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蓝莓干预对认知表现和情绪的影响——基于随机对照试验的系统综述

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蓝莓干预对认知表现和情绪的影响——基于随机对照试验的系统综述

Comparisson of Recrystallization Kinetics and Grain Growth in Polycrystalline Shape memory Alloys

作者： Nikolaj Travica Nathan m D’cunha Nenad Naumovski Katherine Kent Duane D mellor Joseph Firth Ekavi N Georgousopoulou Olivia m.Dean Amy Loughman Felice Jacka Wolfgang marx 胡友春

蓝莓富含多酚,对改善认知能力和调节情绪都有好处。本系统综述基于随机对照试验,评估蓝莓和蓝莓产品对认知和情绪的影响。11篇文章(包括12项研究)被纳入本研究,有9项研究使用冻干蓝莓做干预物、2项研究使用全蓝莓、1项研究使用蓝莓浓缩... 详细信息

蓝莓富含多酚,对改善认知能力和调节情绪都有好处。本系统综述基于随机对照试验,评估蓝莓和蓝莓产品对认知和情绪的影响。11篇文章(包括12项研究)被纳入本研究,有9项研究使用冻干蓝莓做干预物、2项研究使用全蓝莓、1项研究使用蓝莓浓缩物进行干预研究。这些研究分别在儿童(n=5)、年轻人(n=1)和没有认知障碍(n=4)或有认知障碍(n=2)的老年人群中进行。八项研究报告了通过食用或补充不同剂量的蓝莓及不同干预时间对认知改善的能力,特别是对短、长期记忆和空间记忆的改善作用。在情绪方面,一项研究报告显示,在两组间干预,蓝莓产品展现了情绪显著改善的积极影响;而另外四项研究报告蓝莓干预对情绪没有改善。被纳入的所有研究均是低偏倚风险。基于目前的证据,蓝莓干预超过六个月可提高一些认知能力指标。然而,鉴于研究设计、剂量和花青素含量的巨大差异,阻碍了研究间的比较。在未来的试验中,推荐使用标准化的蓝莓干预措施,考虑安慰剂配方,使用一致的认知表现工具进行研究。

关键词：蓝莓花青素黄酮类多酚认知情绪营养食品干预人体

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材料科学与工程（中英文A版） 2020年第2期10卷 76-80页

作者： marcelo Nava Emmanuel Pacheco Rocha Lima Pedro cunha de Lima DETEC Instituto Federal de EducaçãoCiência e Tecnologia da BahiaBarreiras 47808-006Brasil

The non-ferrous SmAs(shape memory alloys)have,normally,two problems that hinder the use in industrial scale:the natural aging and grain *** first degrades the memory effect,while the second,observed during the alloy’s mechanical processing,modifies the phase transformation ***,the study of recrystallization kinetics is important for enabling the control of hardened state as a function of treatment time without allowing the exaggerated grain *** objective of this study is to determine the recrystallization kinetics in different SmAs(Cu-14Al-4Ni,Cu-12Al-0.5Be and Ni-42Ti),based on an empirical law of J-m-A(Johnson-mehl-Avrami),as well as their activation energies for grain growth process according to the empirical Arrhenius *** evaluations of the grain growth kinetics over a wide range of indicated DSC(differential scanning calorimetry)temperatures have been *** results show that the alloy less susceptible to aging in temperatures below the recrystallization peak is the Ni-42Ti,because it presented the highest activation energy,followed by the *** equations that describe the recrystallization kinetics follow the empirical law of *** recrystallization kinetics accompanied by hardness variation was an important tool,working as an advisor for selection of treatment time as a function of temperature.

