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我来自广告主

现代广告 2016年第15期 60-61页

作者： thiago Stelle Teixeira 沃尔沃拉美集团

首次参加戛纳幼狮比赛的我，身负着两点特殊之处。首先，因为同伴有事，此次我是独自一人来戛纳参加幼狮比赛的。这一点恐十白是幼狮赛事中不多见的。幼狮比赛的—般惯例是由一对选手搭档参赛。这一次—个人出战，连我自己都感觉自己像... 详细信息

首次参加戛纳幼狮比赛的我，身负着两点特殊之处。首先，因为同伴有事，此次我是独自一人来戛纳参加幼狮比赛的。这一点恐十白是幼狮赛事中不多见的。幼狮比赛的—般惯例是由一对选手搭档参赛。这一次—个人出战，连我自己都感觉自己像个超人。

关键词：广告主比赛惯例

Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 65-76页

作者： Giuseppe Potrick Stefani Giovana Baldissera Ramiro Barcos Nunes thiago Gomes Heck Cláudia Ramos Rhoden Laboratory of Physiology Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Oxidative Stress and Atmospheric Pollution Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Toxicological Genetics Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Research Group in Physiology Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Postgraduate Program in Integral Attention to Health Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Department of Pharmacologic Sciences Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil

The Metabolic Syndrome (MetS) is a complex condition which is characterized by increased risk factor for cardiovascular diseases, such as dyslipidemia, hypertension and central obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All of these factors alone have a notable relationship with DNA damage. However, when the risks are combined, the extent for major outcomes being related to DNA damage (cancer), the consequence can be accelerated by the metabolic dysfunction. This article will illustrate the scientific evidence of the role of DNA damage in MetS, as well as discuss the interplay of major risks factors (air pollution, physical inactivity and dietary interventions) in genomic stability.

关键词： Metabolic Syndrome DNA Damage Diet Physical Activity Air Pollution

Evaluation of Cytotoxicity of <i>Gossypium barbadense</i>L. Extract in Bone Cord Cells through the Micronucleus Test

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Journal of Biosciences and Medicines 2017年第7期5卷 84-91页

作者： thiago dornelas de Oliveira Joice Meire Rodrigues thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Juscélio Clemente de Abreu Lamara Laguardia Valente Rocha Raquel Xavier Ligeiro Dias Daniel Almeida da Costa Academic of the Graduate Course in Medicine of the University Center of Caratinga Caratinga Brazil Religious Sciences from the Pontifical Catholic University of Sao Paulo Sao Paulo Brazil The Medical School at the Center of Higher Education of Valenca Valenca Brazil The Institute of Health Sciences of the University Center of Caratinga Caratinga Brazil Federal University of Lavras Lavras Brazil Federal University of Vicosa Vicosa Brazil Department of Biochemistry and Molecular Biology at the Federal University of Vicosa Vicosa Brazil Faculty of Medicine of Valenca Valenca Brazil

The cotton plant is a plant belonging to the family Malvaceae and its leaves are often used in folk medicine. The present study aimed to evaluate the mutagenic or antimutagenic activity of the ethanolic extract of Gossypium barbadense L. (EEG) and to analyze its capacity to prevent or repair mutagenic lesions caused by cyclophosphamide (CP). For the Micronucleus test, Swiss mice were divided into 5 groups: negative control;Positive control: treated with 50 mg/kg cyclophosphamide (CP), group receiving EEG 500 mg/kg for 7 days;Group receiving EEG 500 mg/kg for 7 days associated with CP24h before euthanasia;Group who received CP and EEG 500 mg/kg for 7 days. After the treatment period, the animals were euthanized, the bone marrow removed and the blood smear prepared. From this analysis, it was observed that the EEG caused a significant increase in the number of micronucleated erythrocytes, indicating mutagenic activity of the extract. In addition, it was verified that the extract did not present the capacity to prevent, but it presented the capacity of repair of the chromosomal damages caused by CP.

关键词： Gossypium Mutagenesis Phytotherapy

Corticosteroids for severe influenza pneumonia: A critical appraisal

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World Journal of Critical Care Medicine 2016年第1期5卷 89-95页

作者： Wagner Luis Nedel David Garcia Nora Jorge Ibrain Figueira Salluh thiago Lisboa Pedro Póvoa Intensive Care Unit Hospital Nossa Senhora da Concei??o Intensive Care Unit Vila Franca de Xira Hospital D’or Institute for Research and Education Critical Care Department Hospital de Clinicas de Porto Alegre Post-Graduation Program (PPG) Pneumology Universidade Federal do Rio Grande do Sul Polyvalent Intensive Care Unit S?o Francisco Xavier Hospital Centro Hospitalar de Lisboa Ocidental Nova Medical School CEDOC New University of Lisbon

Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit(ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in s evere influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials.

关键词： Influenza Mechanical ventilation Pneumonia Corticosteroids Respiratory failure

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Endobiliary biopsy

World Journal of Gastrointestinal Endoscopy 2022年第5期14卷 291-301页

作者： Riccardo Inchingolo Fabrizio Acquafredda Alessandro Posa thiago Franchi Nunes Stavros Spiliopoulos Francesco Panzera Carlos Alberto Praticò Interventional Radiology Unit "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy Department of Radiology Policlinico Universitario“A.Gemelli”Rome 00186Italy Interventional Radiology Unit Universidade Federal de Mato Grosso do SulCampo Grande 79070-900Brazil 2^(nd)Department of Radiology Interventional Radiology UnitNational and Kapodistrian University of AthensAthens 12461Greece Interventional Gastroenterology Unit Madonna Delle Grazie HospitalMatera 75100Italy Unitéd’Endoscopie Digestive Hôpital Privé“Armand Brillard”3/5 avenue WatteauNogent-sur-Marne 94130France

