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Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： Dao thi thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee Duong Thu Trang nguyen thi Thu Minh Pham Van Cuong Do thi Ngoc Lan nguyen Hai Dang nguyen Tien Dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology Transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

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Comparative study on water-soluble inorganic ions in PM2.5 from two distinct climate regions and air quality

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Journal of Environmental Sciences 2020年第2期32卷 349-360页

作者： Duong Huu Huy Le Tu thanh To thi Hien Norimichi Takenaka Faculty of Food Science and Technology Ho Chi Minh City University of Food Industry140 Le Trong Tan StreetTan Phu DistrictHo Chi Minh CityViet Nam Faculty of Environment University of ScienceVietnam National University–Ho Chi Minh City227 Nguyen Van Cu StreetDistrict 5Ho Chi Minh CityViet Nam Graduate School of Humanities and Sustainable System Sciences Osaka Prefecture University1-1 Gakuen-choNaka-kuSakai-shiOsaka 599-8531Japan

Recently, air quality has significantly improved in developed country, but that issue is of concern in emerging megacity in developing *** this study, aerosols and their precursor gas were collected by NILU filter pack at two distinct urban sites during the winter and summer in Osaka, Japan and dry and rainy seasons in Ho Chi Minh City(HCMC),*** aims are to investigate the contribution of water-soluble inorganic ions(WSIIs) to PM2.5, thermodynamic characterization and possible formation pathway of secondary inorganic aerosol(SIA).The PM2.5 concentration in Osaka(15.8 μg/m^3) is lower than that in HCMC(23.0 μg/m^3), but the concentration of WSIIs in Osaka(9.0 μg/m^3) is two times higher than that in HCMC(4.1 μg/m^3).Moreover, SIA including NH4^+, NO3^-and SO4^2-are major components in WSIIs accounting for 90% and 76%(in molar) in Osaka and HCMC,*** models were used to understand the thermodynamic characterization of urban ***, statistical analysis results indicate that very good agreement(R2> 0.8) was found for all species, except for nitrate aerosol in *** found that when the crustal species present at high amount, those compositions should be included in model calculation(*** the HCMC situation).Finally, we analyzed the characteristics of NH4^+– NO3^-– SO4^2-system.A possible pathway to produce fine nitrate aerosol in Osaka is via the homogeneous reaction between NH3 and HNO3, while nonvolatile nitrate aerosols can be formed by the heterogeneous reactions in HCMC.

关键词： Water-soluble inorganic ions Thermodynamic model PM2.5

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Novel Deletion in Exon 7 of Betaine Aldehyde Dehydrogenase 2(BADH2)

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Rice science 2023年第2期30卷 104-112,I0020-I0030页

作者： VAN Quoc Giang HUYNH Ky nguyen Chau thanh Tung nguyen Loc Hien nguyen van Manh nguyen Nhut thanh VO Cong thanh SWEE Keong Yeap College of Agriculture Can Tho UniversityCan Tho 92000Vietnam Department of Sciences and Technology of Long An Province Long An 850000Vietnam China-Association of Southeast Asian Nations College of Marine Sciences Xiamen University MalaysiaSepang 49000SelangorMalaysia

The fragrance of rice is one of the premium characteristics that breeders want to include in rice varieties due to the higher market value. Nucleotide deletions in exons 2(7 bp) and 7(8 bp) of Betaine Aldehyde Dehydrogenase 2(BADH2) are associated with fragrance in rice. In this study, a new 13 bp deletion in exon 7 of the BADH2 gene was discovered in the Nang Thom Cho Dao(NTCD) variety, and the mutation has been closely related to the genetic background of indica subspecies through the Bayesian phylogenetic approach and haplotype network analysis of the 3 000 Rice Genomes Project. In addition, a set of functional markers(EX07-13F, EX07-13RN, and EX07-13RM) identified the 13 bp deletion only within NTCD(no amplified band) compared with both non-aromatic and other aromatic rice varieties(110 bp band). The deletion of 13 bases instead of 8 bases in exon 7 of BADH2 caused a premature stop codon, which down-regulated the expression of the BADH2 transcript while associated with up-regulation of OsP5CS and the high amount of 2-acetyl-1-pyrroline. It is potential to use the deletion in exon 7 of the BADH2 gene as a novel marker for adulteration and breeding of fragrant rice varieties, particularly for NTCD.

关键词： novel deletion BADH2 fragrant rice functional marker

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Streaming and congestion control using scalable video coding based on H.264/AVC

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 749-754页

作者： nguyen Dieu thanh OSTERMANN Joern Institute of Information Technology University of Hannover Hannover 30167 Germany

this paper presents a streaming system using scalable video coding based on H.264/AVC. The system provides a congestion control algorithm supported by channel bandwidth estimation of the client. It uses retransmission only for packets of the base layer to disburden the congested network. The bandwidth estimation allows for adjusting the transmission rate quickly to the current available bandwidth of the network. Compared to binomial congestion control, the proposed system allows for shorter start-up times and data rate adaptation. The paper describes the components of this streaming system and the results of experiments showing that the proposed approach works effectively for streaming video.