关键词： SmAs NiTi CuAlNi CuAlBe recrystallization kinetics grain growth

Dietary approach in the treatment of nonalcoholic fatty liver disease

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World Journal of Hepatology 2015年第24期7卷 2522-2534页

作者： Silvia marinho Ferolla Luciana Costa Silva maria de Lourdes Abreu Ferrari Aloísio Sales da cunha Flaviano dos Santos martins Cláudia Alves Couto Teresa Cristina Abreu Ferrari Departamento de Clínica médica Centro de Pós-GraduacaoFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Propedêutica Complementar Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de microbiologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

Nonalcoholic fatty liver disease(NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome(mS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis(NASH). Because of the contemporary epidemics of mS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition.

关键词： Fatty liver Dietary carbohydrates Dietary fats Die

Accuracy of gestalt perception of acute chest pain in predicting coronary artery disease

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World Journal of Cardiology 2017年第3期9卷 241-247页

作者： Cláudio marcelo Bittencourt das Virgens Laudenor Lemos Jr márcia Noya-Rabelo manuela Campelo Carvalhal Antonio maurício dos Santos Cerqueira Junior Fernanda Oliveira de Andrade Lopes Nicole Cruz de Sá Jéssica Gonzalez Suerdieck thiago menezes Barbosa de Souza Vitor Calixto de Almeida Correia Gabriella Sant’Ana Sodré AndréBarcelos da Silva Felipe Kalil Beirao Alexandre Felipe Rodrigues marques Ferreira Luís Cláudio Lemos Correia Department of Cardiology Hospital Sao Rafael Department of Cardiology Hospital Português Bahiana School of medicine and Public Health

AIm To test accuracy and reproducibility of gestalt to predict obstructive coronary artery disease(CAD)in patients with acute chest *** We studied individuals who were consecutively admitted to our Chest Pain *** admission,investigators performed a standardized interview and recorded14 chest pain *** on these features,a cardiologist who was blind to other clinical characteristics made unstructured judgment of CAD probability,both numerically and *** the reference standard for testing the accuracy of gestalt,angiography was required to rule-in CAD,while either angiography or non-invasive test could be used to *** order to assess reproducibility,a second cardiologist did the same *** In a sample of 330 patients,the prevalence of obstructive CAD was 48%.Gestalt’s numerical probability was associated with CAD,but the area under the curve of0.61(95%CI:0.55-0.67)indicated low level of ***,categorical definition of typical chest pain had a sensitivity of 48%(95%CI:40%-55%)and specificity of 66%(95%CI:59%-73%),yielding a negligible positive likelihood ratio of 1.4(95%CI:0.65-2.0)and negative likelihood ratio of 0.79(95%CI:0.62-1.02).Agreement between the two cardiologists was poor in the numerical classification(95%limits of agreement=-71%to 51%)and categorical definition of typical pain(Kappa=0.29;95%CI:0.21-0.37).CONCLUSION Clinical judgment based on a combination of chest pain features is neither accurate nor reproducible in predicting obstructive CAD in the acute setting.

关键词： Acute chest pain Clinical judgment Gestalt Coronary artery disease Acute coronary syndrome

Feasibility of Prototyping the Jominy Test Device: Corroborating for Studies and Preliminary Results of the Heating and Data Acquisition Subsystems

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Journal of materials Science and Chemical Engineering 2021年第3期9卷 23-38页

作者： Giulliano A. S. Boaventura Ramon O. B. Santos Renann P. Gama Regina E. S. Cabette mariana F. B. motta Cesar A. Botura Adriano C. m. Rosa Any m. Rosa Wilson F. muniz Carlos D. Jaeger Luiz F. F. Honorato thiago A. Bimestre Edward P. I. Silva Beatriz Santos Livya V. m. Oliveira Theresa C. G. Venuto Henrique C. Sampaio Samuel F. V. Silva Izabela F. L. Calazans Felipe A. Santos Fagner C. F. Santos Fernando H. A. Oliveira Department mechanical Engineering Salesian University Center of Sao Paulo (UNISAL) S&#227 o Paulo Brazil Department management and Business State College of Technology (FATEC) S&#227 o Paulo Brazil Department mathematics International University Center (UNINTER) S&#227 o Paulo Brazil