The differential diagnosis between benign and malignant biliary strictures is challenging and requires a multidisciplinary approach with the use of serum biomarkers,imaging techniques,and several modalities of endoscopic or percutaneous tissue *** diagnosis of biliary strictures consists of laboratory markers,and invasive and non-invasive imaging examinations such as computed tomography(CT),contrast-enhanced magnetic resonance cholangiopancreatography,and endoscopic ultrasonography(EUS).Nevertheless,invasive imaging modalities combined with tissue sampling are usually required to confirm the diagnosis of suspected malignant biliary strictures,while pathological diagnosis is mandatory to decide the optimal therapeutic *** EUS-guided fine-needle aspiration biopsy is currently the standard procedure for tissue sampling of solid pancreatic mass lesions,its diagnostic value in intraductal infiltrating type of cholangiocarcinoma remains ***,the“endobiliary approach”using novel slim biopsy forceps,transpapillary and percutaneous cholangioscopy,and intraductal ultrasound-guided biopsy,is gaining ground on traditional endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography endobiliary forceps *** review focuses on the available endobiliary techniques currently used to perform biliary strictures biopsy,comparing the diagnostic performance of endoscopic and percutaneous approaches.

关键词： Biliary strictures Endoscopic retrograde cholangiography Cholangioscopy Endobiliary forceps biopsy Intraductal ultrasound-guided biopsy Percutaneous transhepatic

Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens

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World Journal of Gastroenterology 2013年第22期19卷 3439-3446页

作者： Marcos Eduardo Lera dos Santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz thiago Ferreira de Souza Fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai Department of Gastroenterology Hospital das Clínicas University of Sao Paulo Medical School Sao Paulo CEP 05403-900 Brazil Cancer Institute of Sao Paulo State Sao Paulo CEP 01246-000 Brazil

AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group.

关键词： Endoscopy Deep sedation Anesthetic administration Anesthetic dose Adverse effects

Chromate and the Environment： Removal and Utilization of Industrial Waste

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Journal of Chemistry and Chemical Engineering 2016年第3期10卷 147-152页

作者： Femando B. Mainier Pedro Paulo B. Leite Marcone F. Reis thiago Teobaldo Silva Engineering School Federal Fluminense University(UFF) Niteroi Rio de Janeiro 24220-261 Brazil

Chromate and dichromate sodium as a function of oxidizer characteristics are used in several industrial areas; for example, in surface protection of coated parts of cadmium, zinc and aluminum （chromate coated treated）, corrosion inhibitors, the treatment of leather, the manufacture of pigments, etc. However, the use of such products has been questioned due to the problems of toxicity and pollution that can be caused in the environmental. The Brazilian environmental agency has established that the concentrations of chromate in water courses are less than 0.5 ppm. In order to reuse chromate （CrO42） from industrial effluent, laboratory experiments have been proposed based on chemical reduction or electrolytic processes, in order to transform these chromate ions in a final mix of oxides （in solid form）, which can then be packed and sent to the production process of sodium chromate. The results of these experiments have become useful industrially （without regard to costs） considering the environmental reuse and the life cycle of the chemical compound.

关键词： Chromate dichromate contamination chemical reduction electrolytic process.

Integration of Tropical Renewable Energies

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Journal of Energy and Power Engineering 2019年第3期13卷 91-96页

作者： Daltro Garcia Pinatti Rosa Ana Conte thiago Hirosse Silva Luis Miguel Paulo Rodolpho de Oliveira Moreira Department of Materials Engineering Lorena School of EngineeringUniversity of S鉶 PauloLorena 12602-810Brazil

Main sources of renewable energy in the tropics are solar thermal and ***-performance concrete(HPC)allows prefabrication of stakes,planks,boards,U-,L-,and I-profiles,prestressed thick-wall cylinders,and arc *** are used to construct fences,level curves,buildings,contention walls,water and anaerobic tanks,and *** production is increased by retention of rain water in the soil by level curves,in riparian tanks,and with *** anaerobic digesters produce biogas,biochar,and liquid *** is partially washed in medium-pressure vessel to obtain vehicular methane gas,which is partially burned in engine generator sets,whose combustion gases are fed into a boiler of a thermoelectric *** cycle is thermal solar regenerative Rankine cycle with heat *** receives hot water from thermal solar parabolic collectors,burns residual biomass and biochar generating steam for a turbogenerator set and combustion gas for condenser dryer silo,whose exhaustion heat goes to anaerobic digesters.

关键词： High-performance concrete profiles thermal solar-biomass energy generation biomass anaerobic digester biogas

Interannual Variability of Energy Flux in Atmospheric Instability Conditions at Pantanal of Mato Grosso-Brazil

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Atmospheric and Climate Sciences 2012年第4期2卷 518-524页

作者： Leone Francisco Amorim Curado José de Souza Nogueira Luciana Sanches Marcelo Sacardis Biudes thiago Rangel Rodrigues Programa de Pós-Graduacao em Física Ambiental-UFMT Brazil

The energy balance partitions in wetlands have gained notoriety due to the dynamics and importance of these areas for regional and local climate. Thus, the study was conducted about seasonal and interannual behavior energy fluxes, as well as the influences of the conditions of atmospheric stability and instability. The results showed highest fluxes happened in instability atmospheric conditions. The fluxes of latent and sensible heat showed seasonal variation, indicating that the water availability in the atmosphere has influence on the site energy partition, but the interannual patterns remained similar during the two years of study.

关键词： Latent Heat Sensible Heat Energy Partition Wetlands