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Thermodynamic Simulation on the Change in Phase for Carburizing Process

Computers, Materials & Continua 2021年第7期68卷 1129-1145页

作者： Anh Tuan Hoang Xuan Phuong Nguyen Osamah Ibrahim Khalaf thi Xuan Tran minh Quang Chau thi minh hao dong Duong Nam Nguyen Ho Chi minh city University of Technology(HUTECH) HoVietnam Ho Chi minh city University of Transport Ho Chi Minh cityVietnam Al-Nahrain University Al-Nahrain Nanorenewable Energy Research CenterBaghdadIraq Hanoi University of Science and Technology HanoiVietnam Industrial University of Ho Chi minh City(IUH) Ho Chi Minh cityVietnam Vietnam Maritime University HaiphongVietnam

The type of technology used to strengthen the surface structure of machine parts,typically by carbon-permeation,has made a great contribution to the mechanical engineering industry because of its outstanding advantages in corrosion resistance and enhanced mechanical and physical ***,carbon permeation is considered as an optimal method of heat treatment through the diffusion of carbon atoms into the surface of alloy *** study presented research results on the thermodynamic calculation and simulation of the carbon permeability *** Fick’s law,the paper calculated the distribution of carbon concentration in the alloy steel after it is absorbed from the surface into the internal of the *** the SYSWELD software,an analysis was performed on the carbon permeability process to determine the distribution of carbon concentrations in 20CrMo steel that was then followed by a detailed analysis of the microstructure of the sample post the carburizing *** to the calculation results,the surface carbon content was 0.9%and steadily decreased into the *** 3 hours,the depth of the absorbent layer was measured at 0.5 mm for both the cylindrical and cubic *** analyzing the phase,the distribution of martensite phases such as ferrite/pearlite and residual austenite was also determined after the carburizing process.

关键词： Carburizing process 20CrMo steel thermodynamic analysis microstructure formation carbon concentration

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. this finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Temperature-insensitive micro-displacement sensor with spindle-shaped structure single mode fiber

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Optoelectronics Letters 2025年

作者： ZHANG Weihua MU Jinlin WANG hao WANG dong YU haozheng TAO Yipeng Engineering Research Center of Optoelectronic Devices and Communication Technology，Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin University of Technology Engineering Infrastructure Department，Autonomous Driving Department Xiaomi EV Company Ltd

A temperature-insensitive micro-displacement sensor based on a spindle-shaped single mode fiber (SMF) is presented and demonstrated. The SMF is bent into a balloon-shaped SMF and burned into a spindle-shaped SMF by a flame. Due to the bending of the fiber， part of the incident light leaks from the fiber core into the fiber cladding， which excites higher order cladding modes. Therefore， modal interference occurs. The experimental results show that the maximum sensitivity of the sensors is -203 pm/μm when micro-displacement varies from 0 to 80 μm. The sensors are insensitive to temperature in the range of 20-70℃. In addition， the sensors have the advantages of simple structure， low cost， small volume， high sensitivity and stability， which can be widely used in numerous high-precision industrial measurements and civil engineering structure monitoring fields.

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公共交往“频道”的校准:媒介化时代我国公共政治交往话语风格的偏误与匡正

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新闻与传播评论 2025年第1期78卷 35-45页

作者：董浩骆正林南京林业大学人文社会科学学院江苏南京210037 南京林业大学文旅产业与城市传播研究中心江苏南京210037 南京大学新闻传播学院江苏南京210023

在当今的媒介化时代,随着互联网等新媒体技术对国家、社会不断的赋权与公共政治的崛起,公共交往在越来越便捷、普遍、常态化、多元的同时,也出现了一定的问题。其中,最为突出的问题是公共交往过程中组织机构与公民话语风格的偏误问题。... 详细信息