This work contributed to a detailed study on a better understanding of the Jominy test, adopted a proportion of study to create the Jominy test device, exhibited favorable conceptions for the development of a prototype of the device, covering the four aspects of the project, being they: test device, test body heating system, test automation and instrumentation using embedded electronics and financial analysis for the elaboration of this project in Brazil. It was possible to observe in the results that the system is efficient, simple and functional, it was possible to obtain the first test carried out in the controlled environment the temperature data in degrees centigrade, the recorded data were automatically launched in microsoft Excel by the PLX DAQ software, making the acquisition of the data. In the matter of preparing the test device, the drawings are presented in the 3D modeling software, cost tables of the materials used for assembly in Brazil. In terms of the heating system, a heating system was adopted that uses electromagnetic induction, the cost of materials related to the heating system design was also presented. Another relevant factor that contributes to the research and improvement of the prototype is the municipality, located in the Paraiba Valley region, located in the state of São Paulo, consisting of a fertile and relevant scenario of regional, national, international and multinational statistics, thus concluding the effectiveness for the mainly metallurgical industries. The results obtained were satisfactory and consistent, when they were created for the Jominy test device with the ability to submit small pieces for testing and mainly essential in the didactic point of view for a higher education institution of engineering and technology.

关键词： Tempering Jominy Test Data Acquisition Heating

巴西里约热内卢一所教学医院的抗结核治疗不合作情况调查

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结核与肺部疾病杂志 2004年第2期7卷 64-68页

作者： C.L.G.Salles m.B.Conde C.Hofer A.J.L.A.cunha A.L.Calcada D.F.menezes L.Sá A.L.Kritski 何广学贺晓新张立兴 UnidadedePesquisaemTuberculose-ServicodePneumologia-DepartamentodeClinicamédica HospitalUniversitárioClementinoFragaFilhodaUniversidadeFederaldoRiodeJaneiroRiodeJaneiro DepartamentodePediatria InstitutodePediatraePuericulturaMartagāoGesteiradaUniversidadeFederaldoRiodeJaneiroRiodeJaneiroBrazil 不详

背景:少数研究已经调查了医院内抗结核治疗不合作的有关因素。目的:确定巴西里约热内卢市住院病人不合作治疗的有关因素。设计:病例对照研究。方法:所有选入研究的病例均在一所教学医院开始抗结核治疗。不合作病例定义为病人中断治疗 60... 详细信息

背景:少数研究已经调查了医院内抗结核治疗不合作的有关因素。目的:确定巴西里约热内卢市住院病人不合作治疗的有关因素。设计:病例对照研究。方法:所有选入研究的病例均在一所教学医院开始抗结核治疗。不合作病例定义为病人中断治疗 60 天仍未返回治疗。经过培训的卫生保健人员采用标准表格对病例组和对照组病人进行随访调查。结果:从 1997 年 1 月 1 日至 12 月 31 日共登记结核病人 228 例。经过查阅病历,剔除了其中的 39 例。对其余 189 例病人进行家庭访视;46 例被确定为病例组,117 例为对照组。在家庭访视以前观察到的抗结核治疗不合作者 66(28.9%)例,家庭访视后不合作治疗者 46 例(20.2%)。多元分析结果显示,治疗不合作的最主要预测指标是:1)没有提供返回治疗卡(OR=0.099;95%CI:0.008-1.2,P=0.07), 2)病人感觉医生服务不周(OR=0.16;95%CI: 0.33-0.015,P=0.001),3)未测血压(OR=0.072; 95%CI:0.036-0.79,P=0.024)。结论:该医院的抗结核治疗不合作相关因素表明,非常需要系统的结核病控制规划。预计实施此类规划,采取特殊方法,将有助于强化抗结核治疗的完成率和治愈率。何广学译贺晓新校。

