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An integrated approach for increasing breeding efficiency in apple and peach in Europe

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Horticulture Research 2018年第1期5卷 825-838页

作者： Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari thierry pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg IRHS INRAAgrocampus-OuestUniversitéd’AngersSFR 4207 QuaSaVUniversitéBretagne Loire42 rue Georges MorelBeaucouzé49071France IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UABBellaterraBarcelonaSpain Universitàdegli Studi di Milano-DiSAA Via Celoria 2Milan20133Italy Biometris Wageningen University and ResearchDroevendaalsesteeg 1Wageningen6708PBThe Netherlands IRTA-Mas Badia Mas BadiaLa Tallada17134Spain Parco Tecnologico Padano Via EinsteinLoc.Cascina CodazzaLodi26900Italy Dipartimento di Scienze Agrarie Alma Mater Studiorum-Universitàdi BolognaBolognaItaly UMR AGAP INRAMontpellier34398France GAFL INRAMontfavet84143France Agroscope Research Division Plant BreedingSchloss 1Wädenswil8820Switzerland Julius Kühn-Institute(JKI) Federal Research Centre for Cultivated Plants Institute for Breeding Research on Fruit CropsPillnitzer Platz 3aDresden01326Germany Research and Innovation Center Fondazione Edmund MachSan Michele all’AdigeTrentoItaly CREA-VE Center of Viticulture and Enologyvia XXVIII Aprile 26Conegliano(TV)31015Italy Plant Breeding Wageningen University and ResearchDroevendaalsesteeg 1P.O.Box 386Wageningen6700AJThe Netherlands Hendrix Genetics Research Technology&ServicesBoxmeer5830 ACThe Netherlands

Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and *** bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private *** complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for *** breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank *** also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection *** FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the *** review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond.

关键词： breeding germplasm breed

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Orexins:A promising target to digestive cancers,inflammation,obesity and metabolism dysfunctions

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World Journal of Gastroenterology 2021年第44期27卷 7582-7596页

作者： Alain Couvineau thierry Voisin pascal Nicole Valerie Gratio Anne Blais INSERM UMR1149/Inflammation Research Center Team“From inflammation to cancer in digestive diseases”labeled by“la Ligue Nationale contre le Cancer”University of ParisDHU UNITYParis 75018France UMR PNCA AgroParisTechINRAUniversitéParis-SaclayParis 75005France

Hypothalamic neuropeptides named hypocretin/orexins which were identified in 1998 regulate critical functions such as wakefulness in the central nervous *** past 20 years had revealed that orexins/receptors system was also present in the peripheral nervous system where they participated to the regulation of multiple functions including blood pressure regulation,intestinal motility,hormone secretion,lipolyze and reproduction *** to these peripheral functions,it was found that orexins and their receptors were involved in various diseases such as acute/chronic inflammation,metabolic syndrome and *** present review suggests that orexins or the orexin neural circuitry represent potential therapeutic targets for the treatment of multiple pathologies related to inflammation including intestinal bowel disease,multiple sclerosis and septic shock,obesity and digestive cancers.

关键词： Orexin Neuropeptide G-protein coupled receptor superfamily Inflammation Metabolic syndrome Cancer

Useful zero friction simulations for assessing MBS codes pascal’s formula giving wheelsets frequency for zero wheel-rail friction

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Theoretical & Applied Mechanics Letters 2022年第3期12卷 145-155页

作者： Jean Pierre pascal pascal Coding Rue d’ErquyPleneuf-Val-Andre F-22370France

Present study provides a simple analytical formula,the“Klingel-like formula”or“pascal’s Formula”that can be used as a reference to test some results of existing railway codes and specifically those using rigid *** develops properly the 3D Newton-Euler equations governing the 6 degrees of freedom(DoF)of unsuspended loaded wheelsets in case of zero wheel-rail friction and constant ***,by solving numerically these equations,we got pendulum like harmonic oscillations of which the calculated angular frequency is used for assessing the accuracy of the proposed formula so that it can in turn be used as a fast practical target for testing multi-body system(MBS)railway *** to the harmonic property of these pendulum-like oscillations,the squareω2 of their angular frequency can be made in the form of a ratio K/M where K depends on the wheelset geometry and load and M on its *** on K and M are useful to understand wheelsets *** analytical formula is derived from the first order writing of full trigonometric Newton-Euler equations by setting zero elastic wheel-rail penetration and by assuming small *** trigonometric equations are numerically solved to assess that the formula providesω2 inside a 1%accuracy for usual wheelsets *** decreasing the conicity down to 1×10^(−4) rad,the relative formula accuracy is under 3×10^(−5).In order to test the formula reliability for rigid contact formulations,the stiffness of elastic contacts can be increased up to practical rigidity(Hertz stiffness×1000).