关键词： Scalable video coding, Congestion control, Bandwidth estimation, Transport protocols, Retransmission

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20-Hydroxyecdysone from Dacrycarpus imbricatus bark inhibits the proliferation of acute myeloid leukemia cells

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 151-153页

作者： Trinh thi Thuy nguyen thanh Tam nguyen thi Hoang Anh Dang Viet Hau Dinh thi Phong Le Quoc Thang Sabrina Adorisio Tran Van Sung Domenico V Delfino Institute of Chemistry Vietnam Academy of Science and Technology Vietnam National Museum of Nature Vietnam Academy of Science and Technology Hue University’s College of Educations Section of Pharmacology Department of MedicineUniversity of Perugia

Objective:To investigate the anti-proliferative effects of 20-hydroxyecdysone isolated from the bark of Dacrycarpus imbricatus(Blume) de ***:Column chromatography was used for isolation of compounds from plant *** structure of the isolated compound was identified by mass spectrometry and nuclear magnetic resonance techniques,including HSQC,HMBC,NOE-difference *** isolated compound was tested for its anti-proliferative activity in acute myeloid leukemia(AML) and OCI-AML ***:Compound 1 was isolated from the ethyl acetate fraction of Dacrycarpus imbricatus barks by column *** chemical structure was identified as 20-hydroxyecdysone(20HE),a cholestane-type ecdysteroid,by a combination of mass spectrometry and nuclear magnetic resonance spectrometric *** goal was to test the anti-proliferative activity of 20 HE using the OCI-AML cell line.20 HE significantly decreased OCI cell number at a concentration of 1 mg/mL,whereas lower concentrations were ***,this decrease was due to partial blockage of the G_1/S phase of the cell cycle,with a reduction of cells in the G_2M phase,not due to increased ***:this indicates that 20 HE significantly decreases the number of cells in the G_1/S phase of the cell cycle in human AML *** is the first time that the anti-proliferative activity of 20 HE against a human tumor cell line has been reported.

关键词： Dacrycarpus imbricatus Ecdysteroid 20-hydroxyecdysone Proliferation Acute myeloid leukemia

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Hybrid model to optimize object-based land cover classification by meta-heuristic algorithm:an example for supporting urban management in Ha Noi,Viet Nam

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International Journal of Digital Earth 2019年第10期12卷 1118-1132页

作者： Quang-thanh Bui Manh Pham Van nguyen thi Thuy Hang Quoc-Huy nguyen nguyen Xuan Linh Pham Minh Hai Tran Anh Tuan Pham Van Cu Center for Applied Research in Remote sensing and GIS(CARGIS) VNU University of ScienceHa NoiViet Nam VNU University of Science Ha NoiViet Nam Vietnam Institute of Geodesy and Cartography Ha NoiViet Nam Ministry of Education and Training Ha NoiViet Nam

this study proposed a novel object-based hybrid classification model named GMNN that combines Grasshopper Optimization Algorithm(GOA)and the multiple-class Neural network(MNN)for urban pattern detection in Hanoi,*** bands of SPOT 7 image and derivable NDVI,NDWI were used to generate image segments with associated attributes by PCI Geomatics *** segments were classified into four urban surface types(namely water,impervious surface,vegetation and bare soil)by the proposed ***,three training and validation datasets of different sizes were used to verify the robustness of this *** all tests,the overall accuracies of the classification were approximately 87%,and the Area under Receiver Operating Characteristic curves for each land cover type was ***,the performance of this model was examined by comparing several statistical indicators with common benchmark *** results showed that GMNN out-performed established methods in all comparable *** results suggested that our hybrid model was successfully deployed in the study area and could be used as an alternative classification method for urban land cover *** a broader sense,classification methods will be enriched with the active and fast-growing contribution of metaheuristic algorithms.

关键词： Urban remote sensing object-based classification neural network grasshopper optimization algorithm

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Numerical investigation of the influence of casting techniques on fiber orientation distribution in ECC

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Frontiers of Structural and Civil Engineering 2022年第11期16卷 1424-1435页

作者： Chung nguyen VAN Hai TRAN thanh Thuc Nhu nguyen Jianchun LI Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh 721400Vietnam School of Civil and Environmental Engineering University of Technology SydneySydneyNSW 2007Australia School of Civil Engineering Hue Industrial CollegeHue 49120Vietnam

Engineered cementitious composites(ECC),also known as bendable concrete,were developed based on engineering the interactions between fibers and cementitious *** orientation of fibers,in this regard,is one of the major factors influencing the ductile behavior of this *** this study,fiber orientation distributions in ECC beams influenced by different casting techniques are evaluated via numerical modeling of the casting *** casting directions and two casting positions of the funnel outlet with beam specimens are modeled using a particle-based smoothed particle hydrodynamics(SPH)*** this SPH approach,fresh mortar and fiber are discretized by separated mortar and fiber particles,which smoothly interact in the computational domain of *** movement of fiber particles is monitored during the casting ***,the fiber orientations at different sections of specimens are determined after the fresh ECC stops flowing in the *** simulation results show a significant impact of the casting direction on fiber orientation distributions along the longitudinal wall of beams,which eventually influence the flexural strength of *** addition,casting positions show negligible influences on the orientation distribution of fibers in the short ECC beam,except under the pouring position.

