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Hepatobiliary phases in magnetic resonance imaging using liverspecific contrast for focal lesions in clinical practice

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World Journal of Hepatology 2022年第7期14卷 1459-1469页

作者： Daniel Alvarenga Fernandes Eduardo Andreazza Dal Lago Felipe Aguera Oliver Bruna Melo Coelho Loureiro Daniel Lahan Martins thiago josé penachim Ricardo Hoelz de Oliveira Barros josé de ArimatéiaBatista Araújo Filho Larissa Bastos Eloy da Costa Áurea Maria Oliveira da Silva Elaine Cristina de Ataíde Ilka de Fátima Santana Ferreira Boin Nelson Marcio Gomes Caserta Department of Radiology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazi Department of Radiology Medical SchoolSão Paulo State University-UNESPBotucatu 18618-970São PauloBrazil Instituto de Radiologia Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo-InRad/HC-FMUSPSão Paulo 05403-010SPBrazil Department of Radiology Sírio-Libanês HospitalSão Paulo 05652-900SPBrazil Department of Pathology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil Liver Transplant Unit Department of SurgerySchool of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil

BACKGROUND Challenging lesions,difficult to diagnose through non-invasive methods,constitute an important emotional burden for each patient regarding a still uncertain diagnosis(malignant x benign).In addition,from a therapeutic and prognostic point of view,delay in a definitive diagnosis can lead to worse outcomes.One of the main innovative trends currently is the use of molecular and functional methods to diagnosis.Numerous liver-specific contrast agents havebeen developed and studied in recent years to improve the performance of liver magnetic resonance imaging(MRI).More recently,one of the contrast agents introduced in clinical practice is gadoxetic acid(gadoxetate disodium).AIM To demonstrate the value of the hepatobiliary phases using gadoxetic acid in MRI for the characterization of focal liver lesions(FLL)in clinical practice.METHODS Overall,302 Lesions were studied in 136 patients who underwent MRI exams using gadoxetic acid for the assessment of FLL.Two radiologists independently reviewed the MRI exams using four stages,and categorized them on a 6-point scale,from 0(lesion not detected)to 5(definitely malignant).The stages were:stage 1-images without contrast,stage 2-addition of dynamic phases after contrast(analogous to usual extracellular contrasts),stage 3-addition of hepatobiliary phase after 10 min(HBP 10’),stage 4-hepatobiliary phase after 20 min(HBP 20’)in addition to stage 2.RESULTS The interobserver agreement was high(weighted Kappa coefficient:0.81-1)at all stages in the characterization of benign and malignant FLL.The diagnostic weighted accuracy(Az)was 0.80 in stage 1 and was increased to 0.90 in stage 2.Addition of the hepatobiliary phase increased Az to 0.98 in stage 3,which was also 0.98 in stage 4.CONCLUSION The hepatobiliary sequences improve diagnostic accuracy.With growing potential in the era of precision medicine,the improvement and dissemination of the method among medical specialties can bring benefits in the management of patients with FLL that are difficult to diagnose.

关键词： Liver Liver neoplasms Liver transplantation Medical oncology Diagnostic imaging Magnetic resonance imaging

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Tribologically induced nanostructural evolution of carbon materials: A new perspective

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Friction 2024年第1期12卷 144-163页

作者： Guilherme Oliveira NEVES Nicolás ARAYA Diego Berti SALVARO thiago de Souza LAMIM Renan Oss GIACOMELLI Cristiano BINDER Aloisio Nelmo KLEIN joséDaniel Biasoli de MELLO Laboratório de Materiais Universidade Federal de Santa CatarinaSanta Catarina 88040-900Brazil Departamento de Ingeniería Mecánica Facultad de IngenieríaUniversidad del Bío-BíoConcepcion 4070-386Chile Universidad de Concepción Concepcion 4070-386Chile SENAI Innovation Institute for Laser Processing Santa Catarina 89218-153Brazil Universidade Federal de Uberlândia Minas Gerais 38408-100Brazil

Carbon-based solid lubricants are excellent options to reduce friction and wear,especially with the carbon capability to adopt different allotropes forms.On the macroscale,these materials are sheared on the contact along with debris and contaminants to form tribolayers that govern the tribosystem performance.Using a recently developed advanced Raman analysis on the tribolayers,it was possible to quantify the contactinduced defects in the crystalline structure of a wide range of allotropes of carbon-based solid lubricants,from graphite and carbide-derived carbon particles to multi-layer graphene and carbon nanotubes.In addition,these materials were tested under various dry sliding conditions,with different geometries,topographies,and solid-lubricant application strategies.Regardless of the initial tribosystem conditions and allotrope level of atomic ordering,there is a remarkable trend of increasing the point and line defects density until a specific saturation limit in the same order of magnitude for all the materials tested.