关键词： Unsuspended wheelsets Klingel formula Rigid contact Harmonic oscillation Multi body system railway codes Code validation

On the origin of the high tensile strength and ductility of additively manufactured 316L stainless steel: Multiscale investigation

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Journal of Materials Science & Technology 2020年第6期41卷 209-218页

作者： Bassem Barkia pascal Aubry Paul Haghi-Ashtiani thierry Auger Lionel Gosmain Frédéric Schuster Hicham Maskrot DEN-Service d’Etudes Analytiques et de Réactivitédes Surfaces CEAUniversitéParis-Saclay91191France Laboratoire de Mécanique des Sols Structures et MatériauxCentralesupélecUMR CNRS 8579UniversitéParis-Saclay92295France Arts et Métiers ParisTech PIMMUMR CNRS 800675013 ParisFrance CEA Cross-Cutting Program on Materials and Processes Skills 91191Gif-sur-YvetteFrance

We report that 316L austenitic stainless steel fabricated by direct laser deposition(DLD),an additive manufacturing(AM)process,have a higher yield strength than that of conventional 316L while keeping high *** interestingly,no clear anisotropy in tensile properties was observed between the building and the scanning direction of the 3D printed *** examination of the as-built parts shows a heterogeneous solidification cellular *** electron microscopy observations coupled with Energy Dispersive X-ray Spectrometry(EDS)reveal the presence of chemical micro-segregation correlated with high dislocation density at cell boundaries as well as the in-situ formation of well-dispersed oxides and transition-metal-rich *** hierarchical heterogeneous microstructure in the AM parts induces excellent strength of the 316L stainless steel while the low staking fault energy of the as-built 316L promotes the occurrence of abundant deformation twinning,in the origin of the high ductility of the AM *** additional post-process treatments,the AM 316L proves that it can be used as a structural material or component for repair in mechanical construction.

关键词： Additive manufacturing Austenitic stainless steel Dislocation structure Twinning Mechanical behavior Anisotropy

Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics

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Communications in Theoretical Physics 2014年第10期61卷 607-616页

作者： Bertrand R.Caré pascal Carrivain thierry Forné Jean-Marc Victor Annick Lesne Laboratoire de Physique Théorique de la Matière Condensée CNRS UMR 7600UPMC University Paris 06F-75005ParisFrance CNRS GDR 3536 UPMC University Paris 06F-75005ParisFrance Institut de Génétique Humaine CNRS UPR 1142 MontpellierFrance Institut de Génétique Moléculaire de Montpellier CNRS UMR 5535University of MontpellierMontpellierFrance Kavli Institute for Theoretical Physics China CAS

Investigating average thermodynamic quantities is not sufficient to understand conformational transitions of a finite-size polymer. We propose that such transitions are better described in terms of the probability distribution of some finite-size order parameter, and the evolution of this distribution as a control parameter varies. We demonstrate this claim for the coil-globule transition of a linear polymer and its mapping onto a two-state model. In a biological context, polymer models delineate the physical constraints experienced by the genome at different levels of organization,from DNA to chromatin to chromosome. We apply our finite-size approach to the formation of plectonemes in a DNA segment submitted to an applied torque and the ensuing helix-coil transition that can be numerically observed, with a coexistence of the helix and coil states in a range of parameters. Polymer models are also essential to analyze recent in vivo experiments providing the frequency of pairwise contacts between genomic loci. The probability distribution of these contacts yields quantitative information on the conformational fluctuations of chromosome regions. The changes observed in the shape of the distribution when the cell type or the physiological conditions vary may reveal an epigenetic modulation of the conformational constraints experienced by the chromosomes.

关键词： coil-globule transition helix-coil transition chromosome conformational capture two-state model

On the Mechanization of Straightedge and Compass Constructions

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Journal of Systems Science & Complexity 2019年第1期32卷 124-149页

作者： SCHRECK pascal Université de Strasbourg UFR de Mathématique et Informatique-ICube

The geometric constructions obtained with only straightedge and compass are famous and play a special role in the development of geometry. On the one hand, the constructibility of ?gures is a key ingredient in Euclid geometry and, on the other hand, unconstructibility gave birth to famous open problems of the ancient Greece which were unlocked only in the nineteenth century using discoveries in algebra. This paper discusses the mechanization of straightedge and compass constructions. It focuses on the algebraic approaches and presents two methods which are implemented; one is due to Lebesgue and the other one was jointly designed by Gao and Chou. Some links between the algebraic approach of constructions and synthetic geometry are described.

关键词： Geometric knowledge-based systems regular chains straightedge and compass constructibility triangle problems Wu's method

GRADIENT FLOW FINITE ELEMENT DISCRETISATIONS WITH ENERGY-BASED ADAPTIVITY FOR EXCITED STATES OF SCHRÖDINGER'S EQUATION

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Journal of Computational Mathematics 2023年第5期41卷 933-955页

作者： pascal Heid Mathematical Institute University of OxfordWoodstock RoadOxford OX26GGUK

The purpose of this paper is to verify that the computational scheme from[Heid et al.,Gradient flow finite element discretizations with energy-based adaptivity for the Gross–Pitaevskii equation,***.436(2021)]for the numerical approximation of the ground state of the Gross–Pitaevskii equation can equally be applied for the effective approximation of excited states of Schr¨odinger’s *** procedure employs an adaptive interplay of a Sobolev gradient flow iteration and a novel local mesh refinement strategy,and yields a guaranteed energy decay in each step of the *** computational tests in the present work highlight that this strategy is indeed able to approximate excited states,with(almost)optimal convergence rate with respect to the number of degrees of freedom.

关键词： Schrodinger’s equation Excited states Gradient flows Adaptive finite element methods

SUSY searches at ATLAS

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Frontiers of physics 2013年第3期8卷 248-256页

作者： pascal Pralavoriot CPPM University Aix-Marseille and CNRS/IN2P3 Marseille France

Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. The ATLAS experiment at the LHC searches for signs of supersymmetry in a large variety of signatures involving events with abnormal production of missing transverse momentum, jets, leptons, third generation fermions, gauge bosons or massive long-lived particles. A summary of the most recent results obtained in these searches is presented.

关键词： supersymmetry (SUSY) ATLAS LHC