在当今的媒介化时代,随着互联网等新媒体技术对国家、社会不断的赋权与公共政治的崛起,公共交往在越来越便捷、普遍、常态化、多元的同时,也出现了一定的问题。其中,最为突出的问题是公共交往过程中组织机构与公民话语风格的偏误问题。鉴于此,文章立足于政治媒介化的时代背景,在公共政治视域下,借用话语理论,以我国公共政治交往话语实践的经验与教训为分析样本,以无责漫谈与话语独白为考察中心,探讨匡正当下公共政治交往话语风格偏误的方法与进路。研究认为,组织机构与公民应该积极、主动地进行话语转换,向彼此靠近,消减组织机构话语的话语独白与公民话语的无责漫谈,加速两者之间的话语循环与流通。具体举措包括:话语实践效果的想象与预测、话语的技术化处理、“中间人”的话语斡旋、话语的场域转化、话语的流通与循环、话语的破圈传播、话语的理性规制、话语中社会意见的冶炼、话语实践智慧的提炼等。

关键词：公共交流交流的无奈话语风格偏误无责漫谈话语独白话语理论

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-dong Wu Xiao-Jiang hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. this provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Environmental Adaptive Control of a Snake-like Robot With Variable Stiffness Actuators

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 745-751页

作者： dong Zhang hao Yuan Zhengcai Cao IEEE College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

this work investigates adaptive stiffness control and motion optimization of a snake-like robot with variable stiffness actuators. The robot can vary its stiffness by controlling magnetorheological fluid(MRF) around actuators. In order to improve the robot's physical stability in complex environments, this work proposes an adaptive stiffness control strategy. this strategy is also useful for the robot to avoid disturbing caused by emergency situations such as collisions. In addition, to obtain optimal stiffness and reduce energy consumption, both torques of actuators and stiffness of the MRF braker are considered and optimized by using an evolutionary optimization algorithm. Simulations and experiments are conducted to verify the proposed adaptive stiffness control and optimization methods for a variable stiffness snake-like robots.

关键词： Adaptive control snake-like robot variable stiffness

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Coherent quantum transport in normal-metal/d-wave superconductor/normal-metal double tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2004年第2期47卷 256-264页

作者： dong Zhengchao FU hao Department of Physics Huaiyin Teachers College Huaiyin 223001 China Department of Physics Huaiyin Teachers College Huaiyin 223001 China

Taking into account the effects of quantum interference and interface scattering, combining the electron current with hole current contribution to tunnel current, we study the coherent quantum transport in normal-metal/d-wave superconductor/ normal-metal (NM/d-wave SC/NM) double tunnel junctions by using extended Blonder-Tinkham-Klapwijk (BTK) approach. It is shown that all quasiparticle transport coefficients and conductance spectrum exhibit oscillating behavior with the energy, in which periodic vanishing of Andreev reflection (AR) above superconducting gap is found. In tunnel limit for the interface scattering strength taken very large, there are a series of bound states of quasiparticles formed in SC.

关键词： effects of quantum interference, tunneling spectroscopy, bound state.

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Past and future of the central double-degenerate core of Henize 2–428

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Research in Astronomy and Astrophysics 2019年第4期19卷 89-94页

作者： dong-hao Wu dong-dong Liu Bo Wang Yunnan Observatories Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences University of Chinese Academy of Sciences Center for Astronomical Mega-Science Chinese Academy of Sciences

It has been suggested that Type Ia supernovae(SNe Ia) could be produced in the conditions of the violent merger scenario of the double-degenerate model, in which a thermonuclear explosion could be produced when a double carbon-oxygen white dwarf(CO WD) merges. It has been recently found that the nucleus of the bipolar planetary nebula Henize 2–428 consists of a double CO WD system that has a total mass of^1.76 M⊙, a mass ratio of^1 and an orbital period of^4.2 h, which is the first and only discovered progenitor candidate for an SN Ia predicted by the violent merger scenario. In this work, we aim to reproduce the evolutionary history of the central double CO WD of Henize 2–428. We find that the planetary nebula Henize 2–428 may originate from a primordial binary that has a^5.4 M⊙primary and a^2.7 M⊙secondary with an initial orbital period of^15.9 d. The double CO WD was formed after the primordial binary experienced two Roche-lobe overflows and two common-envelope ejection *** to our calculations, it takes about^840 Myr for the double CO WD to merge and form an SN Ia driven by gravitational wave radiation after their birth. To produce the current status of Henize 2–428,a large common-envelope parameter is needed. We also estimate that the rate of SNe Ia from the violent merger scenario is at most 2.9 × 10^(-4) yr^(-1), and that the delay time is in the range of^90 Myr to the Hubble time.

关键词： binaries:close stars:individual stars:evolution supernovae:general white dwarfs

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