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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1470-1473页

作者： thibault Vieille Melissa Crotet Celia Turco Paul Monasterolo Hadrien Winiszewski Gael Piton Medical Intensive Care Unit Besancon University HospitalBesancon 25000France Intensive Care Unit Vesoul HospitalVesoul 70000France Department of Digestive Surgical Oncology-Liver Transplantation Unit Besancon University HospitalBesancon 25000France Inserm UMRS-938 Centre de Recherche Saint-Antoine(CRSA)Sorbonne UniversitéParis 10041NY212France Intensive Care Unit Nord Franche Comte HospitalTrevenans 90400France

We suggest that during severe acute pancreatitis(SAP)with intra-abdominal hypertension,practitioners should consider decompressive laparotomy,even with intra-abdominal pressure(IAP)below 25 ***,in this setting,non-occlusive mesenteric ischemia(NOMI)may occur even with IAP below this cutoff and lead to transmural necrosis if abdominal perfusion pressure is not promptly *** report our experience of 18 critically ill patients with SAP having undergone decompressive laparotomy of which one third had NOMI while IAP was mostly below 25 mmHg.

关键词： Acute pancreatitis Abdominal compartment syndrome Decompressive laparotomy Mesenteric ischemia Intra-abdominal pressure Abdominal perfusion pressure

Infrared-active phonons in one-dimensional materials and their spectroscopic signatures

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npj Computational Materials 2023年第1期9卷 331-337页

作者： Norma Rivano Nicola Marzari thibault Sohier Theory and Simulations of Materials(THEOS) École Polytechnique Fédérale de LausanneCH-1015 LausanneSwitzerland National Centre for Computational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneCH-1015 LausanneSwitzerland Laboratory for Materials Simulations Paul Scherrer Institut5232 Villigen PSISwitzerland Laboratoire Charles Coulomb(L2C) Universitéde MontpellierCNRSMontpellierFrance

Dimensionality provides a clear fingerprint on the dispersion of infrared-active,polar-optical *** these phonons,the local dipoles parametrized by the Born effective charges drive the LO-TO splitting of bulk materials;this splitting actually breaks down in two-dimensional ***,we develop the theory for one-dimensional(1D)systems—nanowires,nanotubes,and atomic and polymeric *** an analytical model with the implementation of density-functional perturbation theory in 1D boundary conditions,we show that the dielectric splitting in the dispersion relations collapses as x^(2) log(x)at the zone *** dielectric properties and the radius of the 1D materials are linked by the present work to these red shifts,opening infrared and Raman characterization avenues.

关键词： dimensional splitting dielectric

Safe-event pruning in spacecraft conjunction management

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Astrodynamics 2023年第4期7卷 401-413页

作者： Sébastien Henry Roberto Armellin thibault Gateau Guggenheim School of Aerospace Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Te Punaha Atea-Space Institute The University of AucklandAuckland 1010New Zealand Department of Aerospace Vehicles Design and Control Institut Superieur de I'Aeronautique et de I'EspaceToulouse 31055France

Spacecraft conjunction management plays a crucial role in the mitigation of space *** a conjunction event occurs,resources and time are spent analyzing,planning,and potentially maneuvering the *** work contributes to a subpart of the problem:Confidently identifying events that will not lead to a high collision probability,and therefore do not require further *** method reduces the dimensionality of the data via principal component analysis(PCA)on a subset of ***-risk regions are then determined by clustering the projected data,and events that do not belong to a high-risk cluster are pruned.A genetic algorithm(GA)is developed to optimize the number of clusters and feature selection of the ***,an ensemble learning framework is proposed to combine the suboptimal models for better *** results show that the first set of parameters pruned approximately 50%of the events in the testing set with no false negatives,whereas the second set of parameters pruned 70%of the events and maintained a near-perfect *** results could benefit the optimization of operational resources and allow operators to focus better on the events of interest.