关键词： carbon nanostructures tribology Raman spectroscopy defects quantification tribolayer solid lubrication

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Influence of physical-anatomical wood variables on charcoal physical-mechanical properties

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Journal of Forestry Research 2023年第2期34卷 531-538页

作者： Allan Motta Couto thiago Campos Monteiro Paulo Fernando Trugilho joséTarcísio Lima joséReinaldo Moreira da Silva Alfredo Napoli Diego Pierre de Almeida Department of Forestry Science State University of Mato Grosso do Sul–UEMSAv.Graziela Maciel BarrosoKm 12 Zona RuralAquidauanaMS 79200000Brazil Department of Forestry Engineering and Technology Federal University of Paraná–UFPRA V.Pref.Lothário Meissner 632Jardim BotânicoCuritibaPR 80210170Brazil Department of Forestry Science Federal UniversityLavras–UFLALavrasMG 37200000Brazil Département de Performance Des Systèmes de Production Et de Transformation Tropicaux Centre de Coopération Internationale em Recherche Agronomique pour le Développement–CIRADMontpellierFrance

This research assessed the relationship between wood physical-anatomical variables and charcoal physical-mechanical properties.Nine trees were harvested and mechanically processed into standard pieces for laboratory analysis.The following variables were determined:wood density,fiber length and width,fiber lumen diameter and wall thickness,fiber wall fraction,and vessel frequency.The charcoal was produced in a laboratory and gravimetric yield,relative density,and mechanical properties established.Pearson’s correlation coefficients,multivariate statistical analysis of canonical correlation,and principal component analysis were used to evaluate the relationship between wood and charcoal properties.Fiber width was not significantly correlated with charcoal properties.Charcoal bulk density,hardness,and strength were positively correlated with wood density,fiber length,wall thickness,and wall fraction.Charcoal properties were negatively correlated with fiber lumen diameter and vessel frequency.These results will help identify the best wood with adequate physical-mechanical properties for industrial charcoal proces sing.

关键词： Biomass Density Energy Fiber Vessel

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Behavior of wood basic density according to environmental variables

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Journal of Forestry Research 2022年第2期33卷 497-505页

作者： Gabriel Marcos Vieira Oliveira joséMárcio de Mello Carlos Rogério de Mello joséRoberto Soares Scolforo Eder Pereira Miguel thiago Campos Monteiro Brazil Institute of Agricultural and Forestry Defense of Espírito Santo(IDAF) Av.Lourival Lugon Moulinnº300CentroJerônimo MonteiroES CEP:29.550-000Brazil Department of Forestry Sciences Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Engineering Department Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Forestry Engineering Department Faculdade de TecnologiaUniversity of Brasilia-UnBCampus Universitário Darcy RibeiroCaixa Postal 4357Asa Norte-BrasíliaDF CEP:70910-900Brazil Department of Forestry Engineering and Technology Universidade Federal do Paraná-UFPRAv.Pref.Lothário Meissner632Jardim BotânicoCuritibaPR CEP:80.210-170Brazil

The relationships between climate conditions and wood density in tropical forests are still poorly understood.To quantify spatial dependence of wood density in the state of Minas Gerais(MG,Brazil),map spatial distribution of density,and correlate density with climate variables,we extracted data from the Forest Inventory of Minas Gerais for 1988 trees scaled throughout the territory and measured wood density of discs removed from the trees.Environmental variables were extracted from the database of the Ecological-Economic Zoning of Minas Gerais.For spatial analysis,tree densities were measured at 44 georeferenced sampling points.The data were subjected to exploratory analysis,variography,cross-validation,model selection,and ordinary kriging.The relationships between wood density and environmental variables were calculated using dispersion matrices,linear correlation,and regression.Wood density proved to be highly spatially dependent,reaching a correlation of 96%,and was highly continuous over a distance of 228 km.The distribution of wood density followed a continuous gradient of 514-659 kg m^(−3),enabling corre-lation with environment variables.Density was correlated with mean annual precipitation(−0.57),temperature(0.63),and evapotranspiration(0.83).Geostatistical methods proved useful in predicting wood density in native tropical forests with different climate conditions.Our results confirmed the sensitivity of wood density to climate change,which could affect future carbon stock in forests.

