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Prevalence of Latent Tuberculosis Infection [LTBI] in Prison Officers: A Systematic Review and Meta-Analysis

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Open Journal of Respiratory Diseases 2024年第1期14卷 12-24页

作者： thiago Poss moreira Gustavo Henrique Baraca Sanvezzo Maico Trevisol Renan William Mesquita Luiza Scalcon de Oliveira Lia Beatriz Henke de Azevedo Cleide Viviane Buzanello Martins Lirane Elize Defante Ferreto Health Sciences Center Faculty of Medicine Western Paraná State University Francisco Beltr&#227o Brazil Health Sciences Center Postgraduate Program in Applied Health Sciences Western Paraná State University Francisco Beltr&#227o Brazil

This study aimed to perform a systematic review and meta-analysis to determine the LTBI prevalence in prison officers worldwide. A systematic search was performed in PubMed, WoS, Embase, and BVS, including all articles related to LTBI prevalence and risk factors. After critical evaluation and qualitative synthesis of the identified articles, a meta-analysis was used. Five studies carried out between 2012 and 2022 were included, with a total sample size of 1718 prison officers. The overall LTBI prevalence was 50% [95% confidence interval [CI]: 48% - 52%;n = 816], with high heterogeneity between studies. Smoking [OR = 1.76;CI 95% = 1.26 - 2.46] and males [OR = 2.08;CI 95% = 1.31 - 3.31] were positively related to a higher LTBI prevalence among prison officers. Thus, preventive measures and the rapid and accurate diagnosis of new cases should be emphasized to ensure tuberculosis control, especially among risk groups such as prison officers.

关键词： Latent Tuberculosis Mycobacterium tuberculosis Meta-Analysis Prevalence Occupational Exposure

Effect of Turbidity on Semi-Automatic Analysis of Copepod Size and Abundance Distribution in the Water Column

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Advances in Bioscience and Biotechnology 2024年第6期15卷 380-395页

作者： thiago da Silva Matos Carolina Siqueira dos Reis Laura de Andrade Moura Márcio Abreu Ricardo Coutinho Lohengrin Fernandes IEAPM/UFF Marine Biotechnology Post-Graduate Program Arraial do Cabo Brazil Instituto de Estudos do Mar Almirante Paulo moreira Arraial do Cabo Brazil

Automated image systems to characterize aquatic organisms improve research and enable fast response to environmental risk situations. In November 2015, a dam in Mariana City-MG (Brazil) collapsed and led to the disposal of mud tailings from the mining process to the Doce River. The accident resulted in several casualties and incalculable damage to surrounding communities and the environment. The mud increased water turbidity, an essential condition to the functioning of the image analysis systems, and directly affected the characterization of the organisms, making it impossible to distinguish copepods in the mud, due to the blurred outline. To get a quick response evaluating environmental situations, this work aimed to develop and test different algorithms characterizing and classifying copepods by their size (length and area) using in situ images acquired by the Lightframe On-Sight Keyspecies Investigation device. Field tests were carried out under different turbidity levels throughout the gradient observed in the coastal zone adjacent to the Doce River. The best algorithm reduced nearly 50% of the noise in some images when compared with manual treatment and led to 96% accuracy in measurement and counting. Semi-automated devices that perform post-processing corrections are suitable for fast environmental evaluation under high turbidity scenarios.

关键词： Imaging Zooplankton Doce River LOKI Copepod

Influence of physical-anatomical wood variables on charcoal physical-mechanical properties

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Journal of Forestry Research 2023年第2期34卷 531-538页

作者： Allan Motta Couto thiago Campos Monteiro Paulo Fernando Trugilho JoséTarcísio Lima JoséReinaldo moreira da Silva Alfredo Napoli Diego Pierre de Almeida Department of Forestry Science State University of Mato Grosso do Sul–UEMSAv.Graziela Maciel BarrosoKm 12 Zona RuralAquidauanaMS 79200000Brazil Department of Forestry Engineering and Technology Federal University of Paraná–UFPRA V.Pref.Lothário Meissner 632Jardim BotânicoCuritibaPR 80210170Brazil Department of Forestry Science Federal UniversityLavras–UFLALavrasMG 37200000Brazil Département de Performance Des Systèmes de Production Et de Transformation Tropicaux Centre de Coopération Internationale em Recherche Agronomique pour le Développement–CIRADMontpellierFrance

This research assessed the relationship between wood physical-anatomical variables and charcoal physical-mechanical *** trees were harvested and mechanically processed into standard pieces for laboratory *** following variables were determined:wood density,fiber length and width,fiber lumen diameter and wall thickness,fiber wall fraction,and vessel *** charcoal was produced in a laboratory and gravimetric yield,relative density,and mechanical properties ***’s correlation coefficients,multivariate statistical analysis of canonical correlation,and principal component analysis were used to evaluate the relationship between wood and charcoal *** width was not significantly correlated with charcoal *** bulk density,hardness,and strength were positively correlated with wood density,fiber length,wall thickness,and wall *** properties were negatively correlated with fiber lumen diameter and vessel *** results will help identify the best wood with adequate physical-mechanical properties for industrial charcoal proces sing.