关键词： space situational awareness collision avoidance genetic algorithm(GA) ensemble learning

由两倍汽球 enteroscopy 的小肠 polypectomy : 与优先的囊内视镜检查法的关联

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World Journal of Gastrointestinal Endoscopy 2013年第5期5卷 219-225页

作者： Gabriel Rahmi Elia Samaha Camille Lorenceau-Savale Bruno Landi Joёl Edery thibault manière Jean-Marc Canard Georgia Malamut Gilles Chatellier Christophe Cellier Department of Gastroenterology and Endoscopy University Rene-DescartesGeorges Pompidou European Hospital75015 ParisFrance Department of Clinical Epidemiology European Hospital Georges PompidouUniversity Rene-Descartes75015 ParisFrance

AIM:To investigate the feasibility of small bowel polypectomy using double balloon enteroscopy and to evaluate the correlation with capsule endoscopy(CE).METHODS:This is a retrospective review of a single tertiary ***-five patients treated by enteroscopy for small bowel polyps diagnosed by CE or other imaging techniques were *** correlation between CE and enteroscopy(correlation coefficient of Kendall for the number of polyps,intra-class coefficient for the size and coefficient of correlation kappa for the location) was ***:There were 31 polypectomies and 12 endoscopic mucosal resections with limited morbidity and no *** analysis revealed 27 hamartomas,6 adenomas and 3 *** agreement between CE and optical enteroscopy was observed for both location(Kappa value:0.90) and polyp size(Kappa value:0.76),but only moderate agreement was found for the number of polyps(Kendall value:0.47).CONCLUSION:Double balloon enteroscopy is safe for performing *** CE is useful in selecting the endoscopic approach and to predicting the difficulty of the procedure.

关键词： Small bowel polyps Double balloon enteroscopy Capsule endoscopy Polypectomy Correlation

reinforcement learning building control approach harnessing imitation learning

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Energy and AI 2023年第4期14卷 60-72页

作者： Sourav Dey thibault Marzullo Xiangyu Zhang Gregor Henze Department of Civil Environmental and Architectural EngineeringUniversity of ColoradoBoulderCOUSA National renewable Energy Laboratory GoldenCOUSA renewable and Sustainable Energy Institute BoulderCOUSA

reinforcement learning(RL)has shown significant success in sequential decision making in fields like autonomous vehicles,robotics,marketing and gaming *** success has attracted the attention to the RL control approach for building energy systems which are becoming complicated due to the need to optimize for multiple,potentially conflicting,goals like occupant comfort,energy use and grid ***,for real world applications,RL has several drawbacks like requiring large training data and time,and unstable control behavior during the early exploration process making it infeasible for an application directly to building control *** address these issues,an imitation learning approach is utilized herein where the RL agents starts with a policy transferred from accepted rule based policies and heuristic *** approach is successful in reducing the training time,preventing the unstable early exploration behavior and improving upon an accepted rule-based policy-all of these make RL a more practical control approach for real world applications in the domain of building controls.

关键词： reinforcement learning Building controls Imitation learning Artificial intelligence

Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment

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Bioactive Materials 2023年第11期29卷 279-295页

作者： thibault Colombani Zachary JRogers Khushbu Bhatt James Sinoimeri Lauren Gerbereux Mohammad Hamrangsekachaee Sidi ABencherif Department of Chemical Engineering Northeastern UniversityBostonMA 02115United States Department of Pharmaceutical Sciences Northeastern UniversityBostonMAUnited States Department of Bioengineering Northeastern UniversityBostonMA 02115United States Harvard John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138United States Biomechanics and Bioengineering(BMBI) UTC CNRS UMR 7338University of Technology of Compi`egneSorbonne University60203 Compi`egneFrance