关键词： ECC fiber orientation distribution casting direction casting position

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Simultaneous Quantitative Analysis of Five Components in Angelica sinensis and Angelica acutiloba Acclimatized Growing in Vietnam by High-Performance Liquid Chromatography with Photodiode Array Detector

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 6-10页

作者： thi Minh Tam Pham thi Thu Cuc Le Van thanh nguyen Viet Hung Tran Departments of Microbiology Institute of Drug Quality ControlHo Chi Minh City Departments of Instrumental Analysis Institute of Drug Quality ControlHo Chi Minh City Institute of Drug Quality Control Ho Chi Minh City Faculty of Pharmacy Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

Background:Chinese Danggui(Angelica sinensis)and Japanese Danggui(Angelica acutiloba)are evaluated as the same in using and critical of quality control in Vietnamese *** Vietnam,Japanese Danggui were acclimatized and cultivated in several regions in recent *** the huge climatic difference between Vietnam and Japan,Japanese Danggui grows very well in ***,there are no studies to assess the overall quality of this medicinal *** and Objectives:The aim of this study is to develop a method to identify and assay simultaneously 5 component compounds of these crude herbs:chlorogenic acid,ferulic acid,scopoletin,xanthotoxin and ligustilide by high-performance liquid chromatography with photodiode array detector(HPLC-PDA).Materials and Methods:The procedure was optimized by using column Phenomenex Gemini 5μm PR C18,15 x 4,6 mm with the detection wavelength set at 321 nm for detector PDA and mobile phase was composed of(A)ACN and(B)aqueous solution 1%of acid acetic using a gradient *** were performed at 30°C with a flow rate of 1.0 mL/***:The developped method were fully validated for linearity,accuracy,recovery and met the validation requirements,proved practical applicability for the quality control of these herbs and related ***:The method was successfully applied to the quantification of five markers simultaneously from collected samples.

关键词： Chlorogenic acid Danggui ferulic acid ligustilide scopoletin xanthotoxin

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Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,Thua thien Hue,Vietnam

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Soil Ecology Letters 2024年第1期6卷 131-140页

作者： Khoa Phuc nguyen Tan Trong Tran Huy Dinh Le Phuong Thuy nguyen Hien Thao thi Pham Dien thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,Thua thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

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The impact of green finance,eco-innovation,renewable energy and carbon taxes on CO_(2) emissions in BRICS countries:Evidence from CS ARDL estimation

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Geoscience Frontiers 2024年第4期15卷 449-458页

作者： Muhammad Sadiq Ka Yin Chau nguyen Tran Thai Ha thi Thu Hien Phan thanh Quang Ngo Pham Quang Huy Carbon Economy Research Center Fuzhou University of International Studies and TradeFuzhou 350202China School of Accounting and Finance Faculty of Business and LawTaylor’s UniversityMalaysia Faculty of Business City University of MacaoTaipaMacaoChina Faculty of Finance and Banking Van Lang UniversityHo Chi Minh CityVietnam Zhejiang Shuren University No.8 Shuren streetHangzhou 310015China School of Government University of Economics Ho Chi Minh City(UEH)Ho Chi Minh City 72407Viet Nam Research Group Public Governance and Developmental Issues University of Economics Ho Chi Minh City(UEH)Ho Chi Minh City 72407Viet Nam Ho Chi Minh City University of Economics and Finance(UEF) Ho Chi Minh CityVietnam University of Economics and Human Sciences in Warsaw WarsawPoland

A sharp increase in economic and human development has multiplied the carbon intensity due to which there is a significant need of effective strategies in order to curb carbon ***,the present study aims to examine the effective of green finance,eco-innovation,renewable energy output(REO),renewable energy consumption(REC),and carbon taxes on carbon dioxide(CO_(2))emissions in BRICS countries in the time of ***-sectional autoregressive distributed lag(CS ARDL)is used to test the connection among the *** estimations of CS-ARDL approach validates the effectiveness of green finance,eco-innovation,REO,REC,carbon taxes,and industrialization as the relationship of these factors with carbon emissions is negative in nature in BRICS *** on the evidences,the study recommends the formulation of environmentally friendly practices and advancement in green finances to mitigate carbon emissions.

关键词： Green finance Eco-innovation Renewable energyoutput Carbon taxes Environmental degradation CO_(2)emissions

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