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Prevalence of Pulmonary Tuberculosis and Associated Factors among Patients Admitted to the Amissa Bongo University Hospital Center in Franceville, Gabon

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Journal of Biosciences and Medicines 2023年第7期11卷 160-173页

作者： thiéry ndong mba Cedric Sima Obiang Hilaire Moundounga Kenguele Arnaud Brice Pambo-Pambo Iris Kévin Ivala Zogo mba Ulrich Lowens Onkassa Sah Louis-Clement Obame Engonga Cyrille Bisseye Patrick Mickala Laboratory of Molecular and Cellular Biology (LABMC) Masuku University of Science and Technology (USTM) Franceville Gabon Laboratoire de Recherche en Biochimie (LAREBIO) Masuku University of Science and Technology (USTM) Franceville Gabon Animal Physiology Laboratory Masuku University of Science and Technology (USTM) Franceville Gabon South East Regional Health Department Franceville Gabon

Background: In Gabon, the epidemiology of tuberculosis has been considerably reshaped by the AIDS virus. It is in this context that the present study was conducted to assess the prevalence of pulmonary tuberculosis and associated factors among patients at the Amissa Bongo Regional Hospital in Franceville, Gabon. Patients and Methods: this prospective, cross-sectional study was conducted in the biomedical analysis laboratory of the Amissa Bongo Regional University Hospital in Franceville from 19 June 2021 to 22 January 2022. After agreeing to take part in the study, participants were asked to fill in a questionnaire to collect their socio-demographic data and habits. Clinical signs were also observed. Sputum and gastric fluid samples were collected and examined using the Xpert MTB/RIF test and BAAR smear microscopy. Data were analysed using R software version 3.6.1. The results of the univariate and multivariate analyses were considered significant for p ≤ 0.05. Results: A total of 309 patients were included in this study, 50.81% (n = 157) men and 49.19% (n = 152) women. Of these, 98 had a positive diagnosis of pulmonary tuberculosis, giving an overall prevalence rate of 31.72%. There were 40 women or 40.82% (95% CI: [0.30 - 0.51]) and 58 men or 59.18% (95% CI: [0.48 - 0.69]). A univariate analysis of the prevalence of tuberculosis according to risk factors and clinical signs indicated a certain association between certain variables. However, an in-depth multivariate logistic regression analysis of this prevalence, according to the risk factors and clinical signs observed in the patients in the study, indicated that the age group 15 and 49 years (Adjusted OR = 47.77;95% CI: [4.4;519.7] p = 0.001*), fever (Adjusted OR = 4.83;95% CI: [1.16, 20.12] p = 0.031*), alcohol consumption (Adjusted OR = 12.2;95% CI: 12.2 [2.5;5.9] p = 0. 002*), smoking (Adjusted OR = 9.83;95% CI: [1.78;54.24] p = 0.037), HIV infection (Adjusted OR = 4.63;95% CI: [1.25;17.1] p = 0.022), cough (A

关键词： Prevalence Pulmonary Tuberculosis Ziehl-Neelsen Rapid Acid Staining GeneXpert CHURAB Franceville Gabon

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Prevalence and Risk Factors Associated with Tungiasis among School-Aged Children in the City of Port Gentil, Ogooué-Maritime Province, Gabon in Central Africa

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Journal of Biosciences and Medicines 2022年第11期10卷 176-191页

作者： thiéry ndong mba Cédric Sima Obiang Hilaire Moundounga Kenguele Arnaud Brice Pambo-Pambo Adelaïde Niéguitsila Armel Obiandong Eyivono Ulrich Nzamba Cyrille Bisseye Patrick Mickala Laboratory of Molecular and Cellular Biology (LABMC) University of Science and Technology of Masuku (USTM) Franceville Gabon Laboratory of Research in Biochemistry (LAREBIO) University of Sciences and Techniques of Masuku (USTM) Franceville Gabon Laboratory of Animal Physiology University of Science and Technology of Masuku (USTM) Franceville Gabon Laboratory of Multidisciplinary Research in Environment (LARME) University of Science and Technology of Masuku (USTM) Franceville Gabon

Background: Tungiasis is a skin infestation caused by the female sand flea called Tunga penetrans. Associated with a significant morbidity, this ectoparasite is present in all tropical regions, such as Gabon. Unfortunately, in this country, no study has ever been undertaken on this disease. However, in both urban and rural areas of this country, it causes disfigurement and mutilation of the feet or hands in infested persons, and is sometimes responsible for the school dropout of many children. It is in this context that this timely and relevant research was conducted to assess the prevalence and risk factors associated with Tungiasis in school-aged children in the city of Port Gentil, Ogooué-Maritime province, Gabon in Central Africa. Materials and Methods: this prospective and cross-sectional study took place from May 22 to August 18, 2022, in two popular and underprivileged neighborhoods of the city of Port Gentil. It consisted of a physical diagnosis of the participants, and with the help of a questionnaire submitted to their parents/guardians, numerous data were collected. Entered into an Excel 2016 spreadsheet, the data were exported to the R software in its R Commander interface, for two types of analyses. A univariate and a multivariate analysis, using logistic regression, first on socio-demographic characteristics and then on habitual and environmental behavioral characteristics, was performed and the variables in this analysis reported odds ratios and their 95% confidence intervals. The results were statistically significant at p Results: A total of 637 school-aged children with a mean age of 12.73 years and a standard deviation of 5.44, were registered and examined for this study. Among them, Tunga penetrans infestation was found in 242 children, indicating an overall prevalence of 37.99% (95% CI [0.34 - 0.41]). Univariate and multivariate analyses, using logistic regression, first according to socio-demographic characteristics and then according to risk f

关键词： Prevalence Risk Factors Tungiasis School-Aged Children Port Gentil Ogooué-Maritime Gabon

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肺癌SEMA3B基因的表达及其临床意义

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中华实验外科杂志 2004年第6期21卷 713-714页

作者： mba-ndong N 程邦昌周芳熊美华邵康赫捷武汉大学人民医院心胸外科 430060 中国医学科学院肿瘤医院胸外科

目的　探讨新型候选抑癌基因SEMA3B在肺癌组织中的表达及其与肺癌发生、发展的关系。方法　采用逆转录聚合酶链反应 (RT PCR)方法检测 5 2例肺癌组织及远癌正常肺组织SEMA3B基因产物的表达水平。结果　肺癌组织中SEMA3B的表达率为 5 1... 详细信息

目的　探讨新型候选抑癌基因SEMA3B在肺癌组织中的表达及其与肺癌发生、发展的关系。方法　采用逆转录聚合酶链反应 (RT PCR)方法检测 5 2例肺癌组织及远癌正常肺组织SEMA3B基因产物的表达水平。结果　肺癌组织中SEMA3B的表达率为 5 1.9% (2 7/5 2 )明显低于远癌正常肺组织 10 0 .0 % (5 2 /5 2 ) ,P 0 .0 5 )。结论　SEMA3B表达异常可能在中国人群肺癌发生。

关键词： SEMA3B 肺癌逆转录一聚合酶链反应癌组织中表达

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