Hypoxia is a major factor shaping the immune landscape,and several cancer models have been developed to emulate hypoxic ***,to date,they still have several limitations,such as the lack of reproducibility,inadequate biophysical cues,limited immune cell infiltration,and poor oxygen(O_(2))control,leading to non-pathophysiological tumor ***,it is essential to develop better cancer models that mimic key features of the tumor extracellular matrix and recreate tumor-associated hypoxia while allowing cell infiltration and cancer-immune cell ***,hypoxia-inducing cryogels(HICs)have been engineered using hyaluronic acid(HA)to fabricate three-dimensional microtissues and model a hypoxic tumor ***,tumor cell-laden HICs have been designed to deplete O_(2) locally and induce long-standing *** promoted changes in hypoxia-responsive gene expression and phenotype,a metabolic adaptation to anaerobic glycolysis,and chemotherapy ***,HIC-supported tumor models induced dendritic cell(DC)inhibition,revealing a phenotypic change in the plasmacytoid DC(pDC)subset and an impaired conventional DC(cDC)response in ***,our HIC-based melanoma model induced CD8^(+)T cell inhibition,a condition associated with the downregulation of pro-inflammatory cytokine secretion,increased expression of immunomodulatory factors,and decreased degranulation and cytotoxic capacity of T ***,these data suggest that HICs can be used as a tool to model solid-like tumor microenvironments and has great potential to deepen our understanding of cancer-immune cell relationship in low O_(2) conditions and may pave the way for developing more effective therapies.

关键词： Cryogels Hypoxia Cancer Immunosuppression Drug resistance

Applications of Floquet-Magnus and Fer Expansion Approaches during Cross Polarization Radiation in Solid State NMR

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Journal of Modern Physics 2023年第7期14卷 1136-1156页

作者： Eugene Stephane Mananga thibault Charpentier Program of Physics & Ph. D Program of Chemistry Graduate Center The City University of New York New York NY USA Department of Applied Physics New York University Brooklyn New York USA Department of Engineering Physics and Technology BCC The City University of New York Bronx New York USA CEA IRAMIS Service Interdisciplinaire sur les Systèmes Moléculaires et Matériaux LSDRM UMR CEA/CNRS Gif-sur-Yvette

This paper investigates the concept of Cross Polarization (CP) experiment in addition to revisiting the two potential expansion schemes recently developed in the field of solid-state nuclear magnetic resonance (SSNMR): namely, the Floquet-Magnus expansion and the Fer expansion. We use the aforementioned expansion schemes for the calculation of effective Hamiltonians and propagators when the spin system undergoes Cross Polarization radiation. CP is the gateway experiment into SSNMR. An in-depth comprehension of the underlying mechanics of spin dynamics during the cross-polarization experiment is pivotal for further experimental developments and optimization of more complex solid-state NMR experiments. The main contribution of this work is a prospect related to spin physics;particularly regarding to generalization of the calculation. This work reports original yet interesting novel ideas and developments that include calculations performed on the CP experiment. In fact, the approach presented could play a major role in the interpretation of several fine NMR experiments in solids, which would in turn provide significant new insights in spin physics. The generality of the work points towards potential applications in problems related in solid-state NMR and theoretical developments of spectroscopy as well as interdisciplinary research areas as long as they include spin dynamics concepts.

关键词： Cross Polarization Solid-State NMR Floquet-Magnus Expansion Fer Expansion Spin Dynamics

Determining the spatial distribution of environmental and socio-economic suitability for human leptospirosis in the face of limited epidemiological data

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Infectious Diseases of Poverty 2022年第4期11卷 99-100页

作者： Maximiliano A.Cristaldi thibault Catry Aurea Pottier Vincent Herbreteau Emmanuel Roux Paulina Jacob M.Andrea Previtali Department of Natural Sciences College of Humanities and SciencesNational University of LitoralSanta FeArgentina 不详