关键词： Biomass Density Energy Fiber Vessel

Electrochemical Investigation of Corrosion on AISI 316 Stainless Steel and AISI 1010 Carbon Steel: Study of the Behaviour of Imidazole and Benzimidazole as Corrosion Inhibitors

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Advances in Chemical Engineering and Science 2014年第4期4卷 503-514页

作者： Roberta R. moreira thiago F. Soares Josimar Ribeiro Department of Chemistry Federal University of Espirito Santo Vitoria Brazil

An electrochemical investigation of the corrosion on AISI 316 austenitic stainless steel and AISI 1010 carbon steel in sodium chloride solution (3.0 wt.%) was performed in the absence and presence of imidazole and benzimidazole corrosion inhibitors. The results showed that at any inhibitor concentration (25 ppm to 1000 ppm), there was an increase in the polarisation resistance of both steels. The highest efficiency of corrosion inhibition was obtained using imidazole at a concentration of 50 ppm for both steels, with values of 96% for the AISI 316 stainless steel and 73% for the AISI 1010 carbon steel.

关键词： Stainless Steel Carbon Steel Polarisation Anodic Dissolution Inhibition

Immunoscintigraphy with ^99mTc-Besilesomab in Aid to Fusiariosis Detection in Patients with Relapsed Acute Myeloid Leukemia （AML）： A Case Report and Literature Review

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Journal of Pharmacy and Pharmacology 2017年第4期5卷 207-214页

作者： Elizabeth Campos de Moraes Juliana moreira Silva Flavia Femanda Sichinelle pessoa Luiz Antonio de Abreu Lauriano Pinheiro Diagnostic Center of Nuclear Medicine Dimen at Bandeirantes Hospital Sao Paulo 01507-000 Brazil Clinics Hospital of University of Sao Paulo Medical School Sao Paulo 01246-903 Brazil Neuroscience and Applied Psychology Mackenzie University Sao Paulo 01302-907 Brazil

The aim of this article is to emphasize the importance of nuclear medicine in fungal infection characterization through a case report. Case： patient female, with AML-M2, hospitalized with fever, dyspnea, nausea, myasthenia, abdominal pain and diarrhea. In the physical examination exacerbated lesion in abdominal wall and subcutaneous nodules in upper and lower limbs. The computed tomography of the chest evinced area of attenuation in ground-glass opacities in the middle lobe, tending to consolidation and bilateral nodular opacities with ground-glass halo which suggested an infiammatory/infectious process of fungal etiology. Immunoscintigraphy with ^99mTc-besilesomab （Scintimun） identified focal infectious processes in activity, scattered over cutaneous and subcutaneous tissues, predominantly in extremities. In blood culture test, there was a growth ofFusarium sp. There is a difficulty in the diagnosis of fungal infections, both in clinical and imaging methods. There is no specific method to reaching the target. In addition, fungal diseases can be divided into focally localized or disseminated infections. There is a greater difficulty in the diagnosis of immunocompromised individuals due to the deficiency of basic defense mechanisms. Scintimun （scintigraphy with besilesomab） is a useful tool of nuclear medicine in the diagnosis of infectious and inflammatory diseases to allow the image of the whole-body and in vivo detection of early pathological and physiological phenomena, even before anatomical alterations occur.

关键词： Immunoscintigraphy besilesomab nuclear medicine fusariosis fungal infections immunocompromised.

Inhibitory Effect of the Essential Oil from Hyptis suaveolens （L.） Poit on the Growth and Aflatoxins Synthesis of Aspergillus flavus

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Journal of Life Sciences 2013年第3期7卷 276-281页

作者： Ana Carolina pessoa moreira Egberto Santos Carmo Paulo Alves Wanderley Evandro Leite de Souza Edeltrudes de Oliveira Lima Department of Pharmaceutical Sciences Federal University of Paraiba Joao Pessoa 58051-900 Brazil Academic Unit of Health Federal University of Campina Grande Cuitd 58175-000 Brazil Department of Agriculture Federal University of Paraiba Bananeiras 58220-000 Brazil Laboratory of Food Microbiology Department of Nutrition Federal University of Paraiba Joao Pessoa 58051-900 Brazil

H. suaveolens （L.） Poit has been used in folk medicine revealing a wide pharmacological potential. This study aimed to evaluate the efficacy of the essential oil from 11. suaveolens leaves in inhibiting the growth of A. flavus LM257 and synthesis of aflatoxins Bl and B2. The essential oil at 20, 40 and 80 laL/mL strongly reduced the biomass and spore germination ofA. flavus. A 100% inhibition was found at 40 μL/mL and 80μL/mL, while at 20 μL/mL the growth depressed over 50% for both tested parameters. The essential oil at all assayed concentrations totally inhibited the production of aflatoxin B1 and B2. From these results, the essential oil from 11. suaveolens leaves may be considered as an alternative and effective inhibitor ofA. flavus, in addition to offer some protective effect to the production of aflatoxins.

