *** paper also analyzes the challenges inherent in effectively generating,detecting,and evaluating complex ontology alignments and provides a road map for future work on this topic.

关键词： Ontology matching Complex ontology alignment Real-world ontology Ontology population Complex ontology alignment benchmark

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Analysis of Chaotic Dynamics in a Two-Dimensional Sine Square Map

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Chinese Physics Letters 2010年第2期27卷 33-36页

作者：徐杰隆克平 FOURNIER-PRUNARET Daniele TAHA Abdel-Kaddous CHARGE pascal School of Communication and Information Engineering University of Electronic Science and Technology of China Chengdu 611731 LATTIS INSA Toulouse University 135 avenue de Rangueil 31077 Toulouse 4 France

We study an N-dimensional system based upon a sine map, which is related to the simplified model of an opto-electronic system. The system behavior is analyzed with the tools of nonlinear dynamics （bifurcations in the parameter plane, critical manifolds, basins of attraction, chaotic attractors）. Our study relies on a two-dimensional system （N=2）. It is interesting that this system shows the existence of bounded chaotic orbits, which can be considered for secure transmissions.

关键词： Statistical physics and nonlinear systems

Neuro-symbolic approaches in artificial intelligence

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National Science Review 2022年第6期9卷 35-37页

作者： pascal Hitzler Aaron Eberhart Monireh Ebrahimi Md Kamruzzaman Sarker Lu Zhou Department of Computer Science Kansas State University Center for Open Source Data and AI Technologies (CODAIT) IBM Watson Department of Computing Sciences University of Hartford

Neuro-symbolic artificial intelligence refers to a field of research and applications that combines machine learning methods based on artificial neural networks, such as deep learning, with symbolic approaches to computing and artificial intelligence(AI), as can be found for example in the AI subfield of knowledge representation and reasoning.

关键词： artificial intelligence deep learning knowledge representation and reasoning neuro-symbolic integration

Investigating the Performance of Moving Bed Biofilm Reactor (MBBR) on Treatment of Petrochemical Waste Water for Phenol Removal

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Investigating the Performance of Moving Bed Biofilm Reactor ...

作者： pascal Onu 大连理工大学

学位级别：硕士

The various sources of phenol, adverse effects, human and animal exposure limits reflects the increased environmental concern for its control and eradication in water bodies. This is especially so in view of the fact that it is the rudimental material (basic organic constituent) in the petrochemical industry an industry recognized globally to consist of a complex combination of interdependent operations concerned with separation of crude molecules constituents, molecular cracking, molecular rebuilding and solvent finishing all of which ends up discharging a complex array of solids and fluid streams,Placing in cognizance, the environmental presence of phenol, the relative abundance in the environment and its vulnerability, it will be merely stating the obvious to say they are a menace and perhaps even a catastrophe due to their numerous adverse effects. These effects were highlighted while investigations on phenol removals under dual conditions of low and ambient temperatures were studied.This report mentions also the origin, effect, and characteristics of phenol. It describes also the conventional methods employed for treating phenolic waste waters, such as the activated sludge process being the foundation for most biological processes, Sequencing batch reactors, electrochemical oxidation, photo catalytic *** went further on highlighting of biofilm processes focusing on the MBBR technology a refinement of the activated sludge process, identified as a dynamic compact and cost effective technique within the biological methods because of its excellent traits. Highlights were also made on the various biofilm processes employed in treating phenolic waste waters. During the course of this investigations various concentration of phenol were explored under dual conditions. Under psychrophilic conditions an initial phenol range of 100-500mg/l was studied at 24 hours HRT utilizing phenol and sugar as sole carbon source for the feed waste water following a s

关键词： MBBR phenol petrochemical waste water biological treatment biofilm