关键词：巴西教学医院结核病 HIV 治疗不合作影响因素

Pathogenesis of Chagas disease cardiomyopathy

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World Journal of Clinical Infectious Diseases 2012年第3期2卷 39-53页

作者： Priscila Camillo Teixeira Amanda Farrage Frade Luciana Gabriel Nogueira Jorge Kalil Christophe Chevillard Edecio cunha-Neto Labora-tory of Immunology Heart Institute (Incor) School of Medicine University of Sao Paulo Institute for Investigation in Immunology (III) INCT Division of Clinical Immunol-ogy and Allergy School of Medicine University of Sao Paulo INSERm Aix-marseille University

Chagas disease, or American trypanosomiasis, is a parasitic infection caused by the flagellate protozoanTrypanosoma cruzi. Chagas disease is mainly affecting rural populations in mexico and Central and South America. The World Health Organization estimates that 300 000 new cases of Chagas disease occur every year and approximately 20 000 deaths are attributable to Chagas. However, this organisation classified Chagas disease as a neglected tropical disease. The economic burden of this disease is significant. In many Latin American countries, the direct and indirect costs, including the cost of health care in dollars and loss of productivity, attributable to Chagas disease ranges from $40 million to in excess of $800 million per nation per annum. So, it remains a contemporary public health concern. In chronic phase, mortality is primarily due to the rhythm disturbances and congestive heart failure that result from the chronic inflammatory cardiomyopathy(CCC) due to the persistence presence of parasites in the heart tissue. mechanisms underlying differential progression to CCC are still incompletely understood. In the last decades immunological proteomic genetic approaches lead to significant results which help to disperse the veil covering the knowledge of the pathogenic process. Here, we reported these significant progresses.

关键词： Chagas Pathogenesis Cardiomyopathy Susceptibility Parasitic

子宫内膜癌的mRI分期:欧洲泌尿生殖影像学学会指南

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国际医学放射学杂志 2009年第5期32卷 504-504页

作者： K.Kinkel R.Forstner F.m.Danza L.Oleaga T.m.cunha A.Bergman 邢艳 Institut de radiologie Clinique des Grangettes7chemin des GrangettesCH 1223 Chêne-Bougerie/GenevaSwitzerland

本研究目的是确定子宫内膜癌的mRI分期指南。由欧洲泌尿生殖放射学学会女性生殖系统分会组织，对欧洲10所医学院与1999年-2008年间发表的文献中关于子宫内膜癌mRI参数进行审核评议并取得专家一致意见。结果表明，高场强mRI至少应包括盆... 详细信息

本研究目的是确定子宫内膜癌的mRI分期指南。由欧洲泌尿生殖放射学学会女性生殖系统分会组织，对欧洲10所医学院与1999年-2008年间发表的文献中关于子宫内膜癌mRI参数进行审核评议并取得专家一致意见。结果表明，高场强mRI至少应包括盆腔内器官的矢状面、斜横断面或斜冠状面（子宫体的长、短横断面）的2个T2加权序列。

关键词：子宫子宫内膜分期子宫肿瘤 mRI 妇科肿瘤学

可疑及局部晚期胰腺癌FOLFIRINOX新辅助化疗后的CT评估

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国际医学放射学杂志 2017年第5期 611-611页

作者： m.Wagner C.Antunes D.Pietrasz C.Cassinotto m.Zappa A.S.cunha 董晨风 UPmC Department of RadiologyHopital Pitié SalpêtrièreAssistance Publique-Hopitaux de ParisSorbonne Universités

摘要目的探讨可疑可切除性(BR)及局部晚期(LA)胰腺癌二次手术后FOLFIRINOX(5-氟尿嘧啶/亚叶酸钙/伊立替康/奥沙利铂)新辅助化疗后CT解剖变化与预测可切除性

关键词：胰腺癌 FOLFIRINOX 新辅助化疗局部晚期 CT