关键词： Biomass Climate variables Geostatistics Hardwood Forest inventory Minas Gerais

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Energy Efficiency Technologies for Hydroelectric Power Plants: A Case Study in Brazil

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Journal of Power and Energy Engineering 2022年第5期10卷 90-115页

作者： thiago Averaldo Bimestre josé Antonio Mantovani Júnior Eliana Vieira Canettieri Celso Eduardo Tuna Pedro Magalhães Sobrinho Chemistry and Energy Department School of Engineering S&#227o Paulo State University UNESP Guaratinguetá Brazil Center for Weather Forecasting and Climate Studies National Institute for Space Research CPTEC/INPE Cachoeira Paulista Brazil

Hydroelectricity has great importance for the global macroeconomy. In Brazil, hydroelectricity has been highlighted as the main source of generation of the electric system both for its economic competitiveness and for the abundance of this energy resource. Based on a diagnosis methodology, this article presents a case study in a Brazilian hydroelectric plant in order to optimize the use of energy and propose improvements regarding the rationalization of its application. The systems associated with energy generation were evaluated and the results proved to be potentially advantageous with an estimated savings of 2910 MWh/year in the electricity consumption of the installation itself, with better use of the equipment and the possibility of increasing the power generated.

关键词： Hydropower Plant Renewable Energy Technology Energy Efficiency Energetic Diagnosis Sustainable

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Gas-Solid Flow Behavior in a Pneumatic Conveying System for Drying Applications: Coarse Particles Feeding with a Venturi Device

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Advances in Chemical Engineering and Science 2015年第3期5卷 225-238页

作者： thiago Faggion de Pádua Rodrigo Béttega josé Teixeira Freire Department of Chemical Engineering Federal University of S&#227 o Carlos S&#227 o Carlos Brazil

The feeding of coarse particles (>0.5 mm diameter) directly into a riser operating at positive pressure is important for drying and pre-heating applications. The presence of the feeding device can lead to heterogeneity of drying and heating, and is the main factor responsible for pressure loss in short conveying systems. However, there is a lack of information concerning the axial and radial distributions of coarse particles in this type of configuration, despite the recent advances when dealing with fine particles (FCC catalyst). The present work therefore investigates a vertical venturi feeder with the conveying system operating in dilute-phase regime with 1 mm spherical glass particles. Experimental assays revealed the behavior of the mass flow rate of solids in the system, and pressure measurements were made along the riser in order to evaluate the accuracy of simulations. Euler-Euler simulations provided close estimation of the experimental pressure drop and the pressure drop according to distance in the linear region. Simulation of the fluid dynamics in the riser showed that solids clusters were formed at low concentrations near the feeding device, reflecting heterogeneity in the solid phase volume fraction.

关键词： Pneumatic Conveying Venturi Feeder Coarse Particles Drying CFD

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Interannual Variability of Energy Flux in Atmospheric Instability Conditions at Pantanal of Mato Grosso-Brazil

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Atmospheric and Climate Sciences 2012年第4期2卷 518-524页

作者： Leone Francisco Amorim Curado josé de Souza Nogueira Luciana Sanches Marcelo Sacardis Biudes thiago Rangel Rodrigues Programa de Pós-Graduacao em Física Ambiental-UFMT Brazil

The energy balance partitions in wetlands have gained notoriety due to the dynamics and importance of these areas for regional and local climate. Thus, the study was conducted about seasonal and interannual behavior energy fluxes, as well as the influences of the conditions of atmospheric stability and instability. The results showed highest fluxes happened in instability atmospheric conditions. The fluxes of latent and sensible heat showed seasonal variation, indicating that the water availability in the atmosphere has influence on the site energy partition, but the interannual patterns remained similar during the two years of study.