Background:Leptospirosis is among the leading zoonotic causes of morbidity and mortality *** about spatial patterns of diseases and their underlying processes have the potential to guide intervention ***,leptospirosis is often an underreported and misdiagnosed disease and consequently,spatial patterns of the disease remain *** the absence of accurate epidemiological data in the urban agglomeration of Santa Fe,we used a knowledge-based index and cluster analysis to identify spatial patterns of environmental and socioeconomic suitability for the disease and potential underlying processes that shape ***:We geocoded human leptospirosis cases derived from the Argentinian surveillance system during the period 2010 to *** and socioeconomic databases were obtained from satelite images and publicly available platforms on the *** sets of human leptospirosis determinants were considered according to the level of their support by the literature and expert *** used the Zonation algorithm to build a knowledge-based index and a clustering approach to identify distinct potential sets of *** similarity and correlations between index,clusters,and incidence rates were ***:We were able to geocode 56.36%of the human leptospirosis cases reported in the national epidemiological *** knowledge-based index showed the suitability for human leptospirosis in the UA Santa Fe increased from downtown areas of the largest cities towards peri-urban and suburban *** analysis revealed downtown areas were characterized by higher levels of socioeconomic ***-urban and suburban areas encompassed two clusters which differed in terms of environmental *** highest incidence rates overlapped areas with the highest suitability scores,the strength of association was low though(CSc r=0.21,Present a method to analyze the en

关键词： Spatial epidemiology Underreported misdiagnosed diseases Environmental conditions Socioeconomic groups Knowledge-based index Cluster analysis

Endoscopic ultrasonography drainage and debridement of an infected subcapsular hepatic hematoma:A case report

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World Journal of Gastrointestinal Endoscopy 2022年第5期14卷 335-341页

作者： Theo Doyon thibault maniere Étienne Désilets Facultéde Médecine et des Sciences de la Santé Universitéde SherbrookeSherbrooke J1H 7N4QuébecCanada Department of Gastroenterology Hopital Charles-LemoyneGreenfield Park J4V 2H1QuébecCanada

BACKGROUND Endoscopic ultrasonography(EUS)has evolved in the last years making it not only a diagnostic modality but a therapeutic *** is now used as an alternative technique to percutaneous and surgical *** though EUS is a challenging procedure and not always suitable compared to percutaneous drainage,there is a need for developing new therapeutic approaches to the liver for when percutaneous drainage is not *** SUMMARY We present the case of a 82 years old male who developed an infected subcapsular hepatic hematoma(SHH)of the left lobe following percutaneous biliary *** 2 failed attempts of percutaneous drainage of the SHH and because the patients couldn’t withstand surgery,we conducted a EUS drainage and debridement of the *** a lumen apposing metal stent(LAMS)by a transgastric approach,we were able to gain endoscopic access to the *** our experience in the debridement of walled off pancreatic necrosis using this technique,we were confident it was the right *** four debridement sessions,the computed tomography scan showed a clear regression of the *** To our knowledge,this is the first case of successful endoscopic debridement of a SHH using a LAMS which appear to be feasible and safe in this specific case.

关键词： Intervention endoscopic ultrasonography Complication Hepatic subcapsular hematoma Transmural drainage Lumen apposing metal stent Case report

High Order Schemes on Three-Dimensional General Polyhedral Meshes—Application to the Level Set Method

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Communications in Computational Physics 2012年第6期12卷 1-41页

作者： thibault Pringuey R.Stewart Cant CFD Laboratory Department of EngineeringUniversity of CambridgeTrumpington StreetCambridge CB21PZUK

In this article,we detail the methodology developed to construct arbitrarily high order schemes—linear and WENO—on 3D mixed-element unstructured meshes made up of general convex polyhedral *** approach is tailored specifically for the solution of scalar level set equations for application to incompressible two-phase flow *** construction of WENO schemes on 3D unstructured meshes is notoriously difficult,as it involves a much higher level of complexity than 2D *** due to the multiplicity of geometrical considerations introduced by the extra dimension,especially on mixed-element ***,we have specifically developed a number of algorithms to handle mixed-element meshes composed of convex polyhedra with convex polygonal *** contribution of this work concerns several areas of interest:the formulation of an improved methodology in 3D,the minimisation of computational runtime in the implementation through the maximum use of pre-processing operations,the generation of novel methods to handle complex 3D mixed-element meshes and finally the application of the method to the transport of a scalar level set.

关键词： WENO scheme three-dimensional unstructured mesh mixed element polyhedral element hyperbolic equations level set