关键词： Hyptis suaveolens essential oil Aspergillusflavus mycotoxins inhibitory effect.

Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies

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Acta Pharmaceutica Sinica B 2021年第4期11卷 925-940页

作者： Cláudia Pina Costa Joao Nuno moreira JoséManuel Sousa Lobo Ana Catarina Silva UCIBIO/REQUIMTE MedtechLaboratory of Pharmaceutical TechnologyDepartment of Drug SciencesFaculty of PharmacyUniversity of PortoPorto 4050-313Portugal CNC-Center for Neuroscience and Cell Biology Center for Innovative Biomedicine and Biotechnology(CIBB)University of CoimbraFaculty of Medicine(Pólo I)Coimbra 3004-504Portugal UC-University of Coimbra CIBBFaculty of PharmacyPólo Das Ciências da SaúdeCoimbra 3000-548Portugal FP-ENAS(UFP Energy Environment and Health Research Unit)CEBIMED(Biomedical Research Centre)Faculty of Health SciencesUniversity Fernando PessoaPorto 4249-004Portugal

The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the *** the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising *** addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc *** review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain *** on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal *** results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried *** the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the *** systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years.

关键词： Nose-to-brain delivery Intranasal administration Nanostructured lipid carriers NLC Solid lipid nanoparticles SLN Nanoemulsions In vivo studies Pharmacokinetic Pharmacodynamics

A novel supplement with yeast b-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice

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Journal of Integrative Medicine 2021年第5期19卷 439-450页

作者： Victor Abou Nehmi Gilson Masahiro Murata Ruan Carlos Macêdo de Moraes Gabriely Cristina AlvesLima Danielle Araujo De Miranda Katrin Radloff Raquel Galvao Figuerêdo Costa Joyce de Cassia Rosade Jesus Jéssica Alves De Freitas Nayara Izabel Viana Ruan Pimenta Katia Ramos moreira Leite JoséPinhata Otoch Ana Flávia Marcal pessoa Laboratory of Medical Investigation(LIM-26) Department of SurgeryUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Laboratory of Medical Investigation(LIM-29) Clinic Medical DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Department of Physiology Escola Paulista de Medicina/Universidade Federal de Sao PauloSP 04023062Brazil Max Rubner-Institut Federal Research Institute of Nutrition and FoodKarlsruheBW 76131Germany Cancer and Inflammation Program Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892United States Laboratory of Medical Investigation(LIM-55) Urology DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil D'Or Institute for Research and Education RJ 22281-100Brazil Program in Anesthesiology Surgical Sciencesand Perioperative MedicineUniversity of Sao PauloSao PauloSP 01246903Brazil Brazilian Academic Consortium for Integrative Health(CABSIN) Natural Products CommitteeSao PauloSP 05449-070Brazil

Objective: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics,yeast b-glucans, minerals and silymarin(Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese ***: After an acclimation period, 32 male C57 BL/6 mice were divided into the following groups:nonfat diet(NFD) vehicle, NFD supplemented, high-fat diet(HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet(28 consecutive days). We then evaluated energy homeostasis, inflammation, and mitochondrial protein expression in these groups of ***: After four weeks of supplementation, study groups experienced reduced glycemia, dyslipidemia,fat, and hepatic fibrosis levels. Additionally, proliferator-activated receptor-α, AMP-activated protein kinase-1α, peroxisome proliferator-activated receptor γ co-activator-1α, and mitochondrial transcription factor A expression levels were augmented;however, levels of inhibitor of nuclear factor-κB kinase subunit a and p65 nuclear factor-κB expression, and oxidative markers were reduced. Notably, the cortisol/C-reactive protein ratio, a well-characterized marker of the hypothalamic–pituitary–adrenal axis immune interface status, was found to be modulated by the ***: We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis.

关键词： Supplement Silymarin Prebiotic Obese Mice Steatosis Inflammation Mitochondrial biogenesis

Subacute Cutaneous Lupus Erythematosus in Older Man: Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 25-33页

作者： Debora Trindade Martins thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Sebastiao Celio Horta Coelho Filho Vinicius moreira Paladino Bruna Sande Miguel Vinicius Sande Miguel Daniel Almeida da Costa Livia Cristina de Melo Pino The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects mainly women, presents several clinical manifestations and has no known exact cause. The skin is one of the organs that can be affected, with subacute cutaneous lupus erythematosus (SCLE) being one of the classifications according to cutaneous lupus erythematosus lesions. SCLE is commonly found in young to middle age women and carries characteristics related to sun exposure. In this report, there is a rare case of a male and elderly patient that presents SCLE subgroup initially asymptomatic, with subsequent appearance of macular skin lesions and vitiligo appearance. This is an important case to alert health professionals that the disease can manifest itself and open its clinical profile even in patients of sex and unusual ages.

关键词： Autoimmune-Disease Skin Man Lupus