关键词： Latent Heat Sensible Heat Energy Partition Wetlands

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Postgraduate education among family and community physicians in Brazil:the Trajetórias MFC project

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Family Medicine and Community Health 2020年第3期8卷 1-10页

作者： Leonardo Ferreira Fontenelle Stephani Vogt Rossi Miguel Henrique Moraes de Oliveira Diego joséBrandão thiago Dias Sarti Medical School Universidade Vila VelhaVila VelhaBrazil Commission of Medical Residency Universidade Vila VelhaVila VelhaBrazil Department of Social Medicine Universidade Federal do Espirito SantoVitoriaBrazil

Objective Our objective was to describe the postgraduate education trajectories of family and community physicians in Brazil,where neither primary healthcare nor family and community medicine is recognised as a knowledge area for the purpose of research and postgraduate education(master’s and PhD degrees).Design An observational,exploratory study,using administrative data.A nationwide list of family and community physicians as of late November 2018 was compiled from multiple sources.Data on the mode of specialisation was obtained from the same sources and were correlated with data on master’s and PhD degrees,obtained from the curricula vitae on the Lattes Platform.Setting This study was set in Brazil.Participants 6238 family and community physicians(58.3%female),of whom 2795 had earned a specialist certificate(identified from the list of physicians certified by Sociedade Brasileira de Medicina de Família e Comunidade)and 3957 had completed medical residency(identified from SisCNRM,the national information system for medical residency).Results A master’s degree was held by 747(12.0%)family and community physicians,and a PhD by 170(2.7%);most degrees were in collective health(47.0%and 42%,respectively).Men were more likely than women to hold a master’s degree(adjusted odds ratio(aOR)1.24,95%uncertainty interval(UI)1.07-1.45)and even more likely to a hold PhD(aOR 1.86,95%UI 1.35-2.59).Family and community physicians were also less likely to hold a PhD degree if their master’s degree was professional(oriented towards jobs outside academia)instead of academic(aOR 0.15,95%UI 0.05-0.39)or in some area other than collective health or medicine(aOR 0.41,95%UI 0.21-0.78,compared with a master’s degree in collective health).The postgraduate degree was more likely to precede specialisation for family and community physicians specialising through certification(master’s degree 39.9%,PhD 33%)than through medical residency(master’s degree 9.1%,PhD 6%).Conclusion Family and community physicians in Brazil increasingly earn academic

关键词： MFC collective education

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Inter Seasonality of the Energy Fluxes in Brazilian Savana—Mato Grosso—Brazil

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Atmospheric and Climate Sciences 2014年第2期4卷 219-230页

作者： Leone Francisco Amorim Curado josé de Souza Nogueira Luciana Sanches thiago Rangel Rodrigues Francisco de Almeida Lobo Marcelo Sacardi Bíudes Federal University of Mato Grosso Cuiabá Brazil

Dynamics of flows of matter and energy these biomes are relevant to understanding of environmental processes that govern the biosphere-atmosphere interactions and between ecosystems. This study analyzed inter season and season of energy fluxes in Brazilian Savana through Bowen Ration Method. Results show differences in patterns LE in all season, LE predominant in wet while H in dry. This inversion in patterns of predominant components of the energy balance in wet and dry season because in wet season increase water content in soil and atmosphere due precipitation in this season providing more lost energy for atmosphere in shape LE through soil evaporation and plant transpiration, this results in LE and H in all season of the Brazilian Savana show higher variation in dynamics energy fluxes between surface and atmosphere, as well as energy partition in this biome. Statistics analyses presents than many climate variables influences LE and H in each season indicating complexity in this fluxes. More study is necessary to higher understand patterns energies fluxes in Brazilian Savana.

关键词： Patterns Energies LE H Bowen Ration

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Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum(Vell.)Morong

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 945-949页

作者： Zildene de Sousa Silveira Nair Silva Macêdo thiago Sampaio de Freitas Ana Raquel Pereira da Silva Joycy Francely Sampaio dos Santos Maria Flaviana Bezerra Morais-Braga josé Galberto Martins da Costa Raimundo Nonato Pereira Teixeira Jean Paul Kamdem Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha Laboratorio de Bioprospeccao do Semioarido Universidade Regional do CaririCratoBrazil Laboratorio de Microbiologia e Biologia Molecular Universidade Regional do CaririCratoBrazil Laboratorio de Pesquisas de Produtos Naturais Universidade Regional do CaririCratoBrazil Departamento de Ciencias biologicas Universidade Regional do Cariri-URCACratoCEP:63105-000Brazil Programa de Pos-graduacao em Bioprospeccao Molecular Universidade Regional do Cariri–URCACratoBrazil

Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.Methods: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution method.Results: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.

关键词： Antibiotic activity Enhancement Synergism Chemical compounds Bioactivity

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